Leukemia following allogeneic bone marrow transplantation graft vs leukemia effect. Medical search. Frequent questions

Immune cells from the patient or a transplant donor are used to attack residual leukemia, lymphoma or myeloma cells that remain after chemotherapy. (tlls.org)
Chemotherapy, radiation therapy, targeted therapy, and stem cell or bone marrow transplant are common treatment options for leukemia. (medicalnewstoday.com)
In a newly reported study, an experimental antibody treatment largely prevented gastrointestinal acute graft versus host disease (GI-aGVHD) in the intestines of mice and non-human primates (NHPs) given a bone marrow transplant-allogeneic hematopoietic cell transplant (allo-HCT)-but without causing broad immune suppression. (genengnews.com)
And even when a bone marrow transplant is curative for leukemia or lymphoma, GVHD-in which T cells in the donor graft attack the recipient's own tissues-can still be fatal. (genengnews.com)
A short-chain fatty acid made by bacteria in the gut could play an important role in graft-versus-host disease (GVHD) after allogeneic bone marrow transplant in mice. (oncologynurseadvisor.com)
Although it is proving to be a heterogeneous disease process, the only treatment with proven survival benefit for poor risk AML remains allogeneic hematopoietic cell transplant. (sagepub.com)
Dr Roger Owen (Leeds General Infirmary) gives his opinion on the place of allogeneic transplant in myeloma following the debate. (medicalupdateonline.com)
2 The Blood and Marrow Transplant Clinical Trials Network (BMT CTN) 0102 study showed that patients receiving an autologous SCT (ASCT) followed by an allo-SCT had significantly higher CR rates that patients receiving double ASCTs. (medicalupdateonline.com)
This phase II trial studies the side effect of busulfan, fludarabine phosphate, and post-transplant cyclophosphamide in treating patients with blood cancer undergoing donor stem cell transplant. (mdanderson.org)
Giving chemotherapy such as busulfan and fludarabine phosphate before a donor stem cell transplant helps stop the growth of cells in the bone marrow, including normal blood-forming cells (stem cells) and cancer cells. (mdanderson.org)
Received at least 3 prior anti-myeloma regimens including at least 2 consecutive cycles of lenalidomide, pomalidomide, a proteasome inhibitor, a glucocorticoid and a CD38 antibody (note: induction with or without bone marrow transplant and with or without maintenance therapy is considered one regimen). (themmrf.org)
[11] About one-third to one-half of allogeneic transplant recipients will develop acute GvHD. (wikipedia.org)
The purpose of this study is to assess the effect your disease and the treatment of allogeneic stem cell transplant has upon you before and after your treatment process through questionnaires at certain time points. (mayo.edu)
The primary purpose of this study is to demonstrate the feasibility of sublingual (SL) administration of tacrolimus in blood and marrow transplant (BMT) patients. (mayo.edu)
There's an "incredibly exciting" amount of research and development in the transplant and cellular therapy space that could result in gamechanging treatments for patients facing blood cancers such as leukemia and lymphoma. (managedhealthcareexecutive.com)
1. Bone marrow transplant has improved and evolved dramatically since its inception decades ago. (managedhealthcareexecutive.com)
Outcomes among patients with blood and marrow transplants have improved, thanks to better donor-recipient matching (such as through human leukocyte antigen typing), improved patient support systems, and less toxic treatment regimens, says Devine, who is also senior vice president and senior medical director of research operation at the Center for International Blood and Marrow Transplant Research. (managedhealthcareexecutive.com)
Bone marrow transplant is becoming a safer choice for elderly patients with lymphoma, myeloma, acute leukemia, and myeloid dysplastic syndrome, says Devine. (managedhealthcareexecutive.com)
Allogeneic stem cell transplantation (SCT) results in a high percentage of complete remissions, but it can be associated with significant treatment-related mortality, which has been primarily attributed to conventional myeloablative transplant regimens. (drugpatentwatch.com)
GVHD occurred after a matched unrelated donor, allogeneic bone marrow transplant for acute myeloid leukemia. (cdc.gov)
img class='aligncenter' src='https://scx1.b-cdn.net/csz/news/800a/2023/pitt-study-reframes-un.jpg' alt='Pitt study reframes understanding of graft-versus-host disease' title='A new model of graft-versus-host-disease (GVHD): Early post transplant (left side), GVHD is initiated by progenitor T cells that seed affected tissues from the spleen and lymph nodes via the blood. (awebfind.biz)
Published today in Immunity , the study showed in a mouse model that GVHD, which often affects the skin, gut and liver, is maintained by donor T cells that seed those tissues soon after transplant and not by the continual recruitment of T cells from the blood as previously thought. (awebfind.biz)
GVHD may occur after a bone marrow, or stem cell, transplant in which someone receives bone marrow tissue or cells from a donor. (medlineplus.gov)
This type of transplant is called allogeneic. (medlineplus.gov)
If you have had a bone marrow transplant, call your provider right away if you develop any symptoms of GVHD or other unusual symptoms. (medlineplus.gov)
p>A blood and bone marrow transplant takes unhealthy stem cells out of the bone marrow and replaces them with healthy stem cells, with the intent to treat childhood cancers and nonmalignant blood and bone marrow diseases. (nemours.org)
Principal investigator Edmund K. Waller, MD, PhD, FACP, says the net result of giving the patient a precise number of donor T cells with specific functions "leads to better elimination of cancer with less graft versus host disease and less toxicity from the transplant. (emory.edu)
A new Phase 3 clinical trial at Winship is enrolling participants after extremely encouraging results in the study's first two phases indicate the first-in-class high-precision cell therapy retains the benefits of stem cell transplant without such serious complications as graft versus host disease (GvHD) and disease relapse in patients with certain blood cancers. (emory.edu)
Orca-T combines purified cells from a matched donor to replace a patient's diseased blood and immune system with a healthy one while lowering their risk of developing GvHD and other life-threatening transplant-related side effects. (emory.edu)
Transplantation & Cellular Therapy Meetings of the American Society of Transplantation and Cellular Therapy (ASTCT) and Center for International Blood and Marrow Transplant Research (CIBMTR), and the American Society of Hematology (ASH) annual meeting. (emory.edu)
To create the precision-engineered donor graft, Waller explains that different cellular subsets in the graft are selectively purified and then infused into the transplant recipient in a timed fashion. (emory.edu)
Measurable Residual IDH1 before Allogeneic Transplant for Acute Myeloid Leukemia. (mcw.edu)
Correction to: Impact of pre-transplant induction and consolidation cycles on AML allogeneic transplant outcomes: a CIBMTR analysis in 3113AML patients. (mcw.edu)
Real-World Data Showing Trends and Outcomes by Race and Ethnicity in Allogeneic Hematopoietic Cell Transplantation: A Report from the Center for International Blood and Marrow Transplant Research. (mcw.edu)
DNA Sequencing to Detect Residual Disease in Adults With Acute Myeloid Leukemia Prior to Hematopoietic Cell Transplant. (mcw.edu)
Harmonizing Definitions for Diagnostic Criteria and Prognostic Assessment of Transplantation-Associated Thrombotic Microangiopathy: A Report on Behalf of the European Society for Blood and Marrow Transplantation, American Society for Transplantation and Cellular Therapy, Asia-Pacific Blood and Marrow Transplantation Group, and Center for International Blood and Marrow Transplant Research. (mcw.edu)
0103 Genotype in Survival of Patients After Allogeneic Hematopoietic Stem Cell Transplant. (cdc.gov)

