Loading...
  • treatment
  • If the disease gets worse or intolerable side effects occur, you will be taken off study and alternative treatment options will be discussed. (clinicaltrials.gov)
  • juvenile myelomon
  • 1.2 Determine if response to Tumor Necrosis Factor (TNF) blockade correlates with genetic basis of Juvenile Myelomonocytic Leukemia (JMML) [mutations in NF1, Ras, SHPor levels of TNFa. (clinicaltrials.gov)
  • molecular
  • To investigate molecular mechanism(s) underlying disease evolution, CML-exhibiting p210BCR/ABL transgenic mice were crossed with BXH2 mice that transmit a replication-competent retrovirus. (bloodjournal.org)
  • Led by Stella Chou, MD, researchers in the Chou Laboratory are studying the molecular mechanisms of leukemia and other hematologic abnormalities in children with Down syndrome. (chop.edu)
  • autoimmune
  • Other autoimmune and inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel disease, and pancreatitis, can cause a leukocytosis (or neutropenia). (psychiatryadvisor.com)
  • However, the frequent occurrence of T cell-mediated autoimmune diseases such as type 1 diabetes and multiple sclerosis indicate that the establishment or maintenance of tolerance can fail. (rupress.org)
  • pathogenesis
  • However, previous methods failed to yield this disease at a frequency sufficient enough to allow for its use in the study of CML pathogenesis. (duke.edu)
  • As such, it should be an excellent model for addressing specific issues relating to the pathogenesis and treatment of this disease. (duke.edu)
  • Drug
  • 15 , 16 New approaches are needed to treat drug-resistant forms of CML as well as BCR-ABL-induced B-ALL, a leukemia that does not respond well to available TKIs. (bloodjournal.org)
  • 20 We therefore evaluated the therapeutic effect of Hsp90 inhibition by using a novel water-soluble inhibitor, IPI-504, 22 in drug-resistant animal models of leukemia induced by BCR-ABL-WT and T315I. (bloodjournal.org)
  • cell
  • In addition, PBSC grafts have a higher T cell content, predicting a possibly more powerful anti-leukemia effect. (knowcancer.com)
  • Although CML typically elevates the WBC, polycythemia vera elevates the red blood cell count, and essential thrombocythemia raises the platelet count, all four myeloproliferative diseases overlap and each often results in a leukocytosis (less commonly with essential thrombocythemia). (psychiatryadvisor.com)
  • Patients with an acute leukemia are more likely to be ill at presentation, whereas those with a chronic leukemia are often diagnosed incidentally because of abnormal blood cell counts. (aafp.org)
  • Several mammalian Notch receptors are oncogenic when constitutively active, including Notch1 , a gene initially identified based on its involvement in a (7;9) chromosomal translocation found in sporadic T-cell lymphoblastic leukemias and lymphomas (T-ALL). (asm.org)
  • The human Notch1 gene was originally identified by analysis of a recurrent (7;9) chromosomal translocation [t(7;9)] found in a subset of T-cell lymphoblastic leukemias and lymphomas (T-ALL) ( 9 ). (asm.org)
  • cause
  • Transforming polypeptides also demonstrated moderate to strong activation of the Su(H)/CBF1-sensitive HES-1 promoter, while polypeptides with weak or absent activity on this promoter failed to cause leukemia. (asm.org)
  • multiple
  • This trial is likely to lead to the approval of panobinostat for the therapy of patients with multiple myeloma allowing for a new option with a novel mechanism of action for patients with the disease. (lww.com)