• The term "oncotarget" encompasses all molecules, pathways, cellular functions, cell types, and even tissues that can be viewed as targets relevant to cancer as well as other diseases. (oncotarget.com)
  • The natural HLA-E ligand is a signal peptide derived from classical class Ia HLA molecules that interact with the NKG2/CD94 receptors to regulate natural killer cell functions, but pathogen-derived peptides can also be presented by HLA-E. Here, we describe five peptides from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that elicited HLA-E-restricted CD8 + T cell responses in convalescent patients with coronavirus disease 2019. (ox.ac.uk)
  • The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. (thermofisher.com)
  • The complement system, interacting with its regulatory molecules and cellular receptors, plays a central role in the induction and regulation of immunity. (medscape.com)
  • I have used structural biology to explain pre-T-cell receptor (TCR) self-association in T-cell development, and how the TCR specifically recognises polymorphic Human Leukocyte Antigen (HLA) molecules in the context of viral immunity and aberrant T-cell reactivity. (cardiff.ac.uk)
  • This discrepancy is explained by thymic selection where the fate of T-cell precursors is dependent on the recognition of self-peptides (self-p) presented by MHC molecules on thymic stromal cells ( 28 ). (frontiersin.org)
  • Therefore, the lymphocytes are distinguished by their function and response to antigen, their cell membrane molecules and receptors, their types of secreted proteins, and their tissue location. (pediagenosis.com)
  • We combined the high-throughput of mass cytometry, facilitating the analysis of 57 twin pairs, with cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) of eight selected twin pairs to obtain a comprehensive overview of epitopes, transcriptome and T cell receptor (TCR) clonotypes. (nature.com)
  • The injection of chronically infected mice with a lentiviral vector encoding LCMV MHC class I and II T cell epitopes and a soluble programmed cell death 1 microbody rapidly cleared the virus. (jci.org)
  • Recently, the first set of naturally presented human leukocyte antigen Class I (HLA-I) epitopes of MuV was identified by us. (mdpi.com)
  • Due to the artificial nature of drug/chemical-T-cell epitopes, it is not clear whether thymic selection of drug/chemical-specific T cells is a common phenomenon or remains limited to few donors or simply does not exist, suggesting T-cell receptor (TCR) cross-reactivity with other antigens. (frontiersin.org)
  • Twelve M. ulcerans genome assemblies were analyzed, resulting in the identification of 11 CD8+ and 7 CD4+ T-cell epitopes and 2 B-cell epitopes. (bvsalud.org)
  • The CD4+ T-cell epitopes were capable of inducing interferon-gamma and interleukin-4. (bvsalud.org)
  • They are capable of processing complex antigens into epitopes, which are then displayed on their cell membranes in order to activate the appropriate lymphocytes. (pediagenosis.com)
  • Microbial infection) Acts as a receptor for human cytomegalovirus protein UL11 and mediates binding of UL11 to T-cells, leading to reduced induction of tyrosine phosphorylation of multiple signaling proteins upon T-cell receptor stimulation and impaired T-cell proliferation. (neobiotechnologies.com)
  • Explore our solutions for multiple applications - vaccines, monoclonal antibodies, recombinant proteins, cell or gene therapy. (vwr.com)
  • 2009). Generation of Human Induced Pluripotent Stem Cells by Direct Delivery of Reprogramming Proteins. (igem.org)
  • Endogenous synthesis of antigen results in efficient proteolytic peptide processing and presentation of peptide antigen on MHC class I proteins. (jci.org)
  • However, limited data are available about sequence variability in CD8 + T cell epitope regions of mumps virus (MuV) proteins. (mdpi.com)
  • CD3 epsilon is one of at least four invariant proteins that associate with the variable antigen recognition chains of the T cell receptor and function in signal transduction. (rndsystems.com)
  • Effector proteins interacting with the Fc portion of immunoglobulin M (IgM) include complement and complement receptors. (medscape.com)
  • Partial or complete deficiencies of the components of the complement system, including its receptors and regulatory proteins, are now described in humans and may be of a genetic or familial origin or acquired. (medscape.com)
  • Defects in the expression of complement or complement receptors may result in loss of tolerance to self-proteins and the development of immune complex-mediated autoimmune diseases such as systemic lupus erythematosus (SLE). (medscape.com)
