• Xenotropic murine leukemia virus-related gammaretrovirus (XMRV) has been recently associated with prostate cancer and chronic fatigue syndrome. (cdc.gov)
  • Xenotropic murine leukemia virus-related gammaretrovirus (XMRV) was originally discovered in tissue from patients with familial prostate cancer homozygous for a missense mutation in the RNase L gene, R462Q ( 1 ). (cdc.gov)
  • Friend murine leukemia virus-induced leukemia is associated with the formation of mink cell focus-inducing viruses and is blocked in mice expressing endogenous mink cell focus-inducing xenotropic viral envelope genes. (silverchair.com)
  • The xenotropic murine leukemia virus-related virus (XMRV) was first found in samples from a human prostate tumor in 2006. (nih.gov)
  • XMRV, or xenotropic murine leukemia virus-related virus, is a retrovirus that was first reported in 2006 as a potential cause of prostate cancer. (meassociation.org.uk)
  • No association of xenotropic murine leukemia virus-related viruses with prostate cancer. (cdc.gov)
  • Adoptive transfer experiments show that pediatric BCP-ALL can be targeted by mature NK cells in vivo. (uni-tuebingen.de)
  • It can therefore be proposed that 5-AzaC treatment early after HSCT promotes differentiation of NK cells which can contribute to relevant GvL effects in vivo. (uni-tuebingen.de)
  • However, there is no available information to address that TF affects murine leukemia cells in vitro and in vivo. (upm.edu.my)
  • Here, we investigated in vitro and in vivo effects of TF on murine leukemia WEHI-3 cells. (upm.edu.my)
  • Additional reported applications (for the relevant formats) include: immunoprecipitation 1 , in vitro and in vivo modulation of B cell responses 2-4 , immunohistochemistry of acetone-fixed frozen sections and formalin-fixed paraffin-embedded sections 5,6 , and spatial biology (IBEX) 14,15 . (biolegend.com)
  • To identify structural elements of murine leukemia virus (MLV) RT important for fidelity and drug-resistance in vivo, we developed a D17-based encapsidating cell line (ANGIE P) which is designed to express the amphotropic MLV envelope. (wvu.edu)
  • The major breakthrough is the identification of a biomarker of HIV persistent cells in vivo. (europa.eu)
  • In vivo TR-APC induction elicits clonal expansion of cancer-specific T cells, establishes cancer-specific immune memory, and ultimately promotes leukemia eradication. (lu.se)
  • I will also provide in vivo proof of concept for a therapeutic effect by inhibiting the identified cell surface proteins in mouse models of leukemia. (lu.se)
  • In vivo CRISPR screening identifies an essential role for CXCR4 in MLL-AF9 driven acute myeloid leukemia independently of CXCL12. (lu.se)
  • Antibodies Targeting IL1RAP Show Strong In Vivo Therapeutic Effects and Exhibit a Dual Mode of Action in Acute Myeloid Leukemia. (lu.se)
  • In vivo, shown to reduce tumor size in a murine BCR/ABL xenograft model. (medscape.com)
  • In vivo administration of IL1RAP antibodies in mice transplanted with chronic and blast phase CML cells resulted in therapeutic effects mediated by murine effector cells. (lu.se)
  • The Abelson murine leukemia virus (Ab-MLV or A-MuLV) is a retrovirus (Class VI) used to induce malignant transformation of murine lymphoid cells. (wikipedia.org)
  • The Abelson murine leukemia virus is named for the American pediatrician Herbert T. Abelson, who together with Louise S Rabstein, first described and isolated it. (wikipedia.org)
  • A-MuLV causes a rapidly progressive lymphosarcoma known as Abelson disease in mice, which is a type of leukemia that does not involve the thymus. (wikipedia.org)
  • It can infect B-cells which was shown by the fact that some tumor cells can be seen to have immunoglobulins (Ig) on their surface although most tumor cells do not have characteristic receptors on their surface indicating that they are undifferentiated cells. (wikipedia.org)
  • Detection of residual tumor cells, an indicator for efficacy of GVL, was carried out by adoptive transfer of peripheral blood or spleen cells obtained from treated chimeras into secondary naive BALB/c recipients at different time intervals following bone marrow transplantation. (ox.ac.uk)
  • The virus appears to have infected the human tumor cells while they were in mice. (nih.gov)
  • The team did a genetic search in the strains of mice previously used for xenografting the prostate tumor cells. (nih.gov)
