Leukocyte recruitment adhesion molecules leukocyte. Medical search. Frequent questions

Conclusions/Significance VCAM-1 activation of endothelial cell NADPH oxidase/PKC/PTP1B induces transient ERK1/2 activation that's essential for VCAM-1-reliant leukocyte TEM. (pkc-inhibitor.com)
Outcomes Endothelial cell ERK1/2 is necessary for VCAM-1-reliant leukocyte migration across endothelial cells It really is reported that pharmacological inhibition of ERK1/2 with PD98059 blocks leukocyte transendothelial migration across endothelial cells that communicate multiple adhesion substances [12]. (pkc-inhibitor.com)
To examine the function of VCAM-1 indicators during VCAM-1-reliant leukocyte transendothelial migration, the endothelial cell series mHEVa was utilized since it expresses VCAM-1 however, not various other known adhesion substances for leukocyte transendothelial migration [4]. (pkc-inhibitor.com)
Muller, W.A. (2003) Leukocyte-endothelial-cell interactions in leukocyte transmigration and the inflammatory response. (scirp.org)
Finally, chemokines are discussed as a vital endothelial cell secretory products that contribute to the recruitment of eosinophils and macrophages. (biomedcentral.com)
Reduced number of placenta cells labeled for vascular endothelial growth factor (VEGF), platelet-endothelial cell adhesion molecule (PECAM-1), and intercellular cell adhesion molecule (ICAM-1), important markers of angiogenesis and adhesiveness, were detected in neutrophil depleted mice. (bvsalud.org)
We propose to elucidate the responsible molecular mechanism and the consequences on endothelial cell activation and leukocyte adhesion and transmigration. (grantome.com)
In specific aim 2, we will determine the impact of POP3 on leukocyte-endothelial cell adhesion and transmigration. (grantome.com)

Inflammatory cytokines increase the expression of the adhesion molecules. (nih.gov)
LECs can modulate dendritic cell function, present antigens to T cells on MHC class I and MHC class II molecules, and express immunomodulatory cytokines and receptors, which suggests that their roles in adaptive immunity are far more extensive than previously realized. (jci.org)
The inflammatory process in asthma involves the increased expression of various pro-inflammatory chemokines, cytokines, growth factors, lipid mediators, adhesion molecules, enzymes, and receptors for the same inflammatory mediators 21 . (ersjournals.com)
Doerschuk is interested in the mechanisms through which the lungs produce cytokines, chemokines and other regulatory inflammatory mediators in response to bacterial, viral, and other pathogens that then induce the production of other mediators and adhesion molecules on endothelial cells and result in the recruitment of leukocytes. (unclineberger.org)
Vascular injury results from an inflammatory response that involves a complex sequence of interactions between endothelial and smooth muscle cells, leukocytes, inflammatory cells (eg, macrophages) and their secreted growth factors, and cytokines, which combine with lipoproteins and components of the vascular wall to form a mature atherosclerotic plaque. (mhmedical.com)
Individual peritoneal mesothelial cells (HPMC) are turned on by different stimuli, including bacterias, and regulate leucocyte recruitment through chemokine and cytokines secretion and adhesion molecule appearance [8C11]. (mundial-brasil2014.net)
Thus, located at the boundary between the alveolar airspace and the interstitium, alveolar epithelial cells type II (AEC-II) are ideally situated to regulate the recruitment and activation of different types of leukocytes through the production of chemokines/cytokines in response to inflammatory stimulation from the alveolar space. (biomedcentral.com)
Oscillatory flow induces up-regulation of adhesion molecules and cytokines to mediate monocyte/EC interactions over a dynamic range of shear stress ± 2.6 dyn/cm 2 (P = 0.50, n= 10). (psu.edu)
T helper cells release cytokines that promote IgE production, eosinophil chemoattraction, eosinophil survival and mast cell recruitment. (platformqhealth.com)

