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  • donors
  • Transfusion of daily or every other day granulocytes derived by apheresis of G-CSF and dexamethasone-stimulated donors has been associated in observational and retrospective studies with clearance of life-threatening infections in neutropenic patients, but a single small randomized prospective study did not demonstrate improved survival in neutropenic infected patients who received granulocytes. (clinicaltrials.gov)
  • Since it is time-consuming to find even a single compatible donor for HLA-matched transfusions, being able to collect a full dose from a single donor is much more practical than finding multiple compatible donors. (wikipedia.org)
  • Although patients can receive intensive antibiotherapy and even granulocyte transfusions from healthy donors, the only current curative therapy is the hematopoietic stem cell transplant. (wikipedia.org)
  • Not using plasma donation from female donors for transfusions eliminates the risk of exposing the recipient to pregnancy-related antibodies, and therefore reduces the risk of TRALI. (wikipedia.org)
  • Mice
  • To address the biological relevance of this approach, we compared the efficiency of TSE transmission by blood and blood components when administrated either through transfusion in sheep or by intra-cerebral inoculation (IC) in transgenic mice (tg338) over-expressing ovine PrP. (biomedsearch.com)
  • Transfusion of 200 µL of blood from asymptomatic infected donor sheep transmitted prion disease with 100% efficiency thereby displaying greater virulence than the transfusion of 200 mL of normal blood spiked with brain homogenate material containing 10³ID₅₀ as measured by intracerebral inoculation of tg338 mice (ID₅₀ IC in tg338). (biomedsearch.com)
  • Both foamyviral and lentiviral vectors expressing the human ITGB2 gene under the control of different promoters have been developed and have been tested so far in preclinical LAD-I models (such as CD18-deficient mice and canine leukocyte adhesion deficiency-affected dogs). (wikipedia.org)
  • acquired immune d
  • Bayer WL, Tegtmeier GE, Barbara JAJ (1984) The significance of non-A, non-B hepatitis, cytomegalovirus and the acquired immune deficiency syndrome in transfusion practice. (springer.com)
  • typically
  • In developing countries the donor is sometimes specifically recruited by or for the recipient, typically a family member, and the donation occurs immediately before the transfusion. (wikipedia.org)
  • antibodies
  • Leukocyte filters may prevent TRALI for those patients whose lung injury is due to leukoagglutination of the donor white blood cells, but because most TRALI is due to donor antibodies to leukocytes, filters are not helpful in TRALI prevention. (wikipedia.org)
  • The cause of TRALI is not fully understood, and may have more than one mechanism, but most cases are associated with transfusion of plasma or other blood products that contain some antibodies that the donor developed during pregnancy. (wikipedia.org)
  • Recommendations
  • This guidance document finalizes the draft guidance of the same title dated January 2011 and supersedes the FDA memorandum issued on May 29, 1996, entitled Recommendations and Licensure Requirements for Leukocyte-Reduced Blood Products. (fda.gov)
  • When SHOT has identified risks related to transfusion, it produces recommendations within its annual reports to improve patient safety. (wikipedia.org)
  • cause
  • Plateletpheresis products are also easier to test for bacterial contamination, a leading cause of transfusion-associated deaths. (wikipedia.org)
  • Journal
  • An April 2007 meta-analysis by Dr. Neil Blumberg and others and covering 3093 patients who received leukoreduced blood was published in the scientific journal Transfusion. (wikipedia.org)
  • results
  • In most cases leukoagglutination results in mild dyspnea and pulmonary infiltrates within about 6 hours of transfusion, and spontaneously resolves. (wikipedia.org)
  • Human Leukocy
  • This is due to the association between individuals' genetic heritage and their Human Leukocyte Antigen (HLA) alleles, which are used to match patients to donors. (ubc.ca)
  • Microtransplantation(MST) is an advanced technology to treat malignant hematological diseases and tumors by infusing patients with granulocyte colony-stimulating factor (G-CSF) mobilized human leukocyte antigen (HLA)-mismatched allogeneic peripheral blood stem cells following a reduced-intensity chemotherapy or targeted therapy. (wikipedia.org)
  • occur
  • Transmission of HTLV-I is believed to occur by sexual contact, from mother to child via breastfeeding, and through exposure to contaminated blood, either through blood transfusion or sharing of contaminated needles. (wikipedia.org)
  • sickle
  • Despite these early discoveries, the life expectancy of sickle cell patients only began to improve significantly within the last 30 years, first with the introduction of prophylactic penicillin V in the 1980s, followed by more aggressive blood transfusions, and in 1998, with the introduction of hydroxyurea as a mainstay of treatment. (blogspot.fi)
  • clinical
  • This study aimed to evaluate the clinical, haematological and biochemical responses to autologous blood transfusion and the feasibility of this practice in sheep. (biomedcentral.com)
  • Autologous transfusion in sheep slightly altered the physiological, biochemical and haematological responses of sheep, indicating that the technique proposed is safe and can be applied in the clinical practice of this species. (biomedcentral.com)
  • cell
  • Some of the latest hematology instruments may report Cell Population Data that consist in Leukocyte morphological information that may be used for flagging Cell abnormalities that trigger the suspect of some diseases. (wikipedia.org)