ProteinsAnimal venomsToxinsMammalianAntimicrobialSnakePolypeptidesAntibodiesSynthetic peptideProteaseTarantulaBitisVitroReceptorsAminoDisintegrinsDiphtheriaToxinologyNeurotoxinWaspInsectInhibitoryConeAntitumorCharacterizationTherapeuticNaturallyPotentDrugsExtractMolecularProtein-basedPharmaceuticalMuscleMurineFoundApproachesNaturalStudyScientificMechanismPresentResultsPotentialImportantCellsFamilyTreatmentCell
Proteins5
- [10] Gandecha A., Owen M. R., Cockburn W., Whitelam G. C. Antigen detection using recombinant, bifunctional single-chain Fv fusion proteins synthesised in Escherichia coli Protein Exp. (org.ua)
- The production of artificial silks in the laboratory (for example using recombinant arthropod silk proteins expressed in bacteria) has the potential to deliver new smart protein materials with tunable properties and green chemistry. (edu.au)
- Toxins can be small molecules , peptides , or proteins that are capable of causing disease on contact with or absorption by body tissues interacting with biological macromolecules such as enzymes or cellular receptors . (wikipedia.org)
- 2-6 In vitro, the binding of vWF to GPIb can be promoted by the interaction of vWF with nonphysiological inducers like the antibiotic ristocetin or the snake venom proteins botrocetin or bitiscetin. (ashpublications.org)
- Finally, the further GIX sPLA 2 s are found in venom of marine snails, and GXIA and GXIB sPLA 2 s are plant proteins. (ijbs.com)
Animal venoms4
- Molecules from animal venoms are promising candidates for the development of new drugs. (nature.com)
- More recently, however, animal venoms have been attracting attention and studies have been successful in addressing treatment of accidents. (scielo.br)
- A new generation of drugs is likely to emerge from peptides, including those found in animal venoms. (scielo.br)
- The focus is on toxic components of animal venoms acting on different targets in the cell membrane. (xenbase.org)
Toxins3
- Furthermore, venoms and their toxins have been considered good tools for prospecting for new active drugs or models for new therapeutic drugs. (scielo.br)
- In this review, we discuss some possibilities of using different toxins, especially those from arachnid venoms, which have shown some potential application in diseases involving pain, hypertension, epilepsy and erectile dysfunction. (scielo.br)
- A decade after publication of the first edition, the Handbook of Venoms and Toxins of Reptiles PDF responds to extensive changes in the field of toxinology to endure as the most comprehensive review of reptile venoms on the market. (vet-ebooks.com)
Mammalian2
Antimicrobial2
- Natural antimicrobial peptides (AMPs) with potent antiviral activities are potential hits-to-leads for antiviral drug discovery. (biomedcentral.com)
- Natural antimicrobial peptides (AMPs) are produced in the majority of living organisms as protection against various pathogens, including viruses. (biomedcentral.com)
Snake1
- A family of polypeptides purified from snake venoms, which contain the arginine-glycine-aspartic acid (RGD) sequence. (rush.edu)
Polypeptides1
- My research interests are centred around the structure and function of venom and silk polypeptides produced by arthropods, and their use in biotechnology and medicine. (edu.au)
Antibodies4
- For indirect mapping, peptide-specific rabbit antibodies were raised to block IgE against surface-exposed epitopes on folded Art v 1. (openscience.si)
- [12] Oliinyk O. S., Kaberniuk A. A., Redchuk T. A., Korotkevich N. V., Labyntsev A. U., Romanyuk S. I., Kolibo D. V., Komisarenko S. V. Construction of immune library of murine immunoglobulin genes and screening of single chaine Fv-antibodies to diphtheria toxin B subunit. (org.ua)
- [16] Verdoliva A., Pannone F., Rossi M., Catello S., Manfredi V. Affinity purification of polyclonal antibodies using a new allD synthetic peptide ligand: comparison with protein A and protein G J. Immunol. (org.ua)
- Recombinant Human Novel Coronavirus Spike glycoprotein(S) (D614G), partial (Active) referenced in "Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries", Cell discovery , 2021. (cusabio.com)
Synthetic peptide1
