Multiple myelomaMyeloid neoplasmsHematopoietic cellMyelodysplastic SyndromesChronicHSCTAutologousAntigensMiceRadiotherapyBoneHematologyRecurrenceClonalClinicalCurative treatmentPatients with acuteMPNsSurvivalDiagnosisAdultsChemotherapy2023Drug TherapyLymphoma SocietyMonoclonalAdult acute lymphoblCentersRelapseStem CellMutationsTherapyDisordersCancerGraft-versus-leukemia effectJuvenileFactors
Multiple myeloma3
- His clinical interests include multiple myeloma, stem cell transplantation, and myeloproliferative neoplasm. (aamds.org)
- His particular interest is in transplantation for multiple myeloma, lymphoma, myelodysplastic syndrome, acute leukemia and myeloproliferative neoplasms. (lvhn.org)
- She is board certified in hematology and medical oncology with expertise in Malignant Hematology including Lymphoproliferative neoplasms, Myeloproliferative neoplasms, Acute Leukemia, Multiple Myeloma and interest in Stem Cell transplantation. (ca.gov)
Myeloid neoplasms3
- Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) are myeloid neoplasms characterized by the presentation of overlapping features from both myelodysplastic syndromes and myeloproliferative neoplasms. (encyclopedia.pub)
- Although the classification of MDS/MPN relies largely on clinical features and peripheral blood and bone marrow morphology, studies have demonstrated that a large proportion of patients (~90%) with this disease harbor somatic mutations in a group of genes that are common across myeloid neoplasms. (encyclopedia.pub)
- We have over-expressed SKI to define its intrinsic role in hematopoiesis and myeloid neoplasms, which resulted in a robust competitive advantage upon transplantation, a complete dominance of the stem and progenitor compartments, and a marked enhancement of myeloid differentiation at the expense of other lineages. (edu.au)
Hematopoietic cell6
- Retrospective analysis by the Center for International Blood and Marrow Transplant Research (CIBMTR): Prompt complete remission plus consolidation therapy yields improved survival after allogeneic hematopoietic cell transplantation (allo-HCT) for patients with acute myeloid leukemia (AML) receiving a myeloablative conditioning regimen and not a reduced-intensity conditioning regimen. (ascopost.com)
- He has published extensively on the immunobiology and application of hematopoietic cell transplantation, with nearly 200 scientific abstracts and peer-reviewed publications over the span of his career. (lvhn.org)
- Hematopoietic cell transplantation (HCT) is an integral part of the treatment of acute myeloid leukemia (AML). (apbmt.org)
- Hematopoietic cell transplantation (HCT) is an effective treatment in patients with acute myeloid leukemia (AML). (apbmt.org)
- The Japanese Society of Hematopoietic Cell Transplantation (JSHCT) has been conducting a nationwide survey on HCT since 1993, in which HCTs performed at participating centers are registered with the JSHCT every year. (apbmt.org)
- Mapping MHC haplotype effects in unrelated donor hematopoietic cell transplantation. (cdc.gov)
Myelodysplastic Syndromes3
- Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) constitute a heterogeneous group of clonal myeloid malignancies with clinical, laboratory, morphologic and genetic features that overlap with myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPN). (encyclopedia.pub)
- Dr. Sallman's research focuses on the development of novel, targeted therapeutic strategies for patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). (moffitt.org)
- Phase I and II clinical trials) for patients with myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML) based on the underlying mutational drivers of each disease. (moffitt.org)
Chronic16
- Chronic leukemia is slow growing. (medlineplus.gov)
- Chronic lymphocytic leukemia (CLL) , which is one of the most common types of leukemia in adults. (medlineplus.gov)
- How Is Chronic Myelomonocytic Leukemia Diagnosed? (medlineplus.gov)
- This model has received support from studies showing subpopulations of blood cells harboring initiating but not late somatic mutations in patients with chronic lymphocytic leukemia (CLL), hairy cell leukemia (HCL), and AML. (wikipedia.org)
- Are next-generation sequencing results knocking on Heaven's door for transplantation planning in chronic myelomonocytic leukemia? (haematologica.org)
- Her main interests are chronic leukemias: molecular and clinical aspects. (cml-foundation.org)
- Since 2003, she has worked on multiple research protocols for chronic leukemias and is in charge of CML and CLL projects. (cml-foundation.org)
- INTRODUCTION - An overview of the four classic myeloproliferative neoplasms (MPN): polycythemia vera, essential thrombocythemia, primary myelofibrosis, and chronic myeloid leukemia will be presented here. (medilib.ir)
- See "Clinical manifestations and diagnosis of chronic myeloid leukemia" . (medilib.ir)