The development of acute graft-versus-host disease (GVHD) in 17 patients was found, with time-dependent Cox regression analysis, to be associated with a significant reduction in post-BMT relapse risk (P=.04) and improved disease-free survival (P=.11). (umn.edu)
In experiments with mouse models of GVHD, the researchers showed that blocking a particular Notch activator known as DLL4 effectively prevented GVHD when administered within the first days after transplantation. (genengnews.com)
For their newly reported study Maillard and his lab teamed up with Tkachev, Kean, and colleagues to test the anti-DLL4 strategy using an antibody called REGN421 in a large animal model of GVHD, which the Boston researchers developed to better simulate the human immune system and the effects of GVHD treatment, and allowing them to test the effects of targeting a single pathway. (genengnews.com)
The team confirmed that the Notch pathway involvement in GVHD was conserved across species, and demonstrated in their animal models that just a single dose of the DLL4-blocking antibody given immediately before stem cell transplantation greatly increased survival and prevented signs of GVHD in the intestines, but without causing global immunosuppression. (genengnews.com)
In human patients who receive bone marrow transplants, GVHD can cause severe gut damage from donor cells attacking host cells. (oncologynurseadvisor.com)
These results suggest that decreased butyrate levels could increase GVHD, while restoring butyrate levels could ameliorate the adverse effect. (oncologynurseadvisor.com)
Adoptive Allogeneic T-cell therapy (ATCT) might be curative for MM, however current ATCT protocols often lead to graft versus host disease (GvHD). (biomedcentral.com)
Transplanting only tumor reactive donor T cells that mediate a graft-versus-myeloma (GvM) but not GvHD may overcome this problem. (biomedcentral.com)
These data demonstrate that a transplantation protocol involving only selective tumor-reactive donor T cell families is an effective immunotherapy and results in long-term survival in a mouse model of human MM. The results highlight the need to develop similar ATCT strategies for MM patients that result in enhanced survival without symptoms of GvHD. (biomedcentral.com)
Launch Graft-versus-host disease (GVHD) continues to be an important problem after allogeneic bone tissue marrow transplantation (BMT). (biopaqc.com)
Selective GVHD precautionary approaches keeping a graft-versus-leukemia (GVL) impact are required. (biopaqc.com)
The present studies were conducted to delineate the influence of IL-21 on GVHD and GVL and to elucidate the mechanisms associated with the observed biologic effects. (biopaqc.com)
Chronic or late GVHD may appear months after transplantation and remain present for years [1, 5]. (bvsalud.org)
Patient underwent allogeneic BTM and two days later developed acute GVHD on intestine. (bvsalud.org)
GVHD disease is the most common consequence of allogeneic BMT and the skin is the most commonly affected organ [5, 13]. (bvsalud.org)
Graft-versus-host disease ( GvHD ) is a syndrome , characterized by inflammation in different organs. (wikipedia.org)
GvHD is commonly associated with bone marrow transplants and stem cell transplants . (wikipedia.org)
GvHD can also occur after a blood transfusion , known as Transfusion-associated graft-versus-host disease or TA-GvHD if the blood products used have not been gamma irradiated or treated with an approved leukocyte reduction system. (wikipedia.org)
Soumya, also completed a clinical fellowship program in human bone marrow transplantation in Israel, where in addition to the regular clinical responsibilities, his focus of research was on 'allogeneic cell therapy against malignancy', and pre-clinical research for the 'development of novel treatment for graft-versus- host disease (GVHD). (interestingimmunology.org)
Acute GVHD ranges from mild, moderate or severe, and can be life-threatening if its effects are not controlled. (drcremers.com)
My principle research interests are in the prevention and therapy of graft-versus-host disease (GVHD) and in the use of graft-versus-leukemia to eradicate blood disorders. (harvard.edu)
He had chronic graft versus host disease (GVHD) with skin and pulmonary involvement treated with prednisone (25 mg/d orally), methotrexate (15 mg/wk orally), tacrolimus (1 mg 2×/d orally), and fluticasone/salmeterol (250 µg/50 µg 2×/d inhaled). (cdc.gov)
New research challenges the prevailing hypothesis for how donor stem cell grafts cause graft-versus-host disease, or GVHD, and offers an alternative model that could guide development of novel therapies. (awebfind.biz)
It provides important mechanistic detail about what's going on in the tissues affected by GVHD, which could ultimately inform the development of better therapeutics and lead to better outcomes for stem cell recipients. (awebfind.biz)
While often lifesaving for patients with leukemia and other blood disorders, the treatment also comes with a risk of developing GVHD, a life-threatening disease that occurs when donor alloreactive T cells attack the recipient's healthy tissues. (awebfind.biz)
According to a widely held theory, GVHD is maintained by T cells that continually migrate from secondary lymphoid organs throughout the body-including the spleen and lymph nodes-to affected tissues via the blood. (awebfind.biz)
The analysis showed that each tissue affected by GVHD had unique T cell populations with varying frequencies of each T cell flavor. (awebfind.biz)
With better ways to minimize the risk of GVHD after stem cell transplantation, the procedure could become more widely used to treat a broader range of diseases, including blood disorders such as sickle cell anemia and autoimmune diseases such as lupus and multiple sclerosis. (awebfind.biz)
Graft-versus-host disease (GVHD) is a life-threatening complication that can occur after certain stem cell or bone marrow transplants . (medlineplus.gov)
These cells expand and help prevent both rejection of the graft and GvHD. (emory.edu)
The allogeneic HSCT was the most frequently performed (57.14%) and the most used source of Hematopoietic progenitor cells (HPC) was the peripheral blood (54.29%) and 5.71% of these patients developed the Graft versus Host Disease (GVHD), of which one was affected by acute GVHD and another by chronic GVHD. (bvsalud.org)

