Levels of neutrophil elastase. Medical search. Frequent questions

Low micromolar concentrations of human neutrophil elastase (hNE) applied to the apical surface of a human bronchial cell line (16HBE14o-/beta gamma) increased Na(+) transport about twofold. (nih.gov)
Thus, the manuscript discusses an approach to designing, preparing and assessing the activity of a form cotton nanocellulose modified with chromogenic peptides to detect human neutrophil elastase at levels found in chronic wounds and other inflammatory diseases, and an approach to using the technology as a biosensor. (usda.gov)
Here we explore two forms of nanocellulose as transducer surfaces to enable colorimetric detection of human neutrophil elastase (HNE), and a wide range of inflammatory diseases. (usda.gov)
As Table 1 also shows, the only other protease inhibitors that are FDA-approved for human use are the protein therapeutic serine protease inhibitors, Trasylol, used in heart bypass surgery, and then a growing family of plasma-derived human neutrophil elastase (HNE) inhibitors. (ddw-online.com)

Researchers at Sanford-Burnham Medical Research Institute (Sanford-Burnham) have discovered that an imbalance between an enzyme called neutrophil elastase and its inhibitor causes inflammation, obesity, insulin resistance, and fatty liver disease. (medindia.net)
The imbalance between neutrophil elastase and its inhibitor, α1-antitrypsin, is likely an important contributing factor in the development of obesity, inflammation, and other health problems. (medindia.net)
In order to assess the protease-dependence of the BLM-induced lesion, a group mice was treated with 4-(2-aminoethyl)-benzenesulfonyl fluoride hydrochloride, a serine proteinase inhibitor active toward neutrophil elastase. (biomedcentral.com)
and finally, ( iii ) emphysematous and fibrotic lesions can be significantly attenuated by using a protease inhibitor active against neutrophil elastase. (biomedcentral.com)
Alpha-1 proteinase inhibitor works in the lower respiratory tract where it inhibits neutrophil elastase (NE), the enzyme that damages lung tissue. (hdkino.org)
In clinical trials , alpha-1 proteinase inhibitor therapy increased the plasma levels of AAT. (hdkino.org)
Background: We examined whether tumor growth is enhanced by cecal ligation and puncture (CLP) and suppressed by a neutrophil elastase inhibitor, sivelestat. (elsevierpure.com)
Alpha-1 antitrypsin (AAT) deficiency is an autosomal codominant condition characterized by a decrease in the circulating level of AAT, a member of the serine protease inhibitor (serpin) family of proteins. (mhmedical.com)
Considering the signaling pathway of TGFβ1 (an inhibitor of iNOS mRNA expression), silencing of RNA for TAK-1 upregulates membrane-bound fractalkine tripartite motif 28 (TRIM28)/transcriptional intermediary factor 1β (TIF1β) functions as an E3 ubiquitin ligase and specificity protein 1 negatively regulate TGFβ1 levels to upregulate the generation of peroxynitrite, leading to increased shedding of membrane-bound fractalkine via SP/NK1R signaling. (scientificarchives.com)
Alpha-1 antitrypsin is a neutrophil elastase inhibitor (an antiprotease), the major function of which is to protect the lungs from protease-mediated tissue destruction. (msdmanuals.com)

Although endogenous epithelium-derived serine proteases regulate epithelial Na(+) transport, the effects of neutrophil elastase on epithelial Na(+) transport and epithelial Na(+) channel (ENaC) activity are unknown. (nih.gov)
The lungs are particularly susceptible to the damaging effects of neutrophil elastase. (livepositively.com)

Proteases and in particular neutrophil elastase could act as regulatory factors in the generation of soluble cytokines with mitogenic activity for mesenchymal cells resulting either in emphysema or in fibrosis or both. (biomedcentral.com)
In particular, neutrophil elastase (NE), and other elastolytic proteases, such as cathepsin G, and macrophage elastase are thought to be the main causative factors of tissue damage in this condition. (biomedcentral.com)
Inhibition of neutrophil proteases inhibited neutrophil transmigration on geltrex mix, but not collagen I. These findings highlight the important role of the ECM in determining cell phenotype and response to inhibitors. (nature.com)
Carpal tunnel syndrome high blood sugar levels high send in their testimonials, and several endogenous proteases, including neutrophil elastase (Hammond. (pourchat.com)
Neutrophils release serine proteases such as neutrophil elastase, proteinase 3, cathepsin G. These proteolytic enzymes activate protease-activated receptors (PARs) to induce intracellular signaling. (scientificarchives.com)

