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  • leukaemia
  • We have found a method to dissociate dormant leukaemia cells from their surroundings, where they are safe from attacks by therapeutics," explains Sarah Ebinger, doctoral candidate in the AGV and the article's first author. (eurekalert.org)
  • hematopoietic
  • Blood stem cells (hematopoietic stem cells or HSCs) give rise to all mature blood cells and maintain a balance of self-renewal and expansion. (redorbit.com)
  • Because the loss of normal hematopoietic function is the chief cause of serious illness and death among leukemia patients, it is critical that we understand all aspects of how this occurs and find new strategies to accelerate the recovery of these defects. (redorbit.com)
  • A potential clinical application for the technology developed in this study is in leukemia patients who are treated with hematopoietic (blood cell-forming) cell transplantation. (rxpgnews.com)
  • Preferred Term is Hematopoietic stem cell transplantation. (medindia.net)
  • laboratory
  • The research using laboratory cell cultures shows that a component of green tea known as epigallocatechin-3-gallate (EGCG) [epi-gallo-cat-ekin-3-gal-ate] helps kill leukemia cells by interrupting the communication signals they need to survive. (medicalnewstoday.com)
  • The Mayo Clinic study, led by Neil E. Kay, M.D., shows that green tea\'s EGCG interrupted survival signals, prompting leukemia cells to die in eight of 10 patient samples tested in the laboratory. (medicalnewstoday.com)
  • The laboratory studies also indicated that the CLL cells may be destroyed through p53-independent pathways opened by ISF35, including p73 and p21, providing some insight into the mechanism of re-sensitization. (drugs.com)
  • In tests on leukemia cells in laboratory culture, methadone proved as effective as standard chemotherapies and radiation treatments against non-resistant leukemia cells. (drugs-forum.com)
  • bone formi
  • Until now, according to the Blood paper, no one had defined the important interactions that take place between leukemia cells and osteoblasts (bone forming cells) and osteoclasts, which continually break down bone. (redorbit.com)
  • protein
  • Leukemia results in the expression of a protein, known as CCL3, which slows bone formation. (redorbit.com)
  • The team, led by Dr Veronika Sexl from the University of Vienna, conducted their research on acute lymphoid leukemia (ALL) and chronic myelogenous leukemia (CML), which can both be caused by fusion protein, Bcr-Abl, created through the joining of two or more genes originally coded for separate proteins. (medindia.net)
  • Memorial Sloan
  • One of the future goals is to figure out what it is that really can drive an engraftable cell," says Papapetrou's coauthor, Michael Kharas of Memorial Sloan Kettering Cancer Center. (the-scientist.com)
  • mice
  • ORP4 knockout mice exhibit teratozoospermia due to death of developing spermatozoa, indicating that ORP4 is essential for the survival of specific cell populations 19 . (nature.com)
  • Preliminary lab experiments showed that treatment with bisphosphonates, a commonly used class of drugs for people who suffer from bone loss, partially restored bone loss in mice with leukemia. (redorbit.com)
  • signals
  • Inhibitor drugs such as 'Imatinib' can block vital signals and lead to leukemia cell death, but there are several mutations, which can resist these inhibitors, making them ineffective. (medindia.net)
  • pathways
  • Metabolic pathways are reprogrammed in cancer to support cell survival. (nature.com)
  • These heretofore unresolved fundamental issues are crucial for understanding the signalling pathways required for PLC activation and Ca 2+ homeostasis in T-ALL cells. (nature.com)
  • Cancer cells undergo extensive adaptations in their signaling and metabolic pathways, thereby becoming dependent on certain genes. (medindia.net)
  • These signaling complexes regulate key downstream pathways such as extracellular signal-regulated kinase, c-Jun NH 2 -terminal kinase, p38, and Akt, the outcomes of which determine the B-cell fate ( 5 ). (aacrjournals.org)
  • relapse
  • In November 2014, they described cellular experiments indicating cirmtuzumab might also be effective against cancer stem cells, which appear responsible for the relapse and spread of cancer after conventional therapy. (eurekalert.org)
  • Dr. Irmela Jeremias from Helmholtz Zentrum München and her colleagues have succeeded in finding a small population of inactive leukemia cells that is responsible for relapse of the disease. (eurekalert.org)
  • With the help of modern genetic engineering* and dyes that mark cell growth, the scientists isolated cells and identified a rare cell type that resembled cells triggering relapse. (eurekalert.org)
  • enzymes
  • Treatment of CEM and CEM/R2 cells with cholesterol biosynthesis inhibitors acting on the enzymes squalene epoxidase and lanosterol synthase, both also involved in the 24,25-epoxycholesterol shunt pathway, revealed a connection of this pathway to lanosterol turnover. (springer.com)
  • accumulation
  • Mastocytosis is a heterogeneous group of disorders characterized by the abnormal growth and accumulation of mast cells (MCs) in one or more organ systems. (bloodjournal.org)
  • Peripheral
  • Peripheral blood lymphocytes and T-cell clones produced nanogram quantities of the chemokines RANTES, MIP-lα, MIP-lβ, MCP-l, IL-8 and GRO-α as well as the motogenic cytokine HGF. (hindawi.com)
  • It is, however, controversially discussed whether in peripheral blood CLL cells, constitutively active Akt contributes to cell survival ( 6 , 8 - 11 ). (aacrjournals.org)
  • Peripheral blood mononuclear cells (PBMC) were isolated by density gradient centrifugation and cultured in complete RPMI 1640. (aacrjournals.org)
  • study
  • In this study, leukemia caused low-level and widespread bone thinning and bone loss, similar to osteoporosis, particularly in the long bones. (redorbit.com)
  • In order to study the possible functional importance of the poor chemokine production different T-cell lines were compared with respect to development of motile forms and migration on extracellular matrix components in the absence and presence of various chemokines. (hindawi.com)
  • With the new method, and the software, we can study thousands of cells in a day," he says. (medicalnewstoday.com)
  • FRIDAY, Aug. 1 (HealthDay News) -- Methadone , a drug used to break addiction to heroin and other opioid drugs, appears to be a potent killer of leukemia cells, a new study finds. (drugs-forum.com)
  • viability
  • Exogenous addition of lanosterol had a negative effect on CEM/R2 and a positive effect on sensitive CEM cell viability. (springer.com)