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  • neurotransmitter
  • S )-Glutamate is the primary excitatory neurotransmitter in the vertebrate central nervous system. (aspetjournals.org)
  • To quench the neurotransmitter stimulus, synapses harbor membrane-bound transporters that pump the transmitter out of the synapse and into neighboring cells, allowing the transmitter to be recycled for additional rounds of stimulation. (hhmi.org)
  • synaptic
  • The GABA A receptor, a member of the ligand-gated ion channel family, mediates synaptic inhibition through the gating of chloride ions, resulting in hyperpolarization of the cell membrane. (aspetjournals.org)
  • residue
  • This link, which we call the 'glutamate switch', regulates ATPase activity directly in response to the binding of target ligands by controlling the orientation of the conserved glutamate residue in the DExx motif, switching it between active and inactive conformations. (blogspot.com)
  • NMDAR
  • We wondered if anti-DNA, anti-peptide cross-reactive Abs might bind NMDAR and so potentially affect both cognitive functions and mood. (jimmunol.org)
  • thus, we reasoned that R4A might preferentially bind the open configuration of the NMDAR, enhancing the effects of a true agonist but not functioning as one. (jimmunol.org)
  • domain
  • All AMPARs contain PDZ-binding domains, but which PDZ domain they bind to differs. (wikipedia.org)
  • TC# 9.A.14.7.3) share an ANF receptor family, ligand binding region/domain (M. Saier, unpublished observation). (tcdb.org)
  • These results reveal a new role for this linker domain in glutamate receptor biogenesis and contribute to understanding the cellular controls of receptor assembly and trafficking, which will be important for relating receptor stoichiometry to their neuronal targeting and function. (jneurosci.org)
  • This domain is modeled as a critical linker that transduces ligand-binding energy into channel gating ( Jin and Gouaux, 2003 ). (jneurosci.org)
  • It might also occur between two sensory domains such as PAS domains and occasionally between a DNA-binding HTH domain and a sensory domain. (beds.ac.uk)
  • However, upon occurrence of specific conformational changes due to binding of ligand or other sensory inputs in a linked upstream domain it transmits the signal to the downstream domain. (beds.ac.uk)
  • Point mutations have been reported in the RARα ligand-binding domain of PML-RARα in cases with acquired resistance to RA ( 12 ). (rupress.org)
  • triggers
  • This interaction triggers the ligand translocation across the cytoplasmic membrane energized by ATP hydrolysis. (bu.edu)
  • cyclothiazide
  • Crystallographic data show that these compounds bind within the modulator-binding pocket and that substituents of each compound overlap with distinct moieties of cyclothiazide and CX614. (aspetjournals.org)
  • These can either trap the channel in an opened state, for example PDB entry 6DM1 with the diuretic and anti-hypertensice cyclothiazide bound, or a closed state, both of which inhibit the function of the channel. (ebi.ac.uk)
  • neuron
  • One of the most important neurotransmitters is gamma-aminobutyric acid (GABA), which binds to its type A receptor (GABA A -receptor) to exert an inhibitory influence on the neuron. (llnl.gov)
  • glutamine
  • A tandem where one of the essential glutamates was replaced with glutamine transported only monovalent substrates and displayed a modified stoichiometry. (embopress.org)