- MPNs include polycythemia vera, essential thrombocythemia, chronic myeloid leukemia (CML), primary myelofibrosis, chronic neutrophilic leukemia, and other less well defined entities such as chronic eosinophilic leukemia, not otherwise categorized. (medilib.ir)
- The most common (classic) MPNs are chronic myeloid leukemia ( CML ), essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF). (amboss.com)
- Less common MPNs, which are not associated with the driver mutations, include chronic eosinophilic leukemia (CEL), chronic neutrophilic leukemia , and myeloproliferative neoplasm , unclassifiable. (amboss.com)
- See also " Polycythemia vera " and " Chronic myeloid leukemia " for further detail on these conditions. (amboss.com)
- According to the 2017 World Health Organization (WHO) classification, this category currently includes four adult subtypes: chronic myelomonocytic leukemia (CMML), BCR-ABL1 -negative atypical chronic myeloid leukemia (aCML), MDS/MPN with ring sideroblasts and thrombocytosis (MDS/MPN-RS-T), MDS/MPN-unclassifiable (MDS/MPN-U), and one pediatric entity: juvenile myelomonocytic leukemia (JMML) [ 1 ] . (encyclopedia.pub)
- Polycythemia vera is a chronic myeloproliferative neoplasm characterized by an increase in morphologically normal red cells (its hallmark), but also white cells and platelets. (msdmanuals.com)
- The transfusion medicine organization AABB has formed a task force to study the transmission potential of xenotropic murine leukemia virus-related virus (XMRV), which has been linked to familial prostate cancer and, more recently, to chronic fatigue syndrome (CFS). (medscape.com)
HSCT3
- Continuous efforts have been made in Japan to investigate the role of hematopoietic stem cell transplantation (HSCT) for infants with KMT2A-r ALL, but improvement in outcome was modest. (nih.gov)
- Patients with hematological malignancies (HMs) are at a continuous risk for immunodeficiency, related either to the own malignancy or to the associated therapies, such as antineoplastic drug administration or hematopoietic stem-cell transplantation (HSCT). (lww.com)
- In a multicentre, single-arm, open-label phase 2 study, we enrolled adult patients with Philadelphia-chromosome-negative, primary refractory or relapsed (first relapse within 12 months of first remission, relapse within 12 months after allogeneic haemopoietic stem-cell transplantation [HSCT], or no response to or relapse after first salvage therapy or beyond) leukaemia. (nih.gov)
Autologous2
- Figure 1 shows the trend in the annual number of allogeneic and autologous HCTs in adults with AML reported in the Japanese transplantation registry. (apbmt.org)
- Treatment selection takes into account patient age, fitness, and whether autologous stem cell transplantation (ASCT) is planned. (medscape.com)
Antigens1
- Analysis of transplantation antigens in friend viral leukemia. (jax.org)
Mice5
- Enhancement of virus-induced leukemias and sarcomas in f1 hybrid mice " by B Varet, A Cannat et al. (jax.org)
- Enhancement of virus-induced leukemias and sarcomas in f1 hybrid mice inoculated with parental spleen cells. (jax.org)
- Characterization of effector cells of graft vs leukemia following allogeneic bone marrow transplantation in mice inoculated with murine B-cell leukemia. (ox.ac.uk)
- The role of Thy1.2, L3T4 and Lyt2 T lymphocytes as effector cells of GVL were investigated in (BALB/c x C57BL/6)F1 mice inoculated with murine B-cell leukemia and subsequently conditioned with total lymphoid irradiation and cyclophosphamide (200 mg/kg). (ox.ac.uk)
- p42-deficient leukemia could be transferred by a Mac1+c-Kit+ population that gave rise only to myeloid cells in recipient mice. (ox.ac.uk)
Radiotherapy1
- Aggressive chemotherapy associated with radiotherapy followed by bone marrow transplantation still produces poor outcomes. (lymphomainfo.net)
Bone12
- Leukemia starts in blood-forming tissues such as the bone marrow. (medlineplus.gov)
- When you have leukemia, your bone marrow makes large numbers of abnormal cells. (medlineplus.gov)
- Leukemia happens when there are changes in the genetic material (DNA) in bone marrow cells. (medlineplus.gov)
- She is a member of The American Society of Hematology, the American Board of Internal Medicine, the American Society of Clinical Oncology and the American Society of Blood and Bone Marrow Transplantation. (ca.gov)
- MF is a clonal bone narrow neoplasm which can emerge either as primary MF (PMF), polycythemia vera (PV) or essential thrombocythemia (ET). (antengene.com)
- The disease is primarily characterized by fibrosis in the bone marrow, extramedullary hematopoiesis, anemia, splenomegaly, constitutional symptoms, and possible progression to leukemia that would shorten patients' survival. (antengene.com)