- Evaluation of the effects of phosphorylation of synthetic peptide substrates on their cleavage by caspase-3 and -7. (salvesenlab.org)
Protease2
- Design, synthesis, and in vitro evaluation of aza-peptide aldehydes and ketones as novel and selective protease inhibitors. (salvesenlab.org)
- The Ltc 1 peptide showed a significantly inhibitory effect against the dengue protease NS2B-NS3pro at 37°C, a physiological human temperature, (IC 50 , 12.68 ± 3.2 μM), and greater inhibitory effect was observed at 40°C, a temperature similar to a high fever (IC 50 , 6.58 ± 4.1 μM). (biomedcentral.com)
Tarantula2
- In the present study, two new peptides, phrixotoxins PaTx1 & PaTx2 (29-31 amino acids), which potently block A-type potassium currents, have been purified from the venom of the tarantula Phrixotrichus auratus. (smartox-biotech.com)
- GsMtx-4 is a peptide found in tarantula venom that inhibits mechanosensitive ion channel (MSC) activity. (drugbank.com)
Bitis1
- We have purified bitiscetin from Bitis arietans venom and investigated the mechanism whereby it promotes a form of vWF that is reactive with platelets. (ashpublications.org)
Vitro3
- Previous in vitro studies have shown that the venom of the spider Phoneutria nigriventer (PnV) is a potential source of antineoplastic components with activity in glioblastoma (GB) cell lines. (nature.com)
- The effect of venom was also evaluated on macrophages in vitro . (nature.com)
- A recent in vitro screening of the Phoneutria nigriventer spider venom (PnV) antitumor effects by our group has shown that the venom significantly affected glioblastoma cell lines. (nature.com)
Receptors1
- Biotoxins vary greatly in purpose and mechanism, and can be highly complex (the venom of the cone snail can contain over 100 unique peptides , which target specific nerve channels or receptors). (wikipedia.org)
Amino5
- Methods: Four overlapping peptides incorporating surface-exposed amino acids representing the full-length Art v 1 sequence were synthesized and used to search for IgE reactivity to sequential epitopes. (openscience.si)
- Phrixotoxin-2 is a 31 amino acid peptide that contains three disulfide bridges. (smartox-biotech.com)
- Chlorotoxin is a small 36-amino-acid peptide that selectively binds to glioma cells but not normal brain. (drugbank.com)
- Research peptides are short chains of amino acids used by scientists and researchers in various fields, including biology, chemistry, and medicine. (hi-peptide.com)
- They are typically composed of a short chain of amino acids, much like naturally occurring peptides in the body. (hi-peptide.com)
Disintegrins1
- Disintegrins" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
Diphtheria4
- The cloning of genes of diphtheria toxin's recombinant subunits of Corynebacterium diphtheriae and their expression in Esherichia coli cells. (org.ua)
- 3. Agarwal M, Mondal T, Bose B " Peptides derived from a short stretch of diphtheria toxin bind to heparin-binding epidermal growth factor-like growth factor" , Toxicon, DOI. (iitg.ac.in)
- 6. Agarwal M, Sahoo AK, Bose B. " Receptor-Mediated Enhanced Cellular Delivery of Nanoparticles Using Recombinant Receptor-Binding Domain of Diphtheria Toxin. (iitg.ac.in)
- 9. Kumar A, Das G, Bose B. " Recombinant Receptor-binding Domain of Diphtheria Toxin Increases Potency of Curcumin by Enhancing Cellular Uptake" , Molecular Pharmacology, DOI. (iitg.ac.in)
Toxinology1
- Venom systems are the subject of increasing attention for studies of molecular evolution, trait evolution, pharmacology, drug discovery, and toxinology. (edu.au)
Neurotoxin1
- [4] Aubrey N., Devaux C., di Luccio E., Goyffon M., Rochat H., Billiald P. A recombinant scFv/streptavidin-binding peptide fusion protein for the quantitative determination of the scorpion venom neurotoxin AahI Biol. (org.ua)
Wasp3
- Allergy to bee and wasp venom can lead to life-threatening systemic reactions. (openscience.si)
- To determine a panel of recombinant bee and wasp allergens which is suitable for the identification of bee or wasp as culprit allergen sources and to search for molecular surrogates of clinical severity of sting reactions. (openscience.si)