Healthcare providers may recommend allogeneic stem cell transplantation for severe forms of aplastic anemia. (clevelandclinic.org)
Acquired aplastic anemia is a rare, serious blood disorder, due to failure of the bone marrow failure to produce blood cells. (rarediseases.org)
Although bone marrow failure can occur secondary to other disorders, most aplastic anemia is due to the immune system mistakenly targeting the bone marrow (autoimmunity). (rarediseases.org)
The symptoms of acquired aplastic anemia occur as a consequence of the bone marrow failing to produce enough blood cells. (rarediseases.org)
It is believed that PNH arises in the setting of autoimmune acquired aplastic anemia and bone marrow failure. (rarediseases.org)
Individuals affected with acquired aplastic anemia are also at risk that it will evolve into another similar disorder known as myelodysplasia. (rarediseases.org)
Antithymocyte gobulin, derived from rabbits or horses against human thymocytes, has predominantly been used for the treatment of severe aplastic anemia but also within conditioning for allogeneic HCT in selected protocols, mainly for non-malignant indications. (haematologica.org)
Bone marrow transplantation (BMT) is the treatment of choice for lymphoma, aplastic anemia, various types of leukemia and immunodeficiency disorders [5]. (bvsalud.org)

Graft vs leukemia (GVL) effects independent of graft vs host disease were investigated in allogeneic bone marrow chimeras tolerant of host and donor alloantigens. (ox.ac.uk)
The data suggest that T cells may mediate GVL effects in the absence of graft vs host disease and in circumstances where tolerance to conventional alloantigens is elicited. (ox.ac.uk)
Induction of GVL effects by allogeneic cells tolerant of host MHC suggests that these effects may be independent of graft vs host disease. (ox.ac.uk)
Leukemia remission is when there is no evidence of the disease during treatment. (medicalnewstoday.com)
In other words, it is a period when leukemia is in a state of minimal or undetectable disease activity. (medicalnewstoday.com)
Refractory ALL is a type of leukemia characterized by the failure to achieve complete remission or the recurrence of the disease after initial treatment. (medicalnewstoday.com)
Maillard is co-senior and co-corresponding author of the team's published paper in Science Translational Medicine , which is titled " Notch signalling drives intestinal graft-versus-host disease in mice and nonhuman primates . (genengnews.com)
However, acute graft-versus-host disease (aGVHD) can be potentially fatal in recipients. (genengnews.com)
Our findings suggest we can prevent graft-versus-host disease by bolstering the amount of the microbiome-derived metabolite butyrate," explained study lead author Pavan Reddy, MD, the Moshe Talpaz Professor of Translational Pathology and interim division chief of hematology/oncology at the University of Michigan, Ann Arbor. (oncologynurseadvisor.com)
If the GI gut lining can remain healthy and strong, it can resist the attack by the donor immune system and hopefully prevent graft vs. host disease. (oncologynurseadvisor.com)
Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease [published online ahead of print March 21, 2016]. (oncologynurseadvisor.com)
7 In the recently completed LenaRIC study patients undergoing allo-SCT with reduced-intensity conditioning received lenalidomide for 12 months from day 35 post-transplantation, with DLI for mixed chimerism or persistent disease. (medicalupdateonline.com)
Therapeutic Candidate or Device Allogeneic iPSC derived dopamine progenitors delivered to the brain of Parkinson's disease patients Indication Idiopathic Parkinson's disease Therapeutic Mechanism The cellular product reconstitutes dopaminergic neuron circuits lost owing to the disease Unmet Medical Need There are currently disease modifying therapies. (ca.gov)
Therapeutic Candidate or Device OSSM007: cryopreserved, interferon-gamma-primed bone marrow mesenchymal stem cells (BM-MSC) Indication acute Graft versus host disease (aGVHD) resulting from hematopoietic cell transplantation Therapeutic Mechanism Immunomodulation of host-reactive T cells to induce operational tolerance of donor HSC-derived lymphocytes through direct cell-to-cell contact and secreted paracrine factors. (ca.gov)
Therapeutic Candidate or Device Autologous hematopoietic stem cells transduced with a HexA/HexB expressing lentiviral vector Indication Tay-Sachs disease Therapeutic Mechanism The transplanted gene modified autologous hematopoietic stem cells will engraft in the bone marrow and start producing HexA/HexB expressing immune progeny. (ca.gov)
Sometimes the transplanted cells from a donor can make an immune response against the body's normal cells (called graft-versus-host disease). (mdanderson.org)
Despite chemo-induction therapy and autologous stem cell transplantation (ASCT), the vast majority of patients with Multiple Myeloma (MM) relapse within 7 years and the disease remains incurable. (biomedcentral.com)
8 The pivotal trial testing ATG in the setting of unrelated donors and intensive conditioning suggested a significant reduction in the incidence of chronic graft- versus -host disease without an increase in the risk of relapse. (haematologica.org)
12 Interestingly, ATG reduced the cumulative incidence of acute graft- versus -host disease while it did not affect the rate of chronic graft- versus -host disease. (haematologica.org)
A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. (curehunter.com)
Chronic graft versus host disease (cGVHD) is the most common consequence of allogeneic bone marrow transplantation, and it is associated with morbidity and mortality. (bvsalud.org)
Chronic graft-vs-host disease (cGVHD) is the most common complication following allogeneic BMT [10]. (bvsalud.org)
Many other clinical conditions present substantial skin fibrosis and may be potentially confused with Scleroderma, sometimes leading to a wrong diagnosis (eosinophilic fasciitis, systemic amyloidosis, scleromyxedema, graft-versus-host disease, progeroid disorders, stiff skin syndrome). (bvsalud.org)
Not to be confused with Host-versus-graft disease . (wikipedia.org)
Mouse colon impacted by acute graft-versus-host disease. (wikipedia.org)
Micrographs of grades of skin graft-versus-host disease: Ranging from grade I GvHR (with minimal vacuolization in the epidermis) to grade II GvHR (with vacuolization and dyskeratotic bodies) to grade III GvHR (with sub epidermal cleft formation) and finally to grade IV GvHR (with separation of the dermis from the epidermis). (wikipedia.org)
In the clinical setting, graft-versus-host disease is divided into acute and chronic forms, and scored or graded on the basis of the tissue affected and the severity of the reaction. (wikipedia.org)
In the classical sense, acute graft-versus-host disease is characterized by selective damage to the liver , skin (rash), mucosa , and the gastrointestinal tract . (wikipedia.org)
Newer research indicates that other graft-versus-host disease target organs include the immune system (the hematopoietic system , e.g., the bone marrow and the thymus ) itself, and the lungs in the form of immune-mediated pneumonitis . (wikipedia.org)
[6] Chronic graft-versus-host disease also attacks the above organs, but over its long-term course can also cause damage to the connective tissue and exocrine glands . (wikipedia.org)
Efficacy and Safety of 1% Progesterone Gel to the Forehead for Ocular Chronic Graft-versus-Host Disease. (harvard.edu)
We've managed to be able to reduce the rates of severe graft-versus-host disease-that's the major complication of transplants," says Devine. (managedhealthcareexecutive.com)
3. Cancer is not the only disease benefited by transplantation. (managedhealthcareexecutive.com)
We describe the successful management of Anncaliia algerae microsporidial myositis in a man with graft versus host disease after hemopoietic stem cell transplantation. (cdc.gov)
Recent data indicate that high BAALC expression levels may also be used as marker for residual disease following acute myeloid leukemia treatment. (oncotarget.com)
Graft-versus-host disease and graft-versus-leukemia responses. (medlineplus.gov)
Graft versus host disease can cause severe damage to the skin, liver, intestines and lungs," Waller says. (emory.edu)