  • The nomenclature for the surface proteins utilizes the letters "CD" followed by a number that specifies the surface proteins that define a particular cell type or stage of cell differentiation and are recognized by a cluster or group of antibodies. (pediagenosis.com)
  • 1994). These proteins interact in the regulation of several host cell act and responses as chaperones. (thetechnoant.info)
  • To reduce the risk of analyzing cell line- pathway can be divided into distinct stages based on the specific features, we used several representative cell lines for recombination status of the Ig genes and on the expression each of four major stages in B cell development: pro-B, pre-B, pattern of surface markers and the presence of intracellular proteins [1- 6]. (lu.se)
  • When fluorochrome conjugated antibodies are bound to BD® CompBeads, they have spectral properties very similar to cells. (bdbiosciences.com)
  • The still unanswered questions of the origin of natural antibodies and their possible role in the recognition of antigens and in the initiation of the immune response are discussed in the chapter. (typeset.io)
  • The question proposed in the chapter is whether the postulated recognition factors of the immune system are detectable in serum or are attached to certain cells as natural antibodies. (typeset.io)
  • THE local humoral and cellular events which occur in the skin following cell injury are very similar to those which follow the intradermal injection of soluble antigen in an immunized animal which has antibodies in its circulation. (typeset.io)
  • Cancer immunotherapies can be divided into four major categories: - Cytokines/immunomodulation agents - Monoclonal antibodies - Cell‑based therapies - Oncolytic viruses Though monoclonal antibodies currently represent the largest class of commercialized cancer immunotherapies, cell‑based therapies are rapidly making headway. (technologynetworks.com)
  • B lymphocytes are responsible for forming the antibodies that provide humoral immunity, whereas T lymphocytes provide cell-mediated immunity. (pediagenosis.com)
  • The recognition of specific surface antigens by lymphocytes is made possible because of the presence of specific receptors or antibodies on the surface of B and T lymphocytes. (pediagenosis.com)
  • Unlike the T lymphocytes, where the entire cell is involved in the immune response, B lymphocytes secrete antibodies, which then act as the reactive agent in the immune process. (pediagenosis.com)
  • When antigens come in contact with the lymphocytes in the lymphoid tissues of the body, specific T cells become activated and specific B cells are stimulated to produce antibodies. (pediagenosis.com)
  • Protein-protein interactions among SARS-CoV-2 spike protein, human receptors and antibodies are key determinants of the potency of this virus and its ability to evade the human immune response. (bvsalud.org)
  • Illustrations are provided on the receptor binding domain of coronaviruses, in complex with their cognate partner or (neutralizing) antibodies. (bvsalud.org)
  • cells are activated by interaction with antigens and obtain T indicated that the cell lines representing a defined cell help, they mature into terminally differentiated plasma stage generally presented a high similarity in over- cells secreting large amounts of antibodies [10 -12]. (lu.se)
  • Mouse monoclonal to CD31.COB31 monoclonal reacts with human CD31, a 130-140kD glycoprotein, which is also known as platelet endothelial cell adhesion molecule-1 (PECAM-1). (bioinf.org)
  • Pathogen-specific CD8 + T cell responses restricted by the nonpolymorphic nonclassical class Ib molecule human leukocyte antigen E (HLA-E) are rarely reported in viral infections. (ox.ac.uk)
  • Once the first encounter occurs, these cells can exactly recognize a particular microorganism or foreign molecule because each lymphocyte is capable of targeting a specific antigen and differentiating the invader from self or from other substances that may be similar to it. (pediagenosis.com)
  • SARS-CoV-2 infection markedly down-regulated classical HLA class I expression in Calu-3 cells and primary reconstituted human airway epithelial cells, whereas HLA-E expression was not affected, enabling T cell recognition. (ox.ac.uk)
  • It plays a role in lipid metabolism, inflammation, and atherosclerosis, and is involved in the recognition and uptake of various ligands such as oxidized low-density lipoproteins, long-chain fatty acids, and apoptotic cells. (thermofisher.com)
  • I have unearthed structural mechanisms of HLA polymorphism impacting on drug and food hypersensitivities, as well as Natural Killer cell receptor recognition. (cardiff.ac.uk)
  • 2023. CD4+ T cell-mediated recognition of a conserved cholesterol-dependent cytolysin epitope generates broad antibacterial immunity . (cardiff.ac.uk)
