AssayChemotaxisMACROPHAGESInflammatoryReceptorsStaphylococcusProteinAccumulation of leukocytesCytokinesPlatelet-activaImmune complexesMechanismsMediatorsMicroscopyVitroEndotheliumTissueChemotactic FactorsVascularPolymorphonuclearExtractExtracellularCellularActivityPathogensPathogenesisLungEpidermalActivationNeutrophilsPhagocytosisLigandsCysteineInterferonTranscription factorRecruitmentFamilialComplexCellPulmonaryProteinsPredisposingAutoimmunityCells
Assay5
- Studies of an assay system for dialyzable leukocyte extracts (DLE)--influence of DLE on leukocyte migration inhibition test by HBsAg]. (nih.gov)
- Immunological monitoring in lung cancer: use of the leukocyte migration inhibition assay. (nih.gov)
- 10. Leucocyte migration inhibitory factor assay in Nigerians with urinary schistosomiasis. (nih.gov)
- The capacity for production of migration inhibitory factor was assessed by the agarose droplet cell migration inhibition assay, using peritoneal exudate cells and a CVB3(m) cell lysate or KCl extracted antigens from heart tissues of CVB3(m)-inoculated mice. (nih.gov)
- A two-chamber and two-cell trans-well assay was used to detect the migration ability of macrophages through endothelial cells. (aging-us.com)
Chemotaxis1
- Chemotactic cytokines (chemokines) activate their receptors to evoke the chemotaxis of immune cells in homeostatic migrations or inflammatory conditions towards inflamed tissue or pathogens. (bvsalud.org)
MACROPHAGES4
- Proteins released by sensitized LYMPHOCYTES and possibly other cells that inhibit the migration of MACROPHAGES away from the release site. (lookformedical.com)
- Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES . (lookformedical.com)
- Alveolar macrophages and type II pneumocytes produce CXC chemokines, which attract neutrophils to migrate through the endothelium (inset C1: transendothelial migration), interstitial space, and epithelium (inset C2: transepithelial migration) to reach the alveolar space. (biomedcentral.com)
- The innate immune response provides an immediate response to infection and injury and is mainly mediated by circulating factors and non-lymphocytic cell types that include macrophages, dendritic cells (DCs), neutrophils and other less common leukocytes. (biomedcentral.com)
Inflammatory8
- To study secretion patterns of pro- and anti-inflammatory cytokines, and activation of various cellular subsets of leukocytes in peripheral blood. (wjgnet.com)
- Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. (lookformedical.com)
- Further investigation revealed that celastrol suppressed the IL‑1β‑induced inflammatory responses in orbital fibroblasts through inhibiting the activation of nuclear factor (NF)‑κB. (spandidos-publications.com)
- MMP mRNA expression, protein levels and proteolytic activity can be modulated by numerous factors including venous hydrostatic pressure, hypoxia, tissue metabolites and the inflammatory response. (oaepublish.com)
- 3. The results showed that the anti-inflammatory mechanism of the moutan cortex was multiplex, including direct antagonism against inflammatory mediators, inhibition of leukocyte migration, and inhibition of prostaglandin E2 biosynthesis. (sanxinherbs.com)
- Further studies showed that the mechanism of action was related to inhibiting hepatocyte apoptosis, decreasing the levels of inflammatory factors in serum and liver tissues, and lipid peroxidation in tissues. (sanxinherbs.com)
- These factors initiate the recruitment phase of inflammatory cells into the conjunctival mucosa, which leads to the late phase reaction. (frontiersin.org)
- Eosinophils are multifunctional leukocytes implicated in the pathogenesis of numerous inflammatory processes including parasitic helminth infections and allergic diseases ( Rothenberg, 1998 ). (frontiersin.org)
Receptors2
- Killer cell inhibitory receptors. (embl.de)
- The recognition by pattern recognition receptors of these pathogen-associated molecular patterns and/or damage-associated molecular patterns results in cell signaling and activation of transcription factors such as NF-κB and IFN regulatory factors (IRFs) [ 10 ]. (biomedcentral.com)
Staphylococcus1
- In vitro test showed that the extract of Cortex moutan had a strong inhibitory effect on Staphylococcus aureus, streptococcus hemolyticus, Escherichia coli, Dicoccus pneumoniae, and Vibrio cholerae, and had certain anti-influenza virus effect. (sanxinherbs.com)