The vascular adhesion molecule VCAM-1 mediates leukocyte moving and adhesion to endothelium during VCAM-1-reliant eosinophil infiltration in to the lung in experimental ovalbumin-induced asthma [2], aswell as T-cell infiltration over the blood-brain hurdle Cdh15 in experimental sensitive encephalomyelitis [3]. (pkc-inhibitor.com)
Atherosclerosis starts with dysfunctional changes in the endothelium induced by disturbed shear stress which can lead to endothelial and platelet activation, adhesion of monocytes on the activated endothelium, and differentiation into proinflammatory macrophages, which increase the uptake of oxidized LDL (oxLDL) and turn into foam cells, exacerbating the inflammatory signalling. (hindawi.com)
Nishiwaki, Y., Yoshida, M., Masuda, H. and Isobe, M. (2004) Recruitment of bone marrow-derived endothelial progenitor cells to vascular endothelium involves E-selectin dependent mechanism. (scirp.org)
TNF-a then induces the expression of leukocyte adhesion molecules upon proximal septal capillary endothelium resulting in the recruitment of inflammatory leukocytes to the site. (cdc.gov)
CD11a/CD18 (LFA-1) expressed on lymphocytes is known to play an important role in lymphocyte trafficking (adhesion to vascular endothelium), as well as interactions to antigen presenting cells (APC). (medscape.com)

ICAM-1 is an 85 kDa type I transmembrane glycoprotein that is encoded by Icam1 (Intercellular adhesion molecule 1). (bdbiosciences.com)
2. Leucocyte adhesion molecules CD11/CD18, intercellular adhesion molecule-1 and selectins mediate cardiac, skin and muscle IRI in experimental models and recent studies have begun to evaluate their role in renal IRI. (johnshopkins.edu)
4. Intercellular adhesion molecule-1 has a more prominent role in mediating renal IRI than CD11/CD18 in both rat and mouse models. (johnshopkins.edu)
We have also shown that H-2g significantly upregulates cell surface expression of the adhesion molecule intercellular adhesion molecule-1 (ICAM-1) on human dermal microvascular endothelial cells (HMVECs), but not vascular cellular adhesion molecule-1 or E-selectin. (biomedcentral.com)

The analyzed molecules included the beta 1 integrin or VLA family VLA-1-6, the beta 2 integrins or leukocyte integrins LFA-1, Mac-1, and p150,95, the immunoglobulins LFA-3, CD2, ICAM-1 and VCAM-1 and the selectins ELAM-1 and GMP-140. (nih.gov)
Longitudinal modelling with linear mixed models uncovered 32 proteins displaying different temporal profiles in severe versus non-severe disease, including integrins and adhesion molecules. (medrxiv.org)
Integrins are heterodimeric, transmembrane receptors that function as mechanosensors, adhesion molecules and signal transduction platforms in a multitude of biological processes. (thno.org)
Signaling through the β2 integrins triggers the transport of the attached leukocyte across the blood vessel wall to the site of infection or injury. (medlineplus.gov)
ITGB2 gene mutations that cause leukocyte adhesion deficiency type 1 lead to the production of a β2 subunit that cannot bind with other subunits to form β2 integrins. (medlineplus.gov)
Leukocytes that lack these integrins cannot attach to the blood vessel wall or cross the vessel wall to contribute to the immune response. (medlineplus.gov)
Leukocyte adhesion deficiency type I (LAD I) is a failure to express CD18, which composes the common ß 2 subunit of LFA1 family (ß2 integrins). (medscape.com)

