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  • CTLs
  • Extensive testing of PBMC from vaccinees receiving all three RTS,S formulations failed to reveal CD8 + CTLs to CS protein peptides. (jimmunol.org)
  • Mutations within the HIV-1 genome allow the virus to escape recognition by CTLs and so evade the immune response. (prolekare.cz)
  • Adoptive transfer of large numbers of tumor-reactive CD8 + cytotoxic T lymphocytes (CTLs) expanded and differentiated in vitro has shown promising clinical activity against cancer. (rupress.org)
  • However, such protocols are complicated by extensive ex vivo manipulations of tumor-reactive cells and have largely focused on CD8 + CTLs, with much less emphasis on the role and contribution of CD4 + T cells. (rupress.org)
  • Although CD4 + T cells are critical for orchestrating immunological processes, cancer immunotherapy has focused primarily on tumor-reactive CD8 + CTLs, largely because of their capacity to directly engage and kill transformed cells. (rupress.org)
  • subsets
  • Recent data from large observational studies indicate that the survival benefit of aspirin may be confined to specific molecular subsets defined by phosphoinositide 3-kinase ( PI3KCA ) mutation status and COX-2 expression levels. (aacrjournals.org)
  • We used a variety of different approaches, including gene expression profiling and measurements of nutrient flux, to characterize the basal and activation-induced energetic requirements of naïve and phenotypically-defined subsets of human memory CD8 + T-cells. (frontiersin.org)
  • molecules
  • T cells displaying CD4 molecules (and not CD8 ) on their surface, therefore, are specific for antigens presented by MHC II and not by MHC class I (they are MHC class II-restricted ). (wikipedia.org)
  • stimulation
  • Flow cytometric assays to measure perforin and CD107a expression use fluorescently conjugated antibodies to quantify the amount of perforin within cytolytic vesicles (here shown by antibodies marked with a red signal) and the levels of CD107a (antibodies with green signal) on the surface of the NK cell after stimulation. (bloodjournal.org)
  • response
  • As peripheral blood is readily and safely obtainable from almost any patient, finding useful signatures of disease in this type of specimen could be very valuable both clinically and in understanding the immune response to particular cancers at a systems biology level. (aacrjournals.org)
  • rapid
  • Prompt diagnosis of HLH is essential because it allows for the rapid institution of life-saving immunosuppressive therapies. (bloodjournal.org)
  • vaccines
  • Burbacher TM, Shen DD, Liberato N, Grant KS, Cernichiari E, Clarkson T. Comparison of blood and brain mercury levels in infant monkeys exposed to methylmercury or vaccines containing thimerosal. (autism.com)
  • high
  • A high total serum immunoglobulin E level has been identified as a risk factor for the development of KVE. (medscape.com)
  • mouse
  • The importance of cathelicidins in antiviral skin host defense was confirmed by the observation of higher levels of HSV-2 replication in cathelicidin-deficient mouse skin compared with that seen in skin from their wild-type counterparts. (medscape.com)
  • responsible
  • Almost two decades ago, complementation screening of yeast genes allowed identification of minimally 15 genes responsible for autophagosome formation ( Tsukada and Ohsumi, 1993 ). (frontiersin.org)
  • infection
  • Signs and symptoms such as malabsorption and diarrhoea respectively, may occur with HIV infection causing many HIV patients to have nutritional deficiencies and altered levels of vitamin B12, carnitine, and growth and thyroid hormones - all have been associated with left ventricular dysfunction. (wikipedia.org)
  • found
  • [ 9 ] An inverse correlation between cathelicidin expression and serum immunoglobulin E levels in patients with AD and patients with KVE has also been found. (medscape.com)
  • skin
  • This distinction is important, because, mechanistically, telmophagy allows parasite uptake from the skin as well as blood. (nature.com)