  • The scientists postulate that genetic recombination between these 2 viruses generated XMRV while human prostate tumor cells were being grown in a mouse. (nih.gov)
  • The recombined virus then infected the human tumor cells. (nih.gov)
  • Cancer immunotherapy relies on unleashing the patient´s immune system against tumor cells. (bvsalud.org)
  • To demonstrate proof of concept for a therapeutic effect by inhibiting the identified cell surface proteins in patient-derived xenograft models of leukemia. (lu.se)
  • IL1RAP antibodies block IL-1-induced expansion of candidate CML stem cells and mediate cell killing in xenograft models. (lu.se)
  • However, this is only possible when the host cell is co-infected with a helper virus which provides functions it needs to be able to replicate which it does not code for in its own genome such as a reverse transcriptase and some major structural proteins. (wikipedia.org)
  • HTBS recruits HIV reverse transcriptase, which nucleates DNA synthesis and is aided in elongation by murine leukemia reverse transcriptase. (nature.com)
  • Its roles include regulation of proliferation, promotion of immune system and activation of apoptosis in B cells. (intechopen.com)
  • In these cells, IL-21 does not promote proliferation but enhances apoptosis and chemotaxis. (intechopen.com)
  • Curcumin, a natural polyphenolic compound derived from turmeric (Curcuma longa L), has proven to be a modulator of multiple intercellular signalling pathways linked to inflammation, to proliferation, growth, invasion, drug sensitivity, angiogenesis and metastasis of cancer cells. (researchgate.net)
  • Antimetabolites inhibit cell growth and proliferation. (medscape.com)
  • These agents inhibit the activity of bcr-abl tyrosine kinase, resulting in decreased proliferation and increased apoptosis in Ph-positive cell lines. (medscape.com)
  • In vitro, inhibits BCR/ABL -mediated proliferation of murine leukemic cell lines and human cell lines derived from Philadelphia chromosome-positive chronic myeloid leukemia. (medscape.com)
  • ABSTRACT This study examined haematopoietic stem cells of 19 high-risk cases of myelodysplastic syndrome (MDS) for apoptotic and anti-apoptotic signals and cellular proliferation and correlated these with clinical and cytogenetic subtypes, particularly trisomy 8. (who.int)
  • Here, we show that primitive (CD34(+)CD38(-)) CML cells, in contrast to corresponding normal cells, express a functional interleukin-1 (IL-1) receptor complex and respond with NF-κB activation and marked proliferation in response to IL-1. (lu.se)
  • Amgen, Inc.) for treatment of Philadelphia chromosome-negative relapsed or refractory precursor B-cell acute lymphoblastic leukemia (R/R ALL). (aacrjournals.org)
  • Using a NOD-scid IL2Rgammanull (NSG) xenotransplantation model two modes for NK cell-based therapies in pediatric B cell precursor ALL (BCP-ALL) were explored: First, the adoptive transfer of mature cytokine-activated NK cells into leukemia-bearing mice and second graft-versus-leukemia effects (GvL) mediated by transplant-emerging NK cells. (uni-tuebingen.de)
  • Under cytokine support there are relevant GvL effects towards primary B cell precursor leukemia in huNSG mice providing evidence that also early graft-emerging immature NK cells might contribute to alloreactivity. (uni-tuebingen.de)
  • A new research perspective titled "A murine model for human early/immature T-cell precursor acute lymphoblastic leukemia (EITP ALL)" has been published in Oncoscience. (medicalxpress.com)
  • Characterization of effector cells of graft vs leukemia following allogeneic bone marrow transplantation in mice inoculated with murine B-cell leukemia. (ox.ac.uk)
  • The role of Thy1.2, L3T4 and Lyt2 T lymphocytes as effector cells of GVL were investigated in (BALB/c x C57BL/6)F1 mice inoculated with murine B-cell leukemia and subsequently conditioned with total lymphoid irradiation and cyclophosphamide (200 mg/kg). (ox.ac.uk)
  • Benzoyl peroxide increases UVA-induced plasma membrane damage and lipid oxidation in murine leukemia L1210 cells. (harvard.edu)
  • Effects of murine leukemia viruses on generation of continuous cell li" by J S. Greenberger, M A. Sakakeeny et al. (jax.org)
  • Effects of murine leukemia viruses on generation of continuous cell lines of pluripotential hematopoietic stem cells in vitro. (jax.org)
