Lewis antigen. Medical search. Frequent questions

These antibodies have been verified by Relative expression to confirm specificity to Blood Group Lewis A. Find the Blood Group Lewis A antibody that fits your needs. (thermofisher.com)
Antibodies with Advanced Verification data have been validated for specificity to ensure that the antibody binds to the antigen stated. (thermofisher.com)
First, oral tolerance is never absolute (complete), that is, parenteral immunization of tolerant animals with the tolerated antigen may induce antibody formation at levels inversely proportional to the ingested (tolerizing) dose of the antigen, but, this antibody formation can no longer be boostered by further parenteral immunizations [ 6 ]. (hindawi.com)
We have generated a novel monoclonal antibody (mAb) (mAb 4A11), which detects the blood group antigens Lewis y and H-5-2 (collectively termed the 4A11 antigen). (biomedcentral.com)
Such therapy functions through mediating alterations in antigen or receptor function, modulating the immune system or delivering a specific drug that is conjugated to an antibody that targets a specific antigen. (justia.com)
The fundamental basis of antibody-based cancer therapy is the fact that cancerous tissues express an array of antigens that may be overexpressed, selectively expressed or mutated compared to normal, non-cancerous tissue. (justia.com)
However, a key challenge in developing candidate therapeutic antibodies for cancer is the identification of antigens suitable for antibody-based therapy. (justia.com)
Suitability of an antigen for therapy is dependent on various factors including but not limited to the nature of the antigen (e.g. accessibility, abundance, location of expression on cancerous cells etc.), therapeutic approach, antibody affinity and other pharmacokinetic properties. (justia.com)
We report intracellular accumulation of a secreted antigen-targeted antibody (SATA) that can be used to characterize disease, guide therapy, and monitor response. (lu.se)

Antibodies that detect Blood Group Lewis A can be used in several scientific applications, including Immunohistochemistry, Immunocytochemistry, Flow Cytometry, ELISA and SDS-PAGE. (thermofisher.com)
These antibodies target Blood Group Lewis A in Human, Mouse samples. (thermofisher.com)
Our Blood Group Lewis A monoclonal and polyclonal antibodies are developed in Mouse and Rabbit. (thermofisher.com)
Antibodies against a specific antigen on a cancerous tissue can be used to target and kill the cancerous tissue. (justia.com)
Antibodies to the Lewis antigen are generally IgM. (biorexdiagnostics.com)
Cross-reaction was found between S. equina antigens and antibodies in the sera of Wuchereria bancrofti-infected patients, with the highest levels observed between sera of chronic infected patients and Setaria spp. (who.int)
were tested for antibodies to Toxocara in an indirect enzyme immunoassay (EIA) with an excretory/secretory antigen of Toxocara canis. (cdc.gov)

CD15 (Lewis x), also known as stage specific embryonic antigen-1 (SSEA-1) is a trisacharide determinant (3-fucosyl-N-acetyllactosamine) expressed on several glycolipids, glycoproteins and proteoglycans of various cell types, e.g. granulocytes, mast cells, monocytes, macrophages, cells of gastric mucosa, nervous system or various tumour cells. (exbio.cz)
Benharroch D, Dima E, Levy A, Ohana-Malka O, Ariad S, Prinsloo I, Mejirovsky E, Sacks M, Gopas J: Differential expression of sialyl and non-sialyl-CD15 antigens on Hodgkin-Reed-Sternberg cells: significance in Hodgkin's disease. (exbio.cz)

The inhibitory indirect effects of oral tolerance does not require the simultaneous injection of the tolerated protein and the second antigen: it is still present 72 h after an injection of the tolerated antigen, but does not occur if the tolerated protein is injected after the second antigen [ 10 ]. (hindawi.com)
Compositions comprising a physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen-binding fragment thereof, therapeutic use of the antigen-binding protein, or antigen-binding fragment thereof, methods for detecting cancer as well as kits when used in such methods are also provided. (justia.com)
In one aspect, there is provided an antigen-binding protein, or an antigen-binding fragment thereof that competes with the antigen binding protein as defined herein for binding to AXL receptor tyrosine kinase. (justia.com)
In one aspect, there is provided an antigen-binding protein, or an antigen-binding fragment thereof, as defined herein, comprising a radioisotope or a cytotoxin conjugated thereto. (justia.com)
In one aspect, there is provided a composition comprising a physiologically acceptable carrier and a therapeutically effective amount of the antigen-binding protein, or antigen-binding fragment thereof as defined herein. (justia.com)
In one aspect, there is provided a use of an antigen-binding protein, or an antigen-binding fragment thereof as defined herein in the manufacture of a medicament for treating cancer. (justia.com)
The myeloperoxidase (MPO) antigen is a heme-containing protein found in the primary granules of neutrophils and monocytes. (calbiotech.com)
The authors describe the FDA-approved biomarkers such as Bladder Tumor Antigen, ImmunoCyt, Nuclear Matrix Protein-22, and Fluorescent In Situ Hybridization, as well as the most promising investigational tests (i.e. (elsevierpure.com)
Cancer antigen 19-9 (CA 19-9) is a tumor-associated mucin glycoprotein antigen that is related to the Lewis blood group protein. (medscape.com)

