Clofarabine increases the eradication of minimal residual disease of primary B-precursor acute lymphoblastic leukemia compared to high-dose cytarabine without improvement of outcome. (uke.de)
The survival rates vary by age: 85% in children and 50% in adults.Subtypes include precursor B acute lymphoblastic leukemia, precursor T acute lymphoblastic leukemia, Burkitt's leukemia, and acute biphenotypic leukemia. (rxharun.com)
Acute lymphoblastic leukemia (ALL) is best treated by physicians who have significant experience in the treatment of patients with acute leukemia. (medscape.com)
The use of consolidation chemotherapy in acute lymphoblastic leukemia (ALL) is supported by several studies. (medscape.com)
Tisagenlecleucel , sold under the brand name Kymriah , is a CAR T cells medication for the treatment of B-cell acute lymphoblastic leukemia (ALL) which uses the body's own T cells to fight cancer ( adoptive cell transfer ). (wikimili.com)
In August 2017, the FDA granted approval for the use of tisagenlecleucel in people with acute lymphoblastic leukemia. (wikimili.com)
[4] Its main uses are in non-Hodgkin's lymphoma as part of the chemotherapy regimen CHOP , Hodgkin's lymphoma as part of MOPP, COPP, BEACOPP, or the less popular Stanford V chemotherapy regimen in acute lymphoblastic leukemia (ALL), and in treatment for nephroblastoma . (mdwiki.org)
Etoposide1
Following remission, 1,017 patients were randomly assigned to a third course, MACE (amsacrine, etoposide, and Ara-C), plus a fourth course of MidAc (mitoxantrone and Ara-C) and following an amendment to one or two courses of high-dose Ara-C. Primary end points were cumulative incidence of relapse (CIR), relapse-free survival (RFS), and overall survival (OS). (ox.ac.uk)
Mitoxantrone2
High-Dose Cytarabine Consolidation With or Without Additional Amsacrine and Mitoxantrone in Acute Myeloid Leukemia: Results of the Prospective Randomized AML2003 Trial. (stembook.org)
Patients who achieve a complete remission to initial treatment and then experience a cancer recurrence are said to have relapsed leukemia. (kahlertregionalcancer.org)
When the white blood cell count is under control without medication after treatment with Amsa (Amsacrine), the person is said to be in remission. (pocketpills.com)
While in remission, the dose of Amsa (Amsacrine) is usually reduced and given every 4 to 8 weeks, depending on the number of white blood cells in the blood. (pocketpills.com)
[4] It is also used to induce remission in ALL with dexamethasone and L- Asparaginase , and in combination with prednisone to treat childhood leukemia. (mdwiki.org)
Hodgkin's3
Amsacrine (m-AMSA) is an anticancer agent that displays activity against refractory acute leukemias as well as Hodgkin's and non-Hodgkin's lymphomas. (adooq.com)
As chemotherapy affects cell division, tumors with high growth fractions (such as acute myelogenous leukemia and the aggressive lymphomas , including Hodgkin's disease ) are more sensitive to chemotherapy, as a larger proportion of the targeted cells are undergoing cell division at any time. (wikidoc.org)
[6] This includes acute lymphocytic leukemia , acute myeloid leukemia , Hodgkin's disease , neuroblastoma , and small cell lung cancer among others. (mdwiki.org)
Lymphomas1
These compounds are used to treat a wide range of cancers, including (but not limited to) leukemias , lymphomas , and breast , uterine , ovarian , and lung cancers . (wikidoc.org)
Inhibitors1
Different mitotic inhibitors are used to treat particular types of cancers, such as leukemia, lymphoma, breast cancer, lung cancer and other types of cancers. (whitecrescent.net)
Anticancer1
Therefore, SP600125 has a strong anticancer effect against leukemia cells in a dose and time dependent manner by promoting tubulin polymerization and disrupting the organization of the microtubule cytoskeleton. (hsp90-inhibitors.com)
Chemotherapy3
Treatment for patients with acute myeloid leukemia involves intensive chemotherapy to destroy the leukemic cell population as rapidly as possible and to prevent the emergence of a resistant clone. (medscape.com)
Hospitalization is necessary in patients with acute myeloid leukemia for managing chemotherapy and for treating complications related to the disease and its treatment, usually infections or febrile neutropenic episodes. (medscape.com)
Defining the Optimal Total Number of Chemotherapy Courses in Younger Patients With Acute Myeloid Leukemia: A Comparison of Three Versus Four Courses. (ox.ac.uk)
Topoisomerase1
Amsacrine also expresses topoisomerase inhibitor activity, specifically inhibiting topoisomerase II. (wikipedia.org)
Adults5
The disease is now considered to be the most curable subtype of acute myeloid leukemia (AML) in adults. (nature.com)
Unrelated donor versus matched sibling donor in adults with acute myeloid leukemia in first relapse: an ALWP-EBMT study. (stembook.org)
Chronic lymphocytic leukemia (CLL) - most often affects adults over the age of 55. (rxharun.com)
Acute myelogenous leukemia (AML) - occurs more commonly in adults than in children, and more commonly in men than women. (rxharun.com)
