Lentiviral vector genetic vectors. Medical search. Frequent questions

Several virus types have been studied for use as viral vectors in gene therapy, including adenovirus, lentivirus, retrovirus, and adeno-associated virus (AAV). (biopharminternational.com)
Methods The Cx40 gene fragment was cloned from H9c2 cells by PCR and linked with lentivirus vector pLVX-IRES-Puro to obtain the recombinant plasmid pLVX-Flag-Cx40. (bvsalud.org)

For instance, Agilent has retroviral and lentiviral vector systems that are pseudotyped to achieve a wide target range. (biopharminternational.com)
One example is adoptive cell therapy with T cells that were genetically modified with gamma-retroviral and lentiviral (LV) delivery vectors to express a CD19-specific chimeric The advances in genetic engineering have enabled us to confer T cells new desired functions or delete their specific undesired endogenous properties for improving their antitumor function. (uni-wuerzburg.de)
One example is adoptive cell therapy with T cells that were genetically modified with gamma-retroviral and lentiviral (LV) delivery vectors to express a CD19-specific chimeric antigen receptor (CAR) for cancer treatment. (uni-wuerzburg.de)
The vectors produced here are onco-retroviral and lentiviral vectors. (lu.se)

The market, by retroviral vectors, has been further segmented into lentiviral vectors and gamma-retroviral vectors. (medgadget.com)

Scholars@Duke publication: Transduction of human antigen-presenting cells with integrase-defective lentiviral vector enables functional expansion of primed antigen-specific CD8(+) T cells. (duke.edu)
Compared to adenovirus and AAV, retrovirus-based vectors show relatively low transduction efficiency in-vivo , but their advantage lies in their ability to integrate stably and confer long-term transgene expression in dividing tissues. (biopharminternational.com)
Excellent safety profile, high efficiency of transduction of hepatocytes, and evidence of long-term efficacy deriving from early-phase trials have established AAV vectors as the platform of choice for the treatment of enzyme deficiencies and metabolic disorders. (abdominalkey.com)
Transduction by oncogenic lentiviral vectors of neural stem cells (NSCs), astrocytes, or even mature neurons in the brains of mice can give rise to malignant gliomas. (cellimagelibrary.org)

No adverse effect linked to the use of a retroviral vector has been reported, nor has there been any lack of stability of the graft of genetically modified cells. (inserm.fr)
Based on the state-of-play in Belgium, this chapter discusses examples of regulatory journeys of applications with genetically modified viral vectors and novel vaccine candidates that have been reviewed by GMO national competent authorities in Belgium and in Europe. (intechopen.com)

The lentiviral RNA and the viral proteins then assemble and the newly formed virions leave the host cell when enough are made. (wikipedia.org)
BMSCs can also be engineered to secrete a variety of different proteins in vitro and in vivo that could potentially treat a variety of serum protein deficiencies and other genetic or acquired diseases [ 13 ]. (hindawi.com)
Targeting viral vector particles to predetermined cell types will be obtained through genetic engineering of retroviral envelopes or adenoviral capsid proteins, by using single chain antibody fragments or tumour cell receptor ligands. (europa.eu)
ii) gutless adenoviral vectors, by genetic modifications of the fibre and hexon proteins of the adenoviral capsids, as well as through the use of combined cell type specific and inducible promoters. (europa.eu)
Some vectors, such as adenoviruses, have a fairly broad tropism, and the target range is often modified by engineering part of the envelope proteins. (biopharminternational.com)
Lentiviral gene delivery systems consist of packaging (or helper) plasmids that code for viral structural and regulatory proteins, and a gene transfer vector that contains the transgene expression cassette ( Srinivasakumar, 2001 ). (peerj.com)
Once a vector delivers the transgene inside the nucleus-where DNA is packaged in chromosomes-the cell begins to generate new proteins to improve functioning. (genepossibilitieshcp.com)