- Prof. Depei Wu, Director of Hematology Department at the First Affiliated Hospital Soochow University, and the principal investigator of the study, noted: "MF is a relatively rare form of proliferative neoplasm in the bone narrow that has long lacked effective treatment options before the emergence of targeted therapies. (antengene.com)
- Ex vivo depletion of T cells from bone marrow grafts with CAMPATH-1 in acute leukemia: graft-versus-host disease and graft-versus-leukemia effect. (ox.ac.uk)
- It is now widely accepted that immunocompetent lymphocytes in allogeneic bone marrow grafts exert an antileukemic effect that contributes to the cure of leukemia. (ox.ac.uk)
- Graft vs leukemia (GVL) effects independent of graft vs host disease were investigated in allogeneic bone marrow chimeras tolerant of host and donor alloantigens. (ox.ac.uk)
- Detection of residual tumor cells, an indicator for efficacy of GVL, was carried out by adoptive transfer of peripheral blood or spleen cells obtained from treated chimeras into secondary naive BALB/c recipients at different time intervals following bone marrow transplantation. (ox.ac.uk)
- Overview of Myeloproliferative Neoplasms Myeloproliferative neoplasms are clonal proliferations of bone marrow hematopoietic stem cells, which can manifest as an increased number of functionally normal platelets, red blood cells (RBCs). (msdmanuals.com)
Hematology1
- To complement The ASCO Post 's continued comprehensive coverage of the 2021 American Society of Hematology (ASH) Annual Meeting & Exposition, here are several abstracts selected from the meeting proceedings focusing on allogeneic transplantation for hematologic neoplasms in adults. (ascopost.com)
Recurrence1
- BACKGROUND: Preventing graft-versus-host disease (GVHD) by depletion of T lymphocytes from the stem cell graft for transplantation remains controversial, mainly because of the perceived increase in disease recurrence. (ox.ac.uk)
Clonal1
- In a similar vein, other studies using the HUMARA technology had found that hematologic malignancies are clonal diseases even when there is no apparent chromosomal abnormality, and that there are pre-leukemic clonal populations which precede acute myeloid leukemia (AML). (wikipedia.org)
Clinical3
- Clinical course is highly variable, with a median overall survival (OS) that ranges between 12-24 months and 15-30% probability of progression to acute myeloid leukemia (AML) [ 6 ] . (encyclopedia.pub)
- He has published significantly on this topic including recently in highly regarded journals including Leukemia and Haematologica and these work form the foundation of the clinical trials that he is bringing to patients in order to improve their quality of life and survival. (moffitt.org)
- As an example, Dr. Sallman has focused research and clinical trial efforts on patients who have TP53 mutation (often associated with complex genes/cytogenetics) given their high risk of transformation to acute leukemia and poor survival. (moffitt.org)
Curative treatment2
- however, nearly all cases eventually relapse, and allogeneic stem cell transplantation remains the only curative treatment option for a small subset of patients. (haematologica.org)
- Allogeneic hematopoietic stem cell transplantation is the only curative treatment. (amboss.com)
Patients with acute3
- BACKGROUND: Reduced intensity conditioning regimens permit the delivery of a potentially curative graft-versus-leukemia effect in older patients with acute myeloid leukemia. (ox.ac.uk)
- DESIGN AND METHODS: We have characterized pre- and post-transplant factors determining overall survival in 168 patients with acute myeloid leukemia transplanted using an alemtuzumab based reduced intensity conditioning regimen with a median duration of follow-up of 37 months. (ox.ac.uk)
- Mutations in the CEBPA gene are present in 7%-10% of human patients with acute myeloid leukemia (AML). (ox.ac.uk)
MPNs1
- Myeloproliferative neoplasms (MPNs) are a group of disorders characterized by a proliferation of normally developed (nondysplastic) multipotent hematopoietic stem cells from the myeloid cell line . (amboss.com)
Survival2
- Of these patients 45% went on to undergo stem-cell transplantation, and survival rates at 18 and 24 months were 59% and 52%, respectively. (medpagetoday.com)
- Factors predicting long-term survival after T-cell depleted reduced intensity allogeneic stem cell transplantation for acute myeloid leukemia. (ox.ac.uk)
Diagnosis1
- Myelodysplastic syndrome/myeloproliferative neoplasm (MDS/MPN) overlap syndromes-disorders that include features of both myelodysplastic syndrome (MDS) and myeloproliferative neoplasm (MPN)-are entities whose diagnosis and management have proved challenging. (medscape.com)
Adults2
- It is an honor to bring stem cell transplantation and cellular therapies to adults in the Lehigh Valley and its surrounding communities," Dr. Toor says. (lvhn.org)
