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  • lymphoma
  • This hypothesis has not been confirmed by other reports, although a French study that evaluated occupational exposure to pesticides and lymphoid neoplasms among men appears to support the hypothesis that occupational pesticide exposures may not only be involved in hairy cell leukemia, Hodgkin lymphoma, and multiple myeloma, but also may play a role in non-Hodgkin lymphoma. (medscape.com)
  • mutation
  • Recently, new DNA scanning techniques using whole-exome sequencing identified 5 missense somatic clonal mutations, including a heterozygous mutation in BRAF that results in the BRAF V600E variant protein, which is oncogenic for other tumors as well, was identified in all hairy cell leukemia patients and may be responsible for the pathogenesis, diagnosis, and targeted therapy of hairy cell leukemia. (medscape.com)
  • The BRAF -V600E mutation is a hairy cell leukemia-defining genetic lesion that can be used diagnostically. (uni-bonn.de)
  • The actual cause of the disease is unknown but some study conveyed that it is due some genetic mutation in the cancer cells. (medgadget.com)
  • splenic
  • This pattern probably results from the expression of the integrin receptor alpha4-beta1 by the hairy cells and the interaction of the receptor with the vascular adhesion molecule-1 (VCAM-1) found in splenic and hepatic endothelia, bone marrow, and splenic stroma. (medscape.com)