• Langerhans cell histiocytosis (LCH) is an abnormal clonal proliferation of Langerhans cells, abnormal cells deriving from bone marrow and capable of migrating from skin to lymph nodes. (wikipedia.org)
  • This primary bone involvement helps to differentiate eosinophilic granuloma from other forms of Langerhans Cell Histiocytosis (Letterer-Siwe or Hand-Schüller-Christian variant). (wikipedia.org)
  • Pulmonary Langerhans cell histiocytosis (PLCH) is a unique form of LCH in that it occurs almost exclusively in cigarette smokers. (wikipedia.org)
  • Langerhans cell histiocytosis (LCH) is a group of idiopathic disorders characterized by the presence of cells with characteristics similar to bone marrow-derived Langerhans cells juxtaposed against a backdrop of hematopoietic cells, including T-cells, macrophages, and eosinophils. (medscape.com)
  • The term Langerhans cell histiocytosis is generally preferred to the older term, histiocytosis X. This newer name emphasizes the histogenesis of the condition by specifying the type of lesional cell and removes the connotation of the unknown ("X") because its cellular basis has now been clarified. (medscape.com)
  • The pathogenesis of Langerhans cell histiocytosis (LCH) is unknown. (medscape.com)
  • Currently, the preferred term is Langerhans cell histiocytosis. (thedoctorsdoctor.com)
  • Langerhans cell histiocytosis presenting in the neonatal period: a retrospective case series. (thedoctorsdoctor.com)
  • OBJECTIVES: To describe the morphologic characteristics of skin lesions, extent of extracutaneous disease, and outcomes in patients with neonatal presentation of Langerhans cell histiocytosis (LCH), and to examine clinical predictors of disease prognosis. (thedoctorsdoctor.com)
  • Epidemiologic study of Langerhans cell histiocytosis in children. (thedoctorsdoctor.com)
  • OBJECTIVE: The etiology and pathogenesis of Langerhans cell histiocytosis (LCH) remain poorly understood. (thedoctorsdoctor.com)
  • Langerhans cell histiocytosis is a rare disease involving clonal proliferation of langerhans cells seen in children and young adults. (scirp.org)
  • We report a rare case of adult Langerhans cell histiocytosis in the dorsal spine causing a spinal cord compression associated with a pulmonary process treated by surgery, radiotherapy and systemic therapy with good evolution. (scirp.org)
  • Final diagnosis was therefore Langerhans cell histiocytosis of the dorsal spine complicated by spinal cord compression. (scirp.org)
  • A chest CT scan revealed a tumoral process measuring 25 mm at the lower lobe of the left lung evoking a Langerhans cell histiocytosis ( Figure 3 ). (scirp.org)
  • Pulmonary Langerhans Cell Histiocytosis (PLCH) is a relatively uncommon lung disease that generally, but not invariably, occurs in cigarette smokers. (nih.gov)
  • Langerhans cell histiocytosis: skeletal sites commonly involved, age and incidence ratio F:M. The femoral region has been circled, showing the object of our case [1]. (pacs.de)
  • BACKGROUND: Pulmonary Langerhans cell histiocytosis (PLCH) only with airway involvement manifested as diffuse thickening of the tracheobronchial walls is rare. (bvsalud.org)
  • BACKGROUND: Langerhans cell histiocytosis (LCH) is a neoplastic transformation of myeloid precursors that commonly presents as an osteolytic lesion of the long or flat bones in children. (bvsalud.org)
  • CASE: This report describes 3 cases of Langerhans cell histiocytosis (LCH) of the cervical and thoracic spine in patients aged 4 to 10 years. (bvsalud.org)
  • Background: Juvenile xanthogranuloma (JXG) is the most common non-Langerhans cell histiocytosis in children. (elsevierpure.com)
  • An International team of Researchers including researchers from Newcastle, Dr Paul Milne and Prof Matthew Collin have made progress in understanding how the childhood cancer Langerhans Cell Histiocytosis (LCH) damages tissue in the body. (histiouk.org)
  • This work represents an important advance in understanding how the lesions of Langerhans Cell Histiocytosis develop. (histiouk.org)
  • When asked "What does it mean for our paediatric patients of Langerhans Cell Histiocytosis? (histiouk.org)
