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  • testis
  • Given that the focal areas of Leydig cell hyperplasia are nowadays easily detectable at ultrasonography of the testis (US), as small non-palpable hypoechoic micro-nodules that can show internal vascularization, their finding create a diagnostic challenge versus low-stage malignant germ cell tumors. (clinicaltrials.gov)
  • Cells in Mice
  • Few data have suggested how norepinephrine (NE) and acetylcholine (Ach) regulate the development of Leydig cells in mice at prepuberty, except for data indicating endocrine effects. (hindawi.com)
  • Therefore, a conclusion may be reached that NE and Ach participated in stimulating the development of Leydig cells in mice from prepuberty to adult stage. (hindawi.com)
  • Endocrinology
  • Leydig cell influence," Trends in Endocrinology and Metabolism 20(3): 139-145. (thefreedictionary.com)
  • B. El-Asmar, X. C. Giner, and J. J. Tremblay, "Transcriptional cooperation between NF- κ B p50 and CCAAT/enhancer binding protein β regulates Nur77 transcription in Leydig cells," Journal of Molecular Endocrinology , vol. 42, no. 2, pp. 131-138, 2009. (hindawi.com)
  • R. S. Ge and M. P. Hardy, "Decreased cyclin A2 and increased cyclin G1 levels coincide with loss of proliferative capacity in rat Leydig cells during pubertal development," Endocrinology , vol. 138, no. 9, pp. 3719-3726, 1997. (hindawi.com)
  • vitro
  • This is the first time that we have reported that fluoride impaired cytomembrane and cytoskeleton of the Leydig cells in vitro treated with different doses of fluoride for 24 h by using a scanning electron microscope. (springer.com)
  • Here, we further investigated the differential miRNA expression induced by DOX in mouse spermatogonial (GC1), Leydig (TM3) and Sertoli (TM4) cell lines in vitro . (rsc.org)
  • germ cell
  • C) Microarray analysis results confirm the enrichment for well-established Sertoli cell-specific transcripts, as well as the negative enrichment for Leydig and germ cell markers in the IPs from AMH-Cre: RiboTag mice. (nih.gov)
  • D) Similar analysis in Cyp17iCre: RiboTag IPs revealed a significant enrichment for Leydig cell-specific transcripts and a negative enrichment for germ cell-specific mRNAs. (nih.gov)
  • mice
  • The development of transgenic mice that are homozygous for targeted deletion of genes encoding the ER subtypes provides an opportunity to examine the role of estrogen in Leydig cell function. (popcouncil.org)
  • In this study androgen biosynthesis was analyzed in Leydig cells from mice that were homozygous for targeted deletion of the ERα gene (αERKO). (popcouncil.org)
  • estrogen
  • Leydig cells, which produce the primary male steroid hormone testosterone (T), express the two estrogen receptor (ER) subtypes, ERα and ERβ, and have the capacity to convert testosterone to the natural estrogen 17β-estradiol. (popcouncil.org)
  • Thus, Leydig cells are subject to estrogen action. (popcouncil.org)
  • The results of these experiments indicate that the carcinogenic effect of 17β-estradiol results from an action of this estrogen directly upon the Leydig cells rather than by either the action of some systemic metabolite or the alteration of the general endocrine status of the animals. (aacrjournals.org)
  • receptors
  • Prolactin (PRL) increases the response of Leydig cells to LH by increasing the number of LH receptors expressed on Leydig cells. (wikipedia.org)
  • Firstly, the expression of adrenergic receptors and muscarinic acetylcholine receptors in Leydig cells was investigated. (hindawi.com)
  • It was found that adrenergic receptors ( β 1AR, β 2AR, and α 1D) and muscarinic acetylcholine receptors (M1 and M3) mRNA are expressed in adult Leydig cells. (hindawi.com)
  • diagnosis
  • A diagnosis of Leydig cell hypoplasia is usually made in the neonatal period, following the discovery of ambiguous genitalia, or at puberty, when secondary sex characteristics fail to develop. (wikipedia.org)
  • Franz
  • Franz Leydig was born on May 21, 1821, in Rothenburg ob der Tauber (on the Tauber river). (wikipedia.org)
  • Leydig studied philosophy in Munich from 1840, and medicine at the University of Würzburg from 1842 under Martin Münz (1785-1848), Schenk, and Franz von Rinecker (1811-1883). (wikipedia.org)
  • During his lifetime, Franz Leydig was granted many honours, including personal ennoblement, and an honorary doctorate of science from the University of Bologna. (wikipedia.org)
  • Leydig cells are named after the German anatomist Franz Leydig, who discovered them in 1850. (wikipedia.org)
  • gonadotropin
  • Disorders of sex development Intersexuality, pseudohermaphroditism, and ambiguous genitalia Hypogonadism and hypogonadotropic hypogonadism Familial male-limited precocious puberty (or LH oversensitivity) Follicle-stimulating hormone insensitivity Gonadotropin-releasing hormone insensitivity Inborn errors of steroid metabolism Isolated 17,20-lyase deficiency Combined 17α-hydroxylase/17,20-lyase deficiency 17β-Hydroxysteroid dehydrogenase III deficiency Androgen insensitivity syndrome "OMIM Entry - # 238320 - LEYDIG CELL HYPOPLASIA, TYPE I". omim.org. (wikipedia.org)
  • However, Leydig cells responded robustly to gonadotropin deprivation and LH restoration with acute changes in polysome-associated mRNAs. (nih.gov)