  • In these studies, we have shown data that are consistent with the hypothesis that mink cell focus-inducing viruses (MCF) play an important role in the generation of an erythroproliferative disease developing after injection of certain strains of newborn mice with ecotropic Friend murine leukemia virus (F-MuLV). (silverchair.com)
  • Closely related murine leukemia viruses are known to cause cancers and other diseases in mice. (nih.gov)
  • In the laboratory, these viruses can infect cells from other species, including humans. (nih.gov)
  • The recombination - a common outcome when cells are infected by 2 or more viruses - likely occurred sometime between 1993 and 1996. (nih.gov)
  • Independent segregation of loci for activation of biologically distinguishable RNA C-type viruses in mouse cells. (microbiologyresearch.org)
  • A distinct class of inducible murine-type-C viruses that replicates in the rabbit SIRC cell line. (microbiologyresearch.org)
  • Prevalence of the group-specific (gs) antigen and infectious virus expression of the murine C-type RNA viruses during the life span of BALB/cr mice. (microbiologyresearch.org)
  • Intracellular and virion 35S RNA species of murine sarcoma and leukemia viruses. (microbiologyresearch.org)
  • Many viruses use the microtubule transport system to transport nucleic acid/protein cores to intracellular replication sites after invasion host the cell membrane. (wikipedia.org)
  • It is closely related to murine leukemia viruses, which cause a wide variety of cancers as well as immunological and neurological diseases in mice. (meassociation.org.uk)
  • When retroviruses infect germ cells (sperm or egg), heritable forms of the viruses can arise. (meassociation.org.uk)
  • Administration of gene therapy viruses into skeletal muscle, where distal terminals of motor and sensory neurons reside, has been shown to result in extensive transduction of cells within the spinal cord, brainstem, and sensory ganglia. (frontiersin.org)
  • For successful transgene expression, viruses administered into muscle must undergo a series of processes, including host cell interaction and internalization, intracellular sorting, long-range retrograde axonal transport, endosomal liberation, and nuclear import. (frontiersin.org)
  • Gene therapy viruses are non-replicating, but still hijack host cell machinery to express transgenes of interest in the nucleus. (frontiersin.org)
  • Crucially, some viral vectors (i.e., viruses specifically used to deliver genetic material into cells) have the potential to circumvent the blood-brain- (BBB) and blood-spinal cord barriers (BSCB) when intravenously injected. (frontiersin.org)
  • No evidence of murine leukemia virus-related viruses in live attenuated human vaccines. (cdc.gov)
  • Retroviruses are found in a wide range of mammals, and they can contribute to the development of cancers, such as leukemia or lymphoma, as well as neurological diseases. (meassociation.org.uk)
  • 5-AzaC distinctly enhances immature and mature NK cell subsets and along with this the anti-leukemic response. (uni-tuebingen.de)
  • Leukemic B Cell CTLA-4 Suppresses Costimulation of T Cells. (uc.edu)
  • Specifically designed to inhibit tyrosine kinase activity of the bcr-abl kinase in Ph+ leukemic CML cell lines. (medscape.com)
  • A study by Tang et al has determined that long-term TKI therapy may reduce the abundance of leukemic stem cells in select patients. (medscape.com)
  • Detection of viral nucleic acid in tissue sections of cancerous prostate glands and cloning of the viral integration sites confirmed XMRV as a bona fide human infection with a murine leukemia virus-related retrovirus ( 1 ). (cdc.gov)
  • HTLV-1, the first human retrovirus identified, causes adult T cell leukemia. (meassociation.org.uk)
  • Binding of complement to a foreign substance, or antigen, amplifies and augments the body's innate immune system by means of its role as an opsonin (a factor that enhances phagocytosis of unwanted particles) and as a chemoattractant (a factor that recruits cells to areas of inflammation). (medscape.com)
  • Here, we present a cancer vaccination approach utilizing myeloid lineage reprogramming to directly convert cancer cells into tumor reprogrammed-antigen presenting cells (TR-APCs). (lu.se)
  • It is now widely accepted that immunocompetent lymphocytes in allogeneic bone marrow grafts exert an antileukemic effect that contributes to the cure of leukemia. (ox.ac.uk)
  • Graft vs leukemia (GVL) effects independent of graft vs host disease were investigated in allogeneic bone marrow chimeras tolerant of host and donor alloantigens. (ox.ac.uk)