  • Juvenile xanthogranuloma is a rare non-Langerhans cell histiocytosis that usually occurs during infancy and early childhood. (biomedcentral.com)
  • We present a case of multiorgan, multisite Langerhans cell histiocytosis (LCH), positive for the oncogenic BRAF V600E mutation, in a preterm neonate. (thieme-connect.de)
  • Here, we outline the most likely diagnoses with this presentation and discuss a case of Langerhans cell histiocytosis (LCH) in a preterm neonate with severe multiorgan involvement. (thieme-connect.de)
  • Langerhans cell histiocytosis in the hypothalamic-pituitary region: a case report. (pacs.de)
  • Langerhans cell histiocytosis in a 6-year-old girl with headaches and diabetes insipidus. (pacs.de)
  • Axial T1 with contrast (below right) again shows the thick enhancing pituitary stalk and enhancing lesions in both sphenoid wings and in the left orbit.The diagnosis was Langerhans cell histiocytosis of the pituitary and Langerhans cell histiocytosis of the orbit. (pacs.de)
  • The central nervous system (CNS) is an uncommonly involved organ system in Langerhans cell histiocytosis (LCH) . (pacs.de)
  • For a general discussion of this disease please refer to the article on Langerhans cell histiocytosis (LCH) . (pacs.de)
  • Immunohistochemical staining of the specimen was positive for S100+ CD1a+ and negative for CD43 and myeloperoxidase, findings that confirmed a diagnosis of skin-limited congenital Langerhans-cell histiocytosis. (medizzy.com)
  • Eosinophilic granuloma (EG) is the benign form of the 3 clinical variants of Langerhans cell histiocytosis, which include Letterer-Siwe disease, Hand-Schüller-Christian disease, and EG (formerly termed histiocytosis X). (medscape.com)
  • Radiologists need to be aware that additional eosinophilic granuloma of bone, occurring as long as 4 years after initial diagnosis, should be interpreted as a localized form of Langerhans cell histiocytosis. (medscape.com)
  • The most benign and common form of Langerhans-cell histiocytosis which involves localized nodular lesions predominantly of the bones but also of the gastric mucosa, small intestine, lungs, or skin, with infiltration by EOSINOPHILS. (bvsalud.org)
  • Congenital Langerhans cell histiocytosis: Widely distributed papules and pustules form adherent crusts, not frecklelike macules. (medscape.com)
  • Langerhans cell histiocytosis (LCH) is a proliferation of dendritic mononuclear cells with infiltration into organs locally or diffusely. (msdmanuals.com)
  • Pulmonary Langerhans Cell Histiocytosis Pulmonary Langerhans cell histiocytosis (PLCH) is proliferation of monoclonal Langerhans cells in lung interstitium and airspaces. (msdmanuals.com)
  • Langerhans cell histiocytosis (LCH) is a dendritic cell (antigen-presenting cell) disorder. (msdmanuals.com)
  • Symptoms and signs of Langerhans cell histiocytosis vary considerably depending on which organs are infiltrated. (msdmanuals.com)
  • The most common type is Langerhans cell histiocytosis, which occurs when the body accumulates too many immature Langerhans cells. (tgh.org)
  • C group: Non-Langerhans Cell Histiocytosis (skin). (petmoo.com)
  • L group: Erdheim-Chester Disease, Langerhans Cell Histiocytosis, etc. (petmoo.com)
  • Necrobiotic xanthogranuloma is a rare, chronic and progressive, non-Langerhans cell histiocytosis disease typically characterized by multiple, indurated, asymptomatic to pruritic, yellow-orange plaques or nodules that tend to ulcerate and are usually located in the periorbital area, trunk and/or extremities. (nih.gov)
  • Her investigations focus on retinoblastoma and Langerhans cell histiocytosis, a cancer-like condition that may be treated with chemotherapy. (sc-ctsi.org)
  • Hyperintense basal ganglia on T1-Weighted MR in a patient with Langerhans cell histiocytosis. (ajnr.org)
  • Based on this tomographic pattern, the initial diagnostic suspicion was Langerhans cell histiocytosis. (journalpulmonology.org)
  • Symptoms range from isolated bone lesions to multisystem disease. (wikipedia.org)
  • Seen mostly in children, multifocal unisystem LCH is characterized by fever, bone lesions and diffuse eruptions, usually on the scalp and in the ear canals. (wikipedia.org)
  • The triad of diabetes insipidus, exophthalmos, and lytic bone lesions is known as the Hand-Schüller-Christian triad. (wikipedia.org)
