NeuronalNeuronsExcitotoxicAxonsEpilepsyReceptorsSummarizeTemporalEndogenousInhibitory effectNeurorestorative effectsFunctionalLateralIschemiaHippocampusMechanicalBehaviorBrainNeuroprotectiveNerveModelReceptorInhibitsPotentMolecularInvestigateStudiesResultsRoleAnimalsTreatmentFindingsActivitySideLevelsSmallFigureSystemBlood
Neuronal5
- We designed this study to investigate the potential of extract of Asparagus racemosus against kainic acid (KA)-induced hippocampal and striatal neuronal damage. (raysahelian.com)
- In this review, we summarize the role of Sprouties in the lesioned central and peripheral nervous system with particular reference to Sprouty2 that is upregulated in various experimental models of neuronal degeneration and regeneration. (springer.com)
- On the contrary, knockdown of Sprouty proteins increases proliferation of activated astrocytes and, consequently, reduces secondary brain damage in neuronal lesion models such as kainic acid-induced epilepsy or endothelin-induced ischemia. (springer.com)
- Since oxidative stress activates protein kinase D1 (PKD1) in tumor cells, we investigated the effect of excitotoxicity on neuronal PKD1 activity. (nature.com)
- Before discussing the insights gained from the perforant path lesion model, we first highlight features of neuronal and non-neuronal plasticity that drive adaptive and maladaptive changes in brain circuits. (frontiersin.org)
Neurons4
- Intrastriatal injections of quinolinic acid, an N -methyl-D-aspartate (NMDA) receptor agonist, selectively affect medium-sized GABA-ergic spiny projection neurons, sparing the striatal interneurons and closely mimicking the neuropathology seen in HD. (medscape.com)
- Given the increasing role of adult-generated new neurons in the function of the dentate gyrus, we also compare the response of newborn and mature granule cells following lesioning of the perforant path. (frontiersin.org)
- This classic lesion provided some of the first evidence for structural plasticity following injury in the CNS, and also provides an opportunity to examine the injury response of some of the most highly plastic neurons in the brain, adult-generated newborn granule cells. (frontiersin.org)
- FGFR1) on projecting basal forebrain cholinergic neurons suggests that FGF-2 acts directly on these neurons to induce the lesion-induced sprouting response. (jneurosci.org)
Excitotoxic2
- The excitotoxic lesion in brain was produced by intra-hippocampal and intra-striatal injections of kainic acid to ketamine and xylazine anesthetized mice. (raysahelian.com)
- TEM confirmed that the delivery of kainic acid to god mode inner ear in our model causes characteristic signs of excitotoxic lesions, such as the swelling and retraction of nerve endings, similar to those previously reported in rat models Brugeaud et al. (mschf.org)
Axons1
- Because perforant path axons are lesioned at a site remote from the dentate, this model is particularly useful to evaluate axonal sprouting from other pathways terminating in the dentate gyrus. (frontiersin.org)
Epilepsy3
- The purpose of this study was to evaluate the effects of anakinra, lamotrigine, and their combination on epileptogenesis using the rat lithium-pilocarpine model of temporal lobe epilepsy. (bvsalud.org)
- The P2X7 receptor was identified as a miR-22 target and co-injection of a P2X7 receptor antagonist mitigated the epilepsy phenotype in mice given the ASO inhibitor of miR-22 [ 16 ]. (researchsquare.com)
- On the model of limbic epilepsy caused by the systemic administration of kainic acid and accompanied by neurodegeneration, the possibility of modulating the pathological effects of zinc is shown. (ihna.ru)
Receptors2
- Excitotoxicity refers to the neurotoxic effect of excitatory amino acids in the presence of excessive activation of postsynaptic receptors. (medscape.com)
- A subfamily of G-PROTEIN-COUPLED RECEPTORS that bind the neurotransmitter DOPAMINE and modulate its effects. (lookformedical.com)
Summarize1
- In this review, we summarize a classic injury model, lesioning of the perforant path, which removes the main extrahippocampal input to the dentate gyrus. (frontiersin.org)
Temporal1
- The value of radiosurgery as a "lesion generator" was based on small and large animal studies that defined the critical dose, the volume, and the temporal evolution of the radiosurgical lesion. (surgicalneurologyint.com)
Endogenous1
- Kynurenic acid (KYNA) is an endogenous tryptophan (Trp) metabolite known to possess neuroprotective property. (mdpi.com)
Inhibitory effect1
