AgonistsStriatal dopamineReceptorsSubstantia nigraRatsDopaminergicNeuronsHaloperidolAgonistSerotoninParkinson'sStriatumBehaviorMidbrainDenervationAdrenergicSelectivePathwaysAnterior pituitaryPharmacologyReceptor blockadePituitary stalkProlactinNeuronGlutamateIncreasesAcuteBrainRodentGeneModelReleaseMechanismsImpulsivityDiagnosisFunctionalSurgicalRoleRapidlyEmotionEffectTumorLevelsTreatmentSyndromeControlCellsExpression
Agonists5
- There is much data that indicate that dopamine agonists and antagonists modulate LI in rats and in normal humans. (wikipedia.org)
- Dopamine agonists, such as amphetamines, abolish LI whereas dopamine antagonists, such as haloperidol and other anti-psychotic drugs, produce a super-LI effect. (wikipedia.org)
- Potentially, serotoninergic agonists or antagonists, targeting subtype-selective serotonin receptors, may be viable therapeutic adjuncts in PD. (etsu.edu)
- However, patients with LID receive combination therapies that often include dopamine agonists. (lu.se)
- We hypothesized that such a dopamine antagonist with physicochemical properties similar to agonists would exert antidyskinetic and antipsychotic effects in states of dysregulated dopaminergic signaling while having little negative impact on physiologic dopamine transmission and, hence, minimal liability for side effects related to dopamine -dependent functions. (bvsalud.org)
Striatal dopamine3
- Using the 6-hydroxydopamine lesion model of Parkinson's disease and differential display PCR, we have identified a set of more than 30 genes whose expression rapidly increases in response to stimulation of striatal dopamine D 1 receptors. (jneurosci.org)
- The use of dopamine antagonists as antipsychotics can result in tardive dyskinesia, while drugs such as cocaine that increase striatal dopamine release can cause dependency and addiction (for review, see Hyman, 1996 ). (jneurosci.org)
- OBJECTIVE: the present study used pharmacological, event-related fMRI to test the hypothesis that striatal dopamine is important for the manipulation of information in working memory. (exeter.ac.uk)
Receptors15
- In 1979, Kebabian and Calne determined that at least two dopamine receptors mediated this system, and for the next decade the actions of dopamine were viewed as being mediated by two dopamine receptors, D1 and D2. (psychiatrictimes.com)
- There has been an explosion of interest and information regarding dopamine receptors in the human brain. (psychiatrictimes.com)
- In the last three years, seven distinct dopamine receptors have been identified. (psychiatrictimes.com)
- This article is intended as the clinician's practical guide to the current understanding of dopamine receptors and their role in neuropsychiatric illness. (psychiatrictimes.com)
- For a comprehensive review of dopamine receptors, see Niznik and Van Tol, and Gingrich and Caron. (psychiatrictimes.com)
- Central-type benzodiazepine receptors mediate the antidopaminergic effect of clonazepam and melatonin in 6-hydroxydopamine lesioned rats: involvement of a GABAergic mechanism. (mcmaster.ca)
- Dopamine receptors in the central nervous system. (mcmaster.ca)
- Dopamine acts in the striatum through the D 1 and D 2 subfamilies of G-protein-coupled receptors. (jneurosci.org)
- Serotoninergic nerves are known to modulate sensitization of dopamine receptors (DA-R) in a rodent model of Parkinson's disease (PD). (etsu.edu)
- This effect profile is attributed to interactions at dopamine D2/D3 receptors, with a 6- to 8-fold preference for the D3 subtype. (bvsalud.org)
- It has been found that dopamine D 2 receptors play a critical role in regulating PPI, but the mechanisms underlying the role of dopamine D 2 receptors in regulating PPI remain largely elusive. (psych.ac.cn)
- The review focuses on molecular mechanisms underlying the regulating effect of dopamine D2 receptors on sensory gating, so as to promote the in-depth study of sensory gating function in schizophrenia. (psych.ac.cn)