It is often a feature of chronic obstructive pulmonary disease, and recent studies have shown that the neutrophil and in particular neutrophil elastase, released by activated neutrophils, is implicated in the pathogenesis of chronic bronchitis including the facilitation of bacterial colonisation. (gla.ac.uk)

The enzyme is produced by white blood cells called neutrophils, which play an important role in the body's immune defense against bacteria. (medindia.net)
They found that mice completely lacking the neutrophil elastase enzyme don't get as fat as normal mice, even when fed a high-fat diet. (medindia.net)
This finding helps validate the team's conclusions about neutrophil elastase's role in inflammation and metabolism and also suggests that a medicinal drug could someday be developed to target this enzyme. (medindia.net)
Neutrophil elastase is a critical enzyme that plays a significant role in the human body's immune response and various pathological conditions. (livepositively.com)
Neutrophil elastase, an enzyme produced by neutrophils, has emerged as a crucial player in this intricate defense system. (livepositively.com)
Neutrophil elastase is a proteolytic enzyme belonging to the serine protease family. (livepositively.com)
In conditions like COPD and cystic fibrosis, increased levels of this enzyme result in the destruction of lung tissue and impaired respiratory function. (livepositively.com)
Elevated levels of this enzyme have been observed in conditions like atherosclerosis and myocardial infarction, suggesting its potential contribution to vascular inflammation and plaque destabilization. (livepositively.com)
This gene provides instructions for making a protein called alpha-1 antitrypsin, which protects the body from a powerful enzyme called neutrophil elastase. (medlineplus.gov)
Neutrophil elastase monoclonal antibodies with different levels of enzyme-neutralizing activity are also suitable for detection of neutrophil elastase in ELISA. (biosave.com)

Neutrophilic inflammation is particularly prominent in COPD where neutrophils degranulate with increasing severity of COPD, resulting in uncontrolled release of proteolytic enzymes (neutrophil elastase and matrix metalloproteinase 9-MMP9) that further damage the lungs ( 4 ). (frontiersin.org)
AAT neutralizes several proteolytic enzymes, most notably neutrophil elastase, which can break down matrix proteins of the lung like elastin. (mhmedical.com)
Emphysema results from the unopposed proteolytic burden to the lung that is abetted by decreased levels of AAT. (mhmedical.com)
Lung disease results from the unopposed proteolytic burden to the lung that exists when levels of AAT are decreased and worsened by increased lung inflammation, as from cigarette smoking. (mhmedical.com)

Normal mice on a high-fat diet were also protected against inflammation, insulin resistance, and fatty liver when they were given a chemical compound that inhibits neutrophil elastase. (medindia.net)
How do high neutrophil elastase levels increase inflammation and cause weight gain and other metabolic problems? (medindia.net)
Increased Muc5ac levels in MyD88-deficient mice were also not explained by augmented inflammation, IL-17A, or neutrophil elastase levels. (cdc.gov)
Neutrophil elastase is synthesized as an inactive precursor and is released upon activation of neutrophils during inflammation. (livepositively.com)
While neutrophil elastase plays a crucial role in host defense, its uncontrolled release can contribute to tissue damage and chronic inflammation. (livepositively.com)
Neutrophil elastase plays a significant role in the immune system, inflammation, and various diseases. (livepositively.com)
The purpose of this study was to determine the test-retest reproducibility of AAT serum levels and to determine if between-measurements variability was associated with acute phase markers of inflammation. (copdfoundation.org)
Inflammatory diseases are often characterised by excessive neutrophil infiltration from the blood stream to the site of inflammation, which damages healthy tissue and prevents resolution of inflammation. (nature.com)
In this study, we used the OrganoPlate to develop a humanized 3D in vitro inflammation-on-a-chip model to recapitulate neutrophil transmigration across the endothelium and subsequent migration through the extracellular matrix (ECM). (nature.com)
During an inflammatory response, neutrophils move from the blood to the site of inflammation by transmigrating across the endothelial barrier and through the basement membrane (BM) of the surrounding extracellular matrix (ECM). (nature.com)
The proinflammatory effects of lipopolysaccharide (LPS) are amplified during pre-existing neutrophilic inflammation, as neutrophils augment LPS-mediated proinflammatory signaling [ 3 ]. (scientificarchives.com)