- 2013. Green asparagus (Asparagus officinalis) prevented hypertension by an inhibitory effect on angiotensin-converting enzyme activity in the kidney of spontaneously hypertensive rats. (raysahelian.com)
Neurorestorative effects2
- However, over recent years, it became clear that RTKs cannot be sufficiently activated by growth factors or receptor agonists in the adult and aging brain to exert significant neuroprotective or neurorestorative effects. (springer.com)
- It also can enhance recovery from a traumatic brain injury and/or ischemic attack by decreasing the size of damage and elicit neurorestorative effects, particularly of long-term potentiation (LTP). (mentalhealthdaily.com)
Functional4
- The history of stereotactic radiosurgery goes back almost as far as the history of functional neurosurgery when tools were being developed not only for stereotactic localization but also for lesioning. (surgicalneurologyint.com)
- 24 ] At a time when functional destruction of normal brain required thermal energy or chemical injection, Leksell crossfired photon or proton radiation beams to achieve his goal. (surgicalneurologyint.com)
- Subsequently, functional radiosurgery was compared to microsurgical, chemical, and thermal electrode-based techniques to create a lesion. (surgicalneurologyint.com)
- To address the functional significance of this increase in FGF-2, we assessed the magnitude of cholinergic sprouting in animals receiving chronic intracerebroventricular infusions of neutralizing antibodies specific for FGF-2 and compared it with that observed in lesioned animals receiving infusate controls. (jneurosci.org)
Lateral1
- Antisense oligonucleotides were infused at a constant rate into the cerebral lateral ventricles of rats and their effect on anxiety-like behavior and food intake was monitored. (nartsignaling.com)
Ischemia2
- The effects of ischemia on the accumulation of nitrites in cultures of cerebellar granule cells were studied. (ihna.ru)
- The effects of ischemia (oxygen-glucose deprivation) and reoxygenation on the morphology of cultured rat cerebellar seed cells and the activity of caspase-3 in these cells were studied. (ihna.ru)
Hippocampus4
- The results showed impairment of hippocampus and striatal regions of brain after KA injection marked by an increase in lipid peroxidation and protein carbonyl content and decline in glutathione peroxidase (GPx) activity and reduced glutathione (GSH) content. (raysahelian.com)
- miR-22-3p (hereafter miR-22), a conserved miRNA that is expressed throughout the body, including the brain [ 14 , 15 ], was previously identified among upregulated miRNAs within the mouse hippocampus contralateral to the epileptogenic zone in the intraamygdala kainic acid model of status epilepticus [ 16 ]. (researchsquare.com)
- Here we focus on the perforant path lesion, a brain injury model that interrupts the main excitatory input to the dentate gyrus of the hippocampus. (frontiersin.org)
- caused by systemic administration of kainic acid, it has been shown that convulsive activity correlates with indicators of oxidative stress, apoptosis and expression of the AP-1 transcription factor in the rat hippocampus. (ihna.ru)
Mechanical1
- Surgical approaches for this purpose include destructive lesioning with different mechanical or biologic agents or energy sources, non-destructive electrical modulation, and cellular or chemical augmentation. (surgicalneurologyint.com)
Behavior1
- The treatment alleviated the impairments in activity level, exploratory behavior, and anxiety but had a relatively weak effect on TLE-induced impairments in social behavior and memory. (bvsalud.org)
Brain4
- In animal models of paraoxon intoxication, the combination of oxaloacetic acid (OAA) and glutamate-oxaloacetate transaminase (GOT) were tested for efficacy of preventing brain damage. (mentalhealthdaily.com)
- Radiosurgical techniques were used to create brain lesions without neurophysiologic guidance. (surgicalneurologyint.com)
- 25 ] Application of radiosurgery to intraparenchymal brain lesioning would require more sophistication. (surgicalneurologyint.com)
- Mice lacking miR-22 displayed normal behaviour and brain structure and developed similar status epilepticus after intraamygdala kainic acid compared to wildtype animals. (researchsquare.com)
Neuroprotective1
- 6 Recent experimental studies have shown that licofelone exerts anti-inflammatory properties, 7 anti-asthmatic 8 and neuroprotective effects in the central nervous system. (j-epilepsy.org)
Nerve1
- Furthermore, downregulation of Sprouty2 improves nerve regeneration in the lesioned peripheral nervous system. (springer.com)