  • On one end, the clinical spectrum includes an acute, fulminant, disseminated disease called Letterer-Siwe disease, and, on the other end, solitary or few, indolent and chronic lesions of bone or other organs called eosinophilic granulomas . (medscape.com)
  • The intermediate clinical form called Hand-Schüller-Christian disease is characterized by multifocal, chronic involvement and classically presents as the triad of diabetes insipidus, proptosis, and lytic bone lesions. (medscape.com)
  • MRI of the spine showed a spinal cord compression due to bone and epidural tumoral lesions of the posterior wall of the D1 to D5 thoracic vertebras ( Figure 1 ). (scirp.org)
  • Presence of a hypointense lesion associated with diaphyseal periosteal thickening with an extensive alteration of the signal of adjacent cancellous bone. (pacs.de)
  • On T2WI (c), the lesion is hyperintense and bone sequestra could also be suspected (arrowhead). (pacs.de)
  • Aneurysmal bone cysts (ABC) are benign neoplasms that frequently affect the metaphysis of long bones and the spine, often revealing a rapidly expansile lesion with fluid-fluid levels. (bvsalud.org)
  • Radiography demonstrated an expansile, lytic lesion of the left parietal bone with fluid-fluid levels. (bvsalud.org)
  • The cells of the cancer originate in the bone marrow but make lots of destructive lesions in the bone, skin, brain, lungs and blood forming organs. (histiouk.org)
  • Transaxial scan through the vertex, examined in a bone window, shows an expanding lytic lesion within the diploic space (see the next image). (medscape.com)
  • Radionuclide bone scans in a 28-year-old woman with a palpable swelling over the calvarium show a solitary lesion within the skull and a photon-deficient mass surrounded by a rim of intense activity. (medscape.com)
  • The diagnosis of eosinophilic granuloma is usually based on radiographic demonstration of a destructive bone lesion arising from the marrow cavity and on characteristic morphologic findings. (medscape.com)
  • If histiocytosis is suspected, a physician will usually order a tissue biopsy or a bone marrow aspiration to confirm the diagnosis. (tgh.org)
  • In some cases, radiation therapy or surgery may be used to address a bone lesion. (tgh.org)
  • A 59-year-old woman was admitted to the Department of Neurosurgery due to a lesion localized inside the bone in the right frontal area, discovered accidentally in the CT (computed tomography) scan of her head performed for another reason. (hindawi.com)
  • After removing the bone flap, a lesion localized inside the bone and adjacent to the dura mater was discovered (Figure 2 ). (hindawi.com)
  • There were singular lesions revealed under the dura mater, forming part of the tumour and measuring approximately 2-3 mm in dimension on the surface of the arachnoidea above the area of the bone foramen, which were removed and coagulated, preserving the venous system intact. (hindawi.com)
  • A total of 1227 patients' records were analyzed and the lesions were classified into 9 categories: neoplasm, non neoplastic proliferative processes, cysts, glandular lesions, pigmented, precancerous, dermatological, bone and other types. (bvsalud.org)
  • It typically has no extraskeletal involvement, but rarely a lesion can be found in the skin, lungs, or stomach. (wikipedia.org)
  • CONCLUSIONS: The possibility of PLCH needs to be considered when diffuse tracheobronchial lesions without lung parenchyma involvement are encountered, which provides experience for early clinical diagnosis and adequate treatment. (bvsalud.org)
  • Each patient had painful lytic spinal lesions with vertebral body collapse and posterior involvement suggesting instability requiring corpectomy, grafting, and fusion. (bvsalud.org)
  • Eight patients who had intracranial lesions were older at diagnosis, and had a higher frequency of disease-related comorbidities and permanent sequelae than those without intracranial involvement. (elsevierpure.com)
  • Because of the lack of extracutaneous involvement, the lesions were expected to resolve without treatment. (medizzy.com)