  • Mice were reconstituted with C57BL/6 bone marrow cells depleted of well-defined T-cell subsets or enriched for stem cells by the soybean agglutination method. (ox.ac.uk)
  • Contrary to previous beliefs, stem cells, from which all new blood cells are formed, remain in bone marrow in the blood cancer type acute lymphocytic leukemia. (medicalxpress.com)
  • Malignant, immature white blood cells continuously multiply and are overproduced in the bone marrow. (medicalxpress.com)
  • ALL causes damage and death by crowding out normal cells in the bone marrow, and by spreading (metastasizing) to other organs. (medicalxpress.com)
  • In contrast, TNF often acts on cell types other than osteoclasts, or synergically with RANKL to indirectly promote osteoclastogenesis and bone resorption. (frontiersin.org)
  • Normal bone remodeling requires a delicate balance between the activities of major bone cell types: bone-resorbing osteoclasts and bone-forming osteoblasts, as well as osteocytes. (frontiersin.org)
  • Osteoclasts are bone cells derived from monocyte/macrophage lineage and are exclusively responsible for bone resorption, which contributes to skeletal development, bone homeostasis, and remodeling. (frontiersin.org)
  • Splenic endothelial cell lines support development of dendritic cells from bone marrow. (southernbiotech.com)
  • 15]. The percentage of bone common of which are trisomy 8, mono- marrow blast cells for estimation of the Myelodysplastic syndrome (MDS) is somy 7 and 5q- [11]. (who.int)
  • Comparison of toxicity of benzene metabolite hydroquinone in hematopoietic stem cells derived from murine embryonic yolk sac and adult bone marrow. (cdc.gov)
  • In the current study, we compared the effects of hydroquinone (HQ), a major metabolite of benzene in humans and animals, on mouse embryonic yolk sac hematopoietic stem cells (YS-HSCs) and adult bone marrow hematopoietic stem cells (BM-HSCs). (cdc.gov)
  • Low-power view of hematoxylin-eosin-stained bone marrow showing hypocellularity, with increased adipose tissue and decreased hematopoietic cells in the marrow space. (medscape.com)
  • The clinical presentation of patients with aplastic anemia includes signs and symptoms related to the decrease in bone marrow production of hematopoietic cells. (medscape.com)
  • Antibody neutralizing capabilities are traditionally measured in cell-based live viral infection assays that require BSL3 facilities 6 . (nature.com)
  • Partial transcription of murine type-C viral genomes in BALB/c cell lines. (microbiologyresearch.org)
  • Transfection of ANGIE P cells with wild type or mutated MLV gag-pol expression constructs generated GA-1 virus that was able to undergo only one cycle of viral replication upon infection of D17 cells. (wvu.edu)
  • If the viral DNA is expressed inside a host cell, the resulting RNA and protein molecules can be used to generate new virus particles. (meassociation.org.uk)
  • Considering graft-emerging NK cells mainly immature KIR- NK-cells in stem cell transplanted NSG mice ("humanized NSG") can be detected, thus ideally resembling human NK cell ontogeny of patients post hematopoietic stem cell transplantation (HSCT). (uni-tuebingen.de)
  • Furthermore, the cell death mechanism in the spleen tissue of treated mice was found via apoptosis. (upm.edu.my)
  • We show in gene-targeted mice that also mouse SAMHD1 reduces cellular dNTP concentrations and restricts retroviral replication in lymphocytes, macrophages, and dendritic cells. (nih.gov)
  • CD45R (B220) is also expressed on a subset of abnormal T cells involved in the pathogenesis of systemic autoimmunity in MRL- Fas lpr and MRL- Fas gld mice. (biolegend.com)
  • In this research, Neuro2a cells that are murine neuroblastoma line derived from AJ mice is cultured in DMEM media. (tamucc.edu)
  • Therapeutic cancer vaccination seeks to elicit activation of tumor-reactive T cells capable of recognizing tumor-associated antigens (TAAs) and eradicating malignant cells. (lu.se)
  • It causes leukemia directly by interfering with the normal growth and differentiation processes of lymphocytes. (wikipedia.org)
  • 8. Lui O, Mak N, Leung K. Conjugated linoleic acid induces monocytic differentiation of murine myeloid leukemia cells. (southernbiotech.com)
  • Temporal multimodal single-cell profiling of native hematopoiesis illuminates altered differentiation trajectories with age. (lu.se)
  • Preclinical efficacy for a novel tyrosine kinase inhibitor, ArQule 531 against acute myeloid leukemia. (uc.edu)