Furthermore, VCAM-1-particular leukocyte migration under physiological 1351635-67-0 laminar movement of 2 dynes/cm2 was clogged by pretreatment of endothelial cells with dominant-negative ERK2 K52R or the MEK/ERK inhibitors, PD98059 and U0126, indicating for the very first time that ERK regulates VCAM-1-reliant leukocyte transendothelial migration. (pkc-inhibitor.com)
Intro The transendothelial migration (TEM) of leukocytes is crucial for inflammatory reactions, immune monitoring, leukocyte homing and mobilization of hematopoietic progenitor cells [1]. (pkc-inhibitor.com)
VCAM-1-reliant migration is essential in vivo because, in a number of illnesses, leukocytes migrate on VCAM-1[4]. (pkc-inhibitor.com)
It really is reported that in cytokine-stimulated major ethnicities of endothelial cells, inhibition of ERK1/2 with pharmacological inhibitors, that have extra off-target effects, partly inhibits leukocyte transendothelial migration over the endothelial cells in vitro [12], [13]. (pkc-inhibitor.com)
Furthermore, as the cytokine-stimulated major endothelial cells communicate several adhesion substances that support leukocyte transendothelial migration, it isn't known in these research whether ERK1/2 can be involved with VCAM-1-mediated leukocyte transendothelial migration. (pkc-inhibitor.com)
Furthermore, inhibition of endothelial 1351635-67-0 ERK2 blocks VCAM-1-reliant leukocyte transendothelial migration. (pkc-inhibitor.com)
However, it isn't known whether VCAM-1-mediated leukocyte transendothelial migration needs ERK1/2 or ERK's traditional upstream activator MEK1/2. (pkc-inhibitor.com)
As a result, we driven whether endothelial MEK1/2 and ERK2 are necessary for VCAM-1-reliant leukocyte migration. (pkc-inhibitor.com)
In addition, tumour cells have co-opted some of the signalling molecules of the innate immune system, such as selectins, chemokines and their receptors for invasion, migration and metastasis. (weeksmd.com)
This involves activation and directed migration of leukocytes (neutrophils, monocytes and eosinophils) from the venous system to sites of damage (Box 1), and tissue mast cells also have a significant role. (weeksmd.com)
We discover how the broad-spectrum NOS inhibitor NG-nitro-l-arginine methyl ester (L-NAME) enhances neutrophil migration in response towards the chemokine interleukin (IL)-8 with a mechanism that's reliant on adhesion between L-selectin and P-selectin glycoprotein ligand-1 (PSGL-1). (woofahs.com)
6. Leucocyte adhesion molecules may mediate renal IRI by mechanisms other than simply leucocyte migration, such as signal transduction and cell transport. (johnshopkins.edu)
inhibited mitogen-induced lymphocyte proliferation, cytokine release and leukocyte migration under inflammatory stimulation, which were associated with inhibition of the MAP kinase pathway and intracellular calcium influx. (bvsalud.org)
The junctional adhesion molecule (JAM) family proteins JAM-B and JAM-C are involved in polarized leukocyte transendothelial migration and are expressed by vascular endothelial cells of peripheral tissue and high endothelial venules in lympoid organs. (crcm-marseille.fr)
Monocytic JAML/AMICA1 plays a critical role in regulating monocyte transendothelial migration (TEM) probably via binding to the endothelial coxsackie and adenovirus receptor (CAR) and other tight junction-associated adhesive molecules. (betalifesci.com)

These results suggest that the H-2g and the 4A11 antigen are mediators of leukocyte-endothelial adhesion via ICAM-1. (biomedcentral.com)
These results suggest that H-2g and the 4A11 antigen are potent mediators of leukocyte-endothelial adhesion and monocyte recruitment, and that efforts aimed at targeting this antigen or its signaling pathways may be useful in the treatment of RA. (biomedcentral.com)
In the late phase response, the chemical mediators released by the mast cells promote the expression of vascular cell adhesion molecules and E-selectin. (platformqhealth.com)

JAML may function in transmigration of leukocytes through epithelial and endothelial tissues. (betalifesci.com)
Overproduction of IL-1β increases the expression of adhesion factors on endothelial cells to enable transmigration of leukocytes, and is associated with hyperalgesia and fever[ 5 , 6 ]. (themushroomwhisperer.com)

Thus, the identification of new molecules that can modulate ALI-associated inflammation is highly desirable and is a significant goal of pharmaceutical companies. (hindawi.com)
Many plant-derived secondary metabolites are capable of directly modulating inflammation by altering the production and activity of second messengers, the expression of transcription factors, and the expression of key proinflammatory molecules [ 6 - 8 ]. (hindawi.com)
In this immunohistochemical light-microscopic study we analyzed the expression pattern of adhesion molecules in normal and pathological human corneas (cases of corneal inflammation and degenerative disorders). (nih.gov)
They facilitate adhesion between leukocytes and endothelial cells, enabling leukocyte extravasation into tissues during inflammation. (pharmiweb.com)
VCAMs are involved in mediating the adhesion of leukocytes to vascular endothelial cells, facilitating the recruitment of immune cells during inflammation. (pharmiweb.com)
Chemokines are a superfamily of small, secreted proteins that direct the recruitment of leukocytes to the sites of inflammation. (biomedcentral.com)