Objectives Granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA) are autoimmune vasculitides associated with antineutrophil cytoplasm antibodies that target proteinase 3 (PR3) or myeloperoxidase (MPO) found within neutrophils and monocytes. (bmj.com)
Myeloperoxidase and neutrophil elastase complexed with DNA and the neutrophil-derived S100A8/A9 were elevated in plasma from pSLE patients with active disease and correlated with anti-p40 autoantibodies and disease activity. (northwestern.edu)

Methods: Plasma VWF, ADAMTS-13, angiopoietin-2 (Ang2), and syndecan-1 levels were determined by ELISA. (imperial.ac.uk)
neutrophil elastase was determined by ELISA. (cardiffmet.ac.uk)
Markers of neutrophil activation and death were quantitated by ELISA. (northwestern.edu)

The researchers found that obese humans and mice have increased neutrophil elastase activity and decreased levels of α1-antitrypsin, a protein that inhibits the elastase. (medindia.net)
The same was true in a mouse model genetically modified to produce human α1-antitrypsin, which inhibits neutrophil elastase. (medindia.net)
Our hypothesis is that this phytochemical preparation indirectly inhibits elastase activity. (nutraingredients-usa.com)

It mainly targets enzymes released by neutrophils, especially neutrophil elastase (NE) but also proteinase 3 (PR3) and Cathepsin G (CG). (hycultbiotech.com)

These effects include reduced airway mucus secretion 17 and anti-inflammatory properties, including decreased airway neutrophil accumulation through a reduction in expression of pro-inflammatory cytokines, e.g. interleukin (IL)-8, and adhesion molecule production, e.g. macrophage adhesion molecule-1 18 - 20 . (ersjournals.com)
Since patients with GPA have augmented neutrophil PR3 expression, and PR3-expressing apoptotic cells frustrate macrophage phagocytosis and cellular clearance, we investigated the role of PR3 in stimulating giant cell and granuloma formation. (bmj.com)
Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway. (ufl.edu)

AECOPD triggered by a bacterial and viral co-infection increases circulating levels of the systemic inflammatory marker, serum amyloid A (SAA). (frontiersin.org)
Eucalyptol alsoreduced all inflammatory (MPO, TNF-α, IL-1β, IL-6, KC, and TGF-β1) and redox marker levels (MDA) when compared to the CS group (at least p (greenmedinfo.com)
Excessive neutrophil elastase activity has been implicated in various inflammatory conditions, including chronic obstructive pulmonary disease (COPD), cystic fibrosis, and rheumatoid arthritis. (livepositively.com)
We are currently testing the hypothesis that Dermaval may affect blood levels of metalloproteinases, tissue inhibitors of metalloproteinases, pro-inflammatory cytokines, and chemikines under these experimental conditions. (nutraingredients-usa.com)
Moreover, sivelestat attenuated the levels of inflammatory cytokines and chemokines following spinal cord injury and hence subsequently alleviated secondary damage observed as a reduction in glial scar formation and the promotion of blood vessel formation and stabilization. (dna-alkylating.com)
Human umbilical vein endothelial cells formed confluent vessels against collagen I and geltrex mix, a mix of basement membrane extract and collagen I. TNF-α-stimulation of vessels upregulated inflammatory cytokine expression and promoted neutrophil transmigration. (nature.com)
This multi-step process is enabled by inflammatory receptors and molecules expressed by the endothelial cells which capture the neutrophils and support their extravasation, alongside gradients of chemokines that guide the neutrophils through the ECM. (nature.com)
Conversely, neutrophil transmigration is a potential drug target for treatment of chronic inflammatory conditions. (nature.com)
incidence and prevalence of occupational asthma in various occu- pational cohort studies depend on the agent(s) to which the Asthma has been defined as a chronic inflammatory disorder of workers are exposed and the levels of their exposure. (cdc.gov)

On a more biochemical level, it was shown that topical application of myricetin to mice inhibited the binding of benzo(a)pyrenes to DNA and protein native to epidermal skin cells. (wikipedia.org)
They discovered that neutrophil elastase-deficient mice have increased levels of several factors, including adiponectin, AMPK, and fatty acid oxidation. (medindia.net)
Compared with ODE-challenged WT mice, ODE-challenged, MyD88-deficient mice demonstrated significantly increased Muc5ac immunostaining, protein levels by immunoblot, and expression by quantitative PCR. (cdc.gov)
The enhanced Muc5ac levels in MyD88-deficient mice were not explained by differences in the differentiation program of airway secretory cells in naïve mice. (cdc.gov)
Also, in a strain of mice that develop both emphysema and fibrosis after chronic cigarette-smoke exposure, the presence of elastase in alveolar structures is associated with a positive immunohistochemical reaction for reaction for both TGF-β and TGF-α. (biomedcentral.com)
Differentially regulated genes were validated at the level of gene and protein expression, with genes identified as estrogen-regulated in human confirmed as estrogen-dependent in young estrogen depleted mice in vivo . (biomedcentral.com)