  • Recent observations raise the hypothesis that not only the drug/chemical, but also parts of the haptenated protein or peptides may constitute the important structural determinants for antigen recognition by the TCR. (frontiersin.org)
  • We provide an overview of the data supporting different models of T-cell recognition of drugs and chemicals and discuss speculative models addressing the origin of drug/chemical responsive naive T cells. (frontiersin.org)
  • After antigen recognition and activation, CD8 + cytotoxic T cells may trigger keratinocyte apoptosis. (medscape.com)
  • This junctional region of the TCR chains, also known as the complementarity-determining region 3 (CDR3), is highly diverse and is an important determinant of antigen recognition by T cells. (biomedcentral.com)
  • FYB is a multifunctional protein involved in post-activation T cell signaling, lymphocyte cytokine production, cell adhesion, and actin remodeling. (wikipedia.org)
  • The CD31 antigen is expressed on platelets and endothelial cells at high levels, as well as on T-lymphocyte subsets, monocytes, and granulocytes. (bioinf.org)
  • 2007). Adoptive Transfer of Chimeric Antigen Receptor Re-directed Cytolytic T Lymphocyte Clones in Patients with Neuroblastoma. (igem.org)
  • Injection of a lentiviral vector encoding an MHC class I-restricted T cell epitope of lymphocytic choriomeningitis virus (LCMV) and CD40 ligand induced an antigen-specific cytolytic CD8 + T lymphocyte response that protected the mice from infection. (jci.org)
  • CD62L is expressed on neutrophils, monocytes, T- and B-lymphocyte subsets and NK cells. (bdbiosciences.com)
  • It thus defines L-selectin as a human lymphocyte homing receptor for peripheral lymph node HEV. (bdbiosciences.com)
  • Flow cytometry analysis (surface staining) of human peripheral blood (lymphocyte gate) using anti-human CD8 (clone MEM-31) PerCP. (exbio.cz)
  • Estefanía E, Flores R, Gómez-Lozano N, Aguilar H, López-Botet M, Vilches C: Human KIR2DL5 is an inhibitory receptor expressed on the surface of NK and T lymphocyte subsets. (exbio.cz)
  • Each T lymphocyte develops specificity against a specific antigen. (pediagenosis.com)
  • This tissue is composed of splenic nodules, which are similar to the lymphatic nodules in lymph nodes and are packed with lymphocytes (T lymphocyte cells and B lymphocyte cells). (healthjade.net)
  • B lymphocyte development is a highly ordered process pro- expression analysis without the use of intermediate amplifica- ceeding from the progenitor cells in the bone marrow (BM) to tion steps. (lu.se)
  • Introduction tions of T-cell derived IL-2R are increased in mixed lymphocyte cultures. (who.int)
  • In T cells, after TCR stimulation, a unique region of FYB, pYDGI, allows phosphorylation of the protein by FYN. (wikipedia.org)
  • FYB is also an important protein for actin remodeling of immune cells. (wikipedia.org)
  • Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. (neobiotechnologies.com)
  • 1997). Degradation of Amyloid β-Protein by a Metalloprotease Secreted by Microglia and Other Neural and Non-neural Cells. (igem.org)
  • The engineered BV-2s will be equipped to locate the specific GBMs and label the targeted cells with a tat-GFP fusion protein. (igem.org)
  • Full length human recombinant protein of human CD36 produced in HEK293T cell. (thermofisher.com)
  • CD36, also known as scavenger receptor class B member 3, is a protein that is expressed on the surface of various cell types, including macrophages, platelets, and adipocytes. (thermofisher.com)
  • The protein encoded by this gene serves as a receptor for thrombospondin in platelets and various cell lines, and is the fourth major glycoprotein of the platelet surface. (thermofisher.com)
  • Vaccination by direct injection of lentiviral vector was more effective in sterile alpha motif and HD-domain containing protein 1-knockout (SAMHD1-knockout) mice, suggesting that lentiviral vectors containing Vpx, a lentiviral protein that increases the efficiency of dendritic cell transduction by inducing the degradation of SAMHD1, would be an effective strategy for the treatment of chronic disease in humans. (jci.org)
  • The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). (thermofisher.com)
  • Interferon gamma receptor 1 ( IFNGR1 ) also known as CD119 ( C luster of D ifferentiation 119 ), is a protein that in humans is encoded by the IFNGR1 gene . (wikidoc.org)
  • Viruses belonging to the largest cluster acquired an amino acid substitution in the receptor binding domain of the Spike protein (position 486), evolved faster and spread longer and more widely. (bvsalud.org)
  • 1989). Immortalization of murine microglial cells by a v-raf/ v-myc carrying retrovirus. (igem.org)
  • 1989. Leucocyte Typing IV. (biolegend.com)
  • Trends in Cell Biology. (wikipedia.org)