Immunologists recognized the importance of lymphatic vessels as channels for leukocyte trafficking from peripheral sites to their draining LNs ( 4 - 6 ), and as conduits for soluble antigens that can be taken up directly by LN-resident B cells and immature DCs ( 7 - 10 ), which help regulate the kinetics of antigen presentation. (jci.org)
Elevated concentrations of soluble adhesion molecules may simply reflect ongoing inflammatory processes. (umanitoba.ca)
However, increasing evidence suggests that specific soluble adhesion molecules are immunomodulatory, and that alterations to soluble adhesion molecule profiles may represent a significant risk factor for several diverse diseases. (umanitoba.ca)
Variants of leukocyte adhesion deficiency have also been reported, including fully expressed but nonfunctional CD18 and an E selectin that is expressed but rapidly cleaved from the cell surface (only present in soluble form). (medscape.com)

5. Unlike in heart and muscle, L-selectin does not appear to mediate leucocyte recruitment to postischaemic kidney or tubular damage. (johnshopkins.edu)
These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)

We demonstrated for the first time that gene silencing of endothelial E-selectin using siRNA transfection in human umbilical vein endothelial cells (HUVECs) causes inhibition of EPC adhesion under flow conditions. (scirp.org)
These forms of circuit plasticity involve recruitment of homologous neuronal pathways, inhibition of aberrant electrical signaling, and formation of new connections through synaptogenesis and axonal sprouting throughout the brain and spinal cord ( Murphy and Corbett, 2009 ). (frontiersin.org)

Abstract Sequential interactions between several adhesion molecules and their ligands regulate lymphocyte circulation and leukocyte recruitment to inflammatory foci. (umanitoba.ca)

Some tumor suppressor proteins are involved in maintaining cell adhesion, preventing cells from breaking away and spreading to other parts of the body (metastasis). (pharmiweb.com)
Cell adhesion molecules are a diverse group of proteins that play a crucial role in mediating cell-to-cell interactions and cell-to-extracellular matrix interactions. (pharmiweb.com)
203 proteins were associated with clinical severity, including IL6, markers of monocyte recruitment (e.g. (medrxiv.org)
This value is two to three orders of magnitude higher than previously measured 2D K d values for interacting leukocyte surface proteins. (lu.se)
values for interacting leukocyte surface proteins. (lu.se)
The integrin tails have no intrinsic kinase activity but rather serve as a site for the docking of various kinases and related adaptor proteins that comprise focal adhesions. (thno.org)

In accord with this, H-2g induces ICAM-1-mediated leukocyte-endothelial adhesion. (biomedcentral.com)

Degenerative disorders (in contrast to normal cornea): In corneas with degenerative disorders we found decreased expression of adhesion molecules. (nih.gov)
The decreased expression of adhesion molecules in corneal degenerative disorders is probably a sign of reduced cell-cell and cell-extracellular matrix interactions. (nih.gov)
In addition to smoke-induced alterations to membrane bound endothelial and leukocyte adhesion molecule expression, which may help explain the above phenomena, smoking has a profound influence on circulating adhesion molecule profiles, most notably sICAM-1 and specific sCD44 variants. (umanitoba.ca)
Attenuates TNF-mediated endothelial expression of leukocyte adhesion molecules. (kxcdn.com)
This 3-year-old girl had leukocyte adhesion deficiency type I (LAD I) with complete absence of CD18 expression. (medscape.com)
In milder forms of leukocyte adhesion deficiency I (1-30% expression of CD8), patients may survive to adulthood. (medscape.com)
This leukocyte adhesion deficiency variant is associated with defective expression of the Rap-1 activator CalDAG-GEFI. (medscape.com)

Adhesion molecules are cell surface receptors that are probably important in various cell-cell and cell-extracellular matrix interactions of the cornea. (nih.gov)
Corresponding receptors on leukocytes probably enable a selective recruitment of different leukocyte populations in inflammatory corneal diseases. (nih.gov)