Treatments for leukemia include chemotherapy, radiation therapy, and stem cell transplants. (medicalnewstoday.com)
The condition is among the leading causes of death and long-term adverse health consequences associated with bone marrow transplants. (genengnews.com)
This study, published in Nature Immunology , first examined chemicals made by gut bacteria after the mice received allogeneic bone marrow transplants. (oncologynurseadvisor.com)
Bone marrow transplants can be important components for treating some types of leukemia and lymphoma. (oncologynurseadvisor.com)
One big improvement has occurred in the realm of allogeneic transplants (in which donor cells are used). (managedhealthcareexecutive.com)
Ten to 15 years ago we never sought them for donor transplants (what we call allogeneic transplants). (managedhealthcareexecutive.com)
In terms of allogeneic transplants, the most common indication is acute myeloid leukemia and myelodysplastic syndrome, which is a blood disorder that affects blood formation in older patients. (managedhealthcareexecutive.com)
There are many clinical trials in the cellular therapies space outside of bone marrow transplants, such as CAR-T cell therapy and the use of NK cells, says Ronneberg, noting that a few CAR-T therapies have already received FDA approval. (managedhealthcareexecutive.com)

Neither age, sex, remission number, prior extramedullary leukemia, nor WBC at diagnosis of ALL was statistically significant as a predictor of relapse-free survival. (umn.edu)
These results suggest that allogeneic BMT can result in extended relapse-free survival for some patients with high-risk ALL. (umn.edu)
Some blood cancer patients, especially those with chronic myeloid leukemia (CML), who have a relapse after stem cell transplantation or for whom transplantation isn't successful, may benefit from an immune cell treatment called donor lymphocyte infusion. (tlls.org)
The idea is to make the host cells stronger, to be able to withstand the assault of the donor immune cells while reducing the risk of infection or leukemia relapse," said Reddy. (oncologynurseadvisor.com)
NCI First International Workshop on The Biology, Prevention and Treatment of Relapse after Allogeneic Hematopoietic Cell Transplantation: report from the committee on prevention of relapse following allogeneic cell transplantation for hematologic malignancies. (sagepub.com)
The biggest problem that remains for patients transplanted for hematological malignancies such as leukemia, lymphoma, or multiple myeloma, is relapse, says Devine. (managedhealthcareexecutive.com)
Even with a reduction in treatment related mortality, success with allogeneic SCT is limited by a significant risk of relapse. (drugpatentwatch.com)
Evaluation of pre-HSCT BAALC / ABL1 copy numbers in peripheral blood by ddPCR represents a feasible and rapid way to identify acute myeloid leukemia patients at high risk of early relapse after HSCT. (oncotarget.com)

It generally results in fewer short-term side effects than chemotherapy does. (tlls.org)
Chemotherapy for leukemia can cause various side effects, depending on the specific drugs, the dosage, and the person. (medicalnewstoday.com)
Some supportive therapies, such as anti-nausea medications or growth factors to boost blood cell production, may help manage side effects and improve quality of life during chemotherapy. (medicalnewstoday.com)
Learn more about chemotherapy side effects here. (medicalnewstoday.com)
Autologous transplantation involves extracting a person's stem cells from the bone marrow or blood and freezing them before a person has chemotherapy or radiation therapy. (medicalnewstoday.com)
For example, people who have stem cell transplantation go through intensive chemotherapy before treatment. (clevelandclinic.org)
Daily online exclusives cover late breaking oncology news, safe handling and administration of chemotherapy drugs, side effect management, and new developments in specific cancers. (oncologynurseadvisor.com)
Newer studies with intensive multiagent chemotherapy (eg, the CALGB [Cancer and Leukemia Group B]- 8811 and hyper-CVAD [hyperfractionated cyclophosphamide, vincristine, doxorubicin, and dexamethasone] regimens and the ALL-2 regimen) plus the addition of TKIs for Ph+ ALL and rituximab for CD20-positive ALL have resulted in 3-y survivals of 50% or more in adults. (medscape.com)
It reveals the patient reported no other adverse reaction besides common side effects of IA regimen from the chemotherapy.On day 8, the first dose of nivolumab (1 mg/kg by vein) was started without induction chemotherapy and continued every two weeks for 10 cycles. (pensoft.net)
In recent years, especially after the advent of reduced intensity conditioning in the late 1990s, allogeneic HSCT is increasingly used in older patients and as an effective salvage strategy for patients with lymphoma or myeloma not responding to chemotherapy or autologous HSCT. (longdom.org)
Before having acute myeloid leukemia, the patient received 6 cycles of combination chemotherapy (rituximab, cyclophosphamide, doxorubicin, vincristine, etoposide, and prednisone) to treat high-grade diffuse large B cell lymphoma. (cdc.gov)
Therapy often involves several cycles of chemotherapy, targeted biological treatment, immunological, immunosuppressive and instrument treatment (TPE and depletion procedures performed in cooperation with the IHBT Apheresis Department ), as well as different forms of hematopoietic stem cell transplantation . (uhkt.cz)
Sargramostim is a colony stimulating factor that is FDA approved for the treatment of granulocytopenia following induction chemotherapy in acute myelogenous leukemia , mobilization and following transplantation of autologous peripheral blood progentior cells, myeloid reconstitution after autologous bone marrow transplantation, myeloid reconstitution after allogeneic bone marrow transplantation and bone marrow transplantation failure or engraftment delay. (wikidoc.org)
The recommended dose is 250 mcg/m2/day administered IV over a 2-hour period beginning two to four hours after bone marrow infusion, and not less than 24 hours after the last dose of chemotherapy or radiotherapy. (wikidoc.org)
Hematopoietic stem cell transplantation is also sometimes used for solid tumors (eg, some germ cell tumors) that respond to chemotherapy. (msdmanuals.com)

