Lethal dose doses. Medical search. Frequent questions

Just two milligrams of fentanyl, or the amount that could fit on the tip of a pencil, is considered a potentially lethal dose. (dea.gov)
Shortness of breath that develops within 4 hours of exposure is a sign that the person may have been exposed to a potentially lethal dose. (msdmanuals.com)

In toxicology, the lethal dose (LD) is an indication of the lethal toxicity of a given substance or type of radiation. (wikipedia.org)

The median lethal dose, LD50 (abbreviation for "lethal dose, 50%"), LC50 (lethal concentration, 50%) or LCt50 (lethal concentration and time) of a toxin, radiation, or pathogen is the dose required to kill half the members of a tested population after a specified test duration. (wikipedia.org)
The median infective dose (ID50) is the number of organisms received by a person or test animal qualified by the route of administration (e.g., 1,200 org/man per oral). (wikipedia.org)
Botulinum toxin's median lethal dose (LD50) has been determined across several animal species but not in humans. (medscape.com)

Elimination of butalbital is primarily via the kidney (59%-88% of the dose) as unchanged drug or metabolites. (drugs.com)

some may be killed by much less, while others survive doses far higher than the LD50. (wikipedia.org)
LD50 i.v." The related quantities LD50/30 or LD50/60 are used to refer to a dose that without treatment will be lethal to 50% of the population within (respectively) 30 or 60 days. (wikipedia.org)

The lethal concentration is a lethal dose measurement used for gases or particulates. (wikipedia.org)
For gases and aerosols, lethal concentration (given in mg/m3 or ppm, parts per million) is the analogous concept, although this also depends on the duration of exposure, which has to be included in the definition. (wikipedia.org)
A peak concentration of 8.8 mcg/mL was obtained at 40 minutes after a 650 mg dose. (drugs.com)

however, first-order elimination kinetics are still a good approximation for doses up to 650 mg. (drugs.com)
The elimination of therapeutic doses is through the kidneys either as salicylic acid or other biotransformation products. (drugs.com)

The systemic availability of aspirin after an oral dose is highly dependent on the dosage form, the presence of food, the gastric emptying time, gastric pH, antacids, buffering agents, and particle size. (drugs.com)

Chronic exposure significantly decreased flight duration (−54%), distance (−56%), and average velocity (−7%) after either one or two days of continuous exposure that resulted in bees ingesting field-relevant thiamethoxam doses of 1.96-2.90 ng/bee/day. (nature.com)
Margins of exposure were not calculated for non-cancer effects in this assessment since non-cancer effects occurred at a dose at which tumours were observed and because the information available indicates that exposures of the general Canadian population to 2-nitrotoluene from either environmental media or consumer products are expected to be negligible. (gc.ca)

Subsequently, the first maintenance dose of 50 mg/kg in 500 mL D5W is infused IV over 4 hours, followed by the second maintenance dose of 100 mg/kg in 1000 mL D5W infused IV over 16 hours. (medscape.com)

For outpatients, the maintenance dose is 50-150 mg PO hs, without exceeding 300 mg in 24 hours. (medscape.com)

Reports in the literature suggest that bacteria exposed to lethal doses of ionizing radiation, i. at 4C. (cancer-ecosystem.com)
The overall objective of this study was to characterize the response of cells (K-12 wild-type strain MG 1655) to a lethal dose of eBeam radiation. (cancer-ecosystem.com)

Because resistance varies from one individual to another, the "lethal dose" represents a dose (usually recorded as dose per kilogram of subject body weight) at which a given percentage of subjects will die. (wikipedia.org)

In biological warfare infective dosage is the number of infective doses per minute for a cubic meter (e.g. (wikipedia.org)
for the treatment of enuresis, the dosage for patients older than 6 years is 10-25 mg PO qhs, which can be increased by 10-25 mg every 1-2 weeks for a maximum dose of 50 mg in patients aged 6-12 years and 75 mg in patients older than 12 years. (medscape.com)

The lowest lethal dose (LDLo) is the least amount of drug that can produce death in a given animal species under controlled conditions. (wikipedia.org)
BERLIN (AP) - A German federal court on Tuesday denied two seriously ill men direct access to a lethal dose of a drug, arguing that the country's narcotics law stands in the way and that they could turn to assisted suicide to end their lives. (kfor.com)
Urinary excretion products included parent drug (about 3.6% of the dose), 5-isobutyl-5-(2,3-dihydroxypropyl) barbituric acid (about 24% of the dose), 5-allyl-5(3-hydroxy-2-methyl-1-propyl) barbituric acid (about 4.8% of the dose), products with the barbituric acid ring hydrolyzed with excretion of urea (about 14% of the dose), as well as unidentified materials. (drugs.com)
The amount of fentanyl taken off the streets during this surge is equivalent to more than 36 million lethal doses removed from the illegal drug supply. (dea.gov)

Mixed-effect agents act in both large airways and alveoli in low to moderate doses. (msdmanuals.com)
However, with high doses of type 1 agents, delayed-onset chest tightness or shortness of breath (type 2 effects) may also occur. (msdmanuals.com)

For inpatients, the typical initial dosing is 100 mg/24 hours in divided doses, eventually transitioning (over several weeks) to a maximum dose of 300 mg in 24 hours. (medscape.com)

some recommend giving the loading dose over 60 minutes to reduce the risk of an anaphylactoid reaction). (medscape.com)

Because of the difficulties in counting actual organisms in a dose, infective doses may be expressed in terms of biological assay, such as the number of LD50's to some test animal. (wikipedia.org)

In both studies there was a clear dose-response relationship between average residential THM levels and risk of bladder in men but not in women (see Table). (who.int)