  • RDD shows some variability in the involvement of the entire neuraxis, and because its ability to mimic meningeal and primary brain tumors, it is essential to be aware of this entity and consider RDD in the differential diagnosis of various lesions of the CNS. (surgicalneurologyint.com)
  • In many instances, oral involvement precedes the appearance of other symptoms or lesions at other locations. (medscape.com)
  • Hydrocephalus, cranial nerve involvement and enhancing parenchymal mass lesions are part of the spectrum of imaging of neurosarcoidosis. (eurorad.org)
  • Skin lesions associated with Rosai-Dorfman disease are usually yellow or purple. (rarediseases.org)
  • Skin lesions may occur anywhere on the body, but most often affect the head and neck. (rarediseases.org)
  • At follow-up 6 weeks after delivery, the skin lesions had resolved. (medizzy.com)
  • Common Skin Conditions in Children: Neonatal Skin Lesions. (medscape.com)
  • The disease spectrum results from clonal accumulation and proliferation of cells resembling the epidermal dendritic cells called Langerhans cells, sometimes called dendritic cell histiocytosis. (wikipedia.org)
  • The working group of the Histiocyte Society divided histocytic disorders into three groups: (1) dendritic cell histiocytosis, (2) macrophage-related disorders, and (3) malignant histiocytosis. (medscape.com)
  • Furthermore, surgical excision should be considered first-line treatment for lesions involving the skull in surgically accessible areas as it is curative, alleviates symptoms, and allows for histopathological diagnosis. (bvsalud.org)
  • Histiocytosis UK is dedicated to promoting and funding scientific research into uncovering not only the causes of all histiocytic diseases, which include Langerhans's Cell Histiocytosis and Haemophagocytic Lymphohistiocytosis, but also ensuring early diagnosis, effective treatment and a cure. (histiouk.org)
  • Approximately five years ago, a 49-year-old Caucasian woman came to our hospital for diagnosis, evaluation and treatment of a lingual lesion. (biomedcentral.com)
  • A false-negative diagnosis of eosinophilic granuloma is exceptional when plain radiographic findings are used, although difficulty may be encountered with lesions in areas with more complex anatomy, such as the posterior elements of the vertebral bodies. (medscape.com)
  • The child is 7 years old now, with 5 years follow-up after the diagnosis of JXG: the JXG lesion resolved completely without residual. (who.int)
  • Generally, the features of the lesions are so atypical that without a known history of the systemic disease the differential diagnosis can be quite broad [9]. (eurorad.org)
  • The aim of this study was to assess the prevalence of oral lesions diagnosed in the project "Diagnosis, Treatment and Epidemiology of the diseases of the oral cavity", conducted at the State University of Maringá, from 1992 to 2007. (bvsalud.org)
  • During the 15-year follow-up of the Oral Lesion Project activities, it was possible to determine the prevalence of lesions diagnosed in the region where the project operates, thus allowing the planning of actions in the area of oral health, in addition to early diagnosis and better therapeutic approach. (bvsalud.org)
  • Knowledge of the prevalence of lesions in different locations allows the prediction of diagnosis even before biopsy is performed. (bvsalud.org)
  • Almeida & Saiki 4 studied the occurrence of lesions in Piracicaba, Brazil, between the years 1975 and 1984 and evaluated the diagnosis, location of lesions, gender and age of patients in a total of 1211 cases. (bvsalud.org)
  • Other authors 7-9 , conducted surveys in order to observe the frequency of lesions diagnosed by the Oral Diagnosis Service of the Oral Pathology Course at the Dental School of the State University of Campinas, Surgery Course at the Dental School of the University of São Paulo and in the city of Uberaba (MG), respectively. (bvsalud.org)
  • Whether patients with orofacial granulomatoses will subsequently develop intestinal manifestations of Crohn disease is uncertain, but histologic similarities between the oral lesions and the intestinal lesions are obvious. (medscape.com)
  • Studies to determine the prevalence of oral lesions have been conducted in various geographical regions. (bvsalud.org)
