• At the time of deposit, cell-free preparations of the Mo/A-MuLV strain were considered as suitable reference standards in assays to detect replication competent murine retrovirus--select lots have had titer confirmed by workers outside the ATCC. (atcc.org)
  • This conversion to an infectious particle is brought about by the cleavage of viral proteins by the virus-encoded protease (PR). (pubmedcentralcanada.ca)
  • When poliovirus protease 2A is coexpressed in murine cells, expression of MLV-lacZ RNA is not modified, indicating that translation initiation of MLV gag precursors is a cap-independent mechanism. (asm.org)
  • The mechanism by which the virus induces this disease is not known, but stimulation of innate immune responses by viral DNA might be involved. (virology.ws)
  • So you have had the underlying virus, and then amplified it with that vaccine, and then set off the disease, such that your immune system could no longer control other infections, and created an immune deficiency. (leftbrainrightbrain.co.uk)
  • A major determinant of the thymic disease specificity of Moloney virus genetically maps to the conserved viral core motif in the Moloney virus enhancer. (asm.org)
  • Point mutations introduced into the core site significantly shifted the disease specificity of the Moloney virus from thymic leukemia to erythroid leukemia (N.A. Speck, B. Renjifo, E. Golemis, T.N. Fredrickson, J.W. Hartley, and N. Hopkins, Genes Dev. (asm.org)
  • Indeed, the depletion of PI(4,5)P 2 inhibits virus assembly and leads to an accumulation of Gag at late endosomes and multivesicular bodies ( 38 ). (asm.org)
  • Early work in this field examined the lipid composition of Rous sarcoma virus ( 42 - 44 ) and HIV ( 1 ) but at low resolution using thin-layer chromatography. (asm.org)
  • Although it is a little soon to start treating CFS patients for a virus that may not be causing any sickness, you raise some interesting points. (virology.ws)
  • The Friend virus has been used for both immunotherapy and vaccines. (wikipedia.org)
  • On that note, if I might speculate a little bit," she said, "This might even explain why vaccines would lead to autism in some children, because these viruses live and divide and grow in lymphocytes - the immune response cells, the B and the T cells. (leftbrainrightbrain.co.uk)
  • The results of this comprehensive survey found that the overall lipid content of these viruses mostly matched that of the plasma membrane, which was considerably different from the total lipid content of the cells. (asm.org)