In the R ECOVERY Trial and the REMAP-CAP Trial they used an extremely high and potentially lethal dose: 800 mg at 0 and 6 hours followed by 400 mg at 12 hours and then every 12 hours for up to nine additional days. (expose-news.com)
Botulism is a severe and potentially lethal paralytic disease caused by several botulinum neurotoxin-producing Clostridia spp. (springer.com)

In a chronic/carcinogenicity study, rats exposed to NVP by inhalation showed dose-related increased incidences of hepatocellular carcinomas and nasal cavity adenomas and adenocarcinomas as well as increased incidences of squamous carcinomas of the larynx at the highest dose tested. (gc.ca)
Non-neoplastic effects based on inhalation exposure in repeated-dose studies were observed at the same critical effect level as the neoplastic effects, and the liver and respiratory tract of rats and mice were identified as the target organs. (gc.ca)

Taking a very high dose of Wellbutrin alone or in combination with other drugs can have toxic effects. (addictionresource.net)
Four drams would be fifteen grams of pure quinine, which is a toxic (lethal) dose. (angelfire.com)
Non-lethal doses cause toxic effects. (dermnetnz.org)

In these states, the law allows physicians to offer terminally ill adults the option of a lethal dose of an oral prescription medication, provided the patient meets strict criteria. (medscape.com)
Currently, six states can authorize physicians to offer terminally ill adults the option of a lethal dose of an oral prescription medication. (medscape.com)
The lethal dose for adults is about 12 mg/kg. (medicinenet.com)

The lethal dose for humans is 15-20 mg/kg, although much small doses have also led to death. (dermnetnz.org)

In NHPs, single-dose DPX-rPA was 100% protective against challenge, whereas one animal in the two-dose AVA group and all saline administered animals succumbed to infection. (listlabs.com)
Isoniazid should be administered orally, in a single dose in the morning, 30 minutes before meal. (who.int)
Maximum single dose is 0.5 gram, and maximum dose per day is 2 grams. (angelfire.com)

Survival has been reported following the ingestion of as much as 13.5 grams-or 45 times the maximum daily dose. (addictionresource.net)

Several other countries permit this practice, but notably, Canada, Belgium, Luxembourg, and the Netherlands also allow euthanasia, whereby a physician can administer a lethal drug dose by injection. (medscape.com)

Both R-mephenytoin and its active metabolite R-PEH displayed linear kinetics in the dose range of 50-200 mg. (nih.gov)

Because resistance varies from one individual to another, the "lethal dose" represents a dose (usually recorded as dose per kilogram of subject body weight) at which a given percentage of subjects will die. (wikipedia.org)

Taking a higher dose of Wellbutrin than prescribed, or misusing it, can cause negative side effects, including overdose. (addictionresource.net)
Hydroxychloroquine overdose is associated with cardiovascular, neurological, and other toxicities, occurring with doses over 1500 mg, and higher doses are associated with fatality. (expose-news.com)

In case of liver failure it will reduce the dose. (who.int)

As with all anticonvulsants, dose reduction must be gradual so as to minimize the risk of precipitating seizures. (nih.gov)
10 ml/minute) and slow acetylator status might require a dose reduction of about 100 mg to maintain plasma levels at less than 1 mcg/ml. (who.int)

The court pointed to a "realistic possibility" of obtaining lethal doses of drugs via a doctor, including through organizations that connect people who want to die with doctors who are willing to help. (fox40.com)
Learn more about the lethal doses of commonly abused drugs . (addictionresource.net)
patients must have a life expectancy of 6 months or less, must be a resident of the state where the prescription is obtained, and must be able to self-administer oral drugs at a lethal dose. (medscape.com)

These relatives of nicotine deliver insects a lethal high. (nakedcapitalism.com)

LD50 i.v." The related quantities LD50/30 or LD50/60 are used to refer to a dose that without treatment will be lethal to 50% of the population within (respectively) 30 or 60 days. (wikipedia.org)
The recommended dose is 5-10 mg isoniazid / kg daily at the beginning of treatment, not exceed 300 mg / day. (who.int)

Bugs that chomp down on the neonic-infused leaves get a killer dose of the chemical. (nakedcapitalism.com)
Public Law 91-145 (50 U.S.C. 1521) mandates that all unitary (self-contained) lethal chemical munitions be destroyed by 1994. (cdc.gov)

DEA has determined that four out of ten DEA-tested fentanyl-laced, fake prescription pills contain at least two milligrams of fentanyl-an amount that is considered to be a lethal dose. (dea.gov)

Participants can use more concentrated stock solutions to test concentrations that determine the range for lethal, sub-lethal, or no effect. (nih.gov)

In biological warfare infective dosage is the number of infective doses per minute for a cubic meter (e.g. (wikipedia.org)

The lethal dose is approximately 15 to 20 mg/kg body weight and is rapidly distributed throughout the body's tissues. (medicinenet.com)

The recommended dose is 5-10 mg isoniazid / kg daily and 10-15 mg for intermittent therapy regimens. (who.int)

These data indicate that DPX-rPA may offer improvement over AVA by reducing the doses needed for protective immune responses and is a promising candidate as a new-generation anthrax vaccine. (listlabs.com)

Because of the difficulties in counting actual organisms in a dose, infective doses may be expressed in terms of biological assay, such as the number of LD50's to some test animal. (wikipedia.org)

The WHO's SOLIDARITY Trial used the same dose for hydroxychloroquine as the RECOVERY & REMAP-CAP Trials. (expose-news.com)

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Organisms43

Diseases39

Chemicals and Drugs62

Analytical, Diagnostic and Therapeutic Techniques and Equipment68

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