  • Although curcumin has shown significant efficacy in cell culture studies, it has shown limited efficacy in clinical studies when administered in conventional oral formulations. (researchgate.net)
  • The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein binds to the angiotensin-converting enzyme 2 (ACE-2) receptor on target cells and is the immunodominant target of neutralizing antibodies (nAbs) identified from convalescent and postvaccination plasma 3 . (nature.com)
  • Breaking chemoresistance and radioresistance with [ 213 Bi]anti-CD45 antibodies in leukemia cells. (southernbiotech.com)
  • New monoclonal anti-mouse DC-SIGN antibodies reactive with acetone-fixed cells. (southernbiotech.com)
  • To preclude possible oncogenic activities in infected cells and to prevent binding of vaccine-encoded HER2 by monoclonal antibodies trastuzumab and pertuzumab, genetic modifications of HER2 were introduced in the vaccine. (bvsalud.org)
  • A highly efficient helper virus commonly used when growing A-MuLV in vitro is Moloney murine leukemia virus (M-MuLV). (wikipedia.org)
  • In vitro studies have shown that lymphocyte infection produces tumor cell populations comprising three types of cells: stable productive cells, non-productive cells and cells which produced defective virus particles which are not infective. (wikipedia.org)
  • Hybridoma cell line 273 expresses monoclonal antibody specific for murine leukemia virus (MuLV) gp70. (nih.gov)
  • RNA metabolism of murine leukemia virus II. (microbiologyresearch.org)
  • Endogenous virus-specific RNA in uninfected BALB/c cell line JLS-V9. (microbiologyresearch.org)
  • Virus-specific messenger RNA on free and membrane-bound polyribosomes from cells infected with Rauscher leukemia virus. (microbiologyresearch.org)
  • Polyadenylate rich RNA in the 70S RNA of murine leukemia-sarcoma virus. (microbiologyresearch.org)
  • HIV persistence may arise from ongoing residual virus replication and/or from latently-infected cells defined as the cellular reservoir in which long-lived resting memory CD4+ T cells harbouring an integrated but transcriptionally silent provirus represent the largest pool in the blood (Chomont et al. (europa.eu)
  • 3. Radu DL, Weksler ME, Bona CA. Maintenance of size and function of influenza virus hemagglutinin specific transgenic T-cell clone during life. (southernbiotech.com)
  • Virus-mediated gene therapy has the potential to deliver exogenous genetic material into specific cell types to promote survival and counteract disease. (frontiersin.org)
  • Clinical and Molecular Features of Feline Foamy Virus and Feline Leukemia Virus Co-Infection in Naturally-Infected Cats. (cdc.gov)
  • Detection of murine leukemia virus or mouse DNA in commercial RT-PCR reagents and human DNAs. (cdc.gov)
  • Treatment protocols for chronic myelogenous leukemia are provided below for chronic phase, accelerated phase, and blast phase. (medscape.com)
  • Targeted delivery of tumor necrosis factor-α to tumor vessels induces a therapeutic T cell-mediated immune response that protects the host against syngeneic tumors of different histologic origin. (southernbiotech.com)
  • Using syngeneic murine leukemia models, we demonstrate that TR-APCs acquire both myeloid phenotype and function, process and present endogenous TAAs, and potently stimulate TAA-specific CD4+ and CD8+ T cells. (lu.se)
  • See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)
  • Blinatumomab is a recombinant murine protein that acts as a bispecific CD19-directed CD3 T-cell engager. (aacrjournals.org)
  • Tumor-infiltrating lymphocytes (TIL) and autologous peripheral blood mononuclear cells (PBMC) were isolated from patients undergoing surgery for primary tumors. (aacrjournals.org)
  • Resolving the Pathogenesis of Anaplastic Wilms Tumors through Spatial Mapping of Cancer Cell Evolution. (lu.se)
  • To characterize the function and expression patterns of the identified cell surface proteins in acute myeloid leukemia cells from patients. (lu.se)
  • Other cellular components of the innate immune system include mononuclear phagocytes, dendritic cells, and NK cells. (medscape.com)
  • Aberrant high expression of B lymphocyte chemokine (BLC/CXCL13) by C11b + CD11c + dendritic cells in murine lupus and preferential chemotaxis of B1 cells towards BLC. (southernbiotech.com)
