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  • molecules
  • In addition to the simple Lewis acids, there are several complex molecules that can act as both L- and Z-ligands. (wikipedia.org)
  • Inte:Ligand develops the most innovative and user friendly modeling software platforms and provides expert consulting to inspire the innovative process of designing molecules, filtering ideas, and de-risking candidates assessed in early discovery projects. (wikipedia.org)
  • vitamin D recept
  • Here we show that vitamin D receptor (VDR) ligands inhibit HSC activation and abrogate liver fibrosis, while VDR knockout mice spontaneously developed hepatic fibrosis. (garvan.org.au)
  • Calcitriol (1,25D(3)), which is the active hormonal ligand for the vitamin D receptor (VDR), a member of the NR superfamily, induces osteoblastic cell cycle arrest and expression of genes involved in matrix mineralization in vitro, with over-expression of VDR in mature osteoblasts increasing bone mass in mice. (garvan.org.au)
  • human
  • Human Programed Death Ligand-1 (PDL1/B7-H1/CD274) ELISA Kit or ELISA (enzyme-linked immunosorbant assays) Kits in general, are a valuable research tool for a myriad of applications in a range of scientific settings. (mybiosource.com)
  • Unexpectedly, however, these iNKT TCRs showed greater ligand selectivity toward human CD1d presenting the same lipids. (antibody-antibodies.com)
  • activation
  • Compared with WT-Flt3-32D cells upon ligand stimulation, 32D-Y589F-Flt3 showed enhanced Erk activation and proliferation/survival, whereas 32D-Y599F-Flt3 cells hereby displayed substantially diminished responses. (antibody-antibodies.com)
  • domain
  • GENTAUR antibody-antibodies.com The Marketplace for Antibodies : Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2. (antibody-antibodies.com)
  • channel
  • In addition to its functional significance, desensitization provides one means to examine the conformational coupling of ligand binding to channel gating. (garvan.org.au)
  • The NR2 ligand glutamate was insufficient on its own to induce modification of V557C by MTSET, suggesting that the change in accessibility required channel gating. (garvan.org.au)