Chronic lymphocytDaunorubicin and cytarabineGranulocyte colonyDecitabineChildhood acute lymphoblaEfficacyInductionRemissionEtoposidePatientsLymphomaSAMHD1AzacitidineLymphoblasticCytotoxic drugAdultsChemotherapy aloneCancerAllogeneicChemotherapeuticApoptosisVenetoclaxAnthracyclineTreatmentSurvival RateCommonlyResistanceCellsPhaseSynthesisPatientHigh
Chronic lymphocyt2
- Patients with newly diagnosed chronic lymphocytic leukaemia were shown to experience long-lasting illness remission while receiving the combination of ibrutinib and venetoclax (CLL). (hayatalhikmah.com)
- Certain kinds of small lymphocytic lymphoma and chronic lymphocytic leukaemia are treated with venetoclax alone or combined with obinutuzumab or rituximab. (hayatalhikmah.com)
Daunorubicin and cytarabine1
- Moreover, we showed that both daunorubicin and cytarabine induced reactive oxygen species (ROS) accumulation to induce apoptosis in AML. (oncotarget.com)
Granulocyte colony3
- Induction and consolidation therapy comprising venetoclax plus fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin (FLAG-IDA) was highly effective for the treatment of newly diagnosed AML, according to research. (devbrandcast.com)
- Therefore, this trial evaluates the safety and efficacy of fludarabine, cytarabine, granulocyte colony-stimulating factor (G-CSF), and idarubicin, combined with the B-cell lymphoma-2 inhibitor venetoclax in newly diagnosed AML (ND-AML) and relapsed/refractory AML (R/R-AML). (bjh.be)
- Fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin plus venetoclax represents an effective intensive treatment regimen in ND-AML and R/R-AML patients, associated with deep remissions and a high rate of transition to successful transplantation. (bjh.be)
Decitabine4
- SAMHD1 mediates resistance to anti-cancer nucleoside analogues, including cytarabine, decitabine, and nelarabine that are commonly used for the treatment of leukaemia, through cleavage of their triphosphorylated forms. (biomedcentral.com)
- CNDAC-adapted sublines displayed cross-resistance only to other DCK substrates (e.g. cytarabine, decitabine). (biomedcentral.com)
- This Joint Assessment aims to compare the clinical effectiveness and safety of glasdegib, in combination with low-dose cytarabine, in the target patient population with relevant comparators (azacitidine, decitabine, low-dose cytarabine, and best supportive care) according to the national requirements of EUnetHTA partners. (scuba-capsule.de)
- It makes it impossible for them to receive other chemotherapy drugs in combination with either azacitidine, decitabine, or cytarabine. (hayatalhikmah.com)
Childhood acute lymphobla3
- Evaluated the mRNA gene expression profile of 12 HDAC genes by quantitative serious time polymerase chain reaction in 94 consecutive childhood acute lymphoblastic leukaemia samples and its association with clinical biological functions and survival. (microrna21.com)
- TPMT polymorphisms and minimal residual disease after 6-mercaptopurine post-remission consolidation therapy of childhood acute lymphoblastic leukaemia. (cancercentrum.se)
- The spectrum of acute central nervous system symptoms during the treatment of childhood acute lymphoblastic leukaemia. (cancercentrum.se)
Efficacy3
- We did a meta-analysis of individual patient data to assess the efficacy of adding gemtuzumab ozogamicin to induction chemotherapy in adult patients with acute myeloid leukaemia. (nih.gov)
- Supplementation of each of these three substances significantly enhanced the efficacy of cytarabine treatment in high SAMHD1 cell samples. (scilifelab.se)
- This open-label, multicentre phase I/II study determined the maximum tolerated dose (MTD), safety and efficacy of clofarabine administered with cytarabine and idarubicin in newly diagnosed acute myeloid leukaemia (AML) patients lacking favourable genetic aberrations. (uni-luebeck.de)
Induction4
- We searched PubMed for reports of randomised controlled trials published in any language up to May 1, 2013, that included an assessment of gemtuzumab ozogamicin given to adults (aged 15 years and older) in conjunction with the first course of intensive induction chemotherapy for acute myeloid leukaemia (excluding acute promyelocytic leukaemia) compared with chemotherapy alone. (nih.gov)
- In June 2020, the European Commission granted marketing authorisation for Daurismo® (glasdegib), in combination with low-dose cytarabine, for the treatment of newly diagnosed de novo or secondary AML in adult patients who are not candidates for standard induction chemotherapy. (scuba-capsule.de)
- However, ROS-dependent induction of HO-1 was limiting the apoptotic response that is seen in AML towards cytarabine and daunorubicin treatment. (oncotarget.com)