Measuring alpha-1 antitrypsin (AAT) serum levels is often the first step when investigating for alpha-1 antitrypsin deficiency (AATD). (copdfoundation.org)
In the lungs, alpha-1 antitrypsin deficiency increases neutrophil elastase activity, which facilitates tissue destruction leading to emphysema (especially in smokers, because cigarette smoke also increases protease activity). (msdmanuals.com)

Developing selective inhibitors and exploring novel drug delivery systems are among the avenues being pursued to harness the therapeutic potential of neutrophil elastase. (livepositively.com)

It is primarily produced by neutrophils, a type of white blood cell that forms a vital part of the innate immune system. (livepositively.com)
The initial infection control against F. hepatica is provided by host innate immune leukocytes such as polymorphonuclear neutrophils (PMN), monocytes, eosinophils, and macrophages. (biomedcentral.com)
Neutrophils are the first immune cells to be recruited to inflamed tissue and play a role in the innate immune response. (scientificarchives.com)
Neutrophil elastase (NE) is one of the innate effector molecules that modulate immune responses, and plasma NE levels are elevated in patients with pneumonia [ 4 ]. (scientificarchives.com)

Additionally, the lungs were also assessed for desmosine content and for the determination of elastase levels in the pulmonary interstitium by means of immunoelectron microscopy. (biomedcentral.com)
AAT deficiency is a genetic disorder in which abnormally low levels of the protein AAT allow certain enzymes to attack healthy tissues, especially the lungs . (hdkino.org)
Neutrophil elastase is released from white blood cells to fight infection, but it can attack normal tissues (especially the lungs) if not tightly controlled by alpha-1 antitrypsin. (medlineplus.gov)

We observed substantial brain pathology in SARS-CoV-2-infected dogs, particularly involving blood-brain barrier damage resembling small vessel disease, including changes in tight junction proteins, reduced laminin levels, and decreased pericyte coverage. (cdc.gov)
Neutrophil elastase can break down proteins in the extracellular matrix, facilitating the recruitment of immune cells to the site of infection. (livepositively.com)

Therefore, our result suggests that inhibiting neutropil elastase by administration of sivelestat is actually a promising therapeutic method to inhibit glial scar and promote functional recovery by upregulating angiopoietin-1 following spinal cord injury. (dna-alkylating.com)

Elastase activity that exceeded 50nM was associated with decreased levels of secretory leukoprotease inhabitor and increased levels of bronchial protein leak. (gla.ac.uk)
To test this, tubule formation and angiopoietins expression had been assessed in endothelial cells exposed to various concentrations of recombinant SARS-CoV-2 NSP7 Protein (His) C-6His neutropil elastase. (dna-alkylating.com)
Variants in the SERPINA1 gene can lead to a shortage (deficiency) of alpha-1 antitrypsin or an abnormal form of the protein that cannot control neutrophil elastase. (medlineplus.gov)
For example, the S allele produces moderately low levels of this protein, and the Z allele produces very little alpha-1 antitrypsin. (medlineplus.gov)
INBRX-101 is a precisely engineered recombinant human AAT-Fc fusion protein designed to safely achieve and maintain levels of alpha-1 antitrypsin ("AAT"), found in healthy individuals with the potential for a less frequent dosing interval compared to the weekly infusion interval of the currently available plasma-derived AAT therapies. (wowktv.com)
AATD is an inherited orphan disease affecting an estimated 100,000 patients in the United States and is characterized by deficient levels of the AAT protein, which causes loss of lung tissue and function and decreased life expectancy. (wowktv.com)

This is followed by polymorphonuclear neutrophil (PMN) recruitment, adhesion to vascular endothelial cells, diapedesis (or transmigration), and accumulation or swarming. (frontiersin.org)
Polymorphonuclear neutrophils (PMN) are the most abundant granulocytes and first ones arriving at infection sites. (biomedcentral.com)