  • Led by Sarah K. Tasian, MD, researchers in the Tasian Laboratory are focused on using molecular and genomic approaches to identify targeted cancer treatments and immunotherapies to treat children with high-risk acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). (chop.edu)
  • NK cells are specialized effectors of the innate immune system that destroy their targets by antibody-dependent cell-mediated cytotoxicity, have prominent antitumor effects, and are potent killers of virally infected cells. (medscape.com)
  • We previously demonstrated that systemic immunization with a non-replicating MVA encoding CD40 ligand (CD40L) enhances innate immune cell activation and function, and triggers potent antitumor CD8+ T cell responses in different murine tumor models. (bvsalud.org)
  • Recent findings of XMRV sequences in up to 67% of peripheral blood mononuclear cells (PBMCs) of patients with chronic fatigue syndrome and in 3.4% of PBMCs of healthy controls raise the question whether XMRV could be a blood-borne pathogen ( 5 ). (cdc.gov)
  • Natural-killer (NK) cells are specialized lymphocytes that have cytotoxic properties in addition to their ability to produce cytokines that assist in the orchestration of adaptive immunity. (medscape.com)
  • The adaptive immune system consists of 2 types of lymphocytes: T cells (70-75% of the adaptive immune force) and B cells (10-20% of the adaptive immune force). (medscape.com)
  • This is a multicenter, open-label, Phase 1/2a dose escalation and expansion study of orally administered emavusertib (CA-4948) monotherapy in adult patients with Acute Myelogenous Leukemia (AML) or high risk Myelodysplastic Syndrome (MDS). (rochester.edu)
  • Epidemiologic Investigation of a Cluster of Neuroinvasive Bacillus cereus Infections in 5 Patients With Acute Myelogenous Leukemia. (cdc.gov)
  • Immunotherapy with blinatumomab leads to a strongly improved survival rate-from 66% to 93%-for children with an aggressive form of acute lymphoblastic leukemia (ALL). (medicalxpress.com)
  • A novel 5S RNA-protein (RNP) complex in human and mouse cells has been analyzed using patient autoantibodies. (nih.gov)
  • While a postdoctoral student at MIT, Tomomi Kiyomitsu discovered how dynein has a role as a motor protein in aligning the chromosomes in the middle of the cell during the metaphase of mitosis. (wikipedia.org)
  • In infected cells, the RNA undergoes a process known as reverse transcription, in which DNA copies of the RNA are made and then inserted permanently into the host cells' chromosomes (organized structures of DNA and protein that are located within a cell's nucleus). (meassociation.org.uk)
  • Drugs targeting the programmed cell death protein 1 (PD-1) pathway are approved as therapies for an increasing number of cancer entities, including renal cell carcinoma. (aacrjournals.org)
  • Although amplification of the DNA damage signal through multifactorial protein complex formation of DNA damage checkpoint factors is crucial for proper DNA damage response in two-dimensionally cultured cells, the dynamics of the DNA damage response in three-dimensional tissues or organs remained to be determined. (bioone.org)
  • A cell surface receptor involved in G-protein recruitment and G-protein-coupled signal transduction. (bvsalud.org)
  • Interleukin-21 (IL-21) was first identified in 2000 through screening of a cDNA library from CD3+ human T cells [ 1 ]. (intechopen.com)
  • Methods: Two human ESCC cell lines EC9706 and Eca109 were selected and challenged. (karger.com)
  • However, there is no evidence suggesting that XMRV can infect human germ cells. (meassociation.org.uk)
  • PP2A is a therapeutically targetable driver of cell fate decisions via a c-Myc/p21 axis in human and murine acute myeloid leukemia. (uc.edu)
  • And fourth, its replication deficit in human cells ensures a excellent safety profile. (bvsalud.org)
  • I have expertise in novel therapies for acute myeloid leukemia, stem cell mobilization and homing, as well as stem cell transplantation. (rochester.edu)
  • The essence of MDS is damage of In the current work we examined All our patients were of the high-risk colony-forming units [4], but the defect haematopoietic stem cells of high-risk group and none of them was eligible of the haematopoietic stem cells is not MDS cases for apoptotic and anti-apop- for stem cell transplantation. (who.int)
  • IL4 promotes phagocytosis of murine leukemia cells counteracted by CD47 upregulation. (lu.se)
  • Radiation-induced red cell damage: role of reactive oxygen species. (harvard.edu)
