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  • patients
  • Gene expression profiles were examined in 33 adult patients with T-cell acute lymphocytic leukemia (T-ALL). (bloodjournal.org)
  • This study demonstrates that gene expression profiling can identify a limited number of genes that are predictive of response to induction therapy and remission duration in adult patients with T-ALL. (bloodjournal.org)
  • In the current study, we used oligonucleotide microarrays to determine gene expression profiles in leukemia cells from 33 adult patients with newly diagnosed T-ALL. (bloodjournal.org)
  • Patients were enrolled in the Italian Gruppo Italiano Malattie Ematologiche dell'Adulto (GIMEMA) multicenter clinical trial 0496 for adult patients with newly diagnosed ALL. (bloodjournal.org)
  • Leukemia samples from 18 additional patients were used to test the 3-gene model developed from gene expression profiling. (bloodjournal.org)
  • 27 adult patients with acute lymphocytic leukemia have been analyzed. (mysciencework.com)
  • Patients with acute lymphoblastic leukemia (ALL) should be instructed to immediately seek medical attention if they are febrile or have signs of bleeding. (medscape.com)
  • The overall survival (OS) rate is ~90% in pediatric patients with ALL and only 30% in adult patients with ALL ( 3 , 4 ). (spandidos-publications.com)
  • Adolescent and adult patients receiving pediatric-based regimens with greater use of asparaginase have also achieved better outcomes ( 8 - 10 ). (spandidos-publications.com)
  • However, only a few clinical studies have compared the efficacy and safety of PEG asparaginase with native E. coli asparaginase in adolescent and adult patients with ALL. (spandidos-publications.com)
  • The present study retrospectively compared the relative efficacy and safety of PEG asparaginase and E. coli asparaginase in adolescent and adult patients newly diagnosed with ALL. (spandidos-publications.com)
  • Some patients presenting with acute leukemia may have a cytogenetic abnormality that is cytogenetically indistinguishable from the Philadelphia chromosome (Ph1). (cancer.gov)
  • Since 1978 more than 3000 adult patients with acute lymphocytic leukemia (ALL) have been treated according to the protocols of the German Multicenter Study Group for Adult. (naver.com)
  • 17 Although the number of patients who receive unrelated adult allogeneic donor stem cell transplants continues to increase each year, many patients are unable to find a fully matched donor, which diminishes access to transplantation therapy. (aappublications.org)
  • Nonwhite patients have a lower chance of identifying a fully matched unrelated adult donor because of genetic heterogeneity and lack of nonwhite donors. (aappublications.org)
  • 19 - 23 With advances in the clinical practice of cord blood transplantation, most patients unable to find a fully matched adult donor can identify a partially matched cord blood donor. (aappublications.org)
  • Patients with more than 25% bone marrow involvement are usually referred to as having Burkitt leukemia. (medscape.com)
  • pathways
  • Although benzyloxycarbonyl-Val-Ala-Asp-fluoromethyl ketone inhibited caspase activity in Bcl-2-overexpressing U937 cells, it completely prevented neither the induction of apoptosis or the nuclear translocation of apoptosis-inducing factor, which suggests that evodiamine is, at least in part, able to bypass the resistance of leukemia cells via caspase-independent apoptotic pathways. (aacrjournals.org)
  • induction
  • Adults ≤60 years of age: IV: Induction and Consolidation 2A cycles: 60 mg/m 2 on days 1, 2, and 3 (in combination with vincristine, prednisone, and asparaginase). (drugs.com)