Leukopenia or drug induced. Medical search. Frequent questions

The daily dose and the length of each cycle as well as the length of the treatment free interval depend on the degree of leukopenia/neutropenia caused by gusperimus. (wikipedia.org)
Clopidogrel-Induced Neutropenia after Coronary Stenting: Is Cilostazol a Good Alternative? (hindawi.com)
We report a case of clopidogrel-induced bone marrow toxicity manifesting with severe neutropenia in a patient treated with multiple coronary stents and provide suggestions for an alternative treatment. (hindawi.com)
Blood tests revealed severe leukopenia (white cells 1 × 10 3 / μ L) with marked neutropenia (neutrophils 3%), anaemia (haemoglobin 9.9 g/dL), and an important rise in inflammatory markers (C-reactive protein 122 mg/dL). (hindawi.com)
e.g. concomitant use of carbamazepine and CLZ, two drugs recognized to induce neutropenia). (dot1linhibitor.com)
The patient has been treated with 2 short courses of TMP/SMX that have been limited because of a sulfa-induced neutropenia. (cdc.gov)
Anaemia, neutropenia and leukopenia (usually secondary to neutropenia) can occur in patients receiving zidovudine. (who.int)

Discussion Despite mild leucopenia typically discovered amongst patients with dengue, serious situations aren't often observed, with only one particular earlier reported case of agranulocytosis resulting from dengue infection [Insiripong, 2010]. (dot1linhibitor.com)
Nevertheless, the precise mechanisms of CLZ-induced leucopenia/ agranulocytosis are nevertheless unclear [Guest et al. (dot1linhibitor.com)
No causal relationship has been established.Leukopenia and agranulocytosis have occurred. (drugcentral.org)
6 Gerson S L. G-CSF and the management of clozapine-induced agranulocytosis. (thieme-connect.de)
13 Claas F H, Abbott P A, Witvliet M D, D'Amaro J, Barnes P M, Krupp P. No direct clinical relevance of the human leucocyte antigen (HLA) system in clozapine-induced agranulocytosis. (thieme-connect.de)
14 Amar A, Segman R H, Shtrussberg S, Sherman L, Safirman C, Lerer B, Brautbar C. An association between clozapine-induced agranulocytosis in schizophrenics and HLA-DQB1*0201. (thieme-connect.de)
16 Guest I, Sokoluk B, MacCrimmon J, Utrecht J. Examination of possible toxic and immune mechanisms of clozapine-induced agranulocytosis. (thieme-connect.de)

CBC count with differential may show leukopenia, thrombocytopenia, and eosinophilia in patients with serious drug eruptions. (medscape.com)
Immune Thrombocytopenia (ITP) Immune thrombocytopenia (ITP) is a bleeding disorder usually without anemia or leukopenia. (msdmanuals.com)
Except for heparin , drug-induced thrombocytopenia occurs typically when a drug bound to the platelet or a carrier protein creates a new and "foreign" antigen, causing an immune reaction. (msdmanuals.com)
Heparin -induced thrombocytopenia may occur even when very-low-dose heparin (eg, used in flushes to keep IV or arterial lines open) is used. (msdmanuals.com)

Caution with other CNS drugs, alcohol, drugs that may cause orthostatic hypotension. (empr.com)

Biopsy can be helpful in confirming the diagnosis of a drug eruption (eg, by showing eosinophils in morbilliform eruptions or numerous neutrophils without vasculitis in persons with Sweet syndrome). (medscape.com)

The management of NMS should include 1) immediate discontinuation of antipsychotic drugs and other drugs not essential to concurrent therapy, 2) intensive symptomatic treatment and medical monitoring, and 3) treatment of any concomitant serious medical problems for which specific treatments are available. (psychopharmacopeia.com)