Here, we present a case of an over 60-years old male patient with AML, and the possibility for him to receive an allogeneic hematopoietic stem cell transplantation (allo-HSCT). (pensoft.net)
However, very limited research has been done to investigate how AA secondary to nivolumab therapy may affect the outcome of HSCT. (pensoft.net)
The purpose of this study is to measure the effect of Hematopoietic Stem Cell Transplantation (HSCT) on symptoms of CSF1R-related Leukoencephalopathy. (mayo.edu)
Since then, allogeneic hematopoietic stem cell transplantation (HSCT) has evolved to become a frequently used and effective therapy for many hematologic malignancies. (longdom.org)
In chronic myeloid leukemia (CML), HSCT which is once the mainstay for cure is now largely supplemented by molecularly targeted therapy. (longdom.org)
Allogeneic hematopoietic stem cell transplantation (HSCT) offers a curative treatment for acute myeloid leukemia patients. (oncotarget.com)
We performed absolute quantification of BAALC copy numbers in peripheral blood prior (median 7 days) to HSCT in complete remission (CR) or CR with incomplete peripheral recovery in 82 acute myeloid leukemia patients using digital droplet PCR (ddPCR) technology. (oncotarget.com)
In the future, prospective studies should evaluate whether acute myeloid leukemia patients with high pre-HSCT BAALC / ABL1 copy numbers benefit from additional treatment before or early intervention after HSCT. (oncotarget.com)
Allogeneic HSCT uses human leukocyte antigen (HLA)-matched stem cells derived from a donor. (emory.edu)
In the section on aspergillosis, the revised recommendations include the use of a room with high-efficiency particulate air filters rather than laminar airflow as the protective environment for allogeneic HSCT recipients and the use of high-efficiency respiratory-protection devices (e.g. (cdc.gov)
The Hematopoietic stem cell transplantation (HSCT) is used in children as a definitive treatment for various oncological, immune deficiencies, hemoglobinopathy, and malignancies diseases that involve the hematological system, congenital metabolism disorders, among others. (bvsalud.org)
This is a quantitative, retrospective, observational, descriptive and analytical quantitative approach approaching the medical records of children and adolescents submitted to HSCT in a referral hospital service for this type of transplantation in the state of Rio Grande do Sul North (RN). (bvsalud.org)
The profile of the clinical variables presented by the children and adolescents of this study shows that the most prevalent diagnosis was ALL, the most frequent toxicities were gastrointestinal, cardiac, respiratory and hematological, the most common HSCT was allogeneic peripheral blood and the greatest cause of mortality was sepsis. (bvsalud.org)
Hematopoietic stem cell transplantation not responded to other therapeutic modalities, with (HSCT) is used in children as a definitive treatment an increase in survival after transplantation, for different oncological, immune deficiencies, contributing to its use (YEILIPEK, 2014). (bvsalud.org)

Forty remission patients with high-risk acute lymphoblastic leukemia (ALL) underwent matched allogeneic bone marrow transplantation (BMT) following preparation with cyclophosphamide and fractionated total body irradation (TBI). (umn.edu)
The role of Thy1.2, L3T4 and Lyt2 T lymphocytes as effector cells of GVL were investigated in (BALB/c x C57BL/6)F1 mice inoculated with murine B-cell leukemia and subsequently conditioned with total lymphoid irradiation and cyclophosphamide (200 mg/kg). (ox.ac.uk)
Patients with uveitis who are not responding well to steroid treatment and patients who have side effects from other medicines used to treat uveitis (such as cyclosporine, cyclophosphamide, methotrexate or azathioprine) or have refused treatment because of possible side effects of these medicines may be eligible for this study. (drugpatentwatch.com)
Secondary Objectives: To evaluate the effect of the Fludarabine-(etoposide, doxorubicin, vincristine, prednisone, cyclophosphamide) EPOCH regimen on host T cell depletion and myeloid depletion prior to allogeneic SCT. (drugpatentwatch.com)
Impact of Donor Age in Haploidentical-Post-Transplantation Cyclophosphamide versus Matched Unrelated Donor Post-Transplantation Cyclophosphamide Hematopoietic Stem Cell Transplantation in Patients with Acute Myeloid Leukemia. (mcw.edu)

To determine the treatment-related morbidity and mortality of allogeneic stem cell transplantation using a non-myeloablative conditioning regimen in multiple myeloma. (drugpatentwatch.com)

This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
The clinical and functional effects of TERT variants in myelodysplastic syndrome. (harvard.edu)
Thus, our care covers congenital or acquired non-tumor diseases (anemias, coagulation disorders, etc.), as well as tumor diseases such as leukemia or myelodysplastic syndrome. (uhkt.cz)

Survival after allogeneic transplantation depends on donor-recipient matching, the graft-versus-host response and the development of a graft versus leukemia effect. (emory.edu)

In addition to his research, he treats patients with chronic lymphocytic leukemia, non-Hodgkin lymphoma and multiple myeloma at Seattle Cancer Care Alliance. (wikipedia.org)
Patients with Burkitt leukemia/lymphoma are treated with regimens specific for this diagnosis. (medscape.com)
Leukemia & lymphoma 2020 5 61 (9): 2180-2190. (cdc.gov)

Other promising developments to improve outcomes in allo-SCT include conditioning with radiolabelled anti-CD66, as well as salvage therapy with daratumumab 8 or newer imids which suggest that allo-SCT has the potential to enhance the efficacy of other therapies that may have been less effective pre-transplantation. (medicalupdateonline.com)
An interventional clinical study is where participants are assigned to receive one or more interventions (or no intervention) so that researchers can evaluate the effects of the interventions on biomedical or health-related outcomes. (themmrf.org)
Donor Clonal Hematopoiesis and Recipient Outcomes After Transplantation. (harvard.edu)
High BAALC expression levels at acute myeloid leukemia diagnosis have been linked to adverse outcomes. (oncotarget.com)
This study indicates that transplantation of defined populations of cells can lead to improved patient outcomes," he says, pointing out that it could also have even wider implications. (emory.edu)
Clinical outcomes and characteristics of patients with TP53-mutated acute myeloid leukemia or myelodysplastic syndromes: a single center experience. (cdc.gov)
Predictors of outcomes in adults with acute myeloid leukemia and KMT2A rearrangements. (cdc.gov)

