• The discovery of RELIK extends the host range of lentiviruses to a fifth mammalian order and demonstrates that such viruses can also spread by vertical transmission and intragenomic proliferation, in addition to infectious horizontal transfer. (pnas.org)
  • By dating the invasion of the rabbit genome by the RELIK virus, we provide the first direct evidence that lentiviruses are ancient in origin. (pnas.org)
  • Although the virus we describe is defective, reconstruction of an infectious progenitor could provide novel insights into lentivirus biology and host interactions. (pnas.org)
  • a gammaherpesvirus isolated from goats which is closely related antigenically to ovine herpesvirus-2 (OvHV-2), the sheep associated malignant catarrhal fever virus. (thefreedictionary.com)
  • Evolutionary analyses of the genomic sequences of modern-day lentiviruses have suggested a relatively recent date for their emergence, but the failure to identify any endogenous, vertically transmitted examples has meant that their longer term evolutionary history and origin remain unknown. (pnas.org)
  • Thus, the lack of endogenous "genomic fossils" has precluded studies into the longer term evolutionary history and origin of lentiviruses ( 14 , 15 ). (pnas.org)
  • Despite being ancient, this subgroup contains many of the features found in present-day lentiviruses, such as the presence of tat and rev genes, thus also indicating an ancient origin for the complex regulation of lentivirus gene expression. (pnas.org)
  • Lentiviruses can integrate a significant amount of viral cDNA into the DNA of the host cell and can efficiently infect nondividing cells, so they are one of the most efficient methods of gene delivery . (wikipedia.org)
  • Recently, retroviral vector-mediated gene transfer, as well as the broader gene therapy field, has been re-invigorated with the development of a new class of retroviral vectors which are derived from lentiviruses. (biomedcentral.com)
  • Vectors derived from lentiviruses have provided a quantum leap in technology and seemingly offer the means to achieve significant levels of gene transfer in vivo . (biomedcentral.com)
  • To antagonize APOBEC3-mediated antiviral action, lentiviruses have acquired viral infectivity factor (Vif) as an accessory gene. (biomedcentral.com)
  • The events leading to the discovery and characterization of the animal and human lentiviruses, as described in this paper, are remarkably similar. (biomedfrontiers.org)
  • 2 kb of lentivirus sequence identity (34 in total). (pnas.org)
  • 6. A method according to claim 1, wherein the method excludes administering to the subject (1) a peptide that comprises an amino acid sequence corresponding to a portion of a non-Gag lentivirus polypeptide, or (2) an antigen-presenting cell that has been contacted with a peptide according to (1). (patentsencyclopedia.com)
  • The importance of placing the newly isolated human retrovirus in the group of animal lentiviruses was pointed out by Montagnier , who suggested that relevant information about the pathogenic mechanisms in AIDS might be drawn from comparison with animal models. (biomedfrontiers.org)