In this study, we have evaluated the ability of HIV vectors to transfer genes into retinal cells. (nih.gov)
Lentiviral vectors in gene therapy is a method by which genes can be inserted, modified, or deleted in organisms using lentiviruses. (wikipedia.org)
Lentiviruses are modified to act as a vector to insert beneficial genes into cells. (wikipedia.org)
citation needed] HIV-derived lentiviral vectors have been widely developed for their ability to target specific genes through the coactivator PSIP1. (wikipedia.org)
This target specificity allows for the development of lentiviral gene vectors that do not carry the risk of randomly inserting themselves into normally functioning genes. (wikipedia.org)
A common suicide/reporter gene will first be used for all vectors, and then additional therapeutic genes will be tested. (europa.eu)
This leads to Phase-III of this research programme in which the most powerful targeted vectors will be chosen to be developed further, by inserting novel powerful therapeutic genes into them. (europa.eu)
Viral vector systems are gutted viruses where the packaging signals (e.g., the genetic signals that target the wrapping into the viral particles) are fused to the genes of interest (the payload), and the remaining necessary elements are placed on separate genetic elements, often three or more, says Carsten Carstens, senior scientist, R&D, Agilent Technologies. (biopharminternational.com)
Further research is needed to expand our knowledge of genetic interactions, modifier genes, and environmental factors that influence disease progression. (alliedacademies.org)
In the first part of the study, we engineered CAR T cells through non-viral Sleeping Beauty (SB) transposition of CAR genes from minimalistic DNA vectors called minicircles rather than conventional SB plasmids. (uni-wuerzburg.de)
To enable functional analysis of human transposase-derived genes, we combined forward chemical genetic hypoxanthine-guanine phosphoribosyltransferase 1 ( HPRT1 ) screening with massively parallel paired-end DNA sequencing and structural variant genome assembly and analysis. (biomedcentral.com)
9,10 Before carrying a transgene into a patient's cells, the vectors are modified to remove the viral disease-causing genes as well as their ability to replicate. (genepossibilitieshcp.com)
2 These vectors can be applied for in-vivo approaches and typically deliver small genes or DNA packages due to size limitations. (genepossibilitieshcp.com)
2 Similar to AAVs, these vectors are often used to deliver genetic material into nondividing cells, but they can carry much larger genes if needed for the application. (genepossibilitieshcp.com)

Although several gene delivery approaches have been tested in preclinical animal models, including viral and nonviral approaches, adeno-associated virus (AAV) vector-based gene transfer remains the most popular gene delivery platform for the liver, with a few trials entering phase III. (abdominalkey.com)
In the bigger picture, these new treatment options need to be weighed against the possibility of cure of hemophilia through gene therapy: two adeno-associated virus (AAV) vector-based products have been approved for clinical use, and more are in the pipeline. (cdc.gov)

The market, on the basis of type, has been segmented retroviral vectors, adenoviral vectors, adeno-associated viral vectors, and other viral vectors. (medgadget.com)
The targeting strategies will be implemented in retroviral, lentiviral, and gutless high capacity adenoviral vectors. (europa.eu)
During Phase-I, we will construct the novel targeted retro-, lenti- and adenoviral vectors. (europa.eu)

But adenovirus vectors don't last long, so therapy must be frequently re-administered. (health.am)
Schematic of the adenovirus genome and adenovirus-based vectors. (genemedi.com)
AAV vectors are small, single-stranded DNA viruses that rely on an adenovirus to replicate-hence the name. (genepossibilitieshcp.com)