Since in classic chemotherapies it is observed a decrease in immune response, methotrexate (MTX) was used only to compare the PnV effects on innate immune cells with a highly immunosuppressive antineoplastic drug. (nature.com)
CMV infection has been shown to induce transient abnormalities of in vitro cellular-immune function in otherwise healthy human hosts (2,3). (cdc.gov)

BACKGROUND: Although clozapine is the optimal drug for patients with treatment-resistant schizophrenia, the drug has harmful adverse effects such as leukopenia. (bvsalud.org)
Thus, these drugs may be useful for clozapine-induced leukopenia. (bvsalud.org)
Monitoring leukocyte counts and preventing leukopenia are essential for successful treatment with clozapine for refractory schizophrenia. (bvsalud.org)
These medicines may be a potential option for preventing clozapine-induced leukopenia. (bvsalud.org)
The development of modern second generation antipsychotics such as olanzapine, risperidone, quetiapine, amisulpride, ziprasidone or aripiprazol, however, makes it possible to use the positive effects of this class of drugs without the risks of a clozapine treatment. (thieme-connect.de)
7 Hummer M, Kurz M, Barnas C, Saria A, Fleischhacker W W. Clozapine-induced transient white blood count disorders. (thieme-connect.de)
18 Pisciotta A V, Konings S A. 51Cr release assay of clozapine-induced cytotoxicity: evidence for immunogenic mechanism. (thieme-connect.de)
19 Schuld A, Kraus T, Hinze-Selch D, Haack M, Pollmächer T. Granulocyte colony-stimulating factor plasma levels during clozapine- and olanzapine-induced granulocytopenia. (thieme-connect.de)
Clozapine is associated with a dose-dependent seizure risk at a rate higher than that seen with most other antipsychotic drugs. (psychopharmacopeia.com)

To determine the maximum tolerated dose of irinotecan when administrated with temozolomide every 28 days, in patients with recurrent malignant glioma who were also receiving CYP450 enzyme-inducing antiepileptic drugs (EIAED), and to characterize the pharmacokinetics of irinotecan and its metabolites. (aacrjournals.org)
In 1940, phenytoin (PHT) was found to be an effective drug for the treatment of epilepsy, and since then it has become a major first-line antiepileptic drug (AED) in the treatment of partial and secondarily generalized seizures. (medscape.com)
Antiepileptic drugs should be used carefully, with consideration of medication interactions and potential side effects. (medscape.com)
It is important to understand the mechanisms of action and the pharmacokinetics of antiepileptic drugs (AEDs) so that these agents can be used effectively in clinical practice, especially in multidrug regimens (see the image below). (medscape.com)
Pearls of antiepileptic drug use and management. (medscape.com)
Antiepileptic drugs can be grouped according to their major mechanism of action. (medscape.com)
Some antiepileptic drugs work by acting on combination of channels or through some unknown mechanism of action. (medscape.com)
See also Seizure Disorders in Pregnancy , Women's Health and Epilepsy , Antiepileptic Drugs , and Neural Tube Defects . (medscape.com)

Torres-Navarro I, de Unamuno-Bustos B, Botella-Estrada R. Systematic review of BRAF/MEK inhibitors-induced Severe Cutaneous Adverse Reactions (SCARs). (medscape.com)

The extent to which the findings of increased mortality in observational studies may be attributed to the antipsychotic drug as opposed to some characteristic(s) of the patients is not clear. (nih.gov)
Tardive dyskinesia, a syndrome consisting of potentially irreversible, involuntary, dyskinetic movements may develop in patients treated with antipsychotic drugs.Although the prevalence of the syndrome appears to be highest among the elderly, especially elderly women, it is impossible to rely upon prevalence estimates to predict, at the inception of antipsychotic drug treatment, which patients are likely to develop the syndrome. (drugs.com)
If a patient requires antipsychotic drug treatment after recovery from NMS, the potential reintroduction of drug therapy should be carefully considered. (druglib.com)

