• Tumour antigen-targeted immunotherapy for chronic myeloid leukaemia: is it still viable? (surrey.ac.uk)
  • Various immunotherapy strategies have been trialled in several leukaemias including chronic myeloid leukaemia (CML) and in general, these have been aimed at targeting tumour-associated antigens (TAA). (surrey.ac.uk)
  • The immunogenicity of the CML-specific tumour antigen, BCR-ABL, has been the subject of much debate and its role in the development of the disease and its unique sequence spanning the breakpoint region make it an ideal target for immunotherapy. (surrey.ac.uk)
  • This review aims to discuss the potential of immunotherapy for the treatment of leukaemia, in particular CML, and the prospect of targeting three CML associated antigens: BCR, ABL and HAGE. (surrey.ac.uk)
  • Six other patients (50%) still have an undetectable level of BCR-ABL transcript after a median follow-up of 18 months (range, 9-24 months). (knowcancer.com)
  • There are numerous TAA expressed by CML patients including WT1, proteinase 3, BCR-ABL and HAGE amongst others. (surrey.ac.uk)
  • Blood 98:2887-2893, 2001), this study demonstrated the expression of MHC-peptide complexes on the surface of CML cells and the presence of tetramer-positive CTL activity in CML patients positive for these two HLA alleles. (surrey.ac.uk)
  • However, another study suggests that bcr:abl over-expression may actually increase cell adherence to cell culture plastic. (wikipedia.org)
  • In culture they exhibit much less clumping than many other suspension lines, presumably due to the downregulation of surface adhesion molecules by bcr:abl. (wikipedia.org)
  • Interferon alfa-2b is a prescription medication used to treat chronic hepatitis B, chronic hepatitis C, certain type of genital warts, hairy cell leukemia, malignant melanoma, AIDS-related Kaposi's sarcoma, and follicular lymphoma. (medicineshoppe.com)
  • Cyclophosphamide is a prescription medicine used alone, or in combination with other medications to treat several types of cancer including lymphoma, leukemia, ovarian, and breast cancer. (rxwiki.com)