• Membrane-Bound Transcription Factor Site-1 Protease in PF429242 Bound State: Computational Kinetics and Dynamics of Reversible Binding. (bioportfolio.com)
  • Method to Study Dynamics of Membrane-Bound Plant Transcription Factors During Biotic Interactions in Tomato. (bioportfolio.com)
  • Sequestration of a transcription factor in a cellular membrane and releasing it on demand is an additional layer of gene regulation that is considered a rapid mode to reprogram a gene expression casca. (bioportfolio.com)
  • It is closely related to FMS PROTO-ONCOGENE PROTEIN and is commonly mutated in acute MYELOID LEUKEMIA. (umassmed.edu)
  • A transmembrane protein belonging to the tumor necrosis factor superfamily that was originally discovered on cells of the lymphoid-myeloid lineage, including activated T-LYMPHOCYTES and NATURAL KILLER CELLS. (wakehealth.edu)
  • The IL-6 receptor consists of an α chain and the subunit gp130. (rupress.org)
  • It is synthesized as a single polypeptide chain which is then postranslationally cleaved and processed into two disulfide-linked subunits of approximately 18 and 110 kDa in size. (rush.edu)
  • Cytokine and receptor transcript and protein expression and distribution were determined in urinary bladder after CYP-induced cystitis using quantitative, real-time polymerase chain reaction (Q-PCR), western blotting, and immunohistochemistry. (frontiersin.org)
  • This protein functions as a part of the cytokine receptor complex. (thermofisher.com)
  • The information gain on inflammatory mediators and receptor functions in tissue culture model system are currently applied to the identification of regulatory processes in complex reconstituted systems using 3-dimensional cultures of primary cells isolated from the lung. (roswellpark.org)
  • The anti-parallel bundles that these proteins form have an "up-up-down-down" topology, which is a relevant structure regarding the cytokine binding to their respective receptor complex. (wikipedia.org)
  • Although the IL-31 receptor complex lacks gp130, IL-31RA has similarities to gp130 like its previous descriptors suggest. (wikipedia.org)
  • Analysis of the tissue distribution of the IL-31 receptor complex found that IL-31RA is abundant in dorsal root ganglia of different human tissues. (wikipedia.org)
  • These results provide evidence that a point mutation of a cytokine receptor has the potential to induce autoimmune disease. (rupress.org)
  • Genetic targets through which the receptor signals induce transcription have been established in the examples of acute phase plasma protein genes in liver and other cell types. (roswellpark.org)
  • In this study, the detection of inlubin/activin subunit and ActRI mRNA were examined in first trimester cytotrophoblasts, term cytotrophoblasts, extravillous trophoblast (EVT) cells, immortalized extravillous trophoblast (LEVT) cells, JEG-3 cells, decidual tissue, and decidual cells. (ubc.ca)
  • The cryo-EM structure of a 12-subunit variant of RNA polymerase I reveals dissociation of the A49-A34.5 heterodimer and rearrangement of subunit A12.2. (bioportfolio.com)
  • At the cellular level, activin acts via a family of activin receptor (ActR) subtypes which includes two type I (ActRI and ActRLB) and two type II (II and ILB) receptors. (ubc.ca)
  • In direct ELISAs, no cross-reactivity with recombinant human LIF R alpha is observed. (novusbio.com)
  • Within the ECD, mouse LIF R alpha shares 73% and 90% aa sequence identity with human and rat LIF R alpha, respectively. (novusbio.com)
  • Genetic background and environmental factors, such as bacterial or viral infection, are thought to be involved in its onset. (rupress.org)
  • The signaling action of the OSM receptor has been defined by the suppression of proliferation through mediating G1 arrest in part by the induction of cyclin kinase inhibitors and to trigger induction as well as suppression of genes through transcription factors that include STAT3 and STAT5, AP-1/ATFs, C/EBP and CREB. (roswellpark.org)