Tardive dyskinesia, a syndrome consisting of potentially irreversible, involuntary, dyskinetic movements, may develop in patients treated with neuroleptic (antipsychotic) drugs. (nih.gov)
Whether neuroleptic drug products differ in their potential to cause tardive dyskinesia is unknown. (nih.gov)
As with all antipsychotic agents, tardive dyskinesia may appear in some patients on long-term therapy or may appear after drug therapy has been discontinued. (drugcentral.org)

Several cases of severe hyponatremia induced by linezolid (LZD) were reported. (bvsalud.org)

The main groups include sodium channel blockers, calcium current inhibitors, gamma-aminobutyric acid (GABA) enhancers, glutamate blockers, carbonic anhydrase inhibitors, hormones, and drugs with unknown mechanisms of action (see the image below). (medscape.com)

Other important considerations in the differential diagnosis include central anticholinergic toxicity, heat stroke, drug fever, and primary central nervous system pathology. (druglib.com)

We ruled out a contaminant because the organism did not belong to the normal flora of human skin and because fever resolved after treatment with antimicrobial drugs. (cdc.gov)
Patient 1: A previously healthy 33-year-old man developed P. carinii pneumonia and oral mucosal candidiasis in March 1981 after a 2-month history of fever associated with elevated liver enzymes, leukopenia, and CMV viruria. (cdc.gov)

History of poor tolerability to psychotropic drugs or drug interactions that increase risperidone plasma levels (see full labeling): may use lower initial dose of 12.5mg. (cancertherapyadvisor.com)
Pazopanib is susceptible to drug-drug interactions with agents that inhibit or induce hepatic CYP 3A4 activity. (nih.gov)

Platelet destruction can develop because of immunologic causes (viral infection, drugs, connective tissue or lymphoproliferative disorders, blood transfusions) or nonimmunologic causes (sepsis, acute respiratory distress syndrome). (msdmanuals.com)

Clinical diagnosis of levamisole-induced vasculitis was made and antibiotics were discontinued. (bcmj.org)
Much research is directed at identifying laboratory techniques that can establish a diagnosis of a drug eruption. (medscape.com)
In some cases, biopsy may be helpful in establishing a diagnosis of a drug reaction. (medscape.com)

After US Food and Drug Administration approval in 2019, some US clinicians rapidly implemented BPaL using an initial 600-mg linezolid dose adjusted by serum drug concentrations and clinical monitoring. (cdc.gov)

Both the risk of developing the syndrome and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of neuroleptic drugs administered to the patient increase. (nih.gov)
A potentially fatal symptom complex sometimes referred to as Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs. (druglib.com)
A syndrome of potentially irreversible, involuntary, dyskinetic movements may develop in patients treated with antipsychotic drugs. (druglib.com)
The treatment of Felty's syndrome is based on using classic synthetic and biological disease-modifying drugs (DMARDs). (termedia.pl)
Neuroleptic Malignant Syndrome (NMS) has been reported in association with antipsychotic drugs (see WARNINGS). (drugcentral.org)
Methylphenidate treatment is not indicated in all children with this syndrome and the decision to use the drug must be based on a very thorough assessment of the severity and chronicity of the child's symptoms in relation to the child's age. (medicines.org.uk)

The patient's condition during the admission described in this case report was further complicated by development of mild leukopenia. (bcmj.org)

Linezolid dosing and clinical management was provider driven, and most patients had linezolid adjusted by therapeutic drug monitoring. (cdc.gov)
Using an initial 600-mg linezolid dose daily adjusted by therapeutic drug monitoring and careful clinical and laboratory monitoring for adverse effects, supportive care, and expert consultation throughout BPaL treatment, 3 patients (4.4%) with hematologic toxicity and 4 (5.9%) with neurotoxicity required a change in linezolid dose or frequency. (cdc.gov)

The drugs from the DMARD group, despite reducing the activity of the disease, may cause significant clinical complications. (termedia.pl)