  • Avantor® can help equip your life sciences lab with the products, equipment, and supplies you need - whether you work in cell biology, genomics, proteomics, or other fields. (vwr.com)
  • Journal of Leukocyte Biology, 75, 1147-1155. (igem.org)
  • HLA-E peptide-specific CD8 + T cell clones, which expressed diverse T cell receptors, suppressed SARS-CoV-2 replication in Calu-3 human lung epithelial cells. (ox.ac.uk)
  • c) The gel filtration chromatography of refolded peptide human being leucocyte antigen (pHLA) (MAGE\A3) and biotinylation effectiveness analysis of purified pHLA (MAGE\A3). (fsu93.org)
  • The DCs are then pulsed with synthetic peptide or cell lysate and matured with cytokine or TLR agonists. (jci.org)
  • I have pioneered our molecular understanding of lipid-based immunity by T cells, revealing that it can differ fundamentally from peptide-mediated adaptive immunity. (cardiff.ac.uk)
  • 2023. Complimentary electrostatics dominate T-cell receptor binding to a psoriasis-associated peptide antigen presented by human leukocyte antigen C∗06:02 . (cardiff.ac.uk)
  • The specific antigen that triggers lichen planus is unknown, although it may be a self-peptide (or altered self-peptide), in which case lichen planus would be a true autoimmune disease. (medscape.com)
  • Frequency, specificity, and sites of expansion of CD8+ T cells during primary pulmonary influenza virus infection. (cdc.gov)
  • van den Berg HA, Wooldridge L, Laugel B, Sewell AK: Coreceptor CD8-driven modulation of T cell antigen receptor specificity. (exbio.cz)
  • Thus, analysis of TCR CDR3 sequences has provided a useful means to study clonal expansions, repertoire breadth, and other properties such as CDR3 length polymorphisms, V(D)J gene usage, and sequence specificity of the T cell response. (biomedcentral.com)
  • Lentiviral vector-based dendritic cell vaccines induce protective T cell responses against viral infection and cancer in animal models. (jci.org)
  • In this study, we tested whether preventative and therapeutic vaccination could be achieved by direct injection of antigen-expressing lentiviral vector, obviating the need for ex vivo transduction of dendritic cells. (jci.org)
  • Injected lentiviral vector preferentially transduced splenic dendritic cells and resulted in long-term expression. (jci.org)
  • These properties have made lentiviral vectors advantageous for use in dendritic cell (DC) vaccines. (jci.org)
  • Mice with C5a receptor-deficient dendritic cells promote induction of Treg and Th17 cells. (medscape.com)
  • It is a single-chain membrane glycoprotein of approximately 200 kd that has 4 allotypic forms on myeloid cells (eg, erythrocytes, granulocytes, monocytes), lymphoid cells (mostly B cells), follicular dendritic cells, and glomerular podocytes. (medscape.com)
  • 32-34 kDa) is expressed as alpha/beta heterodimer on majority of MHC I-restricted conventional T cells and thymocytes and as alpha/alpha homodimer on subsets of memory T cells, intraepithelial lymphocytes, NK cells and dendritic cells. (exbio.cz)
  • Negative role of inducible PD-1 on survival of activated dendritic cells. (bio-connect.nl)
  • that is histopathological y very simi- T cel s, B cel s, natural kil er cel s, LMP1 of EBV can transform ro- lar to that caused by hepatitis B vi- macrophages, and dendritic cells, dent fibroblasts and is expressed rus (HBV) in humans, but it does so and this humanized mouse model in most of the human cancers as- through a different mechanism. (who.int)
  • It is expressed on the surface of NK cells, activated monocytes, macrophages, and placental trophoblasts in humans. (biolegend.com)
  • The gene IFNGR1 encodes IFN-γR1, which is the ligand-binding chain (alpha) of the heterodimeric gamma interferon receptor, which is found on macrophages . (wikidoc.org)
  • The dense subepithelial mononuclear infiltrate in oral lichen planus is composed of T cells and macrophages, and there are increased numbers of intraepithelial T cells. (medscape.com)
  • Leukocytes involved in the innate immune response, such as macrophages and DCs, also play a key role in adaptive immunity because they function as APCs. (pediagenosis.com)
  • Cytotoxic T lymphocytes, macrophages, and other leukocytes function as effector cells in different immune responses. (pediagenosis.com)
  • This pulp contains numerous red blood cells, which impart its color, plus many lymphocytes and macrophages. (healthjade.net)
  • The older, more fragile red blood cells may rupture during this passage, and the resulting cellular debris is removed by phagocytic macrophages in the venous sinuses. (healthjade.net)
  • This antibody clone has been verified for purity assessments of cells isolated with EasySep™ kits, including EasySep™ Human CD138 Positive Selection Kit II (Catalog #1877) and EasySep™ Human Whole Blood and Bone Marrow CD138 Positive Selection Kit II (Catalog #17887). (stemcell.com)