- Sera from eighty-seven patients with a detailed documentation of their severity of sting reaction (Mueller grade) and who had been subjected to titrated skin testing with bee and wasp venom were analyzed for bee and wasp-specific IgE levels by ImmunoCAPTM. (openscience.si)
Insect1
Inhibitory3
- We performed this study to identify and characterise the inhibitory potential of the latarcin peptide (Ltc 1, SMWSGMWRRKLKKLRNALKKKLKGE) against dengue virus replication in infected cells. (biomedcentral.com)
- The Ltc 1 peptide exhibited significant inhibitory effects against dengue NS2B-NS3pro and virus replication in the infected cells. (biomedcentral.com)
- Some studies show that Mast Cell Degranulating Peptide (MCDP) augments the release of excitatory and inhibitory transmitter by an action, which is independent of calcium influx, through voltage-dependent channels. (watsonbio.com)
Cone1
- XEN-2174 is a synthetic drug modeled on a peptide from the venom of a cone shell found on Australia's Great Barrier Reef. (drugbank.com)
Antitumor2
- Studies in progress are selecting the venom molecules with antitumor and immunomodulatory effects and trying to better understand their mechanisms. (nature.com)
- The aim of the present work is to purify SOD from the Egyptian honeybee venom Apis mellifera lamarckii , comprehensively discuss their characteristics, with emphasis on their potential antibacterial and antitumor activities. (springeropen.com)
Characterization1
- We reported the purification and characterization of venom SOD from Egyptian honeybee Apis mellifera lamarckii and termed BVSOD. (springeropen.com)
Therapeutic1
- Therefore, further investigation is necessary to develop the Ltc 1 peptide as a new anti-dengue therapeutic. (biomedcentral.com)
Naturally2
- It is an important intermediate in chemical synthesis and occurs naturally, most famously in the venom of bee and ant stings. (drugbank.com)
- The D-stereoisomer is occasionally found in naturally produced peptides (for example, the marine venom peptide contryphan). (drugbank.com)
Potent1
- A new peptide (Ruviprase) purified from the venom of Daboia russelii russelii shows potent anticoagulant activity via non-enzymatic inhibition of thrombin and factor Xa" , Biochimie, DOI. (iitg.ac.in)
Drugs1
- Drug Development: Pharmaceutical companies utilize research peptides to develop new drugs and therapies. (hi-peptide.com)
Extract1
- venom reservoir and sting device were removed, then disrupted in Eppendorf with 2.5 ml of H 2 O, and then centrifuged at 12,000 × g, 5 min, 4 °C. The supernatants were obtained and designated venom extract. (springeropen.com)
Molecular3
- Severities of sting reactions were not associated with results obtained by skin testing, venom-specific IgE levels or molecular diagnosis. (openscience.si)
- at the same time developing protein and peptide-based tools that will allow us to manipulate cellular processes on a molecular level. (stanford.edu)
- This greatly expanded handbook offers a unique resource for biologists, biochemists, toxicologists, physicians, clinicians, and epidemiologists, as well as informed laypersons interested in the biology of venomous reptiles, the biochemistry and molecular biology of venoms, and the effects and treatment of human envenomation. (vet-ebooks.com)
Protein-based2
- Bioengineered yeasts have also been used for vaccine development, reprogramming a protein's fate, directed evolution, and protein-based library screening. (mdpi.com)
- VEGF-targeted active immunotherapies are based on different approaches, from DNA vaccines to peptide or protein-based vaccines [13, 14]. (researchsquare.com)
Pharmaceutical1
- Superoxide dismutase is an important antioxidative stress enzyme which is found in honeybee venom and has a wide pharmaceutical and medical applications. (springeropen.com)
Muscle4
- Performance Enhancement: Athletes and fitness enthusiasts are increasingly interested in the potential benefits of research peptides, such as improved muscle growth and recovery. (hi-peptide.com)
- Growth Hormone Releasing Peptides (GHRPs): Studied for their potential in enhancing growth hormone levels and promoting muscle growth. (hi-peptide.com)
- GHRP Research Peptides for Muscle Growth: What Are They and How Do They Work? (hi-peptide.com)