Blockade but not overexpression of the junctional adhesion molecule C influences virus-induced type 1 diabetes in mice. (crcm-marseille.fr)
Junctional adhesion molecules (JAMs) are endothelial and epithelial adhesion molecules involved in the recruitment of circulating leukocytes to inflammatory sites. (betalifesci.com)
JAML (Junctional adhesion molecule-like), also known as AMICA1 (Adhesion molecule interacting with CXADR antigen 1), a protein related to the JAM family, is restricted to leukocytes and promotes their adhesion to endothelial cells. (betalifesci.com)

Whereas binding was undetectable in solution, the affinity of the CD4/pMHC II interaction could be measured in 2D using CD4- and adhesion molecule-functionalized, supported lipid bilayers, yielding a 2 D Kd of ∼5,000 molecules/μm 2 . (lu.se)
Currently, 18 subtypes have been reported: 12 are type I (dysfunctional lipid-linked oligosaccharide precursor synthesis), and 6 are type II (dysfunctional trimming/processing of the protein-bound oligosaccharide), including leukocyte adhesion deficiency II (CDG-IIc). (medscape.com)

1A29 mAb inhibits Phorbol 12-Myristate 13-Acetate (PMA)-induced aggregation of phytohemagglutinin (PHA)-stimulated splenic blasts, as well as the adhesion of mitogen-stimulated blasts to high endothelial venule (HEV) cells and purified ICAM-1. (bdbiosciences.com)
Furthermore, clarified culture supernatants recovered from C- Fe-treated macrophages raise vascular endothelial cells to an activated state as indicated by the induction of endothelial- leukocyte adhesion molecules ICAM-1, VCAM-1, and E-selectin. (cdc.gov)

Leukocyte adhesion deficiency type 1 is a disorder that causes the immune system to malfunction, resulting in a form of immunodeficiency. (medlineplus.gov)
Starting from birth, people with leukocyte adhesion deficiency type 1 develop serious bacterial and fungal infections. (medlineplus.gov)
One of the first signs of leukocyte adhesion deficiency type 1 is a delay in the detachment of the umbilical cord stump after birth. (medlineplus.gov)
but, in infants with leukocyte adhesion deficiency type 1, this separation usually occurs at three weeks or later. (medlineplus.gov)
In leukocyte adhesion deficiency type 1, bacterial and fungal infections most commonly occur on the skin and mucous membranes such as the moist lining of the nose and mouth. (medlineplus.gov)
A hallmark of leukocyte adhesion deficiency type 1 is the lack of pus formation at the sites of infection. (medlineplus.gov)
Life expectancy in individuals with leukocyte adhesion deficiency type 1 is often severely shortened. (medlineplus.gov)
Leukocyte adhesion deficiency type 1 is estimated to occur in 1 per million people worldwide. (medlineplus.gov)
Mutations in the ITGB2 gene cause leukocyte adhesion deficiency type 1. (medlineplus.gov)
Cox DP, Weathers DR. Leukocyte adhesion deficiency type 1: an important consideration in the clinical differential diagnosis of prepubertal periodontitis. (medlineplus.gov)
Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency. (medscape.com)
Thus the infections in patients with leukocyte adhesion deficiency act similarly as those observed in patients with neutropenia. (medscape.com)
Labial ulceration from which Escherichia coli was cultured in an 8-month-old girl with leukocyte adhesion deficiency type 1 (LAD I). Note the thin bluish scar at the superior aspect of the labia from an earlier cellulitis. (medscape.com)
This 10-month-old patient with severe leukocyte adhesion deficiency type I (LAD I) developed a cervical adenitis caused by Klebsiella pneumoniae. (medscape.com)
Patients with leukocyte adhesion deficiency II manifest the Bombay phenotype (ie, negative for O and H blood group antigens with potential production of anti-H antibody). (medscape.com)
However, IgM and IgG serum levels are within the reference range in patients with leukocyte adhesion deficiency II. (medscape.com)
Leukocyte adhesion deficiency II may be classified as one of the congenital disorders of glycosylation (CDG), a rapidly expanding group of metabolic syndromes with a wide symptomatology and severity. (medscape.com)
Another reported type of leukocyte adhesion deficiency involves dysfunction in platelet aggregation in addition to a defect in leukocyte adhesion. (medscape.com)
Thus, patients with this type of leukocyte adhesion deficiency manifest both severe bacterial infections and bleeding disorder. (medscape.com)