  • This clone is cross reactive with non-human primate. (bioinf.org)
  • PMA-stimulated human peripheral blood granulocytes were stained with CD11/CD18 (clone m24) Alexa Fluor® 647 (filled histogram) or mouse IgG1, κ Alexa Fluor® 647 isotype control (open histogram). (biolegend.com)
  • 1990). Characterization and Expression of the Gene for the Human Fc Receptor γ Subunit. (igem.org)
  • 2009). Physiologic Oxygen Concentration Enhances the Stem-Like Properties of CD133+ Human Glioblastoma Cells In Vitro. (igem.org)
  • 2009). Isolation and characterization of cancer stem like cells in human glioblastoma cell lines. (igem.org)
  • 2004). Fcγ receptor signaling in primary human microglia: differential roles of PI-3K and Ras/ERK MAPK pathways in phagocytosis and chemokine induction. (igem.org)
  • HLA, human leukocyte antigen. (cdc.gov)
  • Human peripheral blood lymphocytes were stained with anti-human CD56 Brilliant Violet 421™ and anti-human CD16 (clone 3G8) Spark YG™ 581 (left), or only stained with anti-human CD56 Brilliant Violet 421™ (right). (biolegend.com)
  • Here we show that co-engagement of CD3 and the complement regulator CD46 in the presence of IL-2 induces a Tr1-specific cytokine phenotype in human CD4 + T cells. (nature.com)
  • Interleukin-21 (IL-21) was first identified in 2000 through screening of a cDNA library from CD3+ human T cells [ 1 ]. (intechopen.com)
  • The human interferon-gamma receptor. (wikidoc.org)
  • Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μl reagent / 100 μl of whole blood or 10 6 cells in a suspension. (exbio.cz)
  • Nevertheless, there are only an estimated 10 12 T cells in the human body ( 26 ). (frontiersin.org)
  • They successfully bound to their respective human leukocyte antigens alleles in in silico docking studies. (bvsalud.org)
  • It has been suggested that cytokine acc leukoreduction prevents transmission of cyc cumulation in plasma of platelet concenc tomegalovirus and decreases alloimmunizac trates (PC) during storage may contribute tion to human leukocyte antigen (HLA), it to development of nonchaemolytic febrile does not prevent allergic reactions. (who.int)
  • Animal models for human tumour mental animals is not easy to answer does induce adult T-cell leukaemia/ viruses that make use of animal virus- for these agents, because cancer bi- lymphoma (ATLL), albeit in monkeys es are scarce. (who.int)
  • T cell receptor zeta/CD3-p59fyn(T)-associated p120/130 binds to the SH2 domain of p59fyn(T)". The Journal of Experimental Medicine. (wikipedia.org)
  • Clone m24 binds the extended/open high affinity conformation of CD11a/CD18. (biolegend.com)
  • CD16 binds aggregated IgG or IgG-antigen complex which functions in NK cell activation, phagocytosis, and antibody-dependent cell-mediated cytotoxicity (ADCC). (biolegend.com)
  • The CR1 receptor preferentially binds C3b that is covalently attached to immune complexes, and it has a weaker affinity for bound C4b and iC3b. (medscape.com)
  • 1995. Leucocyte Typing V. Oxford University Press. (biolegend.com)
  • Influenza nucleoprotein-specific cytotoxic T-cell clones are protective in vivo. (cdc.gov)
  • Linnebacher M, Wienck A, Boeck I, Klar E: Identification of an MSI-H tumor-specific cytotoxic T cell epitope generated by the (-1) frame of U79260(FTO). (exbio.cz)
  • Tumor-specific neoantigens, which are expressed on tumor cells, can induce an effective antitumor cytotoxic T-cell response and mediate tumor regression. (wjgnet.com)
  • CD45R, also designated CD45 and PTPRC, has been identified as a transmembrane glycoprotein, broadly expressed among hematopoietic cells. (neobiotechnologies.com)
  • The HIT2 antibody reacts with CD38, an ~45 kDa type II transmembrane glycoprotein expressed by many cell types, especially leukocytes. (stemcell.com)
  • The antibody MEM-31 recognizes a conformationally-dependent extracellular epitope of CD8, a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. (exbio.cz)
  • CD8 + T cells play a critical role in immunity to viruses. (mdpi.com)
  • Our findings identify an endogenous receptor-mediated event that drives Tr1 differentiation and suggest that the complement system has a previously unappreciated role in T-cell-mediated immunity and tolerance. (nature.com)
  • The identification of lymphocytes as the main cell type responsible for both cellular and humoral immunity started in the early 1950s with the emergence of cell culture techniques. (frontiersin.org)
  • Intratumoral administration of mRNA encoding a fusokine consisting of IFN-β and the ectodomain of the TGF-β receptor II potentiates antitumor immunity. (bio-connect.nl)
  • Cell-mediated and humoral immunity is capable of responding to millions of antigens each day because there is an enormous variety of lymphocytes that have been programmed and selected during cellular development. (pediagenosis.com)
