• The antitumor response criteria (Complete response (CR), partial response (PR), stable disease (SD), progressive disease (PD)) were created based on the criteria for non-Hodgkin's lymphoma and chronic lymphocytic leukemia provided in the National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines in Oncology as well as the criteria for non-Hodgkin's lymphoma by the Lymphoma Study Group of the Japan Clinical Oncology Group (JCOG-LSG).Overall Response (OR)= CR + PR. (clinicaltrials.gov)
  • ATL usually occurs in adulthood and comprises only 1 to 2% of T-cell lymphomas in the United States and Europe, though accounts for a much higher proportion in endemic areas such as Japan. (renalandurologynews.com)
  • Given increased exposure to people from endemic areas and rare cases of HTLV-1 associated lymphomas in people without any identifiable risks, we at least consider testing for HTLV-1/2 antibodies in all newly diagnosed patients with T-cell lymphoma, as the finding of HTLV 1/2 positivity may change the treatment recommendations in critical ways. (renalandurologynews.com)
  • Geographical features and epidemiological approach to endemic T-cell leukemia/lymphoma in Japan. (springer.com)
  • The study purpose is to evaluate the clinical response to multidose administration of anti-Tac monoclonal antibody conjugated with 10 mCi 90Y in patients with Tac-expressing adult T-cell leukemia (ATL). (clinicaltrials.gov)
  • Among the genomic alterations frequently observed in acute-type ATL, the loss of CDKN2A, which is involved in cell-cycle deregulation, was especially characteristic of acute-type ATL compared with chronic-type ATL. (sigmaaldrich.com)
  • To evaluate the efficacy, safety and pharmacokinetic profiles of KW-0761, the anti-CC chemokine receptor 4 (CCR4) antibody, when administered weekly for 8 weeks as an intravenous infusion at a dose of 1.0 mg/kg in relapsed subjects with CCR4-positive adult T-cell leukemia-lymphoma. (clinicaltrials.gov)
  • Of primary concern are those symptoms attendant to suppression of normal bone marrow function, particularly susceptibility to infection due to the predominance of immature and abnormally functioning white blood cells, bleeding tendency owing to decreased platelet count, and anemia due to decreased erythrocyte count. (thefreedictionary.com)
  • Like other forms of leukemia, ATL is characterized by an enlarged spleen, lymph nodes, and liver. (knowcancer.com)
  • Provides information about stem cell transplantation work, newer treatments and related research. (dmoztools.net)
  • HLA class II-positive and HLA class II-negative groups also showed a significant difference in complete remission rate (p = 0.0421), HLA class I/β2 microglobulin expression (p=0.0165), and the number of PD-1 positive tumor infiltrating cells (p=0.0020). (haematologica.org)
  • The smoldering subtype is characterized by circulating abnormal T-cells (often called flower cells) but with a normal absolute lymphocyte count and no more than 5% of the cells being abnormal. (renalandurologynews.com)
  • and (3) increase in or maintenance of the number of abnormal cells in the blood-preleukemic. (thefreedictionary.com)