  • We aimed to develop a sensor technology that can quantitatively measure nAb responses against different isolates of SARS-CoV-2, be adapted for an all-in-solution multiwell format and provide rapid results in 1 hour, which is faster than established ELISA assays measuring SARS-CoV-2 antibody titer (~6 hours) or cell-based neutralization assays (~one to several days). (nature.com)
  • First, MVA is an excellent inducer of innate immune responses leading to type I interferon secretion and induction of T helper cell type 1 (Th1) immune responses. (bvsalud.org)
  • Effects of oxygen metabolites/chemokines on hematopoietic stem cell expansion and preservation. (rochester.edu)
  • Effects of hematopoietic stem cell adhesion on marrow stromal cell cytokine p. (rochester.edu)
  • Successful completion of these projects will identify new therapeutic targets in AML and expand our knowledge regarding how AML cells escape the immune system, findings that might be translated into new therapeutic opportunities in AML and possibly other cancer types. (lu.se)
  • Treatment of the primary marrow inoculum with monoclonal anti-Thy1.2 or anti-Lyt2 abolished the GVL effects and all secondary BALB/c recipients developed leukemia within 60 days. (ox.ac.uk)
  • On the other hand, the treatment with monoclonal anti-L3T4 did not influence the effect of GVL and all treated recipients remained without leukemia. (ox.ac.uk)
  • Monoclonal B-cell lymphocytosis in healthy blood donors: an unexpectedly common finding. (cdc.gov)
  • Previous studies indicate that these KIR-KIR ligand mismatch constellations significantly increase the outcome for patients suffering from adult acute myeloid leukemia whereas adult acute B cell lymphocytic leukemia (B-ALL) seems to be relative resistant to NK cell-mediated cytotoxicity. (uni-tuebingen.de)
  • CD45R is expressed on B cells (at all developmental stages from pro-B cells through mature B cells), activated B cells, and subsets of T and NK cells. (biolegend.com)
  • Differential innate immune cell signatures and effects regulated by toll-like receptor 4 during murine lung tumor promotion. (harvard.edu)
  • Innate immunity resides in the skin, mucous membranes, polymorphonuclear (PMN) cells, complement system, and a select group of cells that possess cytotoxic capabilities. (medscape.com)
  • The major goals of my research are to identify how acute myeloid leukemia (AML) cells suppress the innate immune system and use this knowledge to develop new immunotherapies. (lu.se)
  • I will accomplish this by identifying and mechanistically characterize cell surface proteins that protect leukemia cells against the innate immune system. (lu.se)
  • Indicated for Philadelphia chromosome-positive chronic myeloid leukemia in adults whose disease has progressed or who cannot tolerate other therapies that include imatinib. (medscape.com)
  • Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. (medscape.com)
  • Hyperdiploidy is a genetic condition observed in cancer cells, where the cells contain more chromosomes than usual. (medicalxpress.com)
  • Residing in border regions was linked with a higher risk of dying within five years among children with acute lymphoblastic leukemia, the most common type of pediatric cancer. (medicalxpress.com)
  • Acute lymphoblastic leukemia ( ALL ), is a form of leukemia, or cancer of the white blood cells characterized by excess lymphoblasts. (medicalxpress.com)
  • Application of cold plasma technology for leukemia cancer treatment has been researched and demonstrated. (tamucc.edu)
  • This research study investigates the effect of our newly developed cold plasma technology on neuroblastoma cancer cells and also develop an optimized plasma dosages for feasible cancer treatment. (tamucc.edu)
  • With a basis in stem cell biology, genetics, immunology and cancer, the major goal of our research is to develop new immunotherapies that target leukemia and other malignancies. (lu.se)
  • It is believed that benzene and its metabolites target hematopoietic stem cells (HSCs) to cause toxicity and cancer in the hematopoietic system. (cdc.gov)
  • The generation of receptors specific for antigens is a unique and complex process that generates 10 12 specific receptors for each cell type of the adaptive immune system, including T and B cells. (medscape.com)
  • Benzene is an occupational toxicant and an environmental pollutant that potentially causes hematotoxicity and leukemia in exposed populations. (cdc.gov)