  • Shevach, E. M. S. M. R., Piccirillo, C. A. & Thornton, A. M. Control of T-cell activation by CD4 + CD25 + suppressor T cells. (nature.com)
  • The spleen also acts as the primary reservoir for platelets and as a filter for red blood cells (RBCs), removing damaged or malformed red blood cells from the circulation. (healthjade.net)
  • Aplastic anemia is a disorder of the hematopoietic stem cell that results in a loss of blood cell precursors, hypoplasia or aplasia of bone marrow, and cytopenias in two or more cell lines (red blood cells, white blood cells, and/or platelets). (msdmanuals.com)
  • White blood cells and platelets are not affected. (msdmanuals.com)
  • Симптоми та ознаки Platelets are circulating cell fragments that function in the clotting system. (msdmanuals.com)
  • The leukocyte, neutrophil and platelet recovery over time was calculated and plotted using Kaplan-Meier survival analysis. (exposed-skin-care.net)
  • The study found significant cytokine accumulation during 5 days of storage time in leukocyte contaminated platelet concentrates, suggesting that the platelet storage time has an effect on IL-2R levels. (who.int)
  • We undertook this study to investigate receptor (IL-2R) accumulation is related to whether the cytokine accumulation in PCs the leukocyte content of the platelet comc obtained from single apheresis donors was ponent and can be reduced by prestorage beyond the acceptable limits of WBC conc leukocyte depletion [ 3 ]. (who.int)
  • The most commonly used method for measuring immune cell‑mediated killing is the release assay, where effector cell‑mediated disruption of the target cell membrane results in leakage of its cytoplasmic contents into the culture medium. (technologynetworks.com)
  • 2023. SARS-CoV-2 breakthrough infection induces rapid memory and de novo T cell responses . (cardiff.ac.uk)
  • Impaired selectin-dependent leukocyte recruitment induces T-cell exhaustion and prevents chronic allograft vasculopathy and rejection. (bio-connect.nl)
  • Additional reported applications (for the relevant formats) include: immunohistochemical staining of acetone-fixed frozen tissue sections 6 , immunoprecipitation 3 , stimulation of NK cell proliferation 4 , blocking of phagocytosis 5 , and blocking of immunoglobulin binding to FcγRIII 7,8 . (biolegend.com)
  • This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. (thermofisher.com)
  • The major functions of the spleen include clearance of abnormal erythrocytes, removal of microorganisms and antigens as well as the synthesis of immunoglobulin G (IgG). (healthjade.net)
  • The use of cell lines does, however, introduce a risk the immunoglobulin (Ig)-secreting plasma cell in the spleen, of obtaining cell line-specific features as a result of the trans- gut, or BM [1, 2]. (lu.se)
  • Evidence for a thymus-dependent form of tolerance that is not based on elimination or anergy of reactive T cells. (nature.com)
  • 2023. The allopurinol metabolite, oxypurinol, drives oligoclonal expansions of drug‐reactive T cells in resolved hypersensitivity cases and drug‐naïve healthy donors . (cardiff.ac.uk)
  • immature cell is then subjected to negative selection to delete grouped based on their previously defined pheno- self-reactive cells before it leaves the BM to enter peripheral typic features, and a gene expression pattern for lymphoid organs, where it becomes a mature B cell [9]. (lu.se)
  • T cells play an important role in the pathogenesis of systemic lupus erythematosus (SLE). (biomedcentral.com)
  • The 130kDa version has an extra insertion of 46 amino acids and is preferentially expressed in peripheral T cells. (wikipedia.org)
  • Clonal expansion of T cells correlating with disease activity has been observed in peripheral blood (PB) of SLE subjects. (biomedcentral.com)
  • show that this approach can detect characteristic changes that affect blood cells as a result of malaria, spherocytosis, bacterial and viral infections, and leukemia. (elifesciences.org)
  • Bender BS , Croghan T , Zhang L , Small PA Jr . Transgenic mice lacking class I major histocompatibility complex-restricted T cells have delayed viral clearance and increased mortality after influenza virus challenge. (cdc.gov)
  • Alternatively, the DCs are transduced with a viral vector that expresses the antigen. (jci.org)
  • The expression or unmasking of the lichen planus antigen may be induced by drugs (lichenoid drug reaction), contact allergens in dental restorative materials or toothpastes (contact hypersensitivity reaction), mechanical trauma (Koebner phenomenon), viral infection, or other unidentified agents. (medscape.com)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
