Loading...
  • granules
  • The blast cells contained basophilic granules, and the vacuoles in the cytoplasm and nuclei were oval and bilobed and contained nucleoli (Fig. 3A and B). The blast cells were positive for peroxidase and periodic acid-Schiff staining (PAS) and negative for α-naphthyl acetate esterase. (nih.gov)
  • Patients
  • Patients with leukemias that express the progenitor cell antigen CD34 and/or the P-glycoprotein (MDR1 gene product) have an inferior outcome. (rexhealth.com)
  • I. Determine effect of treatment with the combination on time to response, time to leukemic transformation and frequency of transformation to leukemia in patients with MDS during the phase II segment of the study. (knowcancer.com)
  • I. To estimate the maximum tolerated dose (MTD) and examine the tolerability of daily oral eltrombopag (eltrombopag olamine) (14 days +/- 2 days after initiation of cytarabine) in patients receiving high dose cytarabine and mitoxantrone for the treatment of acute myeloid leukemia patients with hypoplastic bone marrow 14 days +/- 2 days from initiation of cytarabine. (knowcancer.com)
  • 100 x 10^9/L when eltrombopag is administered following high dose cytarabine and mitoxantrone for the treatment of acute myeloid leukemic patients. (knowcancer.com)
  • remission
  • Children with AML who have a white blood cell count (WBC) greater than 100,000 per cubic milliliter, secondary AML, and leukemic cells with a monosomy 7 karyotype have low remission induction rates, whereas children with leukemia cell chromosomal abnormalities t(8;21) and inv 16 have a high likelihood of achieving remission. (meds.com)
  • childhood acute
  • This treatment information summary on childhood acute myeloid leukemia (AML) is an overview of prognosis, diagnosis, classification, and treatment. (meds.com)
  • Children with Down syndrome have an increased risk of leukemia with a ratio of ALL to AML typical for childhood acute leukemia, except during the first 3 years of life when AML (especially M7) predominates. (meds.com)
  • basophilia
  • Overt leukemia from MDS associated with marked basophilia," The Japanese Journal of Clinical Hematology , vol. 33, no. 8, pp. 1031-1035, 1992. (hindawi.com)
  • Secondary
  • 10.Acute interstitial nephritis secondary to deferasirox causing acute renal injury needing short-term dialysis. (edu.au)
  • chemotherapy
  • The patient initially demonstrated clinical improvement as a result of chemotherapy, however, subsequently deteriorated.The gastric and skin manifestations of ABL may be associated with excessive histamine release from basophilic cells.Thus, the administration of H1- and H2-receptor antagonists, proton pump inhibitors and steroids is proposed in order to minimize these associated complications. (nih.gov)
  • treatment
  • This PDQ cancer information summary for health professionals provides comprehensive, peer-reviewed, evidence-based information about the treatment of adult acute myeloid leukemia. (uchile.cl)
  • gene
  • An important gene associated with Acute Basophilic Leukemia is MYB (MYB Proto-Oncogene, Transcription Factor), and among its related pathways/superpathways are Response to elevated platelet cytosolic Ca2+ and NF-kappaB Signaling . (malacards.org)
  • Identification of a transforming MYB-GATA1 fusion gene in acute basophilic leukemia: a new entity in male infants. (jove.com)
  • cells
  • To evaluate histone deacetylase (HDAC) inhibition of histone acetylation in leukemia blast cells. (bioportfolio.com)
  • I. To evaluate the expression of downstream markers of drug activity such as p38, MCL-1, FLT-3, and VEGFR-2 in leukemia blast cells. (bioportfolio.com)
  • To evaluate SNDX-induced expression of p21^WAF1/CIP1 in leukemia blast cells. (bioportfolio.com)
  • The gastric and skin manifestations of ABL may be associated with excessive histamine release from basophilic cells. (nih.gov)
  • Basophilic cells account for 38% of the total nucleated cells. (nih.gov)