7. Other: Allergies to investigational drugs, pregnancy, lactation, participation in other clinical trials within 3 months, and other situations deemed unsuitable by the researcher. (who.int)

LiverTox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. (nih.gov)

ABSTRACT: In the case reported here, cocaine abuse led to levasimole-induced vasculitis and chronic ulcers. (bcmj.org)
This case and others reviewed suggest that early recognition of levasimole-induced vasculitis is needed to prevent ulcers from developing and becoming chronic. (bcmj.org)
Response to antihypertensive drugs in patients with chronic kidney disease (CKD) has great interindividual variability. (bvsalud.org)

According to the TERIS, the teratogenic risk in human pregnancy is undetermined for 91.2% of the drug treatments approved in the United States between 1980 and 2000. (medscape.com)

Should these symptoms occur in children or pregnant patients, the drug should be stopped and not reinstituted. (drugcentral.org)
While these symptoms can occur at low doses, they occur more frequently and with greater severity with high potency and at higher doses of first generation antipsychotic drugs. (drugcentral.org)

Myelotoxic drugs like 6-Mercaptopurin : Risk of serious bone marrow damage increased. (wikipedia.org)

Treatment intensity score was calculated to facilitate comparability of antihypertensive regimens across subjects taking different drugs. (bvsalud.org)
7 , 8 , 10 , 11 However, the rates of chemotherapy-induced FN reported in RCTs vary considerably for commonly used chemotherapy regimens. (jnccn.org)

The following side-effects have been noticed so far: Dysgeusia (abnormal or bad taste) Drug induced leukopenia (very common)[quantify] Significant infections related to therapy. (wikipedia.org)
Her physicians should review her current medications for their teratogenic potential, and drugs that pose a significant teratogenic risk should be discontinued if possible. (medscape.com)

The European Commission assigned orphan drug status to Gusperimus in 2001 for the treatment of granulomatosis with polyangiitis, a serious form of vasculitis frequently associated with permanent disability and/or fatal outcome. (wikipedia.org)

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. (guidelinecentral.com)
All 5 reported using inhalant drugs, and 1 reported parenteral drug abuse. (cdc.gov)

Women planning to become pregnant should avoid all alcohol consumption, smoking, and use of illegal drugs (eg, cocaine) before and during the pregnancy, because these activities may have serious deleterious effects on the fetus. (medscape.com)

In this cohort, effective treatment required less than half the duration recommended in 2019 US guidelines for drug-resistant tuberculosis. (cdc.gov)

If signs and symptoms of TD appear in a patient on INVEGA HAFYERA™ , drug discontinuation should be considered. (janssencarepath.com)

Gusperimus is an immunosuppressive drug. (wikipedia.org)

Observational studies suggest that, similar to atypical antipsychotic drugs, treatment with conventional antipsychotic drugs may increase mortality. (nih.gov)
Ethosuximide has been used since 1958 as a first-choice drug for the treatment of absence seizures without generalized tonic-clonic seizures. (medscape.com)
It became the drug of choice in primary generalized epilepsies and in the mid 1990s was approved for treatment of partial seizures. (medscape.com)
14 Variation in chemotherapy treatment intensity and intent as well as additional risk factors, including patient characteristics and comorbidities, have been identified for chemotherapy-induced FN. (jnccn.org)

Analyses of seventeen placebo-controlled trials (modal duration of 10 weeks), largely in patients taking atypical antipsychotic drugs, revealed a risk of death in drug-treated patients of between 1.6 to 1.7 times the risk of death in placebo-treated patients. (nih.gov)
Atypical antipsychotic drugs have been associated with metabolic changes that may increase cardiovascular/cerebrovascular risk. (janssencarepath.com)
Atypical antipsychotic drugs have been associated with metabolic changes that include hyperglycemia/diabetes mellitus, dyslipidemia, and body weight gain. (psychopharmacopeia.com)

Caution with anticholinergic drugs that may elevate body temperature. (empr.com)