Fiere et al compared consolidation therapy with daunorubicin and cytosine arabinoside (Ara-C) versus no consolidation therapy in adults with ALL, demonstrating a 38% 3-year, leukemia-free survival rate for subjects receiving consolidation and maintenance therapy compared with 0% for those receiving maintenance therapy without consolidation. (medscape.com)
Cancer6
Leukemia is a cancer of the blood or bone marrow.It is a form of cancer that affects the body's ability to make healthy blood cells. (rxharun.com)
Amsa (Amsacrine) belongs to the group of cancer-fighting medications called antineoplastics. (pocketpills.com)
Amsa (Amsacrine) is used to treat acute adult Leukemia (cancer of the white blood cells) in people who have been treated previously with other cancer medications. (pocketpills.com)
Amsa (Amsacrine) kills cancer cells by interfering with their growth and reproduction. (pocketpills.com)
As well as interfering with the growth and reproduction of cancer cells, Amsa (Amsacrine) can interfere with some of your normal cells. (pocketpills.com)
A study by the Cancer and Leukemia Group B (CALGB) did not show a benefit to consolidation therapy. (medscape.com)
Relapse2
Allogeneic Stem Cell Transplantation following Relapse post Autologous Stem Cell Transplantation in adult patients with Acute Myeloid Leukemia: A retrospective analysis of 537 patients from the Acute Leukemia Working Party of the EBMT. (stembook.org)
Pretransplant Metabolic Distress Predicts Relapse of Acute Myeloid Leukemia After Allogeneic Stem Cell Transplantation. (stembook.org)
Immature1
Acute leukemia - is characterized by a rapid increase in the number of immature blood cells. (rxharun.com)
Prognosis1
The term acute myeloid leukemia (AML) collectively refers to a mixture of distinct diseases that differ with regard to their pathogenetic evolution, genetic abnormalities, clinical features, response to therapy, and prognosis. (ashpublications.org)
Patients6
Impact of conditioning intensity on outcomes of haploidentical stem cell transplantation for patients with acute myeloid leukemia over 45 years of age. (stembook.org)
A high BMI is a risk factor in younger patients with de novo acute myelogenous leukemia. (stembook.org)
Outcome of patients with abnl(17p) acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation. (stembook.org)
In Section III, Dr. Martin Tallman describes the evaluation and management of patients with acute promyelocytic leukemia, a notable example of therapeutic progress in a molecularly defined entity of leukemia. (ashpublications.org)
Patients admitted to hospitals that lack appropriate blood product support facilities, leukapheresis capabilities, or physicians and nurses familiar with the treatment of patients with leukemia should be transferred to an appropriate (generally, tertiary care) hospital. (medscape.com)
PURPOSE: The optimum number of treatment courses for younger patients with acute myeloid leukemia (AML) is uncertain. (ox.ac.uk)
Subtype3
Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML), with the first description as a distinct entity in 1957. (nature.com)
Most lymphocytic leukemias involve a specific subtype of lymphocyte, the B cell. (rxharun.com)
One subtype is B-cell prolymphocytic leukemia, a more aggressive disease. (rxharun.com)
Treatment2
Immediate treatment is required in acute leukemia because of the rapid progression and accumulation of the malignant cells, which then spill over into the bloodstream and spread to other organs of the body. (rxharun.com)
Whereas acute leukemia must be treated immediately, chronic forms are sometimes monitored for some time before treatment to ensure maximum effectiveness of therapy. (rxharun.com)
Cells5
Chronic leukemia - is characterized by the excessive buildup of relatively mature, but still abnormal, white blood cells. (rxharun.com)
In lymphoblastic or lymphocytic leukemias - the cancerous change takes place in a type of marrow cell that normally goes on to form lymphocytes, which are infection-fighting immune system cells. (rxharun.com)
In myeloid or myelogenous leukemias - the cancerous change takes place in a type of marrow cell that normally goes on to form red blood cells, some other types of white cells, and platelets. (rxharun.com)
That SP600125 induces endoreduplication signals, promotes tubulin polymerization, a critical process in cell division, and induces delayed apoptosis in leukemia Aurora kinases cells. (hsp90-inhibitors.com)
Therefore, the upregulation of p21 expression may contribute to G2 M arrest in the early stages, and then Cdk2 may regulate endoreduplication by treating leukemia cells in the middle stages in the presence of SP600125. (hsp90-inhibitors.com)
Occur1
Chronic leukemia mostly occurs in older people, but can occur in any age group. (rxharun.com)
Historically, acute promyelocytic leukemia (APL) was considered to be one of the most fatal forms of acute leukemia with poor outcomes before the introduction of the vitamin A derivative all- trans retinoic acid (ATRA). (nature.com)