It may also be a helpful treatment for patients with relapsed myeloma after allogeneic stem cell transplantation. (tlls.org)
The efficacy of allo-SCT in MM relies on the transplanted immune system having an anti-tumour effect on the host bone marrow, the so-called graft-versus-myeloma (GvM) effect. (medicalupdateonline.com)
12 however, the finding in the Myeloma XI study that lenalidomide maintenance therapy was associated with a significant improvement in PFS but with little further improvement in depth of response 13 suggests that the graft is providing an adjunct to highly effective maintenance therapy rather than the other way around. (medicalupdateonline.com)
We used an MHC-matched/miHA-disparate B10.D2 → Balb/c bone marrow transplantation (BMT) murine model and MOPC315.BM MM cells to develop an ATCT protocol consisting of total body irradiation, autologous-BMT and infusion of selective, myeloma-reactive lymphocytes of T cell receptor (TCR) Vβ 2, 3 and 8.3 families (MM-auto BMT ATCT). (biomedcentral.com)
Pre-stimulation ex vivo of allogeneic T cells by exposure to MOPC315.BM MM cells in the presence of IL-2, anti-CD3 and anti-CD28 resulted in expansion of the myeloma-reactive T cell TCRVβ 2, 3 and 8.3 subfamilies. (biomedcentral.com)
Survival of patients with multiple myeloma (MM) beyond 7 years remains rare even after autologous stem cell transplantation (ASCT) and treatment with novel agents [ 1 ]. (biomedcentral.com)
To test this rationale, we used the allogeneic B10.D2 → Balb/c BMT model with MOPC315.BM myeloma cells. (biomedcentral.com)
Donor immunization with myeloma Id in the setting of a non-myeloablative allogeneic SCT may represent a novel strategy for the treatment of multiple myeloma. (drugpatentwatch.com)
Objectives: Primary Objectives: To induce cellular and humoral immunity in allogeneic stem cell donors and recipients against the unique idiotype expressed by the recipient's myeloma. (drugpatentwatch.com)

Detection of residual tumor cells, an indicator for efficacy of GVL, was carried out by adoptive transfer of peripheral blood or spleen cells obtained from treated chimeras into secondary naive BALB/c recipients at different time intervals following bone marrow transplantation. (ox.ac.uk)
This is called a graft versus tumor (GVT) effect. (tlls.org)
Healthcare providers call this "graft-versus-tumor" effect (GVT). (clevelandclinic.org)
Graft-versus-tumor effects after allogeneic hematopoietic cell transplantation with nonmyeloablative conditioning. (sagepub.com)
New therapeutic concepts in anti-tumor therapy aim to modulate the patient's immune system to increase its aggressiveness or targeted effects toward tumor cells. (frontiersin.org)
Much of the curative potential of allografts is attributed to the graft-versus-tumor (GvT) response that aims to destroy residual tumor cells that persist after induction therapy and ASCT [ 5 ]. (biomedcentral.com)

In the field of hematopoietic stem cell transplantation, Maloney has played a role in the development of lower-toxicity, non-myeloablative techniques for the treatment of blood cancers. (wikipedia.org)
Stem cell transplantation, or bone marrow transplantation, is a treatment option for leukemia and other blood cancers. (medicalnewstoday.com)
Allogeneic stem cell transplantation uses donor stem cells to treat and sometimes cure certain blood disorders and blood cancers. (clevelandclinic.org)
What cancers are treated with allogeneic stem cell transplantation? (clevelandclinic.org)
Not all cancers or blood diseases respond to stem cell transplantation, including allogeneic stem cell transplantation. (clevelandclinic.org)
10 Data from the European Society for Blood and Marrow Transplantation (EBMT) megafile database indicates that the graft-versus-tumour effect achieved with allo-SCT is weaker and PFS rates lower in MM than in other types of haematological cancers. (medicalupdateonline.com)
Myelodysplastic syndromes (MDS) are a group of blood cancers in which your bone marrow doesn't make enough healthy blood cells. (healthline.com)
p>In addition to childhood cancers and blood disorders, Nemours treats nonmalignant bone marrow disorders, immune system deficiencies and some metabolic disorders with allogeneic blood and bone marrow transplantation. (nemours.org)

Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. (sagepub.com)
Acute lymphoblastic leukemia termed as ALL is defined as a type of blood malignancy that is detectable through the accumulation of B and T lymphocyte progenitor cells in the bone marrow [ 4 ]. (springeropen.com)
Myositis has been described in case-patients who were immunosuppressed because of rheumatoid arthritis, solid organ transplantation, and hematologic malignancy ( 1 - 5 ). (cdc.gov)

Moreover, the cytotoxic effect of the developed nanodrug on the Jurkat cell line was evaluated which illustrated that survival rate in the studied cell line reaches its minimum value (100% lethality, 0.0% survival) after treatment for 48 h. (springeropen.com)
Overall, the BSA-Au nanozymes can be used as the nanodrug for treatment of T-type lymphoblastic leukemia via reducing the expression of anti-apoptotic genes, increasing the effect of common anticancer drugs such as Adriamycin and ara-C, and consequently increasing the survival of patients with leukemia. (springeropen.com)
The platform technology used in this study can be applied to include additional populations of cells that may further improve survival and decrease complications for patients with leukemia and MDS undergoing allogeneic stem cell transplantation," he says. (emory.edu)