  • CD31 (PECAM-1) is an adhesion receptor with signaling function that is implicated in vascular wound healing, angiogenesis and transendothelial migration of leukocyte inflammatory responses. (bioinf.org)
  • These T cell responses were identified in the blood at frequencies similar to those reported for classical HLA-Ia-restricted anti-SARS-CoV-2 CD8 + T cells. (ox.ac.uk)
  • Complement and complement receptors play a critical role in immune defense by initiating the rapid destruction of invading microorganisms, amplifying the innate and adaptive immune responses, and mediating solubilization and clearance of immune complexes. (medscape.com)
  • The immune system must distinguish not only between self and non-self, but also between innocuous and pathological foreign antigens to prevent unnecessary or self-destructive immune responses. (nature.com)
  • A CD4 + T-cell subset inhibits antigen-specific T-cell responses and prevents colitis. (nature.com)
  • Robust SARS-CoV-2 T cell responses with common TCR? (cardiff.ac.uk)
  • Therefore, murine airway CD8 + T cell-responses to aspiration of Aspergillus conidia may be mediated in part by the ability of conidia to germinate in the host lung tissue. (cdc.gov)
  • It is now clear that the ability of T cells to promote an effective immune response depends on a large repertoire of unique T-cell receptors (TCRs) generated and selected in the thymus. (frontiersin.org)
  • Subsequently, the investigators identified a specific clone as containing pro-proliferative effects that was sensitive to neutralization by the soluble IL-21R. (intechopen.com)
  • An in vitro technique is described for assessing the chemotactic activity of soluble substances on motile cells. (typeset.io)
  • The 3G8 antibody clone blocks neutrophil phagocytosis and stimulates NK cell proliferation. (biolegend.com)
  • Endogenous biomolecules (such as lactate dehydrogenase) or previously added exogenous labels (such as the radioisotope 51Cr) that leak into the media are then measured as an indirect readout of the damage caused by effector cells. (technologynetworks.com)
  • FYB regulates cytokine production in T cells as well as in activated NK cells through the FYN-ADAP axis. (wikipedia.org)
  • IL-21R is a type-1 cytokine receptor and belongs to the IL-2R and IL-15R family. (intechopen.com)
  • Potent T\cell activation could be generated with improved affinity of the TCR by directed molecular evolution. (fsu93.org)
  • Hence, investigating how genetic predisposition and environmental triggers shape the interactions of individual immune cells is vital to understand the pathophysiology of autoimmune diseases including MS. (nature.com)
  • This class of personalized therapies involves collecting immune cells from an individual, engineering them to recognize and kill cancer cells, before culturing, and reintroducing them into the same individual. (technologynetworks.com)
  • The utilization of this nomenclature has spread to other immune cells and cytokines all of which contribute to the acquired immune response. (pediagenosis.com)
  • Functionally, there are two types of immune cells: regulatory cells and effector cells. (pediagenosis.com)
  • The density of CR1 receptors on cell surfaces varies with the cell type and with the activation of the cell for neutrophils and monocytes. (medscape.com)
  • However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)
  • On the other hand, T cells constitute the main pathogenic effector cells in delayed hypersensitivity reactions ( 4 - 6 ). (frontiersin.org)
  • The principal cells of the adaptive immune system are the lymphocytes, APCs, and effector cells. (pediagenosis.com)
  • The regulatory cells assist in orchestrating and controlling the immune response, while effector cells carry out the elimination of the antigen (microbial, non microbial, or toxin). (pediagenosis.com)
  • Moskophidis D , Kioussis D . Contribution of virus-specific CD8+ cytotoxic T cells to virus clearance or pathologic manifestations of influenza virus infection in a T cell receptor transgenic mouse model. (cdc.gov)
  • In a drop of blood we can identify all major blood cells and characterize their pathological changes in several disease conditions in vitro and in patient samples. (elifesciences.org)
  • Blockade of LFA-1 augments in vitro differentiation of antigen-induced Foxp3⁺ Treg cells. (bio-connect.nl)
  • While many methods have been developed to screen and evaluate the efficacy of immune cell‑mediated killing, there is a need for a more robust in vitro assay to accurately predict the in vivo behavior of therapies. (technologynetworks.com)
  • [ 8 ] T cells in oral lichen planus contain mRNA for TNF and secrete TNF in vitro. (medscape.com)
  • Dubremetz and Soete, 1996)) bring about a rise in bradyzoite antigen appearance and the advancement of cyst-like buildings of in vitro. (thetechnoant.info)
