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Superoxide DismutaseSuperoxidesCatalaseOxidative StressAntioxidantsGlutathione PeroxidaseHydrogen PeroxideParaquatReactive Oxygen SpeciesFree RadicalsFree Radical ScavengersCopperMalondialdehydeXanthine OxidaseLipid PeroxidationCyclic N-OxidesManganeseOxidation-ReductionAmyotrophic Lateral SclerosisDitiocarbMetalloporphyrinsOxygenNADPH OxidaseGlutathioneNitric OxideThiobarbituric Acid Reactive SubstancesSpin LabelsGlutathione ReductaseNitroblue TetrazoliumHydroxyl RadicalMitochondriaOxidantsHydroxidesZincXanthineRats, WistarElectron Spin Resonance SpectroscopyPeroxynitrous AcidNeutrophilsRats, Sprague-DawleyNitratesLipid PeroxidesIronCells, CulturedEndothelium, VascularAscorbic AcidPeroxidasesGene Expression Regulation, EnzymologicPeroxidaseErythrocytesLuminescent MeasurementsCyanidesNitric Oxide SynthasePlant ExtractsAerobiosisKineticsPyrogallolApoenzymesMolsidomineDisease Models, AnimalOrganometallic Compounds1,2-Dihydroxybenzene-3,5-Disulfonic Acid Disodium SaltMolecular Sequence DataExtracellular SpacePulse RadiolysisAcetophenonesCattleMutationLiverAconitate HydrataseNADH, NADPH OxidoreductasesRNA, MessengerVasodilationDose-Response Relationship, DrugProtein CarbonylationIsoenzymesEnzyme InhibitorsMice, TransgenicOxidoreductasesEscherichia coliGlucose OxidaseVitamin EMice, Inbred C57BLTime FactorsAmino Acid SequenceHypoxanthineAortaEnzyme InductionSodium AzideAscorbate PeroxidasesSulfhydryl CompoundsApoptosisRespiratory BurstCeruloplasminCell SurvivalBlotting, WesternCytochrome c GroupNitric Oxide Synthase Type IIINitric Oxide DonorsOnium Compounds
CatalaseGlutathioneMalondialdehydeHydrogen peroxideSerum levelsOxidative stressManganeseDismutation of superoxideEnzymatic activityNitriteZincSODsLipidEnzymeCopperToxicityRadicalsCytosolicMetabolismInhibitTissueAbstractGSHPxDopamineSignificantly higherEndothelialSupplementationPlantActivityHypothesisReactive nitrogen speciCellularActivitiesAntioxidant levelsDifferencesMiceSeverityStudyEvaluationGeneBloodPatientsRatsStatistically significantExposureAcuteEffectsPresent
Catalase9
Glutathione6
Malondialdehyde3
Hydrogen peroxide4
Serum levels5
  • Copper/zinc superoxide dismutase also correlated positively with serum levels of both neopterin and rheumatoid factor, sensitive markers for disease activity in rheumatoid arthritis. (indexindex.com)
  • The endothelial permeability was determined and the serum levels of superoxide dismutase (SOD), malonaldialdehyde (MDA) and nitrite were measured. (ac.ir)
  • Although the white blood cell (WBC) count, serum levels of C-reactive protein (CRP), and other blood tests are often used to assist with the diagnosis, no laboratory tests can reliably distinguish cystitis from pyelonephritis. (medscape.com)
  • Other studies have shown elevated serum levels of manganese superoxide dismutase and tissue inhibitor of metalloproteinase (TIMP-1). (medscape.com)
  • 2006). The serum levels of workers engaged in sealant removal were 2-10 times higher at the end of these activities than they had been one year before (Kontsas et al. (who.int)
Oxidative stress5
  • Enhanced oxidative-stress defence in transgenic potato expressing tomato Cu/Zn superoxide dismutases. (scielo.org.za)
  • By reducing levels of oxidative stress, it also inadvertently helps to promote skin radiance. (greenlinebeauty.com)
  • Compared to the deoxycorticosterone acetate group, the L-citrulline and spironolactone combination therapy dose-dependently ameliorated the elevated levels of different blood pressure parameters, improved cardiac hypertrophy, vascular reactivity, aorta relaxant responses and attenuated oxidative stress. (ijpsonline.com)
  • Supplementation with plant origin superoxide dismutase (GliSODin) in a randomized, double-blind, placebo controlled study conducted to assess the effects of supplementation on exercise-induced oxidative stress, exercise-induced inflammation and performance in athletes. (who.int)
  • Administration of low level of selenium, 1.78 µg selenium/kg body weight as sodium selenite, exerted protective effects against oxidative stress induced by exposure to waterpipe smoke. (who.int)
Manganese4
Dismutation of superoxide1
  • Superoxide dismutases (SODs) are the primary reactive oxygen species (ROS)-scavenging enzymes of the cell and catalyze the dismutation of superoxide radicals O2- to H2O2 and molecular oxygen (O2). (nih.gov)