It seems PCR and Rapid Antigen Test shortages are still having an impact here in the ACT. (mix106.com.au)
It comes after ACT Health on Tuesday announced it would only be handing out one rapid antigen test kit per person at the Kambah testing site, due to supply issues. (mix106.com.au)
To have the hassle to get back into my own country, that's the issue," Lewis said Tuesday (March 15), recounting her experience trying to get the rapid antigen test required for re-entry to Canada. (mapleridgenews.com)

The three above-stated common Lewis phenotypes represent the presence or absence of Lewis and Secretor enzymes. (wikipedia.org)
Blood group phenotypes relating to expression of ABO antigens in individual kidneys were identified. (gu.se)
Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. (thermofisher.com)
Although not much significant differences were observed in phenotypes of most blood group systems, major insights were observed when comparing Orang Asli with aboriginal Australians and cosmopolitanMalaysians.This study serves as the first of its kind to utilize genomic data to interpret blood group antigen profiles of the OrangAsli population. (bvsalud.org)
The advent of high-throughput genome sequencing technology has facilitated the prediction of blood group antigen phenotypes based on genomic data. (bvsalud.org)
In this study, we analyzed data from a large Korean population to provide an updated prevalence of blood group antigen phenotypes, including rare ones. (bvsalud.org)
The mutations of fucosyltransferase genes α(1,2)-fucosyltransferase (FUT2 or Se) and α(1,3/1,4)- fucosyltransferase (FUT3 or Le), are responsible for the polymorphism of Lewis blood group phenotypes. (tmu.edu.tw)

Project 1: the role of PTPN22.6 in Intermediate Uveitis and Project 2: cord blood mononuclear cells as an alternative source for Chimeric Antigen Receptor-mediated cancer immunotherapy. (bham.ac.uk)
The development of novel T cell receptor - and chimeric antigen receptor - engineered T cell therapies for the treatment of cancer. (bham.ac.uk)
The present invention relates to antigen-binding proteins, or antigen-binding fragments thereof that bind to a glycan on the AXL receptor tyrosine kinase. (justia.com)
The present invention also relates to antigen-binding proteins, or antigen-binding fragment conjugated to a radioisotope or cytotoxin, and wherein said antigen-binding proteins, or antigen-binding fragment is internalised into a cell upon binding to AXL receptor tyrosine kinase. (justia.com)
2017. Genetic variants related to disease susceptibly and immunotolerance in the Duffy Antigen Receptor for Chemokines (DARC, FY) gene in the black lion tamarin (Leontopithecus chrysopygus, Primates). (fordham.edu)

Michael Breimer started his research in the Department of Medical and Physiological Chemistry isolating and structurally characterising blood group AB(O)H and related carbohydrate antigens. (gu.se)

The link between the Lewis blood group and secretion of the ABO blood group antigens was possibly the first example of multiple effects of a human gene: the same enzyme (fucosyltransferase2) which converts the Le-a antigen to Le-b is also responsible for the presence of soluble A, B and H antigens in bodily fluids. (wikipedia.org)
Immune responses to products secreted by the eggs (soluble egg antigens, SEA) result in the formation of granulomas that are composed of macrophages, eosinophils, lymphocytes, and fibroblasts [ 17 ]. (hindawi.com)
We have shown that this antigen, in soluble form, as well as a glucose analog of H-5-2 (H-2g), are potent mediators of angiogenesis. (biomedcentral.com)

CA19-9 (sialyl Lewis[a] antigen) was originally described as a gastrointestinal system and pancreas specific tumour marker. (endocrine-abstracts.org)
DESCRIPTION (provided by applicant): The carbohydrate antigen sialyl-Lewis a (sLea) is widely expressed on epithelial tumors of the gastrointestinal tract, on breast cancer cells, and also on small cell lung cancer cells but is expressed minimally or not at all on normal tissues. (sbir.gov)
There are several structural relatives of Lewis x, e.g. sialyl-Lewis x or sulphated Lewis x. (exbio.cz)
Current biomarkers for lung cancer includes carcinoma embryonic antigen (CEA), sialyl Lewis X antigen (SLX), squamous cell carcinoma (SCC) antigen, and cytokeratin fragment (CYFRA) 21-1, but these are not sensitive enough to detect tumors early, the researchers said. (india4u.com)