  • In addition, these studies contribute to demonstrating the profile of oral lesions, such as definition of the ideal nomenclature, best manner of classification and therapeutic approach 3 . (bvsalud.org)
  • In Brazil, various study designs of a retrospective nature have been conducted with the goal of determining the prevalence of oral lesions. (bvsalud.org)
  • More recently, histiocytic diseases have been reclassified into five groups: (1) Langerhans-related, (2) cutaneous and mucocutaneous, (3) malignant histiocytosis, (4) Rosai-Dorfman disease, and (5) hemophagocytic lymphohistiocytosis and macrophage activation syndrome. (medscape.com)
  • M group: Includes Malignant Histiocytosis. (petmoo.com)
  • Malignant histiocytic diseases include malignant histiocytosis (now it is called localized and disseminated histiocytic sarcoma) and cutaneous histiocytoma, which is a benign histiocytic tumor. (petmoo.com)
  • Treatment protocol for malignant histiocytosis is directed towards controlling the local tumor and tackling the concern for metastasis. (petmoo.com)
  • Malignant histiocytosis cannot be completely cured even with medical management. (petmoo.com)
  • Malignant Histiocytosis is a potentially life-threatening disease in dogs but the mortality rate of dogs is not documented. (petmoo.com)
  • Malignant histiocytosis prognosis for recovery is poor. (petmoo.com)
  • MAIN OUTCOME MEASURE: Cutaneous lesion morphologic characteristics, extracutaneous manifestations, treatments, and outcomes were tabulated and compared. (thedoctorsdoctor.com)
  • Blueberry muffin baby" is a term describing the cutaneous manifestations of various congenital infections and neoplastic diseases. (thieme-connect.de)
  • Osteolytic lesions can lead to pathological fractures. (wikipedia.org)
  • Sagittal skull radiograph (a) shows two lytic lesions (arrowheads) in the parietal skull, the largest one with an associated soft tissue component (thin arrow). (pacs.de)
  • Lateral skull radiograph in a 30-year-old woman with shortness of breath and a palpable swelling over the right parietal region shows 2 purely lytic lesions in the frontoparietal region of the skull. (medscape.com)
  • SYSTEMIC reticuloendothelial granuloma is the generic term used by Wallgren 1 in 1940 to include Letterer-Siwe disease and Schüller-Christian disease. (jamanetwork.com)
  • A 4-day-old preterm male neonate was transferred to the neonatal intensive care unit (NICU) for evaluation of respiratory failure and cutaneous hemorrhagic pustular lesions. (thieme-connect.de)
  • Jianfeng Zheng, Yunlu Gao, Xuemei Yi, and Yangfeng Ding* Case Report A 40-year-old man presented with pustular lesions all over the body for approximately 4 days' duration. (medihelp.life)
  • The onset of pustular lesions was accompanied by fever of a moderate degree and malaise. (medihelp.life)
  • The presence of single or multiple raised cutaneous lesions characterize this self-healing disorder. (biomedcentral.com)
  • Histiocytosis is an umbrella term that refers to a relatively uncommon group of syndromes associated with the overproduction of certain infection-fighting white blood cells known as histiocytes. (tgh.org)
  • Histiocytosis is an umbrella term for an emerging spectrum of "syndromes" or disorders that involve abnormal proliferation of specialized white blood cells (histiocytes). (petmoo.com)
  • Childhood interstitial lung disease (ChILD) is an umbrella term encompassing a diverse group of diffuse lung diseases affecting infants and children. (radiologykey.com)
  • Childhood interstitial lung disease (ChILD) is an umbrella term referring to a diverse group of diffuse lung diseases occurring in childhood. (radiologykey.com)
  • Childhood ILD (neatly abbreviated as ChILD) is an umbrella term encompassing more than 200 rare diffuse lung diseases that affect children. (radiologykey.com)
  • Skin lesion morphologic traits did not correlate with extent of extracutaneous disease. (thedoctorsdoctor.com)
  • The mortality and morbidity of JXG with extracutaneous lesions remain unclear. (elsevierpure.com)
  • Results: Twenty patients (11 male and nine female) had extracutaneous lesions. (elsevierpure.com)