- Histamine H receptor activation reduces the impairment in prepulse inhibition (PPI) of the acoustic startle response and Akt phosphorylation induced by MK-801 (dizocilpine), antagonist at N-Methyl-d-Aspartate (NMDA) receptors. (psych.ac.cn)
- In order to determine whether signaling at the central ghrelin receptors is necessary for maintenance of normal levels of impulsive behavior, DRL performance was assessed following ghrelin receptor blockade with central infusion of a ghrelin receptor antagonist. (nature.com)
- CONCLUSIONS: These results support models of dopamine function that posit a 'gating' function for dopamine D2 receptors in the striatum, which enables the flexible updating and manipulation of information in working memory. (exeter.ac.uk)
Substantia nigra3
- Similar results were achieved by selectively inhibiting dopamine synthesis with a-methyl-p-tyrosine or through bilateral lesions of the substantia nigra with 6-hydroxydopamine. (erowid.org)
- Differences in the behavioral profile of circling under amphetamine and apomorphine in rats with unilateral lesions of the substantia nigra. (mcmaster.ca)
- In the present work, we describe the effects of dopamine depletion after the administration of 6-hidroxidopamine (6-OHDA) into the substantia nigra pars compacta of male rats submitted to the pilocarpine model of epilepsy. (scielo.br)
Rats6
- At the highest regimen, the mean firing rate of 5-HT neurons was 100% higher than in control rats, but unaffected in NE-lesioned rats. (biopsychiatry.com)
- OBJECTIVE: Using 6-hydroxydopamine-lesioned rats as a model, we aimed to establish whether an adjunct treatment with the D2/3 agonist ropinirole impacts on patterns of LID-related neuroplasticity and drug responses. (lu.se)
- 2018-02-23 Rotational behavior of rats bearing unilateral 6-OHDA lesions of the nigrostriatal dopaminergic pathway after amphetamine challenge (5 mg/kg, i.p.) before (stipled bars) and 6 weeks after (cross-hatched bars) micrografting of fetal dopaminergic cells into either the striatum or nigra (single grafts) and micrografting into both the striatum and nigra (double grafts). (netlify.app)
- Intravenous α-calcitonin gene-related peptide (αCGRP) (8-37) produced CPP and elicited NAc dopamine release selectively in rats treated with dural IMs. (arizona.edu)
- Prior lesion of the rACC or treatment with systemic sumatriptan or αCGRP (8-37) abolished RVM lidocaine-induced CPP in IM-treated rats. (arizona.edu)
- Sumatriptan treatment blocked NAc dopamine release in IM-treated rats receiving RVM lidocaine. (arizona.edu)
Dopaminergic11
- It is likely that a significant proportion of the 4-15% of de novo patients recruited for recent clinical trials with antiparkinsonian drugs who have no evidence of nigrostriatal dopamine denervation on functional imaging (subjects without evidence of dopaminergic deficit (SWEDDs)) have tremulous syndromes other than PD. (bmj.com)
- This is supported by long term follow-up showing minimal clinical deterioration, no response to dopaminergic therapy and in some cases no evidence on repeat functional imaging of dopamine denervation. (bmj.com)
- Dopaminergic pathways, sometimes called dopaminergic projections, are the sets of projection neurons in the brain that synthesize and release the neurotransmitter dopamine. (netlify.app)
- New York: Man kan se ADHD som slutresultatet ("the final common path- way") av en rad olika of the three dopaminergic genesDRD2, D beta H, and DAT1. (netlify.app)
- Evidence shows that dopamine first evolved as a neurotransmitter for movement, implicating the nigrostriatal pathway as the most ancestral of the four dopaminergic pathways. (netlify.app)
- Cyanide and central nervous system : a study with focus on brain dopamine of cyanide, in particular, the effects on dopaminergic pathways were studied. (netlify.app)
- It is present in axons and terminals of a subpopulation of dopaminergic neurons acid (dopac) and the rat mesolimbic dopaminergic pathway: drug effects and The most prominent dopamine pathways originate in the midbrain. (netlify.app)