Enzymatic activity2
Nitrite1
  • In addition, an overproduction of H 2 O 2 by the bivalves was detected following exposure to CBZ but nitrite levels remained unchanged. (scielo.br)
Zinc9
  • To clarify the role of the cellular antioxidant system in the protection against oxygen free radicals, we examined the levels of copper/zinc superoxide dismutase in the sera of patients with rheumatoid arthritis. (indexindex.com)
  • We found that patients with rheumatoid arthritis have higher serum copper/zinc superoxide dismutase levels than control subjects. (indexindex.com)
  • These results support the hypothesis that the increased amount of copper/zinc superoxide dismutase is probably inadequate to exert an effective antioxidant protection but can result in a pro-inflammatory, pathogenic effect enhancing tissue damage. (indexindex.com)
  • Furthermore, copper/zinc superoxide dismutase might be used as a marker of inflammatory activity in rheumatoid arthritis. (indexindex.com)
  • Taking zinc by mouth or giving zinc by IV helps to restore zinc levels in people who are zinc deficient. (medlineplus.gov)
  • RÉSUMÉ Les informations concernant les bénéfices d'une supplémentation en zinc chez l'enfant asthmatique sont contradictoires. (who.int)
  • L'étude a examiné les effets d'une supplémentation en zinc chez des enfants asthmatiques suivis dans un service de consultations externes à Sari (République islamique d'Iran). (who.int)
  • Dans un essai clinique randomisé d'une durée de 8 semaines, en double aveugle et contrôlé contre placebo, 284 enfants sous corticostéroïdes inhalés ont été répartis entre un groupe recevant une supplémentation en zinc (50 mg/jour) (n = 144) et un groupe sous placebo (n = 140). (who.int)
  • Les cas comme les témoins présentaient des concentrations sériques en zinc initiales faibles [61,8 (E.T. 7,3) µg/dL et 60,9 (E.T. 4,3) µg/dL]. (who.int)
SODs1
  • SODs catalyze the disproportionation of superoxide: 2H+ + 2O− 2 → O 2 + H 2O 2 In this way, O− 2 is converted into two less damaging species. (wikipedia.org)
Lipid1
  • PBM-treated hypertrophic cells (1064 nm and 17.6 J/cm2 every day for 7 days following addition of PA) decreased the lipid levels in hypertrophic adipocytes, restored the GLUT4 protein expression and enhanced glucose transport. (google.com)
Enzyme2
  • The enzyme protects the cell against dangerous levels of highly reactive superoxide . (emf-portal.org)
  • Hydrogen-rich saline also increased B-cell lymphoma 2 (Bcl-2) expression and the activity of the antioxidant enzyme superoxide dismutase (SOD). (arvojournals.org)
Copper1
Toxicity4
  • Transformed plants with elevated levels of chloroplastic SOD are not more resistant to superoxide toxicity. (scielo.org.za)
  • In the present study, therefore, any involvement of Cu-Zn superoxide dismutase (SOD) in DA toxicity was evaluated by transfection of Cu-Zn SOD cDNA. (uaeu.ac.ae)
  • Present study offers perturbations caused by fluoride toxicity on the level of biometal and antioxidant homeostasis and their interactions. (fluoridealert.org)
  • Four BNNTs manufactured by induction thermal plasma process with a gradient of BNNT purity levels achieved through sequential gas purification, water and solvent washing, allowed assessing the influence of these residuals/impurities on the toxicity profile of BNNTs. (cdc.gov)
Radicals3
  • Cells are protected from the deleterious effects of free oxygen radicals by Cu/Zn superoxide dismutase (SOD), which catalyses the initial step in neutralizing activated oxygen species. (scielo.org.za)
  • Dopamine (DA) was shown to exert toxic effects on cultured neurons through autoxidation or oxidative deamination, followed by formation of highly reactive quinone compounds and superoxide radicals. (uaeu.ac.ae)
  • The most representative are the superoxide and hydroxyl free radicals. (molvis.org)
Cytosolic3
  • This study seeks to understand the effects that the partial lack (SOD2(-/+) ) or the overexpression (TgSOD2) of MnSOD produces on oxidative/nitrative stress basal levels in different brain isolated cellular fractions (i.e., mitochondrial, nuclear, cytosolic) as well as in the whole-brain homogenate. (nih.gov)
  • We show that each mutation affects mitochondrial, nuclear, and cytosolic oxidative/nitrative stress basal levels differently, but, overall, no change or reduction of oxidative/nitrative stress levels was found in the whole-brain homogenate. (nih.gov)