- Since its establishment in 2010, the Adult AML Working Group within the JSHCT has been using this registry data to complete several studies focusing on various aspects of HCT in adults with AML, with particular attention paid to patient-, disease-, and transplantation-related factors. (apbmt.org)
Chemotherapy2
- This phase III trial studies how well blinatumomab works in combination with chemotherapy in treating patients with newly diagnosed, standard risk B-lymphoblastic leukemia or B-lymphoblastic lymphoma with or without Down syndrome. (policylab.us)
- T-prolymphocytic leukemia (T-PLL) is an aggressive mature T-cell neoplasm that responds poorly to conventional chemotherapy and has a dismal outcome. (haematologica.org)
20231
- Genetic Aspects of Myelodysplastic/Myeloproliferative Neoplasms" Encyclopedia , https://encyclopedia.pub/entry/10288 (accessed December 10, 2023). (encyclopedia.pub)
Drug Therapy1
- The use of two or more chemicals simultaneously or sequentially in the drug therapy of neoplasms. (lookformedical.com)
Lymphoma Society2
- Dr. Abdulhaq is a board member of the Leukemia and Lymphoma Society, Central California Chapter and she also serves as the chair of Cancer Committee at Community Medical Centers. (ca.gov)
- According to the Leukemia and Lymphoma Society , the disease is often underreported or misdiagnosed, with common misdiagnoses including non-Hodgkin lymphoma, acute myeloid leukemia (AML), leukemia cutis, melanoma, and lupus erythematosus. (medpagetoday.com)
Monoclonal2
- Treatment of the primary marrow inoculum with monoclonal anti-Thy1.2 or anti-Lyt2 abolished the GVL effects and all secondary BALB/c recipients developed leukemia within 60 days. (ox.ac.uk)
- On the other hand, the treatment with monoclonal anti-L3T4 did not influence the effect of GVL and all treated recipients remained without leukemia. (ox.ac.uk)
Adult acute lymphobl1
- The Philadelphia chromosome positive arm of the UKALLXII/ECOG2993 study for adult acute lymphoblastic leukemia (ALL) enrolled 266 patients between 1993 and 2003 (pre-imatinib cohort). (ox.ac.uk)
Centers3
- 99% of transplantation centers in Japan. (apbmt.org)
- 300 transplantation centers nationwide, with a penetration rate exceeding 99% 1 . (apbmt.org)
- However, no transmission event of XMRV through blood transfusion or transplantation has been identified, according to a February 18 fact sheet from the Centers for Disease Control and Prevention, Atlanta, Georgia. (medscape.com)
Relapse1
Stem Cell2
Mutations2
- This set of evidence led to the suggestion in 2005 that driving mutations in leukemia are acquired in a step-wise manner. (wikipedia.org)
- JAK2 exon 12 mutations in patients with Philadelphia (Ph) chromosome-negative myeloproliferative neoplasms]. (cdc.gov)
Therapy1
Disorders1
- Myelodysplastic/myeloproliferative neoplasms (MDS/MPN) include disorders that manifest both dysplastic and proliferative features. (medilib.ir)
Cancer6
- Which type of leukemia you have depends on the type of blood cell that becomes cancer and whether it grows quickly or slowly. (medlineplus.gov)
- Acute lymphocytic leukemia (ALL) , which is the most common type of cancer in children. (medlineplus.gov)
- Cancer Care provides free, professional support services for people affected by myeloproliferative neoplasms, as well as treatment information and financial help with cancer-related costs and treatment co-pays. (cancercare.org)
- 1 Division of Leukemia and Lymphoma, Children's Cancer Center, National Center for Child Health and Development, Tokyo, Japan. (nih.gov)
- In June 2008, she undertook a training at the Department of Leukemias at the MD Anderson Cancer Center in Houston. (cml-foundation.org)
- Dr. Texeira has recently undertaken a 4-weeks preceptorship at the Leukemia Department in M.D. Anderson Cancer Center (University of Texas). (cml-foundation.org)
Graft-versus-leukemia effect2
- Although T-cell depletion is increasingly used to reduce the risk of graft-versus-host disease its impact on the graft-versus-leukemia effect and long-term outcome post-transplant is unknown. (ox.ac.uk)
- These data confirm the presence of a potent graft-versus-leukemia effect after a T-cell depleted reduced intensity conditioning allograft in acute myeloid leukemia and identify CsA exposure as a manipulable determinant of outcome in this setting. (ox.ac.uk)
Juvenile1
- For comparison, we similarly characterize 23 cases with overlapping features of MDS and myeloproliferative neoplasm (MDS/MPN), namely juvenile myelomonocytic leukemia (JMML), and 8 cases of AML with myelodysplasia-related changes (AML-MRC). (nature.com)
Factors2
- The treatments for leukemia depend on which type you have, how severe the leukemia is, your age, your overall health, and other factors. (medlineplus.gov)
- Various factors including age, sex, performance status (PS), disease status, cytogenetic risk, donor type, graft source, sex mismatch between the donor and the recipient, and year of transplantation were all shown to impact OS 2 . (apbmt.org)