Model2
- Inhibiting miR-22 using intracerebroventricular injection of an ASO increased the frequency of spontaneous seizures, indicating a protective role in the model [ 16 ]. (researchsquare.com)
- We have utilized lithium-pilocarpine model of SE in adult Wistar rats to assess the potential effect of licofelone on seizure susceptibility. (j-epilepsy.org)
Receptor1
- Intrastriatal injections of kainic acid, an agonist of a subtype of glutamate receptor, produce lesions similar to those seen in HD. (medscape.com)
Inhibits1
- previously named ML3000) is a substrate analogue of arachidonic acid which inhibits cyclooxygenase type 1 and 2 (COX1 and COX2) and 5-lipoxygenase (5-LOX), decreasing prostaglandins and leukotrienes production. (j-epilepsy.org)
Potent1
- Pharmacological Mechanisms of Antidepressant Drug Action Most antidepressants have potent pharmacological effects that cause increased synap- tic levels of the monoamine neurotransmitters NE andor 5-HT and in some cases DA. (forexsignal300.com)
Molecular1
- FGF-2 immunoreactivity was localized within GFAP-positive hypertrophic astrocytes distributed specifically within the denervated outer molecular layer after the lesion. (jneurosci.org)
Investigate1
- Thus, in the present study we investigate possible effects of licofelone on prevention and termination of SE. (j-epilepsy.org)
Studies1
- These latter studies suggest that a unique post-lesion environment affects development of dendritic spines and new synapses in deafferented laminae. (frontiersin.org)
Results1
- In general, the results demonstrated that ointments, due to occlusiveness and the ability to maintain moisture under the damaged area, offered improvements when compared to lesions without any treatment. (blogspot.com)
Role1
- It plays a key role in functions such as: amino acid synthesis, citric acid cycle, fatty acid synthesis, gluconeogenesis, glyoxylate cycle, and the urea cycle. (mentalhealthdaily.com)
Animals1
- In fact, many of these animals exhibited virtually no sprouting at all despite histological verification of complete lesions. (jneurosci.org)
Treatment3
- Over 50 of these chemicals are proved or presumptive as cancer causation agents in humankind [url=https://nextgenrealty.com/bulletin/summary5/brief11/]purchase kamagra gold 100mg mastercard[/url] erectile dysfunction treatment injection therapy. (wgc2010.sk)
- The Control, Treatment, and Reference Standard groups were able to close the lesion, as measured by the wound healing rate determination and follow-up photographs. (blogspot.com)
- For long time, metronidzole (MTZ) was considered as a basic drug for blastocystosis treatment, however reports of treatment failure as well as its well-known side effects has promoted the search for more safe and effective alternatives. (blogspot.com)
Findings1
- Our findings showed that anticonvulsive effects of licofelone on SE could be mediated by iNOS. (j-epilepsy.org)
Activity1
- 5 Licofelone was developed in order to find compounds with anti-inflammatory activity to obviate the gastrointestinal side-effects related to non-steroidal anti-inflammatory drugs and its safety profile compared to these agents has been authenticated in healthy individuals. (j-epilepsy.org)
Side2
- Hold Mechanism of Medicines of Latvia is constant a community media rivalry between 7-11 November 2016 to recommend reporting of suspected medicines side effects, as element of an EU-wide awareness week. (wgc2010.sk)
- Shape Intermediation of Medicines of Latvia is on-going a venereal media toss one's hat in the ring between 7-11 November 2016 to kick upstairs reporting of suspected medicines side effects, as part of an EU-wide awareness week. (wgc2010.sk)
Levels2
- Upon simultaneous administration of oxaloacetic acid and glutamate-oxaloacetate transaminase, levels of blood glutamate rapidly plummet. (mentalhealthdaily.com)
- Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS. (lookformedical.com)
Small1
- 10 Anticancer effects of this agent in lung, 11 colon and small intestine 12 have been proved. (j-epilepsy.org)
Figure1
- Figure 5: Occlusal radiograph showing buccal expansion of the lesion Click here to view. (chuchouzhuangzhi.com)
System1
- We also evaluated whether the nitrergic system could participate in this effect of licofelone. (j-epilepsy.org)
Blood2
- Does asparagus extract or fresh vegetable effect high blood pressure? (raysahelian.com)
- Specifically, researchers documented that blood-glutamate scavengers (oxaloacetic acid and glutamate-oxaloacetate transaminase) provided neuroprotection against the paraoxon. (mentalhealthdaily.com)