During more recent years, his reseach has been conducted in the field of regenerative medicine, focussed on antigen expression and immune recognition of human embryonic stem cells and bioartificial heart valves, the latter tissues being of animal origin. (gu.se)

Unbranched type 1 and 2 oligosaccharides represent i antigen. (wikipedia.org)
Branched type 1 and 2 oligosaccharides are I antigens. (wikipedia.org)
In neonates, i antigen oligosaccharides predominate (high in cord blood samples). (wikipedia.org)
BACKGROUND: The human Lewis histo-blood group system belongs to a family of structurally related oligosaccharides. (tmu.edu.tw)

The proteins produced by the FUT2 and FUT3 genes modify type I oligosaccharide chains to create Lewis antigens. (wikipedia.org)
The enzyme fucosyltransferase 3 (FUT3), encoded by Le gene, adds a fucose to the precursor oligosaccharide substrate, converting it to the Le-a antigen. (wikipedia.org)

The biomarker signature includes 9 metabolites as well as the carbohydrate antigen 19-9 (CA19-9), which is currently the only blood-based biomarker in clinical use for pancreatic cancer. (medscape.com)

The 4A11 antigen is selectively expressed in skin, lymphoid organs, the thymus and synovium, and is upregulated on RA synovium compared with normal synovium, suggesting a role in leukocyte recruitment and homing. (biomedcentral.com)

Moreover, the MAPK signaling pathway involves glycoprotein synthesis of Lewis antigens. (ncku.edu.tw)

Second, parenteral reexposure to a tolerated antigen blocks the initiation of immune responses to a second unrelated antigen-the effect we have named "indirect effect of oral tolerance" [ 7 , 8 ] and is also known as "bystander suppression" [ 3 , 9 ]. (hindawi.com)
Haemodialysis patients who were and are unable to eliminate the virus positive for hepatitis B virus surface antigen because of their impaired immune systems. (who.int)

The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. (thermofisher.com)
Lewis antigens are synthesized by intestinal epithelial cells, circulate in plasma and are passively absorbed onto red blood cells. (biorexdiagnostics.com)

Lewis antigens are expressed on the surface of red blood cells, endothelium, kidney, genitourinary and gastrointestinal epithelium. (wikipedia.org)
Lewis antigen expressions on the gastric epithelium serves as receptors targeted by H. pylori. (ncku.edu.tw)
In conclusion, a higher p38 expression in gastric epithelium counteracting JNK activity in children may contribute to lower Lewis antigen expression and colonization density than in adults after H. pylori infection. (ncku.edu.tw)

Recent clinical evidence suggests that high serum levels of the tumor‑produced mucin 16 (MUC16) and cancer antigen 125 (CA125) have a negative impact on the effectiveness of RTX clinical activity in up to 40% of patients with follicular lymphoma. (spandidos-publications.com)

The cancer diagnostics market is on the verge of explosion, as the researchers approach major technological breakthroughs in tumor diagnosis and therapy, discover new specific antigens, and unlock the mystery of the genetic basis of the disease. (aarkstore.com)
Since the pioneering use of 131 I in differentiated thyroid cancer in the 1940s, remarkable achievements in nuclear medicine endoradiotherapy have been demonstrated, mainly in the treatment of neuroendocrine neoplasms by using 177 Lu-labeled somatostatin analogs or in the treatment of advanced prostate cancer using prostate-specific membrane antigen-directed radionuclide therapy. (snmjournals.org)
More recently, the prostate-specific membrane antigen (PSMA) has been established as a theranostic target for prostate cancer. (snmjournals.org)
Cancer antigen 19-9 (CA 19-9) is used to help differentiate between cancer of the pancreas and other conditions, as well as to monitor treatment response and recurrence. (medscape.com)
AR-regulated human kallikrein-related peptidase 2 (free hK2) is a prostate tissue-specific antigen produced in prostate cancer and androgen-stimulated breast cancer cells. (lu.se)
In Sweden, there has been a steady prostate-specific antigen (PSA) velocity for the diagnosis of pros- decrease in age-standardized breast cancer mortality in women up tate cancer (15). (lu.se)

The phenotype prevalence of clinically significant blood group antigens, including MNSs, RHCE, Kidd, Duffy, and Diego, was predicted through genotype analysis and corroborated the existing literature. (bvsalud.org)

The H gene of the ABO system encodes a fucosyltransferase that adds fucose to type 2 precursor substances on the surface of RBCs to make H antigen. (wikipedia.org)

citation needed] Le(a+b-) individuals have at least one functional Lewis gene (Le) but are homozygous for nonfunctional Secretor alleles (sese). (wikipedia.org)