  • In an attempt to evaluate the immune response of renal cell carcinoma (RCC) patients, tumor lesions and / or blood samples from 12 RCC patients underwent deep T cell receptor (TCR) sequencing. (oncotarget.com)
  • They tend to enhance the effects of complement and are highly important in the binding of opsonized immune complexes on B cells. (medscape.com)
  • Opsonized immune complexes (coated by C3b and C4b) bind to CR1, mostly on red blood cells, and are cleared through the liver where they can be transferred to CR3-bearing phagocytes and endocytosed. (medscape.com)
  • Results are described which indicate that, when antibody-antigen complexes are incubated in fresh serum, a heat-stable substance (or substances) is produced which acts directly as a chemotactic stimulus on the polymorphs. (typeset.io)
  • This heat-stable chemotactic substance is not produced when antibody-antigen complexes are incubated in serum which has been heated at 56°C for 30 minutes. (typeset.io)
  • It is suggested that the reaction due to cell injury is similar to that due to antibody-antigen interaction because damage to cells causes the local formation of antibody-antigen complexes. (typeset.io)
  • CD31 is a known ligand for the receptor. (stemcell.com)
  • IFNGR2 , encodes IFN-γR2, the non-ligand-binding partner of the heterodimeric receptor. (wikidoc.org)
  • CD18, in association with integrin α chain CD11a, CD11b, and CD11c forms LFA-1, Mac-1, and α X β 2 , respectively, and plays an important role in leukocyte adhesion. (biolegend.com)
  • Recognizes the epsilon -chain of the CD3/T cell antigen receptor complex (McMichael, A.J. et al . (rndsystems.com)
  • Because allelic exclusion leads to the expression of only one TCR chain in mature T cells [ 29 ], each unique CDR3 sequence is a proxy for T cell clonotype. (biomedcentral.com)
  • Subsequent differentiation allows for rear- analysis of a set of mouse B lineage cell lines rep- rangements of the Ig light-chain (IgL) genes that replace the resenting defined stages of B cell development us- surrogate light-chain genes on the surface of the B cell [8]. (lu.se)
  • 2007). Monoclonal T-Cell Receptors: New Reagents for Cancer Therapy. (igem.org)
  • During thymic selection, T cells that have not yet encountered their cognate antigen are considered naive T cells. (frontiersin.org)
  • In the present study, sequences of 40 CD8 + T cell epitope candidates, including previously and newly identified, obtained from Jeryl-Lynn mumps vaccine strains were compared with genomes from 462 circulating MuV strains. (mdpi.com)
  • Characteristics of the influenza virus-specific CD8+ T cell response in mice homozygous for disruption of the H-2lAb gene. (cdc.gov)
  • In the near future, novel chemo-/gene-therapies might be applied to treat cancer patient converting cancerous cells into normal differentiated cells. (intechopen.com)
  • We did not observe any overlap of CDR3 amino acid sequences or a preferential Vβ or Jβ gene usage among the top 100 expanded clones from all SLE patients. (biomedcentral.com)
  • Interferon gamma receptor 1 has been shown to interact with Interferon-gamma . (wikidoc.org)
  • In bone tissue marrow ST 2825 produced murine macrophage lines, interferon gamma (IFN-) elevated bradyzoite antigen appearance and this were linked to nitric oxide (NO) creation (Bohne et al. (thetechnoant.info)
  • Interleukin-21 (IL-21) is produced by activated T cells and it plays many diverse roles by regulating the functions of normal and abnormal cells. (intechopen.com)
  • HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY LILRB3 (RC211228, Right lane) cDNA for 48 hrs and lysed. (thermofisher.com)
  • They are part of a much larger group of compounds, the eicosanoids, which, although ubiquitous as a group, are produced by a variety of cell type-, tissue-, and species-specific biosynthetic pathways. (jci.org)
  • The role of autoimmunity in the pathogenesis is supported by many autoimmune features of oral lichen planus, including its chronicity, onset in adults, predilection for females, association with other autoimmune diseases, occasional tissue-type associations, depressed immune-suppressor activity in patients with oral lichen planus, and the presence of autocytotoxic T-cell clones in lichen planus lesions. (medscape.com)
  • T and B lymphocytes are unique in that they are the only cells in the body capable of recognizing specific antigens present on the surfaces of microbial agents and other pathogens. (pediagenosis.com)
  • 2023. CD1 lipidomes reveal lipid-binding motifs and size-based antigen-display mechanisms . (cardiff.ac.uk)
  • 2023. DeepAIR: A deep learning framework for effective integration of sequence and 3D structure to enable adaptive immune receptor analysis . (cardiff.ac.uk)