- Dopaminergic means "related to dopamine " (literally, "working on dopamine"), dopamine being a common neurotransmitter. (netlify.app)
- Dopaminergic substances or actions increase dopamine-related activity in the brain. (netlify.app)
- Dopaminergic brain pathways facilitate dopamine-related activity. (netlify.app)
- CPP was blocked by intra-NAc α-flupenthixol, a dopaminergic antagonist. (arizona.edu)
Neurons2
- Progressive loss of nigrostriatal dopamine (DA) neurons is the neuropathological hallmark of Parkinson's disease (PD). (jneurosci.org)
- For example, cocaine administration leads to altered responsiveness of striatal medium spiny neurons to dopamine ( Henry and White, 1991 ). (jneurosci.org)
Haloperidol1
- The dopamine receptor antagonist haloperidol was also effective in this regard. (erowid.org)
Agonist4
- Parlodel (bromocriptine mesylate) is a dopamine receptor agonist used to treat certain conditions caused by a hormone imbalance in which there is too much prolactin in the blood (hyperprolactinemia), and to treat these disorders when they are caused by brain tumors that can produce prolactin. (rxlist.com)
- Parlodel® (bromocriptine mesylate) is an ergot derivative with potent dopamine receptor agonist activity. (rxlist.com)
- The chemical design idea was to develop a new type of DA D3/D2 receptor type antagonist built on agonist rather than antagonist structural motifs. (bvsalud.org)
- The compound, initially tested in patients with hematological malignancies and solid tumors, acts as a bitopic antagonist of the G protein-coupled receptor (GPCR), dopamine receptor D2 (DRD2), and an allosteric agonist of the mitochondrial protease caseinolytic protease P (ClpP). (oncozine.com)
Serotonin1
- Functional analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis resulted in the differentially expressed proteins in the FM and OA groups are mostly involved in the coagulation and complement system-related pathways, serotonin pathways, dopamine pathways, glutamate pathways and acute phase reactions. (ncl.edu.tw)
Parkinson's3
- Also at this time researchers discovered that dopamine depletion in the striatum played a role in Parkinson's disease. (psychiatrictimes.com)
- Current evidence indicates that symptoms of Parkinson's disease are related to depletion of dopamine in the corpus striatum. (nih.gov)
- Administration of dopamine is ineffective in the treatment of Parkinson's disease apparently because it does not cross the blood-brain barrier. (nih.gov)
Striatum1
- Dopamine acting in the striatum is necessary for normal movement and motivation. (jneurosci.org)
Behavior2
- For clinicians to make effective use of the new drugs that will emerge from this active research area, they will need to understand how dopamine affects behavior and keep abreast of the developments in dopamine pharmacology. (psychiatrictimes.com)
- We further evaluated the impact of ghrelin on dopamine-related gene expression and dopamine turnover in brain areas key in impulsive behavior control. (nature.com)
Midbrain1
- In the brain, the principal dopamine systems arise from cells in the midbrain and the hypothalamus. (psychiatrictimes.com)
Denervation1
- I found that progressive denervation may alter DA signaling by three independent mechanisms depending on degree of denervation and macroscopic morphology of the lesion. (jneurosci.org)
Adrenergic3
- adrenergic receptor antagonists i.e. typically propranolol (Inderal) are used in management of hypertrophic obstructive cardiomyopathy. (pharmacology2000.com)
- The effectiveness of adrenergic antagonists in this setting is likely due to reduced outflow tract pressure gradients. (pharmacology2000.com)
- adrenergic receptor antagonists have also shown helpful in management of acute dissecting aortic aneurysm due to -blocker-mediated reduction in myocardial contractility and reduced rate of force development . (pharmacology2000.com)
Selective5
- Although these results strongly implicate dopamine release in the long-term neurochemical effects of MDMA, protection was also provided by selective 5-HT 2 antagonists indicating that the neurotoxicity is dependent upon the release of both dopamine and 5-HT. (erowid.org)
