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  • secretion
  • hCG and transforming growth factor- (TGF-) β increase LIF secretion by the cultured endometrial epithelial cells derived from follicular and secretory phases of the menstrual cycle [ 15 ]. (hindawi.com)
  • proteins
  • However, scientists at the University of California, San Francisco (UCSF), have discovered that two proteins -- KRAS and leukemia inhibitory factor (LIF) -- help create cancer stem cells and that the latter can be targeted to block them. (eurekalert.org)
  • neuronal
  • Our data establish LIF as a Muller cell derived neuronal survival factor which controls an intrinsic protective mechanism that includes Edn2 signaling to support photoreceptor cell survival and to preserve vision in the injured retina. (jneurosci.org)
  • survival
  • Survival and death of photoreceptors in degenerative diseases of the retina is controlled by a multitude of genes and endogenous factors. (jneurosci.org)
  • Activated Muller cells and/or other cells may then produce and release fibroblast growth factor 2 (FGF2) to support survival of viable photoreceptors ( Rattner and Nathans, 2005 ). (jneurosci.org)
  • This suggests that LIF is the key factor regulating an endogenous defense mechanism to ensure survival and function of retinal cells. (jneurosci.org)
  • regeneration
  • Our results have implications for the development of therapeutic strategies for brain repair and suggest that LIF may be useful, in combination with other factors, in promoting regeneration in the adult brain. (jneurosci.org)
  • stimulate
  • Treatment with exogenous growth factors can mitigate this limitation, suggesting that the brain environment is normally deficient in permissive cues and that it may be possible to stimulate the latent regenerative potential of endogenous progenitors with appropriate signals. (jneurosci.org)