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  • chronic lymphocy
  • Reporting results from a first-in-human phase I clinical trial, researchers at University of California San Diego School of Medicine have found that treatment with cirmtuzumab, an experimental monoclonal antibody-based drug, measurably inhibited the "stemness" of chronic lymphocytic leukemia cancer (CLL) cells - their ability to self-renew and resist terminal differentiation and senescence. (ucsd.edu)
  • The aim of the study was to evaluate the frequency of IGHV3-21 gene usage and its clinical significance for patients with B-cell chronic lymphocytic leukemia (CLL) in Ukraine. (exp-oncology.com.ua)
  • rats
  • Contents of scvalene, sterols and their derivatives were studied in lymphoid tissues as well as in liver and kidney tissues of normal rats and the animals with Shvetz experimental leukosis. (msk.ru)
  • Palamarchuk V.I., Trikash I.O., Antonenko L.V., Content of squalene and sterols in tissues of the hemopoietic system in normal rats and in experimental leukemia, Voprosy meditsinskoi khimii, 1983, vol: 29(3), 64-67. (msk.ru)
  • Amount of cholesterol was distinctly decreased but content of scvalene, lanosterol, 7-dehydrocholesterol and 7-beta-hydroxycholesterol--increased in erythrocyte membranes of rats with Shvetz experimental leukosis. (msk.ru)
  • Palamarchuk V.I., Trikash I.O., Alterations in composition of sterols and in properties of erythrocyte membranes in rats with Shvetz experimental leukemia and after UV irradiation, Voprosy meditsinskoi khimii, 1983, vol: 29(3), 67-70. (msk.ru)
  • gene
  • A gene-editing technology that made headlines recently for successfully treating a baby with leukemia may one day be used to treat other types of cancers, experts say. (lifemag.org)
  • Chronic myeloid leukemia (CML) is a clonal myeloproliferative disorder associated with chromosomal translocation between chromosomes 9 and 22, which forms a fusion gene of BCR-ABL encoding BCR-ABL fusion protein. (biomedcentral.com)
  • chromosomal
  • We describe a 32-year-old male patient with chronic myeloid leukemia (CML) who was detected to have sex chromosomal abnormality during evaluation for Philadelphia chromosome. (exp-oncology.com.ua)
  • drug
  • When an existing drug was given that blocks the de novo pathway in a leukemia cell, the dCTP nucleotide was still produced by the nucleoside salvage pathway, and the leukemia cell survived. (eurekalert.org)
  • Earlier this year, UC San Diego researchers launched a phase Ib/II clinical trial to evaluate the combined effectiveness of a standard of care drug called ibrutinib (marketed as Imbruvica) with cirmtuzumab to B-cell malignancies, which include leukemias and lymphomas. (ucsd.edu)
  • research
  • Some of the band's performances raise money for The Ryan Gibson Foundation, a Dallas-based nonprofit dedicated to leukemia research. (healthcanal.com)
  • Types
  • It would be of great interest to study the quantity of LSCs during follow-up and their prognostic impact on different types of leukemia. (exp-oncology.com.ua)
  • Virus
  • Also, Dr. Jacob Furth announced that he had studied Dr. Friend's pathologic material and that leukemia truly had been found to result from the new virus, which quickly became known as the Friend leukemia virus. (mssm.edu)
  • Journal
  • The study, led by Dr. Caius Radu, an associate professor of molecular and medical pharmacology at UCLA, and Dr. David Nathanson, an assistant professor of molecular and medical pharmacology, was published in the Journal of Experimental Medicine . (eurekalert.org)
  • By the next year, Dr. Friend had published her work in the Journal of Experimental Medicine, under the careful editing of Peyton Rous. (mssm.edu)
  • accounts
  • CLL accounts for roughly one quarter of new cases of leukemia (21,000) annually and roughly 4,500 deaths each year. (ucsd.edu)