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  • Remission
  • Children with AML who have a white blood cell count (WBC) greater than 100,000 per cubic milliliter, secondary AML, and leukemic cells with a monosomy 7 karyotype have low remission induction rates, whereas children with leukemia cell chromosomal abnormalities t(8;21) and inv 16 have a high likelihood of achieving remission. (meds.com)
  • malignant
  • Other genetic abnormalities in PDGFRB lead to various forms of potentially malignant bone marrow disorders: small deletions in and chromosome translocations causing fusions between PDGFRB and anyone of at least 30 genes can cause Myeloproliferative neoplasms that commonly involve eosinophilia, eosinophil-induced organ injury, and possible progression to aggressive leukemia (see blow). (wikipedia.org)
  • gene
  • ETV6 (i.e. translocation-Ets-leukemia virus) protein is a transcription factor that in humans is encoded by the ETV6 (previously known as TEL) gene. (wikipedia.org)
  • The gene is located on human chromosome 33 at the p13 position, consists of 14 exons, and is well-known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. (wikipedia.org)
  • FIP1L1 gene fusions between it and either the platelet-derived growth factor receptor, alpha (PGDFRA) or Retinoic acid receptor alpha (RARA) genes are causes of certain human diseases associated with pathologically increased levels of blood eosinophils and/or Leukemias. (wikipedia.org)
  • syndrome
  • 10 ] Interestingly, the majority of children with Down syndrome and AML can be cured of their leukemia. (meds.com)
  • lymphoid leukemia
  • In a 2010 study by the University of California, Berkeley's School of Public Health, researchers found that children with acute lymphoid leukemia (ALL) had almost twice the chance of having been exposed to three or more X-rays compared with children who did not have leukemia. (wikipedia.org)
  • GVHD
  • To evaluate the incidences of grades II-IV acute GVHD. (clinicaltrials.gov)
  • Acute GVHD most commonly occurs within the first 100 days after transplant and, while it can affect any part of the body, it typically affects the patient's skin, liver, stomach and intestines. (aamds.org)
  • chromosome
  • The RUNX1 and CBFB genes are targets of chromosome rearrangements that create oncogenic fusion genes in leukemia. (wikipedia.org)
  • Other genetic abnormalities in PDGFRB lead to various forms of potentially malignant bone marrow disorders: small deletions in and chromosome translocations causing fusions between PDGFRB and anyone of at least 30 genes can cause Myeloproliferative neoplasms that commonly involve eosinophilia, eosinophil-induced organ injury, and possible progression to aggressive leukemia (see blow). (wikipedia.org)
  • The gene is located on human chromosome 33 at the p13 position, consists of 14 exons, and is well-known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. (wikipedia.org)
  • malignancy
  • However, in the past a number of different terms were used for BPDCN due to their uncommon immunophenotypic, histopathological and clinical features, including blastic NK leukemia/lymphoma, histiocytic lymphoma or histiocytic associated hematologic malignancy, cutaneous a granular CD4+ CD56+ hematodermic neoplasm and NK-cell lymphoma or myelo-monocytic precursor - related lymphoma (5-12). (czytelniamedyczna.pl)
  • platelet
  • FIP1L1 gene fusions between it and either the platelet-derived growth factor receptor, alpha (PGDFRA) or Retinoic acid receptor alpha (RARA) genes are causes of certain human diseases associated with pathologically increased levels of blood eosinophils and/or Leukemias. (wikipedia.org)
  • inflammation
  • inflammation of the myocardium that persists after an acute bacterial infection. (thefreedictionary.com)
  • As a positive acute phase reactant, AAT is increased in acute inflammation. (wikipedia.org)
  • These bands fuse and intensify in early inflammation due to an increase in alpha-1 antichymotrypsin, an acute phase protein. (wikipedia.org)
  • Haptoglobin is raised as part of the acute phase response, resulting in a typical elevation in the alpha-2 zone during inflammation. (wikipedia.org)
  • Symptoms
  • Typically, most symptoms do not occur during the early stages of leukemia, and children may experience different symptoms. (wikipedia.org)
  • protein
  • Overall, these findings validate inhibition of RUNX1- CBFβ-SMMHC protein-protein interaction as a novel therapeutic avenue for leukemia with inv(16) and AI-10-49 as a specific inhibitor of CBFβ-SMHHC oncoprotein. (wikipedia.org)
  • ETV6 (i.e. translocation-Ets-leukemia virus) protein is a transcription factor that in humans is encoded by the ETV6 (previously known as TEL) gene. (wikipedia.org)
  • cells
  • When a child has leukemia, the cells do not respond to the signals telling them when to stop and when to produce cells, regardless of the available space. (wikipedia.org)