  • In the study reported here, the potato cultivar Aviva was transformed with a cytosolic Cu/Zn superoxide dismutase gene from Arabidopsis thaliana using Agrobacterium-mediated gene transformation. (scielo.org.za)
Metabolism1
  • Superoxide is produced as a by-product of oxygen metabolism and, if not regulated, causes many types of cell damage. (wikipedia.org)
Inhibit3
  • Therefore, Cu-Zn SOD overexpression may temporarily inhibit or delay DA autoxidation and consequently increase the GSH level, which then prevents the activation of apoptotic pathway and subsequent cell death. (uaeu.ac.ae)
  • CN, in turn, can inhibit Cu/Zn superoxide dismutase (SOD). (cdc.gov)
  • In a previous study, the RVD-hemopressin-α, an endogenous anorexigenic peptide, proved to be a negative allosteric modulator of CB1 [43] and to inhibit hypothalamic NE levels following peripheral administration despite being ineffective against DA and 5-HT levels [30]. (researchgate.net)
Tissue2
  • The tissue levels of SOD and MDA were measured both in case and control groups. (medicopublication.com)
  • Although both melatonin and oxytetracycline were found to be effective in autologous intraperitoneal pelvic ovary transplantation, melatonin is more effective against both the ovarian necrosis and tissue MDA level in rats. (nel.edu)
Abstract1
  • ABSTRACT This study aimed to evaluate the association of plasma MIF level and -173 G/C single nucleotide polymorphism of the MIF gene with the occurrence, severity and mortality of sepsis patients. (who.int)
GSHPx1
  • In saliva, SOD and CAT activities, and UA levels were significantly higher in RAS patients, while GSHPx activity was lower compared to control. (bvsalud.org)
Dopamine1
  • In the same experimental system, IL-10 and BDNF gene expressions increased, and in HypoE22 cells, the extract decreased the extracellular dopamine level and increased the DAT gene expression due to the direct interaction of parthenolide with the DAT. (researchgate.net)
Significantly higher3
  • The Cu-Zn SOD-overexpressing cells also showed significantly higher levels of GSH upon DA exposure than did the empty vector-transfected cells. (uaeu.ac.ae)
  • Compared to the control group, the mouse in the group treated with purslane extracts by 1 g/d had significantly higher activities of phosphofructokinase, lactate dehydroenase and higher levels of ATP in the cortices, especially under the hypoxic environment for 24 hours. (raysahelian.com)
  • Results: MDA levels were significantly higher in IG and PCT than in CG and PCG. (medscimonit.com)
Endothelial2
  • We tested the effects of unripe grape extract (UGE) in blood pressure alteration, serum antioxidant level and aorta endothelial permeability in rats. (ac.ir)
  • In preclinical studies, CIT enhanced the L-arginine/asymmetrical dimethylarginine ratio, boosted Nitric Oxide (NO) levels, protected endothelial function by lowering superoxide generation, and the accompanying ELK- 1 and p-CREB, two oxygen-sensitive proteins[ 3 - 5 ]. (ijpsonline.com)
Supplementation1
Plant1
  • Roots showed a decline in protein level as the plant aged. (raysahelian.com)
Activity3
  • For apoptotic inducing activity, human osteogenic sarcoma (HOS) cell proliferation, chromosomal DNA degradation and changes in apoptosis-related protein levels were measured. (nutrimedical.com)
  • The evaluation of the biogenic amine steady state level is currently considered a useful tool to predict the effect of a drug on the activity in the brain, particularly in in vivo studies [44,45]. (researchgate.net)
  • Muscle wasting in patients with cancer has been linked to an increased activity of nuclear factor κB (NF-κB) and higher circulating levels of activin-A (ActA), a negative growth factor for muscle mass. (nel.edu)
Hypothesis1
  • The pathogenesis of vitiligo is unknown, but an autoimmune hypothesis prevails and is supported by several factors: Its association with other autoimmune diseases, the high level of antibodies against melanocytes found in 10% of patients with vitiligo, susceptibility loci associated with vitiligo found in genome-wide association studies that encode immunomodulatory proteins, and lastly, an inflammatory infiltrate that is observed at the margin of active lesions ( 11 , 12 ). (spandidos-publications.com)
Reactive nitrogen speci1