A lentiviral vector carrying therapeutic transgenes are then introduced to the culture to infect them. (wikipedia.org)
Viral vector methods are used in effective transfer of therapeutic gene into the target cells. (medgadget.com)
To this end, all new vectors will express the same identical therapeutic transgene, which will allow comparisons to be made across all novel viral vectors produced. (europa.eu)
From existing therapies to those currently in clinical trials, lentiviral vector (LV) adherent cell culture continues to be dependable way to develop and study innovative therapeutic interventions in healthcare. (corning.com)
The large number of proof-of-concept studies in animal models showing therapeutic efficacy following AAV vector gene transfer is evidence of a potentially rich pipeline of GT drugs that could potentially be brought to the clinic and change the way genetic diseases could be treated, particularly liver diseases. (abdominalkey.com)
Gene-addition tools introduce a functional gene, sometimes called a therapeutic gene or transgene, directly into the nucleus of target cells using a molecular delivery vehicle known as a vector. (genepossibilitieshcp.com)

Due to their efficient gene delivery, viral vectors have been successfully used in T-cell engineering to provide gene transfer medicinal products for the treatment of human disease. (uni-wuerzburg.de)
Lentiviral vectors are a robust gene delivery tool for inducing transgene expression in a variety of cells. (bvsalud.org)

Adenoviruses feature double-stranded DNA as their genetic material. (genepossibilitieshcp.com)

Targeting vector particles to the relevant cell type without losing particles to non-relevant cells is therefore an important goal in vector engineering. (hstalks.com)
Only surface targeting of vector particles may make this possible. (hstalks.com)
Retroviral vectors are envelope particles that bind with their surface receptor for cell entry. (hstalks.com)
Recombinant lentiviral particles carrying Flag-Cx40 were obtained by cotransfection with packaging plasmids into HEK293T cells. (bvsalud.org)

Ongoing anti-cancer gene therapy clinical trials have highlighted the need for more efficient and safer vectors. (europa.eu)
This proposal brings together European leaders with expertise covering from the development of novel viral vectors to the implementation of clinical trials of gene therapy. (europa.eu)
We thus aim to obtain well characterized, safe, and efficient gene therapy vectors, as well as pre-clinical data supporting the further testing of such vectors in clinical trials. (europa.eu)

Nonintegrating lentiviral vectors are being developed as a efficient and safe delivery system for both gene therapy and vaccine purposes. (duke.edu)

We have also showed that this dual vector system can generate regulatable bulk cell lines (expressing high levels of TetR) that are able to modulate transgene expression either by varying doxycycline concentration and/or by varying the amount of CTetOE vector genomes per cell. (nih.gov)
Our general objective is the development of new generations of targeted viral vectors for the treatment of liver and brain cancer by directing viral entry and by restricting transgene expression. (europa.eu)

Lentiviruses are a subclass of retroviruses that have a similar structure, including genetic material consisting of double-stranded RNA and reverse transcriptase. (genepossibilitieshcp.com)

The characteristics, efficiency, and toxicity of targeted vectors will first be assessed in vitro on relevant cell lines and primary cell cultures, then in vivo using animal models of brain and liver cancer. (europa.eu)
Once new generation targeted viral vectors are generated, they will be sent to the appropriate partners for the in vitro testing of the efficiency of the novel vectors in various cell lines. (europa.eu)
The in vitro testing will allow selection of the most efficient vectors which will then be chosen to be further studied. (europa.eu)
This platform is used to produce viral vectors for gene transfer, both in vivo and in vitro. (lu.se)
In this thesis, human glia-to-neuron direct conversion and engineered viral vectors are explored using pre-clinical in vitro and ex vivo models. (lu.se)

But a failure to distribute enough modified genetic information to the patient's body has prohibited gene therapy from being more widely used. (health.am)
Gene therapy relies mainly on viruses-which transport genomes inside the cells they infect-to deliver genetic material into a patient's cells. (health.am)
Indeed, thanks to lentiviral vectors, the new genetic information is introduced in a stable and random way into the patient's genome. (inserm.fr)
The CAR-T cell manufacturing platform is based on the ex vivo genetic engineering of a patient's T cells to express CAR, followed by the reinfusion of the T cells into the patient. (biomedcentral.com)