Clinical improvement has been reported independent of the presence or absence of chronic airway infection 11 and with antibiotic levels below the minimum inhibitory concentrations of several pathogenic bacteria 15 . (ersjournals.com)
Correlation of alpha-1 antitrypsin levels and exosome associated neutrophil elastase endothelial injury in subjects with SARS-CoV2 infection. (ufl.edu)
DNA, which are released from the contents monia AND neutrophil extracellular traps, of neutrophils as a defense mechanism to respiratory tract infection AND neutrophil trap and destroy microorganisms1. (bvsalud.org)

The degree of neutrophil influx has been shown to be associated, not only with worse lung function, but also the rate of progression of airflow obstruction. (gla.ac.uk)
The results showed that both interleukin 8 and leukotriene B4 correlate with the degree of neutrophil influx and elastase activity, although the relationship with interleukin 8 and neutrophil influx appeared to be curvilinear. (gla.ac.uk)

it is not surprising that key objectives of Healthy People 2020 target improving physical activity levels in both children and adults. (diabetesjournals.org)

Thus, the colorimetric sensor is sensitive enough to be useful as a point of care diagnostic for elastase which is a biomarker for chronic wounds and a number of chronic diseases. (usda.gov)
In conditions such as psoriasis and chronic wounds, excessive neutrophil elastase activity contributes to tissue damage and delayed healing. (livepositively.com)

Neutrophil elastase is a serine protease that is abundant in the airways of individuals with cystic fibrosis (CF), a genetic disease manifested by excessive airway Na(+) absorption and consequent depletion of the airway surface liquid layer. (nih.gov)
Excessive levels of SAA can antagonize the protective actions of FPR2/ALX that involve engagement of specialized pro-resolving mediators, such as resolvin-D1. (frontiersin.org)

Murine CT26 colon carcinoma cells were injected subcutaneously into the back of each mouse and tumor growth and serum cytokine levels were assessed. (elsevierpure.com)

In this study we investigate in experimental animal models of emphysema and fibrosis whether neutrophil elastase may constitute a pathogenic link between these two pathologies. (biomedcentral.com)
The results of the present study strongly suggest that neutrophil elastase may represent a common pathogenic link between emphysema and fibrosis. (biomedcentral.com)

Finally, ODE-induced Muc5ac levels were enhanced in MyD88-deficient airway epithelial cells in vitro. (cdc.gov)

We retrospectively analyzed a sample of 255 patients from a community respirology practice with chronic obstructive pulmonary disease (COPD) in whom AAT serum levels were measured twice, on separate visits. (copdfoundation.org)

Graduate level immune system science explained in simple, concise, animated videos. (molddetoxdiet.com)
The immune system relies on neutrophil elastase to combat invading pathogens. (livepositively.com)
Neutrophils are potent immune effectors against bacterial infections. (scientificarchives.com)
Therefore, neutrophils may collaborate with macrophages to modulate immune response via PAR 2 signaling. (scientificarchives.com)

Biosensors were prepared to illustrate the highly sensitive levels of detection that are achievable. (usda.gov)

Due to this accumulation of polymers in hepatocytes, blood alpha-1 trypsin levels will decrease leading to chronic uninhibited tissue breakdown. (hycultbiotech.com)

Results showed that the glucose dose on day 2 produced a 175% in HNE levels, compared to baseline values. (nutraingredients-usa.com)
The primary endpoint of the trial is the mean change in the average functional AAT ("fAAT") concentration as measured by anti-neutrophil elastase capacity from baseline to average serum trough fAAT concentration at steady state (C trough,ss ). (wowktv.com)

Iron levels were detected by immunofluorescence staining and colorimetric assays. (stanfordchildrens.org)

Alpha 1 Antitrypsin-Deficient Macrophages Have Impaired Efferocytosis of Apoptotic Neutrophils. (ufl.edu)

Despite not having a standardized measurement parameter, the excess of neutrophil extracellular traps corresponds conception, manuscript to the severity of tissue damage observed in patients with respiratory tract infections, revealing the important prognostic role design, literature search, data of the neutrophil response and NETosis process in pulmonary infectious diseases. (bvsalud.org)

PMN may display neutrophil extracellular traps (NETs), consisting of nuclear DNA, decorated with histones, enzymes, and antimicrobial peptides. (biomedcentral.com)

