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  • cisplatin-induced hear
  • Our recent financing enables us to expand the scope of our development efforts, and the clinical evaluation of OTO-104 for the prevention of cisplatin-induced hearing loss is a priority based on the high unmet medical need, attractive market potential, and preclinical proof-of-concept presented in this publication," said David A. Weber, Ph.D., president and CEO of Otonomy. (cnbc.com)
  • cytotoxicity
  • uses a different tactic to prevent off-target cytotoxicity: baiting chemotherapy drugs into cleverly designed intracellular nanotraps. (sciencemag.org)
  • In vitro, these Au-ODN composite "nanotraps" resisted degradation by DNase I, spontaneously implanted themselves into the cytoplasm of L02 normal human liver cells, inhibited the translocation of DOX into nuclei, and prevented DOX-induced cytotoxicity. (sciencemag.org)
  • Functionally, stimulation of TLR2 induced synthesis and drug efflux activity of ABCB1/MDR1 p-gp in murine and human CD11b + -myeloid cells, thus inhibiting chemotherapy-mediated cytotoxicity. (jimmunol.org)
  • CIPN
  • it blocks tumor cell growth while protecting neurons and reducing or preventing CIPN," Dr. Kelley said. (iu.edu)
  • That's because patients have been asking for a better quality of life as oncologists have been able to improve survival, and there has been a particular push for more attention to CIPN in the US, where patients tend to be more demanding, and as other side-effects can now be better managed," he says. (cancerworld.net)
  • What is a puzzle with CIPN is that, while it is known that nerve endings start to be damaged and can get progressively worse with chemotherapy, currently there is no way to tell what an individual's risk is for developing neuropathy. (cancerworld.net)
  • cancers
  • CR also protects against spontaneous cancers and against carcinogen-induced cancers ( 10 - 12 ), raising the possibility that CR and reduced IGF1 may increase stress resistance by similar mechanisms. (pnas.org)
  • While it only occurs in certain classes of chemotherapies used in some cancers, the treatments are among the more common, such as taxanes for breast cancer, and platinum agents for colorectal tumours (see table below). (cancerworld.net)
  • Rising interest upon the interrelationship among the apoptotic and autophagy paths in the circumstance of cancers chemotherapy is normally offering interesting discoveries. (cylch.org)
  • neuropathy
  • It is believed that neuropathy develops over time as a cumulative effect of chemotherapy that alters functions in neurons-or nerve cells. (iu.edu)
  • Oncologists are often faced with a difficult decision about whether to stop or alter potentially life-saving treatment, and problems with neuropathy are a common reason for patients themselves deciding to stop therapy. (cancerworld.net)
  • However, more information is needed on why patients develop neuropathy and how it impacts their mood, ability to function, and their quality of life. (clinicaltrials.gov)
  • dose
  • Screen a 2500-compound library of FDA-approved drugs (Enzo Life Sciences) in human iHC screen for requisite otoprotective effects ("hits") against an LD50 dose of cisplatin. (ca.gov)
  • When it happens, the dose of chemotherapy is adjusted right away or chemotherapy may have to be stopped temporarily. (cancer.ca)
  • When considering both the exposure rate and half-life, it appears that similar doses of iron-52, yttrium-86, and iodine-124 deliver a high dose rate immediately after injection and during the following few hours. (irsn.fr)
  • sensory
  • Development of a screen using inner ear sensory hair cell-like cells made by direct lineage reprogramming, for discovering drugs to ameliorate hearing loss during cancer chemotherapy. (ca.gov)
  • Attenuate
  • The results suggested that the oral administration of CI SCFE combined with BLM could markedly prolong the life span, attenuate the BLM-induced pulmonary fibrosis, suppress the production of pro-inflammatory cytokines (interleukin-6), tumor necrosis factor-α, activities of myeloperoxidase, and malondiadehyde. (mdpi.com)
  • complication
  • For example, they can experience epistaxis (nosebleeds), they tend to bruise easily, their gums bleed and in a life-threatening complication, they can suffer intracranial haemorrhage. (pharmiweb.com)
  • drugs
  • This proposal uses state-of-the-art stem cell techniques to develop a screen to discover drugs that prevent hearing loss due to life-saving chemotherapy. (ca.gov)
  • Chemotherapy drugs affect cells that are actively growing and dividing, such as blood cells in the bone marrow, cells lining the mouth and gastrointestinal (GI) tract and hair follicle cells. (cancer.ca)
  • Fatigue may be caused by anemia, specific chemotherapy drugs, poor appetite or depression. (cancer.ca)
  • Some chemotherapy drugs can cause temporary changes in taste and smell, which can make food less appetizing. (cancer.ca)
  • Hair loss (alopecia) is a common side effect of many, but not all, chemotherapy drugs. (cancer.ca)
  • Hair follicles are damaged by chemotherapy because the drugs affect cells that are growing quickly. (cancer.ca)
  • It happens because chemotherapy drugs often affect the cells that line the gastrointestinal (GI) tract. (cancer.ca)
  • synthesis
  • simple tools to protect your personal information and of Ketone focus by cryopreserved synthesis with mountaineering and populations in areas with supplementation control: a human folate Table. (greggandjenny.com)
  • disease
  • Develop and optimize induced human hair cell-like cell screening technology for cisplatin ototoxicity (Aim 1), for use in otoprotectant screening (Aim 2) and disease modeling (Aim 3). (ca.gov)
  • cardiac
  • Enalaprilat increases PPARβ/δ expression, without influence on PPARα and PPARγ, and modulate cardiac function in sub-acute model of daunorubicin-induced cardiomyopathy. (semanticscholar.org)
  • Diseases
  • simple tools to protect your personal information and your and onset P in diseases with installment cause evaluating Potential lens before country. (greggandjenny.com)
  • acute
  • This study demonstrated that intratympanic administration of 6% OTO-104 protected against ototoxicity observed following both acute and repeat administration of the chemotherapeutic agent cisplatin. (cnbc.com)
  • dietary
  • simple tools to protect your personal information and your and work of riling two dietary intense trial studies with the tissue of type accommodation for valley problem in oil emergency amounts. (greggandjenny.com)