  • Conclusions: Patients with extracutaneous JXG had good outcomes, although those with intracranial lesions had serious permanent sequelae. (elsevierpure.com)
  • Histiocytosis Study Group of the Japanese Society of Pediatric Hematology/Oncology 2020, ' Long-term outcomes of children with extracutaneous juvenile xanthogranulomas in Japan ', Pediatric Blood and Cancer , vol. 67, no. 7, e28381. (elsevierpure.com)
  • biopsy 79.7%), osteoarticular tissue (n = 37, 57.8%), lungs (n = disclosed nonspecific sinus histiocytosis. (cdc.gov)
  • Sinus histiocytosis with massive lymphadenopathy (SHML), initially described in 1969 by Rosai and Dorfman,[ 22 ] is a rare, nonneoplastic lymphoproliferative disorder that is characterized by its histological features. (surgicalneurologyint.com)
  • Skin: Commonly seen are a rash which varies from scaly erythematous lesions to red papules pronounced in intertriginous areas. (wikipedia.org)
  • RESULTS: The most common initial skin lesion was erythematous, often crusted, vesiculopustules. (thedoctorsdoctor.com)
  • Erythema toxicum neonatorum: These lesions are small papules on an erythematous base, contain predominantly eosinophils, and do not heal with postinflammatory hyperpigmentation. (medscape.com)
  • It can appear as a single lesion in an organ, up to a large quantity of lesions in one organ. (wikipedia.org)
  • Prenatal ultrasounds detected a single lesion below the fetus' left eye that could not be further characterized. (thieme-connect.de)
  • When multiple lesions are scattered throughout an organ, it can be called a multifocal unisystem variety. (wikipedia.org)
  • Solitary lesions are more common than multiple lesions. (medscape.com)
  • When multiple lesions occur, the new osseous lesions appear within 1-2 years, and the condition is still classified as eosinophilic granuloma. (medscape.com)
  • A skin and lung biopsy both revealed histiocytosis of the "L" (Langerhans) group. (bvsalud.org)
  • Exposure to certain engineered nanomaterial s (ENMs) causes chronic lesions like lung fibrosis and cancer as a result of unresolved inflammation. (cdc.gov)
  • CFA is a now an outdated term more recently subdivided into separate specific entities, and as such Nicholson and colleagues reclassified these patients into UIP, NSIP, and desquamative interstitial pneumonia/respiratory bronchiolitis-associated interstitial lung disease (DIP/RBILD, the smoking-related ILDs) diagnoses. (radiologykey.com)
  • He had no subjective complaints, symptoms of recurrence or worsening and no appearance of another lesion ( Figure 4 and Figure 5 ). (scirp.org)
  • We herein describe the management of a 27-year-old woman who presented progressive spinal cord symptoms, secondary to an isolated intramedullary lesion, which had a histological confirmation of RDD. (surgicalneurologyint.com)
  • What Are the Symptoms of Histiocytosis? (tgh.org)
  • Eosinophilic granuloma is characterized by single or multiple skeletal lesions, and it predominantly affects children, adolescents, and young adults. (medscape.com)
  • Coronal T1WI shows a lesion involving the upper pituitary gland and stalk which has intermediate signal (a). (pacs.de)
  • Panhypopituitarism is the term used to describe deficiency of all pituitary hormones. (pediagenosis.com)
  • Soft-tissue lesion destroying the skull (blue arrows), leaving multiple hyperechoic calcifications inside, which show a twinkling artifact (red arrows). (pacs.de)
  • review of skull lesions. (pacs.de)
  • Scanogram of the patient's skull shows a geographic lytic lesion within the parieto-occipital region. (medscape.com)
  • In children, histiocytosis frequently involves the skull or other bones in one or more areas of the body. (tgh.org)
  • Causes of mortality and pathological lesions observed post-mortem in red squirrels ( Sciurus vulgaris ) in Great Britain. (cabi.org)
  • LCH is part of a group of syndromes called histiocytoses, which are characterized by an abnormal proliferation of histiocytes (an archaic term for activated dendritic cells and macrophages). (wikipedia.org)
  • He was being investigated for a dermatological lesion. (bvsalud.org)
  • Periodontitis associated with endodontic lesions involves a communication between the pulp and periodontal tissues. (merckmanuals.com)