An autologous stem cell transplantation uses your own blood stem cells. (clevelandclinic.org)
While both treatments help your bone marrow to develop new blood cells, studies show allogeneic stem cell transplantations work by causing the donor cells to attack unhealthy cells. (clevelandclinic.org)
This blood disorder affects your body's ability to produce red blood cells. (clevelandclinic.org)
Allogeneic stem cell transplantation may cure some blood disorders FA causes. (clevelandclinic.org)
This disorder affects white blood cells. (clevelandclinic.org)
Allogeneic stem cell transplantation replaces damaged white blood cells. (clevelandclinic.org)
Healthcare providers consider several factors before recommending allogeneic stem cell transplantation to treat blood disorders or cancer. (clevelandclinic.org)
Red and white blood cells and platelets are formed in the bone marrow. (rarediseases.org)
AML is a type of blood cancer with excess immature white blood cells in bone marrow. (pensoft.net)
White blood cells of the donor's immune system which remain within the donated tissue (the graft) recognize the recipient (the host) as foreign (non-self). (wikipedia.org)
The binding of Campath stimulates destruction of the malignant lymphocytes and reduction or elimination of cancerous cells throughout the bone marrow, blood and lymph system. (broomeoncology.com)
The purpose of this study is to evaluate the effects that psychological and health behavior factors have on quality of life, level if sickness, and death after blood and bone marrow transplantation. (mayo.edu)
In addition, we are committed to graft engineering and vaccine development to enhance the ability of transplantation to control blood diseases. (harvard.edu)
Bone marrow is the place for the production of the hematopoietic cells which differentiate in to three groups: red blood cells, white blood cells and platelets. (longdom.org)
Allogeneic stem cell transplantation involves infusion of stem cells from a healthy donor's blood or bone marrow to a recipient. (awebfind.biz)
In MDS, many of the blood cells made in the bone marrow are irregular (dysplastic). (healthline.com)
New blood cells (called "stem cells") begin in the bone marrow - the red spongy material found inside the bones - and are released to the bloodstream when mature. (nemours.org)
Orthopedists (bone specialists) and orthopedic surgeons at Nemours Center for Cancer and Blood Disorders make our pediatric orthopedics programs among the largest and most respected in the world. (nemours.org)
Unrelated Donor Cord Blood Transplantation in Children: Lessons Learned Over 3 Decades. (mcw.edu)
Peripheral blood has largely replaced bone marrow as a source of stem cells, especially in autologous hematopoietic stem cell transplantation, because stem cell harvest is easier and neutrophil and platelet counts recover faster. (msdmanuals.com)
Umbilical cord hematopoietic stem cell transplantation has been restricted mainly to children because there are too few stem cells in umbilical cord blood for an adult. (msdmanuals.com)
Because cord blood contains immature stem cells, HLA matching appears less crucial than for the other types of hematopoietic stem cell transplantation. (msdmanuals.com)
Allogeneic transfusion of whole blood and fractionated blood components remains a controversial topic with respect to transfusion triggers and practices. (medscape.com)
Technology making the transfusion of allogeneic blood products feasible includes Karl Landsteiner's landmark identification of the human blood groups A, B, and O in 1901. (medscape.com)

Immunity of patients surviving 20 to 30 years after allogeneic or syngeneic bone marrow transplantation. (wikipedia.org)
Allogeneic hematopoietic cell transplantation (allo-HCT) has lifesaving potential for patients with hematological malignancies and bone marrow disorders, the authors wrote. (genengnews.com)
Allogeneic marrow transplantation in patients with acute myeloid leukemia in first remission: a randomized trial of two irradiation regimens. (sagepub.com)
The treatment regimen for patients with ALL is determined primarily by the Philadelphia chromosome status of the leukemia and the age of the patient. (medscape.com)
More specifically, the development of minimal intensity or so called "nonmyeloablative" conditioning regimens paved the way towards the application of allogeneic HCT in older patients and all of those who probably would not tolerate classical intensity conditioning. (haematologica.org)
Most interestingly, applying a differential dose escalation strategy, they identified the optimal TBI dose for patients with high-risk myelodysplastic syndromes and chronic myelomonocytic leukemia (450 cGy) and patients with low-risk myelodysplastic syndromes and myeloproliferative neoplasms (300 cGy). (haematologica.org)
10 Both trials included patients with acute leukemia and myelodysplastic syndromes. (haematologica.org)
Now the median age is close to 60, and many patients in their 60s and 70s are eligible for transplantation. (managedhealthcareexecutive.com)
Some MDS patients have a deletion in the long arm of chromosome 5, which is associated with acute myeloid leukemia (AML). (healthline.com)
Winship is one of several clinical trial sites for the Precision-T study evaluating the safety and efficacy of Orca-T, a cell therapy that combines purified cells from a matched donor, in patients with acute myeloid leukemia (AML), acute lymphocytic leukemia (ALL) and high-risk myelodysplastic sydromes (MDS). (emory.edu)
Patients should not receive Sargramostim until the post marrow infusion ANC is less than 500 cells/mm3. (wikidoc.org)

The infusion's goal is to attack or suppress leukemia cells by inducing an intense immune reaction against the patient's cancer cells. (tlls.org)
On day 138, the 11th dose of nivolumab was administered, and patient's platelet count was 53×109/L. However, immediately after the 11th dose, there was a sudden decrease in platelet count to 32×109/L. As the following 12th dose of nivolumab was served, the patient's platelet counts gradually dropped to 5×109/L. This result may reveal bone marrow damage, and it was possibly attributed to the nivolumab treatment. (pensoft.net)
The patient's bone marrow biopsy and aspirate was conducted. (pensoft.net)
Hematopoietic stem cell transplantation may be autologous (using the patient's own cells) or allogeneic (using cells from a donor). (msdmanuals.com)

Treatment of the primary marrow inoculum with monoclonal anti-Thy1.2 or anti-Lyt2 abolished the GVL effects and all secondary BALB/c recipients developed leukemia within 60 days. (ox.ac.uk)
On the other hand, the treatment with monoclonal anti-L3T4 did not influence the effect of GVL and all treated recipients remained without leukemia. (ox.ac.uk)

Leukemia Society of America, Clinical Scholar Award. (rochester.edu)
We document successful treatment of A. algerae infection after hemopoietic stem cell transplantation, provide an update on clinical features and management, and discuss possible routes of transmission and risk-mitigation strategies. (cdc.gov)
The identification of cytogenetic, molecular, and clinical factors impacting on outcome at acute myeloid leukemia (AML) diagnosis improved risk stratification [ 1 , 2 ]. (oncotarget.com)

Learn about remission from acute myeloid leukemia (AML). (medicalnewstoday.com)
Pagel, John 2013-03-03 00:00:00 The incidence of acute myeloid leukemia (AML) is expected to increase in conjunction with our ageing population. (sagepub.com)
6] Case reports have described AN associated with hematologic malignancies, including acute myeloid leukemia, and even benign gastrointestinal neoplasms. (medscape.com)
As an Immune checkpoint blockade therapy (ICB), nivolumab has demonstrated efficacy in Acute Myeloid Leukemia (AML) and various other malignancies. (pensoft.net)
Intermediate doses of unfractionated TBI have been successfully used by other colleagues in diseases such as chronic myeloid leukemia. (haematologica.org)
A 27-year-old female was admitted, in a Hematology Center, in 1997, with previous diagnosis of chronic myeloid leukemia since 1994. (bvsalud.org)
Earlier, he discovered that a very specific biologically active region of the chicken anemia virus derived protein apoptin (VP3) can allosterically bind to the SH3 domain of BCR-ABL oncoprotein, and induce rapid apoptosis in chronic myeloid leukemia cells - an effect that is potentially superior to that of current gold standard BCR-ABL inhibitor imatinib. (interestingimmunology.org)
I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
Leukemia and 25.71% had Acute Myeloid Leukemia as the main diagnosis. (bvsalud.org)
Development of TP53 mutations over the course of therapy for acute myeloid leukemia. (cdc.gov)