- These peptides have gained attention due to their role in regulating various physiological processes, including muscle growth and repair. (hi-peptide.com)
Murine1
- The venom was effective at impairing tumor development in murine xenogeneic model, activating the innate immune response and increasing tumor infiltrating macrophages. (nature.com)
Found1
- Narses is become away Alternative Methods in the origin for Damodara to save ' found ' silicon and to conform ' n't formed, ' but it is particularly recombinant advisers for Damodara and Rana Sanga's V. Damodara includes to quite be himself resource and Hell on the Malwa updates that will badly deal representing him and his first program. (andrewlost.com)
Approaches1
- General approaches have been elaborated to active venom components identification, isolation, structure-function analyses and use as high-precision tools modulating neural membrane receptor activity. (xenbase.org)
Natural3
- It is the synthetic form of a natural peptide extracted from the venom of the Conus Geographus sea snail. (drugbank.com)
- During this time, he has developed HPLC-mass spectrometry interfaces, methods of analysis for natural products, drug and pesticide analysis, peptide and protein analysis. (edu.au)
- GHRPs are a family of peptides designed to mimic the natural mechanisms that regulate the release of growth hormone in the body. (hi-peptide.com)
Study1
- These teledermatologists would directly refer on passing the last perception of peptide and study of all queries thrilled. (andrewlost.com)
Scientific1
- Growth Hormone Releasing Peptides, often abbreviated as GHRPs, are a class of synthetic peptides used in scientific research to investigate their potential in stimulating the release of growth hormone (GH) from the pituitary gland. (hi-peptide.com)
Mechanism1
- [17] [18] Biotoxins can be classified by their mechanism of delivery as poisons (passively transferred via ingestion, inhalation, or absorption across the skin), toxungens (actively transferred to the target's surface by spitting, spraying, or smearing), or venoms (delivered through a wound generated by a bite, sting, or other such action). (wikipedia.org)
Present1
- Amyloid B-protein/amyloid A4 is a peptide present in the neuritic plaques, neurofibrillary tangles and cerebrovascular deposits in patients with Alzheimer's disease and Down's syndrome (trisomy 21) and may be involved in the pathogenesis of Alzheimer's disease. (embl.de)
Results1
- Results: Mugwort-allergic patients and humanized mice sensitized by allergen inhalation showed IgE reactivity and/or basophil activation mainly to folded, complete Art v 1 but not to unfolded, sequential peptide epitopes. (openscience.si)
Potential1
- In this comprehensive guide, we'll explore the fascinating realm of research peptides, from their definition to their range of potential uses. (hi-peptide.com)
Important1
- Conclusions: Identification of the new major conformational IgE binding site on Art v 1, which can be blocked with IgG raised against non-IgE reactive Art v 1 peptides, is an important basis for the development of a hypoallergenic peptide vaccine for mugwort allergy. (openscience.si)
Cells2
- 11. Das AB, Loying P, Bose B. " Human recombinant Cripto-1 increases doubling time and reduces proliferation of HeLa cells independent of pro-proliferation pathways. (iitg.ac.in)
- The venom increased monocytes, neutrophils and NK cells, and this effect was the opposite of that observed in the animals treated with MTX. (nature.com)
Family1
- The peptide predicted from this insert is very similar to the Kunitz family of serine proteinase inhibitors. (embl.de)
Treatment1
- Treatment with the Ltc 1 peptide reduced the viral RNA in a dose-dependent manner with EC 50 values of 8.3 ± 1.2, 7.6 ± 2.7 and 6.8 ± 2.5 μM at 24, 48 and 72 h, respectively. (biomedcentral.com)
Cell2
- Mast Cell Degranulating Peptide (MCDP) is a neurotoxic agent isolated from bee venom. (watsonbio.com)
- Mast Cell Degranulating Peptide (MCDP) inhibited non-competitively the binding of both radiolabelled dendrotoxin and beta-bungarotoxin but with relatively low potency. (watsonbio.com)