Protein8
- For example, the Slit protein that mediates axonal chemorepulsion has also been shown to inhibit the directed migration of leukocytes in response to chemoattractants. (wikipedia.org)
- Protein factor(s) released by sensitized lymphocytes (and possibly other cells) that inhibit the movement of LEUKOCYTES , especially polymorphonuclear cells, away from their site of release. (bvsalud.org)
- 60B8AG;CAGB;calgranulin B;Calgranulin-B;calprotectin L1H subunit;CFAG;CGLB;L1AG;leukocyte L1 complex heavy chain;LIAG;MAC387;MIF;migration inhibitory factor-related protein 14;MRP14;MRP-14;NIF;P14;protein S100-A9;S100 calcium-binding protein A9;S100-A9. (avivasysbio.com)
- The predominant site of peripheral complement protein synthesis is the liver, where hepatocytes constantly produce and replenish circulating complement factors [ 20 ]. (biomedcentral.com)
- The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. (cusabio.com)
- TGFB3 is a gene encoding a protein named transforming growth factor beta-3 proprotein in human and belongs to TGF-beta family. (cusabio.com)
- To explore the expression of extracellular signal-regulated kinase1/2 (ERK1/2), its correlated upstream protein epidermal growth factor receptor (EGFR) and its downstream transcription factor E twenty-six (ETS)-like 1(ELK-1)in the damage of the diabetic rat skin, and to explore the role of ERK1/2 on the recessive damage to diabetic rat skin. (e-ijd.org)
- The structure of a Ca(2+)-binding epidermal growth factor-like domain: its role in protein-protein interactions. (embl-heidelberg.de)
Accumulation of leukocytes1
- 2004). Certainly, it has previously been demonstrated that the protective effect of Linomide is connected to its inhibitory influence on hepatic accumulation of leukocytes (Klintman et al. (m-entrepreneurship.com)
Cytokines1
- To prevent premature instigation, it is necessary for T-cells to mature in an environment completely isolated from any potentially activating factors (antigens, cytokines, steroids, receptor antagonists, adhesion molecules, etc. (wikipedia.org)
Platelet-activa1
- PAF, platelet-activating factor. (silverchair.com)
Immune complexes4
- 2. Complement factors and circulating immune complexes in children with urinary schistosomiasis and asymptomatic malaria. (nih.gov)
- 5. Immunoglobulin classes, complement factors and circulating immune complexes in chronic sinusitis patients. (nih.gov)
- 6. Circulating immune complexes, immunoglobulin classes (IgG, IgA and IgM) and complement components (C3c, C4 and Factor B) in diabetic Nigerians. (nih.gov)
- It is initiated by lymphokines , such as the macrophage activation factor (MAF) and the macrophage migration-inhibitory factor (MMIF), immune complexes, C3b, and various peptides, polysaccharides, and immunologic adjuvants. (lookformedical.com)
Mechanisms4
- The mechanisms by which P. gingivalis and its virulence factors interact with host immune cells and contribute to the pathogenesis of periodontitis and CVD are far from completely understood. (intechopen.com)
- Investigating the risk factors and mechanisms underlying CVD should help to develop effective treatment strategies. (oaepublish.com)
- The basic route and mechanisms for leukocyte migration across the endothelium remain poorly defined. (rupress.org)
- Therefore, studying the mechanisms that regulate or disrupt skin immune cell interactions, migration and infiltration requires sophisticated yet cost-effective systems to advance new therapeutics, cosmetics and diagnostic modalities. (immune3d.com)
Mediators1
- A number of profibrotic mediators including platelet-derived growth factor (PDGF), fibroblast growth factor (FGF) and transforming growth factor-β are believed to play important roles in the pathogenesis of IPF. (ersjournals.com)
Microscopy1
- for example, intravital microscopy has produced great insight into leukocyte-endothelial interactions in many organs, but it is still technically challenging in the lung. (biomedcentral.com)
Vitro2
- The aim of this study is to demonstrate the transference of PPD hypersensibility in an in vitro model, with dialysable colostral leukocyte extract (DCLE) of PPD+ and PPD-mothers, through measurements of leukocyte migration inhibition factor activity (LIF) from blood obtained of the umbilical cord of newborns from PPD+ mothers. (nih.gov)