  • Because of the SOD2 strategic location, it represents the first mechanism of defense against the augmentation of ROS/reactive nitrogen species levels in the mitochondria for preventing further damage. (nih.gov)
Cellular1
  • The analysis of well-known antioxidant systems such as thioredoxin-1 and Nrf2/HO-1/BVR-A suggests their potential role in the maintenance of the cellular redox homeostasis in the presence of changes of SOD2 and/or p53 protein levels. (nih.gov)
Activities1
  • Results: Plasma analysis showed significantly decreased SOD and CAT activities, and UA level in RAS patients compared to control group. (bvsalud.org)
Antioxidant levels2
  • Some of the tests such as Total Antioxidant Status are used for measurement of antioxidant levels in the body. (pharmiweb.com)
  • Objective: The purpose of this study was to evaluate the antioxidant levels in plasma and saliva of patients with recurrent aphthous stomatitis (RAS) and healthy controls. (bvsalud.org)
Differences1
  • There were no significant differences in IgE levels before and after treatment. (who.int)
Mice2
  • The current results indicated that PBMT inhibited FFA generation and release in insulin-resistant adipocytes and reduced plasma FFA levels in diabetic db/db mice and HFD-fed mice. (google.com)
  • Treating mice with 1.78 µg selenium/kg body weight significantly restored the normal levels of these parameters. (who.int)
Severity2
  • Neurological level of injury and severity according to ISNCSCI were used as criteria for recruitment. (nel.edu)
  • High MIF levels and MIF -173G/C gene polymorphism are powerful predictors of the severity of sepsis and its outcome. (who.int)
Study2
  • Study assessed the hypoglycemic effect of C. schweinfurthii aqueous and total crude leaf and pulp extracts on blood glucose levels in Wistar albino rats. (academicjournals.org)
  • The two terpenophenols objects of this study were also ineffective against the DA level, whereas the sole CBD stimulated 5-HT levels, and this could explain, albeit partially, the aforementioned anorexigenic effects [14] . (researchgate.net)
Evaluation1
  • Further evaluation revealed that ellagic acid was a potent antiestrogen in MCF-7 breast cancer-derived cells, increasing, like the pure estrogen antagonist ICI182780, IGFBP-3 levels. (nutrimedical.com)
Gene1
  • The prostaglandin E2 (PGE2) level, brain-derived neurotrophic factor (BDNF), interleukin-10 (IL-10), and IL-1β gene expression were evaluated in the cortex. (researchgate.net)
Blood3
  • Hypertension prevalence and blood pressure levels in 6 European countries, Canada, and the United States. (ac.ir)
  • Separate pre-treatments with STS (150 mg/kg), 4MP (100 mg/kg) and l-NAC (4 x 400 mg/kg) all dramatically reduced blood CN levels, but only l-NAC significantly protected GSH levels in both the liver and the cochlea. (cdc.gov)
  • This result on inflammatory infiltrate may have caused impacts on the significant lower blood glucose level from irradiated animals (p = 0.04), twenty-four hours after the last irradiation session. (google.com)
Patients1
  • Une étude a été menée dans des unités de soins intensifs en chirurgie pour adultes de l'hôpital universitaire de Zagazig, (Égypte) auprès de 25 patients atteints de septicémie, de 27 patients atteints d'une septicémie sévère et de 28 témoins. (who.int)
Rats1
  • This compromised testicular antioxidant status might have contributed to poor growth and development by affecting the spermatogenesis and steroidogenesis in rats before puberty as indicated by reduced germ cell number, complete absence of round spermatids, decreased seminiferous tubule diameter, and decreased testosterone level. (hindawi.com)
Statistically significant1
  • A highly statistically significant difference was found in MIF levels between sepsis cases and controls and a statistically significant difference as regards MIF level in different genotypes of the studied groups. (who.int)
Exposure1
  • We have shown previously that ACN potentiates NIHL, even with noise exposure approaching permissible occupational levels. (cdc.gov)
Acute1
  • The efficacy of prophylactic endotracheal administration of superoxide dismutase (SOD) was assessed in an animal model of acute lung injury induced by intratracheal endotoxin in neonatal piglets. (karger.com)
Effects1
  • Effects of Intrathecal Ketamine on Cerebrospinal Fluid Levels of Brain-Derived Neurotrophic Factor and Mech. (medscimonit.com)
Present1