- Thus, hippocampal and septal lesions interfere with the development of LI, as do lesions in selective portions of the nucleus accumbens. (wikipedia.org)
- In particular, compounds modulating D1 receptor signaling had a stronger effect in the L-dopa-only group, whereas both amantadine and the selective NMDA antagonist MK801 produced a markedly larger antidyskinetic effect in L-dopa-ropinirole cotreated animals. (lu.se)
- Here, we used functional Magnetic Resonance Imaging (fMRI) to investigate the effects the selective dopamine D(3) receptor antagonist GSK598809 on brain activation to food images in a sample of overweight and obese binge-eating subjects. (exeter.ac.uk)
- METHODS: Twenty healthy human subjects were scanned twice, once after placebo and once after sulpiride 400 mg, a selective DA D2 receptor antagonist, while performing a verbal working memory task requiring different levels of manipulation. (exeter.ac.uk)
Pathways3
- In addition, manipulations of putative dopamine pathways in the brain also have the expected effects on LI. (wikipedia.org)
- Dopamine Pathways. (netlify.app)
- 2006. Public domain Dopamine Pathways He. (netlify.app)
Anterior pituitary1
- The dopamine cells of the hypothalamus project via the tuberoinfundibular tract to the infundibulum and anterior pituitary. (psychiatrictimes.com)
Pharmacology2
- Preclinical Pharmacology of [2-(3-Fluoro-5-Methanesulfonyl-phenoxy)Ethyl](Propyl)amine (IRL790), a Novel Dopamine Transmission Modulator for the Treatment of Motor and Psychiatric Complications in Parkinson Disease. (bvsalud.org)
- At the level of in vivo pharmacology , IRL790 displays balancing effects on aberrant motor phenotypes , reducing l-DOPA -induced dyskinesias in the rodent 6-hydroxydopamine lesion model and reducing psychostimulant-induced locomotor hyperactivity elicited by pretreatment with either d-amphetamine or dizocilpine , without negatively impacting normal motor performance. (bvsalud.org)
Receptor blockade1
- In 1963, Carlsson first postulated that the effects of neuroleptics were secondary to dopamine receptor blockade. (psychiatrictimes.com)
Pituitary stalk2
- 150 ng/mL) may occur as a result of compression of the pituitary stalk by other space-occupying lesions in the region. (medscape.com)
- Increased prolactin levels possibly indicating a lesion in the hypothalamus or pituitary stalk. (doctorlib.info)
Prolactin2
- In this area, dopamine acts directly to inhibit the release of prolactin. (psychiatrictimes.com)
- Dopamine antagonist administration evaluates prolactin secretory reserve. (doctorlib.info)
Neuron1
- 1 Description 2 How to mature 3 Special requirements 4 Neuron location More dopamine is generated. (netlify.app)
Glutamate1
- Catatonia is caused by neurochemical abnormalities including low GABA activity in the frontal cortex, low dopamine (D2) activity in the basal ganglia, high glutamate-N-methyl-D-aspartate (NMDA)-activity in the parietal cortex, or a combination of these. (mhaus.org)
Increases1
Acute2
- Acute renal angle of the aqueous and thus clearing cells is the lesion. (marcagloballlc.com)
- Our data show that dopamine may play an important role on seizure severity in the pilo's model acute period, which seems to be due to dopamine inhibitory action on motor expression of seizure. (scielo.br)
Brain5
- Neuropsychological studies in pathological gamblers have identified core deficits in risky decision-making, which resemble the changes observed in patients with brain lesions with damage to the ventromedial prefrontal cortex. (cambridge.org)
- However, levodopa, the metabolic precursor of dopamine, does cross the blood-brain barrier, and presumably is converted to dopamine in the brain. (nih.gov)
- Computed tomography (CT) scanning and MRI studies of the brain may be important in ruling out intracranial lesions when the diagnosis of hepatic encephalopathy is in question. (medscape.com)
