• After screening, patients underwent leukapheresis. (onclive.com)
  • In FELIX, patients underwent leukapheresis after screening and received bridging therapy during obe-cel manufacturing. (cancernetwork.com)
  • Leukapheresis (/ˌluˈkʌfɜːriːsɪs/ ) is a laboratory procedure in which white blood cells are separated from a sample of blood. (wikipedia.org)
  • Participant undergoing leukapheresis procedure. (ukzn.ac.za)
  • Working in partnership with highly experienced, trained South African National Blood Service (SANBS) staff and a medical doctor, the leukapheresis procedure will take place at Inkosi Albert Luthuli Central Hospital. (ukzn.ac.za)
  • White blood cells will be collected by a procedure called leukapheresis. (uab.edu)
  • The activated immune cells-your personalized Provenge dose-is given by infusion within about three days of the leukapheresis procedure. (prostate.net)
  • Leukapheresis - This procedure is done to collect large quantities of white blood cells. (healthengine.com.au)
  • PBMCs were isolated from leukapheresis products of healthy volunteers by density gradient centrifugation. (nih.gov)
  • Leukapheresis after high-dose chemotherapy and autologous peripheral blood progenitor cell transplantation: a novel approach to harvest a second autograft. (wikipedia.org)
  • Following enrollment and leukapheresis, patients could receive optional non-chemotherapy bridging, which could have included either corticosteroids or localized radiation. (cancernetwork.com)
  • To make your personalized dose, you must undergo a process called leukapheresis, which involves having your blood drawn either through a vein or through a central venous catheter placed into a large vein near the heart. (prostate.net)
  • Under this study, up to 10 patients with ALS will undergo leukapheresis. (houstonmethodist.org)
  • Twenty-six patients were infused with CART cells (median 81 days after leukapheresis) and were analyzed for the overall response (OR) 3 months later. (frontiersin.org)
  • Low frequency of differentiated CD3 + CD27 - CD28 - T cells at leukapheresis represents a novel pre-infusion blood biomarker predicting a favorable response to CART cell treatment in r/r DLBCL patients. (frontiersin.org)
  • Materials and methods - Sixty-eight processes of leukapheresis of 57 patients affected by refractory/relapsed B cell lymphoma and 9 patients affected by acute lymphoblastic leukemia who were eligible for anti-CD19 CAR-T cell treatment performed between June 2019 and October 2022 were analyzed. (bloodtransfusion.it)
  • Timely Leukapheresis May Interfere with the « Fitness » of Lymphocytes Collected for CAR-T Treatment in High Risk DLBCL Patients. (c3m-nice.fr)
  • 15 mg of prednisone daily or equivalent), or patients who have received any other form of immunosuppressive therapy within 7 days prior to leukapheresis. (moffitt.org)
  • In this process, T cells are collected from patients via leukapheresis and then re-engineered to express chimeric antigen receptors. (medscape.com)
  • Leukapheresis is used in evolving CAR-T cell therapy to obtain leukocytes from a cancer patient or donor which can be modified and given to the patient as a therapeutic dose. (wikipedia.org)
  • Leukapheresis may be performed to decrease a very high white blood cell count, to obtain blood cells from a patient (autologous) or donor (allogeneic) for later transplant into the patient, or to obtain cells for research purposes. (wikipedia.org)
  • Leukapheresis is the process by which a large number of total nucleated cells are separated from the blood of a single donor, resulting in a high concentration of PBMC, such as lymphocytes (T cells, B cells, and NK cells), monocytes and dendritic cells. (bioscience.co.uk)
  • Most donor stem cells are collected through a process called leukapheresis. (medlineplus.gov)
  • citation needed] Leukapheresis may be performed to obtain the patient's own blood cells for a later transplant. (wikipedia.org)
  • Another novel use of cells obtained through leukapheresis is to stimulate a patient's immune system to target prostate cancer cells. (wikipedia.org)
  • Kymriah is manufactured by harvesting the patient's own T-cells using leukapheresis and engineering these cells to attack a specific target on leukemia cells, CD19. (childrensmercy.org)
  • Major complications associated with therapeutic leukapheresis procedures include pulmonary leukostasis, acute renal failure, and sometimes even death. (marketsandmarkets.com)
  • Therapeutic leukapheresis is associated with certain complications, such as those arising from a decreased WBC count and the possibility of adverse interactions with anticoagulation solutions. (marketsandmarkets.com)
  • The global leukapheresis market in terms of revenue was estimated to be worth $70 million in 2023 and is poised to reach $100 million by 2028, growing at a CAGR of 8.3% from 2023 to 2028. (marketsandmarkets.com)
  • The Leukapheresis Devices Market is estimated to be valued at US$ 29.9 Mn in 2023 and is expected to exhibit a CAGR of 7.9% over the forecast period 2023 to 2030, as highlighted in a new report published by Coherent Market Insights. (makuv.com)
  • Patient received a live vaccine administration within 4 weeks prior to leukapheresis. (moffitt.org)
  • Patient is currently participating in another investigation treatment study or has participated in a study of an investigational agent within 4 weeks prior to leukapheresis. (moffitt.org)
  • Results - Leukapheresis volume was reduced by almost fivefold (median: 185 to 40 mL), resulting in a higher product concentration in one bag. (bloodtransfusion.it)
  • The IMMBASE study will collect leukapheresis samples at only one timepoint from 30 participants. (ukzn.ac.za)
  • cite journal}}: CS1 maint: multiple names: authors list (link) * National Institute for Health and Clinical Excellence, Leukapheresis for inflammatory bowel disease[permanent dead link] (guidance). (wikipedia.org)
  • Diagnostic LeukApheresis (DLA) is a standard clinical method that is frequently used to isolate mononuclear cells (MNCs) from blood for various applications. (utwente.nl)
  • By donating these cells through a process called leukapheresis , you help scientists across the US and abroad advance cell-based therapies to fight diseases, improve treatments, and save lives. (hemacenter.com)
  • Leukopaks are enriched leukapheresis products collected from peripheral blood and consist of various blood cells, including lymphocytes, monocytes, and dendritic cells. (marketsandmarkets.com)
  • The EasySep™ Release Human APC Positive Selection Kit is designed to isolate cells that are labeled with APC-conjugated antibodies from fresh or previously frozen peripheral blood mononuclear cells or washed leukapheresis samples by immunomagnetic positive selection. (stemcell.com)
  • A leukapheresis donation is very safe, and our trained medical team is by your side every step of the way. (hemacenter.com)
  • Their Tregs will subsequently be isolated and expanded from the leukapheresis product in the cGMP facility at Houston Methodist Hospital in order to develop and validate the Treg manufacturing process for the ultimate purpose of obtaining FDA approval in future trials. (houstonmethodist.org)
  • It is a sub-study within the Females Rising with Education, Support, and Health (FRESH) study which has been conducting leukapheresis to inform HIV cure strategies. (ukzn.ac.za)
  • This leukapheresis study proposes to continue our work in developing and optimizing our Treg manufacturing process. (houstonmethodist.org)
  • Hypocalcemia, decreased calcium levels also occurs in a large volume of leukapheresis procedures. (marketsandmarkets.com)
  • 6 months prior to leukapheresis and >3 months prior to lymphodepletion. (bcan.org)
  • 10. Subject is fit for leukapheresis and has adequate venous access for the cell collection. (bcan.org)
  • Additionally, biocompatible materials such as amphiphilic/zwitterionic polymers can also be explored as coating materials for use in leukapheresis membranes for enhanced hemocompatibility. (marketsandmarkets.com)