In vivo gene therapy is the sample injection of viral vectors containing transgenes into the patient. (wikipedia.org)

In this lab bacteria are grown to produce DNA, which we use in further experiments such as viral vector production. (lu.se)

We have developed a lentiviral vector system based on the HIV that can transduce terminally differentiated neurons of the brain in vivo. (nih.gov)
Many cell types, like neurons, do not divide in adult organisms, so lentiviral gene therapy is a good candidate for treating conditions that affect those cell types. (wikipedia.org)

The efficient gene transfer into photoreceptor cells by HIV vectors will be useful for gene therapy of retinal diseases such as retinitis pigmentosa. (nih.gov)

And lentiviral vectors, while stable, fail to deliver genetic material to enough defective human cells. (health.am)

The market, by pharmaceutical and biotechnology companies, is expected to hold the largest share in the market owing to the increasing demand for therapies, whereas the research institutes segment is projected to be the fastest growing segment due to growing awareness and specificity of viral vectors in treating the diseases. (medgadget.com)

For instance, in April 2018, GE Healthcare, a subsidiary of General Electric Company, launched a ready-to-run factory-in-a-box to speed up the manufacturing of viral vector-based therapeutics, including viral vector-based vaccines, oncolytic viruses and gene and cell therapies. (medgadget.com)
Genetic insights have not only deepened our understanding of the mechanisms at play but also hold great promise for the development of targeted therapies and personalized treatments [ 1 ]. (alliedacademies.org)
Genetic insights into neuromuscular disorders have sparked a new era of targeted therapies and personalized medicine. (alliedacademies.org)
1-4 With several therapies approved in the past decade and research ongoing across various delivery vectors, make sure you understand how gene addition works. (genepossibilitieshcp.com)
4. Genetic therapies. (genepossibilitieshcp.com)
https://www.nhlbi.nih.gov/health-topics/genetic-therapies. (genepossibilitieshcp.com)

The characteristics, efficiency, and toxicity of the novel vectors will be compared to standard vectors in current use. (europa.eu)
Viruses are used as vectors because of their efficiency at entering cells, and there are several different types of viral vectors used for gene addition. (genepossibilitieshcp.com)

I'm very pleased to present the lecture on surface-mediated targeting of lentiviral vectors. (hstalks.com)
To understand the strategies to achieve surface targeting, we first have to look at the entry routes of retroviral vectors. (hstalks.com)

In an R&D setting, this becomes preferable if the same reagent is transfected (for example, CAS9 delivery vectors) since all the work is in the generation of the viral stock, not in the infection," Carstens says. (biopharminternational.com)
Finally, we combined our developed Cas9 RNP tool with CAR transposition from MC vectors into a single-step protocol and successfully generated PD-1 knockout CAR+ T cells. (uni-wuerzburg.de)
The high level of gene transfer rate and efficient genome editing, superior safety profile as well as ease-of-handling and production of non-viral MC vectors and Cas9 RNP position our developed non-viral strategies to become preferred approaches in advanced cellular and gene-therapy. (uni-wuerzburg.de)
These results collectively demonstrate the potential of Cas9-based activators as a powerful genetic perturbation technology. (cdc.gov)

