Loading...
  • remission
  • PURPOSE: Randomized phase III trial to compare the effectiveness of bone marrow transplantation using untreated or treated bone marrow in treating patients with acute leukemia in first or second remission. (clinicaltrials.gov)
  • OBJECTIVES: I. Compare the efficacy of T-cell-depleted vs unmodified allogeneic marrow rescue with regard to disease-free survival, post-transplantation leukemic relapse rate, incidence and severity of graft-versus-host disease, quality of engraftment and hematopoietic reconstitution, and immunoreconstitution following transplantation in patients with acute leukemia in first or second remission. (clinicaltrials.gov)
  • Cancer Center
  • Most recently an experimental drug from Merck & Co. showed effectiveness in treating certain types of leukemia that have proven resistant to both Novartis AG's Gleevec medicine and Bristol-Myers Squibb Co.'s recently launched Sprycel, according to researchers at the M.D. Anderson Cancer Center. (ndri.com)
  • This is a relatively small population that can potentially benefit from the drug, but for those who have these mutations, this research opens the door to a tremendous option for them," said Francis Giles, professor in the department of leukemia at M.D. Anderson Cancer Center, who reported the data. (ndri.com)
  • chromosome
  • Many leukemias involve genetic rearrangements, called translocations, in which some of the genetic material (genes) on a chromosome may be shuffled or swapped between a pair of chromosomes. (adam.com)
  • Infection
  • A small amount of cerebral spinal fluid (CSF) can be removed and sent for testing to look for leukemia cells or determine if there is an infection or other problems. (nyhq.org)
  • The leukemia cells then crowd out healthy blood cells and can affect your ability to fight infection. (ndri.com)
  • genetic
  • Merck's drug also showed activity against a genetic mutation sometimes present in myeloproliferative disorders, or MPD, a group of blood diseases that can evolve into leukemia, the research showed. (ndri.com)
  • Based on the genetic factors of the leukemia ( cll ) it can be a slow-growing disease that may not require therapy for a long time, if ever. (healthtap.com)