- Data from in vitro studies have shown that nintedanib interferes with processes active in fibrosis such as fibroblast proliferation, migration and differentiation, and the secretion of ECM. (ersjournals.com)
Endothelium1
- These findings suggest a novel mechanism, the "transmigratory cup", by which the endothelium provides directional guidance to leukocytes for extravasation. (rupress.org)
Tissue3
- Other factors might also provide chemorepulsive effects on immune cells, and these inhibitory effects might be regulated by the tissue microenvironment. (wikipedia.org)
- All of these factors adversely affect the integrity of spared neurons and thus accentuate tissue damage beyond the initial site of trauma. (biomedcentral.com)
- Tissue recruitment of leukocytes is coordinated by secrete. (m-entrepreneurship.com)
Chemotactic Factors3
- Chemotactic Factors" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (ucdenver.edu)
- This graph shows the total number of publications written about "Chemotactic Factors" by people in this website by year, and whether "Chemotactic Factors" was a major or minor topic of these publications. (ucdenver.edu)
- Below are the most recent publications written about "Chemotactic Factors" by people in Profiles. (ucdenver.edu)
Vascular5
- MMPs could also affect vascular smooth muscle (VSM) cell proliferation, migration, differentiation and/or apoptosis. (oaepublish.com)
- This endothelial structure was comprised of highly intercellular adhesion molecule-1- and vascular cell adhesion molecule-1-enriched vertical microvilli-like projections that surrounded transmigrating leukocytes and drove redistribution of their integrins into linear tracks oriented parallel to the direction of diapedesis. (rupress.org)
- Nintedanib is a potent small molecule inhibitor of the receptor tyrosine kinases PDGF receptor, FGF receptor and vascular endothelial growth factor receptor. (ersjournals.com)
- Nintedanib (international non-proprietary name), formerly known by its development code BIBF 1120, is a small molecule that was originally designed as an ATP-competitive inhibitor of fibroblast growth factor receptor (FGFR)-1 and vascular endothelial growth factor receptor (VEGFR)-2. (ersjournals.com)
- It has been believed that the vascular endothelial growth factor (VEGF) plays a dominant role during the initiation and progression of DR, whose transcriptional expression in the retina was controlled by hypoxia-inducible factor-1α (HIF-1α) [ 3 ]. (ijbs.com)
Polymorphonuclear2
- Although ALI has been described in neutropenic patients, activation and transmigration of circulating neutrophils (polymorphonuclear leukocytes [PMNs]) are thought to play a major role in the early development of ALI [ 2 ]. (biomedcentral.com)
- Neutrophils (polymorphonuclear leukocytes [PMNs], colored blue) enter a pulmonary capillary (left). (biomedcentral.com)
Extract1
- Modulation of cell-mediated responses with dialyzable leukocyte extract containing transfer factor. (nih.gov)
Extracellular2
- LAP is required to maintain the Transforming growth factor beta-3 (TGF-beta-3) chain in a latent state during storage in extracellular matrix. (cusabio.com)
- Various diverse extracellular proteins possess Ca(2+)-binding epidermal growth factor (EGF)-like domains, the function of which remains uncertain. (embl-heidelberg.de)
Cellular1
- Assays for these factors are used as tests for cellular immunity. (bvsalud.org)
Activity4
- Clobetasol also reduces the number of human leukocyte antigen & also inhibits phospholipase A2 activity via formation of lipocortin. (medcarebd.com)
- Migration inhibitory factor activity was not detected in cultures of splenic leukocytes from ts 1 survivors of CVB3(m)-inoculated ts 1 survivors, but it was readily detected in cultures of splenic leukocytes from CVB3(m)-inoculated normal adolescent mice. (nih.gov)
- Ligation of PRRs induces downstream-signaling pathways modifying the activity of transcription factors that regulates the expression of genes linked to inflammation. (intechopen.com)
- Several ECM proteins such as laminin, tenascin and thrombospondin contain domains with homology to epidermal growth factor (EGF) and exhibit growth promoting activity. (embl-heidelberg.de)