- Compared to Regimen B (i.e. additional doxorubicin during induction and additional cyclophosphamide and cytarabine during consolidation chemotherapy), patients receiving Regimen A had fewer problems with pain and nausea. (ox.ac.uk)
Remission3
- Criteria for defining a complete remission in acute myeloid leukaemia revisited. (rug.nl)
- What do atomic bomb survivors teach us about therapy-free remission in people with chronic myeloid leukaemia? (nature.com)
- In three cases of acute promyelocytic leukaemia remission was induced with cytosine arabinoside, daunarubicin and vincristine. (karger.com)
Etoposide3
- four of nine being associated with toxicity of 5 days of etoposide and cytarabine. (nih.gov)
- Lenalidomide monotherapy and in combination with cytarabine, daunorubicin and etoposide for high-risk myelodysplasia and acute myeloid leukaemia with chromosome 5 abnormalities. (ox.ac.uk)
- The two main drugs are cytarabine and daunorubicin, but others such as idarubicin, mitoxantrone and etoposide can be used. (technologynetworks.com)
Patients7
- Patients with high risk myelodysplasia (HR-MDS) and acute myeloid leukaemia (AML) with chromosomal changes involving deletion of the long arm of chromosome 5 (del5q), especially with complex karyotype, rarely have a durable response to combination chemotherapy. (ox.ac.uk)
- The problem, however, is that many patients respond poorly to the treatment due to high levels of SAMHD1, which can break down the active substance in cytarabine ,ara-CTP. (scilifelab.se)
- Patients with high levels of SAMHD1 have a much lower survival rate when treated with cytarabine, suggesting that a way to inhibit the effects of the enzyme could be a promising strategy to improve existing AML treatments. (scilifelab.se)
- A clinical study is now planned to evaluate the effects of combining cytarabine and hydroxyurea in newly diagnosed patients. (scilifelab.se)
- CNDAC was tested in 13 acute myeloid leukaemia (AML) cell lines, in 26 acute lymphoblastic leukaemia (ALL) cell lines, ten AML sublines adapted to various antileukaemic drugs, 24 single cell-derived clonal AML sublines, and primary leukaemic blasts from 24 AML patients. (biomedcentral.com)
- which remains standard-of-care for patients with acute myeloid leukaemia (AML). (seanruddlab.com)
- Sixty percent of newly diagnosed patients with acute myeloid leukaemia (ND-AML) receiving frontline therapy attain a complete response, yet 30-40% of patients relapse. (bjh.be)
Lymphoma2
- Causal models of leukaemia and lymphoma. (medscape.com)
- The estimated overall incidence of acute lymphoblastic leukaemia (ALL) and lymphoblastic lymphoma in Europe is 1.28 per 100 000 individuals annually, with significant age-related variations (0.53 at 45-54 years, ∼1.0 at 55-74 years and 1.45 at 75-99 years). (medscape.com)
SAMHD14
- Hence, SAMHD1 inhibitors are promising candidates for the sensitisation of leukaemia cells to nucleoside analogue-based therapy. (biomedcentral.com)
- Although the cytosine analogue CNDAC was anticipated to inhibit SAMHD1, SAMHD1 mediated intrinsic CNDAC resistance in leukaemia cells. (biomedcentral.com)
- In cytarabine-adapted AML cells, increased SAMHD1 and reduced DCK levels contributed to cytarabine and CNDAC resistance. (biomedcentral.com)
- SAMHD1 had a larger impact on cytarabine activity than on nelarabine/ AraG activity in acute myeloid leukaemia (AML) cells, but more strongly affected nelarabine/ AraG activity in ALL cells. (uni-frankfurt.de)
Azacitidine2
- The adverse effects of azacitidine are generally similar to those seen with cytarabine. (pocketdrugguide.com)
- Azacitidine is an antimetabolite antineoplastic with general properties similar to those of cytarabine. (pocketdrugguide.com)
Lymphoblastic4
- Acute lymphoblastic leukaemia in infancy: experience in MRC UKALL trials. (nih.gov)
- Acute lymphoblastic leukaemia (ALL) is rare under 1 year and has a poor prognosis. (nih.gov)
- The nucleoside analogue nelarabine, the prodrug of arabinosylguanine (AraG), has been known for decades to be effective against acute lymphoblastic leukaemias of T-cell (T-ALL), but not of B-cell (B-ALL) origin. (uni-frankfurt.de)
- Prospective evaluation of quality of life in children treated in UKALL 2003 for acute lymphoblastic leukaemia: A cohort study. (ox.ac.uk)
Cytotoxic drug2
- The overwhelming majority of neutrophilic eccrine hidradenitis (NEH) is seen in people with cancer, especially leukaemia, who receive chemotherapy with a cytotoxic drug. (wikipedia.org)
- So far, one of the most common drugs used to treat AML is cytarabine (ara-C), a cytotoxic drug that disrupts cell growth. (scilifelab.se)
Adults2
- Adults with small lymphocytic leukaemia or chronic lymphocytic leukemia are treated with venetoclax. (hayatalhikmah.com)