Lewis-b antigen is found only in secretors: people who possess the Se allele and thus have FUT2 activity. (wikipedia.org)

Screening for the virus with either nucleic acid amplification tests (NAATs) or antigen tests is an effective administrative control for early detection of individuals with COVID-19 and allows employers to take steps to prevent workplace spread. (cdc.gov)
Worldwide, nearly 100 companies are developing or manufacturing tests for antigen detection [6-7]. (cdc.gov)
Biorex Diagnostics manufacture Anti LE a and Anti-LE b blood grouping reagents for the in vitro detection and identification of the human LE a and LE b blood group antigens by direct agglutination. (biorexdiagnostics.com)
Detection of microbial antigens in metal working fluid s. (cdc.gov)

Human blood group antigen distribution was determined by using a typing assay with saliva samples. (cdc.gov)
This sialylated Lewis A blood group antigen is identified by a radioimmunometric assay. (medscape.com)

Instead, Lewis antigens are components of exocrine epithelial secretions, and are subsequently adsorbed onto the surface of the red cell. (wikipedia.org)
Cells with high surface expression of Le(x) antigen exhibit strong self-aggregation, based on calcium-dependent Le(x)-Le(x) interaction. (exbio.cz)
crude female worm surface antigen (CFSWA). (who.int)

Cawkwell, Lewis Blair (2018). (bham.ac.uk)

This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. (thermofisher.com)

Generating and characterising chimeric antigen receptors to target the tumour vasculature. (bham.ac.uk)

Here we demonstrate how to activate antigen-specific TEM cells, induce adoptive DTH in Lewis rats and monitor the inflammatory response. (jove.com)
Moreover, H-2g or the 4A11 antigen activate the endothelial janus kinase 2 (JAK2)/STAT3 pathway, as demonstrated by inhibition by chemical inhibitors of these pathways as well as antisense oligodeoxynucleotides directed against these signaling intermediates. (biomedcentral.com)

Automated glycan assembly of Lewis type I and II oligosaccharide antigens. (mpg.de)

In absence of a functional Lewis gene (lele), neither Le(a) nor Le(b) are synthesized, leading to the Le(a-b-) phenotype. (wikipedia.org)

NIOSH researchers also provided a framework (see Figure 2) for using antigen tests to identify SARS-CoV-2 infections in the workforce. (cdc.gov)
The framework proposed by NIOSH researchers and based on scientific literature recommends that employers consider using an antigen test screening program. (cdc.gov)

The Lewis antigen produced on free type 1 precursor substance passively adsorbs onto the surfaces or red blood cells. (wikipedia.org)

They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. (thermofisher.com)

The Lewis antigen system is a human blood group system. (wikipedia.org)
The Lewis blood group system is a human blood group system, classified by the expression of glyocoproteins called Lewis (LE) antigens. (biorexdiagnostics.com)
In the presence of active S. equina infection, antigens from the adult and microfilaraemic stages showed the highest degree of cross-reaction with human sera. (who.int)

H. pylori colonization intensity and Lewis antigens were significantly higher in GES-1 than in HSFE cells, whereas IL-8 and IL-6 levels were significantly higher in HSFE than in GES-1 cells after infection. (ncku.edu.tw)
c-Jun N-terminal kinase (JNK) siRNA and inhibitor (SP600125) experiments showed that Lewis antigen expression and H. pylori colonization were reduced in GES-1 cells but increased in HSFE cells. (ncku.edu.tw)
CD20 is a B-cell-specific antigen expressed on malignant FL cells. (spandidos-publications.com)
Blood group antigens, which are prominently expressed in red blood cells, are important in transfusion medicine. (bvsalud.org)

We aimed to investigate whether differences in H. pylori-induced MAPK responses mediate gastric Lewis antigens expression and colonization density differently in children and adults. (ncku.edu.tw)
Based on A antigen expression, a hypothesis explaining why blood group A2 kidneys could be successfully transplanted to O recipients was postulated. (gu.se)

These rapid antigen tests are being used widely in schools, at various mass gatherings, and by sports organizations [2-5]. (cdc.gov)

Oligosaccharide branching increases with age, thus adults have mostly I antigen. (wikipedia.org)

As of Feb. 28, the cheaper antigen test is allowed, provided it is authorized by the country in which it is taken, overseen by either a laboratory, health-care entity or via tele-health, and taken within 24 hours of boarding a flight or arriving at the land border. (mapleridgenews.com)

Differences in the distribution of RBC antigens defining the blood group types among different populations have been well established. (bvsalud.org)

Anatomy7

Organisms4

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Chemicals and Drugs56

Analytical, Diagnostic and Therapeutic Techniques and Equipment6

Phenomena and Processes10

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Protein9

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