This vector efficiently produced Tet-ON regulatable immortalized (293T) and primary (human mesenchymal stem cells and human primary fibroblasts) cells. (nih.gov)
LV adherent cultures offer specific properties that make them a logical choice, such as the ability to target non-dividing cells, integrate their genetic cargo into a target chromosome, and increase their versatility by modifying various molecular properties. (corning.com)
Delivery and success of gene therapy for human cells has the potential of increasing five to ten times with the introduction of the GRPE into the lentiviral vector. (health.am)
Ultimately, introducing GRPE elements into viral vectors could enhance the ease and effectiveness of gene therapy, which typically uses transplanted human stem cells. (health.am)
In both cases, cells may be treated either with a viral or non-viral vector carrying the corrected copy of the gene. (biopharminternational.com)
Carstens points out that the greatest limitation of viral vector systems is their tropism, that is, the type of cells that a virus will naturally infect. (biopharminternational.com)
It is obvious that upon in vivo applications, vectors will encounter a large variety of cell types besides the actual target cells relevant for therapy. (hstalks.com)
The advances in genetic engineering have enabled us to confer T cells new desired functions or delete their specific undesired endogenous properties for improving their antitumor function. (uni-wuerzburg.de)
In conclusion, we provide a novel platform for virus-free genetic engineering of CAR T cells that can be broadly applied in T-cell cancer therapy. (uni-wuerzburg.de)
In the absence of an HLA-compatible donor, the research teams have proposed a treatment by gene therapy which consists of taking blood stem cells carrying the genetic anomaly from patients (CD34+ hematopoietic stem cells), then correct in the laboratory by introducing the healthy WAS gene using a lentiviral vector developed by Anne Galy's team at Généthon, where the clinical batches of vectors were also produced. (inserm.fr)
In this study, we developed a non-genetic engineering technology for rapidly manufacturing a large amount of cancer-specific T cells by utilizing a unique anti-cancer/anti-CD3 bispecific antibody (BsAb) to directly culture human peripheral blood mononuclear cells (PBMCs). (biomedcentral.com)
Contrary to our aim, overexpression of Bcl-2 induced cell death in the producer HEK293T cells, resulting in failure to produce usable vector titre. (bvsalud.org)
Objective To establish a stable strain of H9c2 cardiomyocytes overexpressing Cx40 and preliminarily investigate the effect of lentiviral vector-mediated Cx40 protein overexpression on the proliferation of H9c2 cells and its related mechanisms. (bvsalud.org)
We propose that most differentiated cells in the CNS upon defined genetic alterations undergo dedifferentiation to generate a NSC or progenitor state to initiate and maintain the tumor progression, as well as to give rise to the heterogeneous populations observed in malignant gliomas. (cellimagelibrary.org)
AdV vector in blood activates vascular endothelial cells to release von Willebrand factor (vWF), induces platelets to expose the adhesion molecule P-selectin, and promotes the formation of platelet-leukocyte, ultimately leading to thrombocytopenia and bleeding [48]. (genemedi.com)
ATDC5 cells and primary human periosteum-derived cells (hPDCs) were transduced with lentiviral vectors expressing HLA-B27 or HLA-B7. (bmj.com)
2 These vectors are suitable for ex-vivo treatment and have the ability to both carry large loads of material into the targeted cell's genome and integrate with nondividing cells. (genepossibilitieshcp.com)
2. Nowakowski A, Andrzejewska A, Janowski M, Walczak P, Lukomska B. Genetic engineering of stem cells for enhanced therapy. (genepossibilitieshcp.com)
But, how do you pick the best way to get the vector into your cells to express the reporter? (promegaconnections.com)
The vectors are also used for in vivo modifications of cells, e.g. for reprogramming. (lu.se)

To evaluate this approach for deriving safety-modified lentiviral vectors, we created HIV-1 vectors engineered to delete the Rev-response element (RRE) during reverse-transcription by sandwiching the RRE between two non-functional hygromycin phosphotransferase sequences. (peerj.com)
In conclusion, reduced expression of Bcl-2 driven by a weaker promoter improved vector yield, and led to the production of functional cardioprotective Bcl-2 in primary cardiomyocytes. (bvsalud.org)

Some experimental applications of lentiviral vectors have been done in gene therapy in order to cure diseases like Diabetes mellitus, Murine haemophilia A, prostate cancer, chronic granulomatous disease, and vascular diseases. (wikipedia.org)
The Americas is projected to dominate the global viral vector manufacturing market due to a well-developed healthcare sector and rising prevalence of autoimmune and chronic diseases. (medgadget.com)
Arts, a professor of medicine in the Division of Infectious Diseases and HIV Medicine, learned that lentiviral carriers lack sufficient genetic material necessary for treatment. (health.am)