The rheumatoid arthritis (RA) synovial pannus is characterized by a number of processes, including monocyte recruitment, leukocyte-endothelial adhesion, and angiogenesis. (biomedcentral.com)

The 4A11 antigen is selectively expressed in skin, lymphoid organs, the thymus and synovium, and is upregulated on RA synovium compared with normal synovium, suggesting a role in leukocyte recruitment and homing. (biomedcentral.com)
Human leukocyte antigen testing in all women who undergo silicon breast implantation could in the future enable us to better evaluate the risk of potential side effects. (biomedcentral.com)
When these cells are activated at the site of the allergen or antigen entry, the release of these chemicals result in the recruitment of additional eosinophils and basophils. (platformqhealth.com)

Basic and translational studies address the mechanisms of host defense that focus on leukocyte recruitment, edema, and lung injury using in vivo, translational, imaging, cell biological, immunological, and molecular approaches. (unclineberger.org)
The principal objective of our research is to investigate the mode, dynamics and mechanisms of leukocyte transmigration, the final stage in the leukocyte adhesion cascade, that describes the movement of leukocytes from the vascular lumen into inflamed and/or injured tissues. (qmul.ac.uk)

Leukocyte rolling in postcapillary venules of inflamed tissues is reduced in L-selectin-deficient mice and mice treated with L-selectin blocking antibodies, but the glycoprotein ligand for L-selectin in inflamed venules is unknown. (rupress.org)

The 1A29 antibody can reportedly inhibit leucocyte infiltration in in vivo systems, blocks induction of experimental allergic encephalomyelitis, and reduces NK-cell adhesion to tumor cells. (bdbiosciences.com)

A key approach is the application of confocal intravital microscopy that enables rigorous and direct means of investigating the interactions of leukocytes with different components of microvessel walls (endothelial cells, pericytes and the vascular basement membrane) in real-time in vivo. (qmul.ac.uk)

The ligands of the manganese ions are 3 histidine side-chains, an aspartate side-chain and a water molecule or hydroxy ligand, depending on the Mn oxidation state (respectively II and III). (wikipedia.org)
This disease is a defect in fucose metabolism (lack of fucosylation of the carbohydrate selectin ligands) that results in failure to express the ligand for E and P selectin, sialyl Lewis-X (CD15s) expressed on leukocytes and endothelial cells. (medscape.com)

We review the evidence that tobacco smoking dysregulates specific components of the adhesion cascade, which may be a common factor in several smoking-induced diseases. (umanitoba.ca)

abstract = "Leukocyte recruitment to endothelial cells is a critical event in inflammatory responses. (psu.edu)

For neutrophils, a four-step mechanism is believed to coordinate recruitment of these inflammatory cells to sites of tissue injury and to the provisional extracellular matrix (ECM) that forms a scaffolding upon which fibroblast and endothelial cells proliferate and migrate, thus providing a nidus for reconstitution of the normal microenvironment5. (weeksmd.com)

In vivo , injection of H-2g intraperitoneally into the periotoneum of mice resulted in monocyte recruitment. (biomedcentral.com)