- Effect of the dopamine D3 receptor antagonist GSK598809 on brain responses to rewarding food images in overweight and obese binge eaters. (exeter.ac.uk)
- Because glioblastoma is an infiltrative disease and, at the time of diagnosis, tumor cells may have spread from the primary lesion into the adjacent brain tissue, surgical resection is often followed by adjuvant radiation and temozolomide chemotherapy. (oncozine.com)
Rodent1
- The overall findings demonstrate that an adulthood serotoninergic nerve lesion enhanced PCA-evoked DA exocytosis in a rodent model of severe PD, while susceptibility to oxidative stress was unchanged. (etsu.edu)
Gene1
- rs5326 is positioned in the 5′ untranslated region (UTR) of the DRD1 gene, which encodes the dopamine receptor D1, and was associated with an increased risk of ICDs. (netlify.app)
Model2
- Ablation of ChI dramatically reduces LID in a mouse model of PD created by 6-OHDA lesion. (neurodegenerationresearch.eu)
- Since the hippocampus is one of main structures in the development of this experimental model of epilepsy, the dopamine levels in this region were also determined after drug administration. (scielo.br)
Mechanisms1
- Because it is a very weak inhibitor of norepinephrine (NE) and dopamine (DA) reuptake, its mechanisms of action remain to be elucidated. (biopsychiatry.com)
Impulsivity1
- Reference Petry, Stinson and Grant 4 Common risk factors have been identified, including genetic markers influencing dopamine transmission, and personality traits linked to impulsivity. (cambridge.org)
Diagnosis1
- In this brief overview, the presentation, classification, and general investigation of pituitary lesions is followed by a discussion of the diagnosis and management of specific secretory subtypes. (bmj.com)
Functional1
- To investigate whether tenascin-C and tenascin-R may play important functional roles in the lesioned central nervous system, we have analysed their expression in the olivocerebellar system of the adult rat after 3-acetylpyridine-induced degeneration of nerve cells in the inferior olivary nucleus. (researchgate.net)
Surgical2
- Ideally investigate while memantine, alone with any lesion whose sample of suxamethonium can be needed in surgical intervention. (adailymiscellany.com)
- Guidelines from the Endocrine Society for the treatment of Cushing's syndrome recommend surgical resection of primary lesions as initial treatment of underlying Cushing's disease. (conduent.com)
Role3
- Dopamine plays an important role in controlling movement, emotion and cognition. (psychiatrictimes.com)
- The role of dopamine signaling in epileptogenesis. (scielo.br)
- RATIONALE: Dopamine (DA) plays an important role in working memory. (exeter.ac.uk)
Rapidly1
Emotion1
- In this pathway dopamine functions in emotion and reward systems. (netlify.app)
Effect1
Tumor1
- Treatment is aimed at correcting (or preventing) tumor compression by excising the disease-causing lesion, and at reducing GH and IGF-I levels to normal values. (orpha.net)
Levels1
- These are D2 antagonists that act by reducing dopamine levels. (netlify.app)
Treatment1
- Pharmacologic options for the treatment of acromegaly include: somatostatin analogs, growth hormone receptor antagonists and dopamine analogs. (conduent.com)
Syndrome1
- Lesion does not cross midline, which is typical of pigmented lesions in this syndrome. (medscape.com)
Control2
- Non-healing leads to optimize control cutaneous lesions has variable region. (adailymiscellany.com)
- In the cerebellar cortex, tenascin-C mRNA in Golgi epithelial cells was down-regulated 3 days after the lesion and returned to control values 80 days after the lesion. (researchgate.net)
Cells1
- After a lesion, the density of cells containing tenascin-R transcripts increased significantly in the inferior olivary nucleus and in the white matter of the cerebellar cortex. (researchgate.net)
Expression1
- Moreover, the expression of LID was partially attenuated by preventing ERK activation or a muscarinic receptor antagonist. (neurodegenerationresearch.eu)