- Adults with acute myeloid leukaemia who are 75 years or older or cannot take regular chemotherapy due to other medical issues may also be treated with venetoclax in combination with other medications. (hayatalhikmah.com)
Chemotherapy alone1
- These results show the susceptibility of infants to the toxicity of intensive chemotherapy and do not support the use of short term high-dose chemotherapy alone in the management of infant leukaemia. (nih.gov)
Cancer4
- Gemtuzumab ozogamicin was the first example of antibody-directed chemotherapy in cancer, and was developed for acute myeloid leukaemia. (nih.gov)
- Leukaemia - Also in 2005, a team of researchers including Monica Guzman, PhD, of the University of Rochester Medical School, showed that Parthenolide was a potent anti-leukaemia aid and could kill cancer stem cells, without damaging healthy cells. (canceractive.com)
- All three substances have previously been used or tested when treating various forms of cancer but so far they have not been systematically tested in combination with cytarabine. (scilifelab.se)
- National Cancer Research Institute Childhood Leukaemia Sub-Group and UK Childhood Leukaemia Clinicians Network None. (ox.ac.uk)
Allogeneic2
- Donor cell-derived leukaemia (DCL) is an uncommon complication of allogeneic hematopoietic stem cell transplantation (HSCT). (lidsen.com)
- 75 years old) followed by cytarabine consolidations and/or allogeneic stem-cell transplantation (ASCT). (dovepress.com)
Chemotherapeutic1
- This study aims to analyse the role of HO-1 in regulating apoptosis in AML cells in response to two front-line chemotherapeutic agents used for AML, cytarabine and daunorubicin. (oncotarget.com)
Apoptosis2
- Currently, little is known about HO-1 and its role in human acute myeloid leukaemia (AML) to regulate apoptosis in response to chemotherapy. (oncotarget.com)
- HDACs one is vital in en hancing cytarabine induced apoptosis in pediatric AML, not less than partly mediated by Bim. (microrna21.com)
Venetoclax1
- Venetoclax has shown significant activity in older and unfit individuals with newly diagnosed acute myeloid leukaemia when combined with hypomethylating drugs or low-dose cytarabine. (hayatalhikmah.com)
Anthracycline1
- The combination of cytarabine for 7 days with an anthracycline or anthracenedione for 3 days (the 7+3 regimen) is recommended. (medscape.com)
Treatment5
- Technology Networks spoke to Kate Nash , research communications manager at Leukaemia UK, to find out more about the current landscape of AML treatment and the innovative research projects aiming to improve the lives of those with the disease. (technologynetworks.com)
- The combination treatment in mice did not show any adverse side effects beyond those already known with cytarabine alone. (scilifelab.se)
- it has also been used in the treatment of acute myeloid leukaemia. (pocketdrugguide.com)
- This is the pharmaceutical Joint Assessment PTJA12 - on glasdegib for the treatment of acute myeloid leukaemia (AML). (scuba-capsule.de)
- Here we show that HO-1 expression in AML samples was increased in response to both cytarabine and daunorubicin treatment, and micro RNA (miRNA) silenced HO-1 expression in combination with either daunorubicin or cytarabine induced a greater apoptotic responses in AML cells. (oncotarget.com)
Survival Rate1
- In AML mice, we were also able to show a significantly prolonged average survival rate when cytarabine was combined with an RNR inhibitor" said Nikolas Herold, in a press release from Karolinska Institutet. (scilifelab.se)
Commonly1
- It was also compared in the studies to the drug Cytarabine, commonly used at that time for leukaemia. (canceractive.com)
Resistance1
- In 24 CNDAC-adapted acute myeloid leukaemia (AML) sublines, resistance was driven by DCK (catalyses initial nucleoside phosphorylation) loss. (biomedcentral.com)
Cells2
- Administration of low-dose cytarabine results in immediate S-phase arrest and subsequent activation of cell cycling in murine stem cells. (rug.nl)
- Elacytarabine is the elaidic acid ester derivative of cytarabine, designed to enter cells independently of nucleoside transporters. (figshare.com)
Phase1
- Cytarabine acts by interfering with DNA synthesis specifically at the S-phase of the cell cycle. (arogga.com)
Synthesis1
- Variation in sensitivity of DNA synthesis to ara-C in acute myeloid leukaemia. (ox.ac.uk)
Patient1
- NEH was first described in 1982 in a patient with acute myeloid leukaemia (AML) who had received cytarabine as chemotherapy. (wikipedia.org)
High1
- High exposure to VPA can lead to carnitine depletion causing a misbalance between the intra-mitochondrial beta-oxidation and the microsomal co-oxidation, a pathway that produces toxic metabolites such as 4-en-VPA which inhibits ammonia elimination. (unav.edu)