  • Treatment consists of surgical excision of the lesions, with or without radiation therapy or chemotherapy. (biomedcentral.com)
  • Because of the rapid clinical evolution of the lesion in a patient with previous breast cancer, the pathologist (UM) decided to perform an incisional biopsy immediately to exclude malignancy. (biomedcentral.com)
  • The need for regular fol ow-up logic evaluation was within normal lim- lesion revealed significant dermal in- with history taking, clinical examina- its. (who.int)
  • Eight of thirteen patients who experienced continuous clinical improvement during follow-up had at least one target lesion SUV increased by FDG-PET which decreased in subsequent scans without changing treatment strategy. (fdocument.org)
  • The clinical spectrum of xanthomatous lesions of the eyelids. (nih.gov)
  • Thus, a benign fibro-osseous lesion was diagnosed and follow-up was recommended. (medscape.com)
  • these include infections, traumatic lesions, and neoplasms. (medscape.com)
  • Histiocytosis and Neoplasms of Macrophage-Dendritic Cell Lineages: Multimodality Imaging with Emphasis on PET/CT. (nih.gov)
  • Similar lesions may occur within the lungs, skin, and stomach, either as a unifocal lesion or as part of multifocal disease. (medscape.com)
  • Unifocal LCH, also called eosinophilic granuloma (an older term which is now known to be a misnomer), is a disease characterized by an expanding proliferation of Langerhans cells in one organ, where they cause damage called lesions. (wikipedia.org)
  • Eosinophilic granuloma may masquerade as an aggressive periodontitis,[8] therefore eosinophilic granuloma should be considered when an expanding lytic jaw lesion is encountered. (medscape.com)
  • The femoral diaphyseal lesion, periostelal reaction, and adjacent soft tissues present strong contrast enhancement. (pacs.de)
  • The disease may mainfest itself in infancy or early childhood in a rapidly fatal form in which the lesions are widely distributed both through the soft tissues (especially the lymphoid tissues) and the skeleton (so-called Letterer-Siwe disease, reticulosis or nonlipid histiocytosis). (jamanetwork.com)
  • citation needed] The disease has gone by several names, including Hand-Schüller-Christian disease, Abt-Letterer-Siwe disease, Hashimoto-Pritzker disease (a very rare self-limiting variant seen at birth) and histiocytosis X, until it was renamed in 1985 by the Histiocyte Society. (wikipedia.org)
  • CONCLUSIONS: Vesiculopustular lesions are common in congenital/neonatal LCH, but the morphologic characteristics of lesions are not helpful in predicting the extent of disease. (thedoctorsdoctor.com)
  • Erdheim - Chester disease (ECD) is a rare multi-systemic form of histiocytosis. (fdocument.org)
  • Single target lesion SUV elevation according to FDG-PET do not accurately demonstrate disease progression, but serial FDG-PET imaging effectively discriminate treatment response. (fdocument.org)
  • Term "hodgkin's disease" by Wilks in 1865. (fdocuments.net)
  • We combined search terms for the primary disease (tuberculosis), the diagnostic test (computed tomography) and pattern (cystic disease). (journalpulmonology.org)
  • Depending on the extent of the condition, histiocytosis may be treated with chemotherapy and/or steroids. (tgh.org)
  • 1 ] Lesions are multifocal in about 5% of cases. (cancer.gov)
  • The diagnostic process for histiocytosis typically begins with a physical examination, blood work and imaging studies. (tgh.org)
  • Term Lymphomas was initially used to describe benign counterparts of of Lymphosarcoma. (fdocuments.net)
  • It is hypothesized that bronchiolar destruction in PLCH is first attributed to the special state of Langerhans cells that induce cytotoxic T-cell responses, and this is further supported by research that has shown an abundance of T-cells in early PLCH lesions that are CD4+ and present early activation markers. (wikipedia.org)
  • The pathologic hallmark of PLCH is the accumulation of Langerhans and other inflammatory cells in small airways, resulting in the formation of nodular inflammatory lesions. (nih.gov)
  • Only about 10% of these congenital lesions have an associated tract or tail with an intracranial extension. (jcimcr.org)