At the level of the single channel, submicromolar concentrations of hNE increased activity of near-silent ENaC approximately 108-fold in patches from NIH-3T3 cells expressing rat alpha-, beta-, and gamma-ENaC subunits. (nih.gov)
To prevent uncontrolled damage, the activity of neutrophil elastase is tightly regulated. (livepositively.com)
Modulating neutrophil elastase activity may hold therapeutic value in managing these cardiovascular conditions. (livepositively.com)
Lifestyle factors such as physical activity level could significantly reduce risk. (cardiffmet.ac.uk)
The aim of this study was to determine the effect of physical activity level on haematological predictors of cardiovascular risk. (cardiffmet.ac.uk)
Increased levels of physical activity were associated with reduced red cell (p = 0.001), white cell (p = 0.002) and platelet counts (p = 0.001) and with reduced plasma neutrophil elastase concentration (p = 0.001). (cardiffmet.ac.uk)
Hence, the authors conclude that increased levels of physical activity improve the flow properties of blood and thus reduce the risk of developing cardiovascular disease. (cardiffmet.ac.uk)
P40 expression and autoantibody levels correlate with disease activity. (northwestern.edu)
Markers of neutrophil activation and death also correlate with these autoantibodies and with disease activity, suggesting that neutrophils express L1 and are a source of p40. (northwestern.edu)

We hypothesized that neutrophil elastase is among the key determinants of vascular endothelium disruption/destabilization and impacts angiopoietins expression soon after spinal cord injury. (dna-alkylating.com)

Is neutrophil elastase the missing link between emphysema and fibrosis? (biomedcentral.com)
Secretory leukoprotease inhabitor is thought to be the most critical anti-elastase in the upper airways whereas alpha-1-antitrypsin is thought to be less important, although more important at the alveolar level protecting against the development of emphysema. (gla.ac.uk)

The neutrophils respond by upregulating integrins that allow attachment to the endothelium and subsequently aid their movement through the BM 1 . (nature.com)

Sepsis also caused low levels of surfactant function and platelet counts. (nih.gov)

Considering that an AAT serum level below 1.13 g/L should trigger further investigations to confirm the AAT status, discrepancies between the test-retest AAT levels resulted in reconsidering requirement for further investigation in 22% of patients. (copdfoundation.org)
Serum AAT levels showed weak intra-individual reproducibility which could lead to AATD status misclassification and potentially a missed diagnosis of AATD. (copdfoundation.org)

Equally, studying neutrophils using in vivo animal models has important ethical implications and can inaccurately model human physiology 5 . (nature.com)

SAA is a functional agonist for formyl peptide receptor 2 (FPR2/ALX), where it promotes chemotaxis and survival of neutrophils. (frontiersin.org)
Keyword phrases: Neutrophil elastase, Spinal cord injury, Glial scar, Angiopoietins, Functional recovery, Neuropathic painIntroduction Spinal cord injury (SCI) is usually a clinically devastating condition that could bring about either temporary or permanent disability in young adults [49, 76]. (dna-alkylating.com)
Without enough functional alpha-1 antitrypsin, neutrophil elastase destroys alveoli and causes lung disease. (medlineplus.gov)

Targeting neutrophil elastase has emerged as a potential therapeutic strategy for mitigating these diseases. (livepositively.com)
Given its implication in various diseases, neutrophil elastase has become an attractive target for therapeutic intervention. (livepositively.com)
Understanding the intricate mechanisms and dysregulation of neutrophil elastase provides opportunities for therapeutic interventions that may improve patient outcomes and quality of life. (livepositively.com)

Anatomy25

Organisms8

Diseases20

Chemicals and Drugs91

Analytical, Diagnostic and Therapeutic Techniques and Equipment12

Phenomena and Processes28

Disciplines and Occupations1

Information Science3

Human neutroph4

Inhibitor10

Effects of neutrophil elastase2

Proteases5

Particular neutrophil elastase1

Enzyme10

Proteolytic4

Inflammation11

Myeloperoxidase2

ELISA3

Inhibits3

Proteinase1

Macrophage3

Inflammatory9

Mice6

Alpha-1 antitryp2

Inhibitors1

Innate4

Lungs3

Proteins2

Sivelestat1

Protein6

Polymorphonuclear2

Infection3

Influx2

20201

Chronic wounds2

Excessive2

Cytokine1

Pathogenic2

Airway1

COPD1

Immune4

Detection1

Trypsin1

Baseline2

Colorimetric1

Macrophages1

Respiratory1

Antimicrobial1

Activity9

Vascular1

Emphysema2

Endothelium1

Platelet counts1

Serum2

Vivo1

Functional3

Therapeutic3