Pathogens1
- Leukocyte migration is a key event both in host defense against invading pathogens as well as in inflammation. (silverchair.com)
Pathogenesis1
- To build physiologically relevant 3D platforms begins with an in-depth understanding of disease pathogenesis and the factors that contribute to disease biology. (immune3d.com)
Lung1
- Pulmonary stromal-derived factor-1 expression and effect on neutrophil recruitment during acute lung injury. (ucdenver.edu)
Epidermal3
- Epidermal growth factor-like domain. (embl-heidelberg.de)
- A sequence of about thirty to forty amino-acid residues long found in the sequence of epidermal growth factor (EGF) has been shown [ ( PUBMED:2288911 ) ( PUBMED:6334307 ) ( PUBMED:6607417 ) ( PUBMED:3282918 ) ] to be present, in a more or less conserved form, in a large number of other, mostly animal proteins. (embl-heidelberg.de)
- Several complementary DNA clones encoding related HRGs were identified, all of which are similar to proteins in the epidermal growth factor family. (embl-heidelberg.de)
Activation1
- The drug blocks the effect of macrophage migration inhibitory factor and decreases the activation of plasminogen to plasmin. (medcarebd.com)
Neutrophils1
- Bronchoalveolar lavage fluid leukocytes from patients also demonstrated significantly impaired function, and lavage supernatant reduced phagocytosis in healthy neutrophils by 43% ( P = 0.0001). (atsjournals.org)
Phagocytosis1
- C5a also impaired killing of Pseudomonas aeruginosa by, and migration of, PBNs, indicating that effects were not restricted to phagocytosis. (atsjournals.org)
Ligands1
- Many of the chemorepellents that affect neuronal cell migration, including netrins, semaphorins, slit ligands, and ephrins have recently been implicated in the motility of immune cells. (wikipedia.org)
Cysteine1
- P. gingivalis expresses a broad range of virulence factors, of these cysteine proteases (gingipains) are of special importance both for the bacterial survival/proliferation and for the pathological outcome. (intechopen.com)
Interferon1
- Some of these differences may be related to the bifurcation of toll-like receptor signaling that distinguishes interferon regulatory factor 7-mediated type I interferon production from nuclear factor-κB-driven proinflammatory cytokine expression. (biomedcentral.com)
Transcription factor1
- The transcription factor FoxP3 partakes dominantly in the specification and function of FoxP3+ CD4+ T regulatory cells (Tregs), but is neither strictly necessary nor sufficient to determine the characteristic Treg transcriptional signature. (gsea-msigdb.org)
Recruitment1
- 2002). It really is extensively held that leukocyte recruitment is often a rate-limiting step in endotoxin-induced liver harm (Hewett et al. (m-entrepreneurship.com)
Familial1
- Predisposing familial and genetic factors have been implicated in CVD. (oaepublish.com)
Complex1
- We have determined, at high resolution (1.5 A), the crystal structure of such a domain, from human clotting factor IX, as a complex with Ca2+. (embl-heidelberg.de)
Cell2
- As outlined lined above, there's a paucity of analysis especially relating to the connection involving Rab GTPases and development factors, especially IGF-1, in cancer cell migration and invasion. (m-entrepreneurship.com)
- White blood cell s (also called leukocytes) are cells of the immune system . (biologyonline.com)
Pulmonary1
- As nintedanib is also an inhibitor of platelet-derived growth factor receptor (PDGFR)-α and β, it was selected for development as a potential treatment for idiopathic pulmonary fibrosis (IPF). (ersjournals.com)
Proteins1
- Although RA likely develops overtime through a multitude of factors, the expansion of self-antigen specific T cells and B cells that produce autoantibodies targeting synovial proteins are ultimately important in sustaining disease chronicity over time. (immune3d.com)
Predisposing1
- Predisposing factors include poor hygiene and overwashing, use of over-the-counter medications, and nonretraction of the foreskin. (medscape.com)
Autoimmunity1
- To varying extents, environmental factors also contribute to the development of autoimmunity. (biomedcentral.com)
Cells1
- A mononuclear phagocyte colony-stimulating factor (M-CSF) synthesized by mesenchymal cells. (lookformedical.com)