Leukocyte binding to vascular cell adhesion molecule-1 (VCAM-1) causes signaling occasions in endothelial cells that are essential during VCAM-1-reliant TEM. (pkc-inhibitor.com)
This Review summarizes the emergent evidence that LECs are important in maintaining peripheral tolerance, limiting and resolving effector T cell responses, and modulating leukocyte function. (jci.org)
The molecules are found on the cell surface, where they facilitate adhesion to neighboring cells or the extracellular matrix, creating stable cell structures and supporting tissue organization. (pharmiweb.com)
These molecules are essential for embryonic development, wound healing, immune cell recognition, and many other physiological functions. (pharmiweb.com)
Among the superfamily of cell adhesion molecules, in this article, we mainly focus on Ig-Superfamily CADMs: the members of the Immunoglobulin superfamily of cell adhesion molecules, which play diverse roles in immune responses, neural development, and cell signaling. (pharmiweb.com)
PECAM-1 is expressed on the surface of platelets and endothelial cells and is involved in cell adhesion and signaling during immune responses. (pharmiweb.com)
Ig-superfamily CADMs are involved in mediating cell-to-cell adhesion, helping cells stick together and form tissues and organs. (pharmiweb.com)
A novel molecular magnetic resonance imaging agent targeting activated leukocyte cell adhesion molecule as demonstrated in mouse brain metastasis models. (ox.ac.uk)
Upregulation of endothelial ALCAM (activated leukocyte cell adhesion molecule) is a key element for leukocyte recruitment in neurological disease. (ox.ac.uk)
Calculations indicated, however, that CD4/pMHC II binding would increase rates of T-cell receptor (TCR) complex phosphorylation by threefold via the recruitment of Lck, with only a small, 2-20% increase in the effective affinity of the TCR for pMHC II. (lu.se)
Recruitment of inflammatory cells is prerequisite to beta-cell-injury. (crcm-marseille.fr)
Expressed at the plasma membrane of polymorphonuclear leukocytes, JAML/AMICA1 also enhances myeloid leukemia cell adhesion to endothelial cells. (betalifesci.com)
Integrin mediated cellular adhesion is dynamic process that is both indicative of and influenced by cell status. (thno.org)

Our experiments have shown the importance of E-selectin in EPC adhesion to HUVECs and the potential utility of gene silencing of E-selectin in EPC recruitment. (scirp.org)
Yoshida, M. and Gimbrone, M.A. Jr. (1997) Novel roles for E-selectin in endothelial-leukocyte adhesion. (scirp.org)
To investigate whether leukocyte-expressed PSGL-1 is mediating L-selectin-dependent rolling, we reconstituted lethally irradiated wild-type mice with PSGL-1 −/− bone marrow cells. (rupress.org)

We next sought to determine whether H-2g could induce monocyte recruitment. (biomedcentral.com)

In both preventive and therapeutic treatments, ellagic acid reduced the vascular permeability changes and neutrophil recruitment to the bronchoalveolar lavage fluid (BALF) and to lung compared to the vehicle. (hindawi.com)

Dysregulation of these molecules can lead to various diseases, including cancer metastasis, autoimmune disorders, and developmental abnormalities. (pharmiweb.com)

[ 1 , 2 ] The clinical picture is characterized by marked leukocytosis and localized bacterial infections that are difficult to detect until they have progressed to an extensive level secondary to lack of leukocyte recruitment at the site of infection. (medscape.com)

Signals emanating from focal adhesions have been shown to promote survival, differentiation and proliferation [ 5 ]. (thno.org)

The procedure of TEM requires the sequential moving and strong adhesion of leukocytes on vascular adhesion substances accompanied by the diapedesis from the certain leukocytes [1]. (pkc-inhibitor.com)

Eosinophils are thought to possess both distinct and shared neutrophil adhesion pathways. (platformqhealth.com)

Adhesion molecules are, therefore, central and critical components of the immune and inflammatory system. (umanitoba.ca)

His graduate research focused on understanding leukocyte recruitment and the biophysics of adhesion molecule mobility and surface localization by developing quantitative fluorescence microscopy techniques. (gaborskilab.org)

Anatomy38

Organisms11

Diseases18

Chemicals and Drugs116

Analytical, Diagnostic and Therapeutic Techniques and Equipment25

Phenomena and Processes46

Disciplines and Occupations3

Technology, Industry, Agriculture1

Information Science4

Endothelial cell8

Cytokines9

Endothelium5

Intercellular4

Integrins7

Migration15

Mediators3

Transmigration of leukocytes2

Inflammation6

Soluble4

Mediate2

Inhibition2

Lymphocyte1

Proteins6

Induces1

Expression7

Receptors2

Junctional3

Lipid2

ICAM2

Deficiency19

Angiogenesis1

Antigen3

Mechanisms2

Antibodies1

Infiltration1

Interactions1

Ligands2

Cascade1

Abstract1

Neutrophils1

Vivo1

Cell13

Selectin3

Monocyte recruitment1

Neutrophil recruitment1

Diseases1

Site of infection1

Differentiation1

Sequential1

Eosinophils1

Immune and inflammatory1

Fluorescence1