He had no allergic history and denied any animal bite and recent ingestions of new drugs or diet components. (hindawi.com)
This disorder is indistinguishable from ITP except for the history of drug ingestion. (msdmanuals.com)
3) All had a clear history of trauma and induced sepsis, and the trauma severity rating (ISS) was = 16 points. (who.int)

Following intramuscular administration of prochlorperazine edisylate, the drug has an onset of action within ten to twenty minutes and a duration of action of three to four hours. (drugs.com)
Occasionally it is necessary to lower the dosage of prochlorperazine or to discontinue the drug. (drugcentral.org)

Histopathology of an exanthematous drug eruption may show both superficial and deep perivascular inflammatory cell infiltrates. (medscape.com)
Superficial perivascular inflammatory infiltrate with numerous eosinophils characteristic of an exanthematous drug eruption. (medscape.com)

Certain circumstances may increase the risk of the occurrence of torsade de pointes and/or sudden death in association with the use of drugs that prolong the QTc interval. (educationaldoseillustrator.com)

These might be: Other immunosuppressant drugs : Risk of infections increased. (wikipedia.org)
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. (nih.gov)
Avoid the use of drugs that also increase QTc interval and in patients with risk factors for prolonged QTc interval. (educationaldoseillustrator.com)
While all of the drugs in the class have been shown to produce some metabolic changes, each drug has its own specific risk profile. (janssencarepath.com)
At least 2 systems are used to classify the risk associated with specific medications: the US Food and Drug Administration (FDA) system and the automated Teratogen Information System (TERIS). (medscape.com)

These recommendations do not represent approval by the Food and Drug Administration (FDA) or approved labeling for the particular products or indications in question. (cdc.gov)

However, trifluoperazine HCl is not the first drug to be used in therapy for most patients with non-psychotic anxiety because certain risks associated with its use are not shared by common alternative treatments (i.e., benzodiazepines). (nih.gov)
For most drug treatments introduced in the past 2-3 decades, the information available to pregnant women and their physicians is insufficient to determine whether the benefits exceed the teratogenic risks. (medscape.com)

Individuals on CLZ remedy are typically on this drug as the final therapeutic choice, providing them using a pharmacological lifeline. (dot1linhibitor.com)

What Drugs, Substances, or Supplements Interact with Geodon? (rxlist.com)
Lim itations of Until new, commercially available exams are Drug Tests developed, drug testing of patients receiving buprenorphine primarily should be to detect the consensus panel cautions that drug test substances of abuse [url=https://samoore.com/products/buy-online-lisinopril/] heart attack left or right order lisinopril 5 mg mastercard[/url]. (ehd.org)

When the drug is stopped, the platelet count typically begins to increase within 1 to 2 days and recovers to normal within 7 days. (msdmanuals.com)

Anatomy3

Organisms3

Diseases28

Chemicals and Drugs37

Analytical, Diagnostic and Therapeutic Techniques and Equipment21

Phenomena and Processes7

Technology, Industry, Agriculture1

Information Science1

Health Care5

Neutropenia7

Agranulocytosis7

Thrombocytopenia4

Orthostatic hypotension1

Neutrophils1

Concomitant1

Immune2

Clozapine9

Antiepileptic8

Reactions1

Antipsychotic drug3

Tardive3

Severe1

Mechanisms1

Differential1

Fever2

Interactions2

Lymphoproliferative1

Diagnosis3

Serum1

Syndrome6

Mild1

Linezolid2

Complications1

Clinical trials1

Liver1

Chronic3

20001

Occur2

Bone1

Regimens2

Significant2

Vasculitis1

Parenteral2

Cocaine1

Tuberculosis1

Discontinuation1

Immunosuppressive1

Treatment4

Atypical3

Anticholinergic1

History3

Prochlorperazine2

Inflammatory2

Prolong1

Risk5

Food and Drug Admin1

Treatments2

Therapeutic1

Substances2

Typically1