People who receive closely matched bone marrow tissue and cells usually do better. (medlineplus.gov)
eg, bone, bone marrow, and skin grafts) Genetically identical (syngeneic [between monozygotic twins]) donor tissue (isografts) Genetically. (msdmanuals.com)

They are considered key to the immunoregulatory effects of immune globulin in immune-mediated disorders. (medscape.com)

Treatment for acute myelogenous leukemia by low-dose, total-body, irradiation-based conditioning and hematopoietic cell transplantation from related and unrelated donors. (sagepub.com)
Allogeneic bone marrow transplantation, as we understood it, allows saving lives, but cannot take place without donors. (longdom.org)
If the geno-identical transplantation is impossible, we will direct ourselves towards the national and international register donors of bone marrow. (longdom.org)
Allogeneic hematopoietic stem cell transplantation is limited mainly by lack of histocompatible donors. (msdmanuals.com)
The deduced probable HLA-C*03:187-associated human leukocyte antigen haplotype (A*24:02-B*35:01-C*03:187-DRB1*11:01) revealed in Taiwanese unrelated hematopoietic bone marrow stem cell donors. (cdc.gov)

Cancer Care provides free, professional support services for people affected by myeloproliferative neoplasms, as well as treatment information and financial help with cancer-related costs and treatment co-pays. (cancercare.org)
Each treatment option can have side effects that vary for different people. (medicalnewstoday.com)
The healthcare team will work closely with the person to manage side effects and provide supportive care throughout treatment. (medicalnewstoday.com)
Role of signal transduction inhibition in treatment of acute myelogenous leukemia/myelodysplasia. (rochester.edu)
In this paper, the bovine serum albumin protected gold nanozymes (BSA-Au nanozymes) were utilized as a novel nanodrug for treatment of acute T-type lymphoblastic leukemia (Jurkat) by production of excessive ROS and effect on the expression of anti-apoptotic genes. (springeropen.com)
The results showed that the expression of anti-apoptotic genes was significantly reduced after treatment of the Jurkat cell line with the BSA-Au nanozymes (p-value of 0.001) as the potential nanodrug while their expression in the normal PBMC was not affected by the nanodrug. (springeropen.com)
Although a number of commercial drugs are designed and characterized for the treatment of ALL, these chemical anticancer drugs show several harmful side effects [ 8 ]. (springeropen.com)
The Allogeneic bone-marrow transplantation represents the only curative treatment and requires a compatible donor HLA. (longdom.org)

Characterization of effector cells of graft vs leukemia following allogeneic bone marrow transplantation in mice inoculated with murine B-cell leukemia. (ox.ac.uk)
The increased understanding of immune tolerance and allogeneic antileukemic immune reactivity has led several investigators to develop optimized conditioning protocols and new strategies to manipulate the effector cells either within the graft or in vivo . (haematologica.org)

In the last two decades allogeneic hematopoietic cell transplantation (HCT) has been used with increasing frequencies in hematologic malignancies with curative intent. (haematologica.org)

Allogeneic transplantation involves using stem cells from a donor - often a family member but sometimes a nonrelative. (medicalnewstoday.com)

In allogeneic stem cell transplantation, healthcare providers replace unhealthy stem cells with donated healthy stem cells. (clevelandclinic.org)

It is now widely accepted that immunocompetent lymphocytes in allogeneic bone marrow grafts exert an antileukemic effect that contributes to the cure of leukemia. (ox.ac.uk)

If one of the brothers and sisters is compatible, we speak about geno-identical allogeneic transplantation having the advantage of reducing the complications post-transplantation. (longdom.org)

In a proof of concept in vivo study, we also observed a therapeutic effect of adoptively transferred IL-15 expanded and IL-21 boosted NK cells in combination with image guided high precision radiation therapy using a luciferase-transduced RMS xenograft model. (frontiersin.org)
NUDT15 polymorphism influences the metabolism and therapeutic effects of acyclovir and ganciclovir. (cdc.gov)

[ 6 ] IVIG contains natural antibodies, accounting for some of its effects. (medscape.com)

Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. (curehunter.com)

Donor lymphocyte infusion has been helpful in treating relapsed CML after allogeneic bone marrow transplantation. (tlls.org)

People in remission from AML may be candidates for allogeneic stem cell transplantation. (clevelandclinic.org)

The technique for umbilical cord hematopoietic stem cell transplantation is still in its infancy, but it is gaining interest. (msdmanuals.com)

Help us continue to provide free programs and services to anyone affected by cancer. (cancercare.org)
Wound healing and trans-well assays demonstrated that the restored expression of TFF1 promoted cell mobility in gastric cancer cells, and this effect was attenuated by the knockdown of Piezo1. (bvsalud.org)
Refractory ALL is a more challenging form of leukemia because the cancer cells have become resistant to standard treatments. (medicalnewstoday.com)
The conventional T cells help eliminate the cancer in the patient through a process called "graft-versus-leukemia. (emory.edu)

There are no contraindications to autologous hematopoietic stem cell transplantation. (msdmanuals.com)

Anatomy15

Organisms11

Diseases41

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment48

Psychiatry and Psychology1

Phenomena and Processes20

Disciplines and Occupations1

Anthropology, Education, Sociology and Social Phenomena1

Information Science3

Named Groups1

Health Care11

Transplant37

GVHD31

Aplastic anemia8

Disease37

Transplants8

Relapse8

Chemotherapy15

HSCT14

Cyclophosphamide5

Morbidity and morta1

Myelodysplastic Syndrome3

Versus host1

Lymphoma3

Outcomes7

Myeloma9

Tumor6

Cancers8

Malignancy3

Survival3

Blood24

Patients11

Patient's4

Recipients2

Clinical3

Myeloid10

Tissue2

Disorders1

Donors5

Treatment8

Effector cells2

Hematologic malignancies1

Cells from a donor1

Unhealthy stem cells1

Antileukemic1

Post-transplantation1

Therapeutic2

Antibodies1

Life expectancy1

Infusion1

Remission1

Umbilical1

Cancer4

Autologous hematopoietic1