The ability to sequence the entire genome makes it possible to follow exactly the sites of integration of the new genetic material and to ensure their harmlessness with regard to the physiological functions of the target cell. (inserm.fr)
The human genome contains thousands of genetic elements with apparent sequence similarity to transposons, but their evolutionary divergence hinders the identification of elements that may serve as substrates for endogenous human transposases in general [ 6 ], and PGBD5 in particular [ 4 ]. (biomedcentral.com)

After identifying the problem, researchers introduced the element into a lentiviral vector, successfully and significantly improving the quality and quantity of the gene therapy. (health.am)
In classical genetics, forward chemical genetic screens have been successfully used to identify spontaneous mutations in bacteria, yeast and fly [ 7 - 10 ]. (biomedcentral.com)
Indeed, HPRT1-based forward genetic screens have been successfully used to characterize chemical mutagens [ 12 , 13 ]. (biomedcentral.com)

each of the vectors has its own advantages, limitations, and range of applications," Vicaire says. (biopharminternational.com)
However, there are persistent concerns and limitations with the use of viral vectors for CAR T cell generation with regard to safety, cost and scale of vector production. (uni-wuerzburg.de)

A compilation of research experiences in stem cell, viral vector and vaccine production. (corning.com)

During Phase-II production of the most efficient vectors will be scaled up, and distributed to all appropriate partners for the in vivo testing and comparison in available models. (europa.eu)
During virus production, GRPE coordinates the production and filling of the container with the genetic material of HIV-1, or the desired human gene. (health.am)
This was circumvented by exchanging the CMV promoter to the cardiac-specific NCX1 promoter, leading to the successful production of a lentiviral vector which could induce cardioprotective expression of Bcl-2. (bvsalud.org)
The Cell and Gene Therapy core is an open-access infrastructure and our services include AAV and LV vector production, cloning services, iPS reprogramming, iPS-edits and CRISPR experimental designs. (lu.se)

Lentiviral vectors in gene therapy have been pioneered by Luigi Naldini. (wikipedia.org)
Lentiviral vectors (LVs) are considered one of the most promising vehicles to efficiently deliver genetic information for basic research and gene therapy approaches. (nih.gov)
Thus, we will develop novel targeted viral vectors for applications to cancer gene therapy. (europa.eu)
Advances in gene therapy offer promising treatment for genetic abnormalities, tumors and resistance to toxic chemotherapies. (health.am)
Viral vectors show promise as a delivery mechanism for gene therapy, but which virus types are commercially viable? (biopharminternational.com)
The potential opportunity of a vector depends on the type of gene therapy being developed, says Gaurav Chaudhary, CEO of Roots Analysis, a business research and consulting firm. (biopharminternational.com)
Each viral vector system is characterized by an inherent set of properties that affect its suitability for gene therapy or other specific applications, says Florence Vicaire, global gene therapy business development leader, Cytiva (formerly part of GE Healthcare). (biopharminternational.com)
Depending on the application, the ideal vector either has an extremely broad tropism or extremely narrow if the objective is gene therapy of a very specific cell type (in this case this is a safety precaution)," Carstens elucidates. (biopharminternational.com)
Beti-Cel Becomes the First Lentiviral Vector Gene Therapy in the U.S. (asgct.org)
The approval makes beti-cel, marketed as Zynteglo, the first lentiviral vector gene therapy for patients with a severe genetic disease in the U.S. (asgct.org)
A second lentiviral vector gene therapy from bluebird bio, elivaldogene autotemcel (eli-cel) for cerebral adrenoleukodystrophy (CALD) , has a Prescription Drug User Fee Act (PDUFA) date of Sept. 16. (asgct.org)
A framework for identifying targets for individualized therapy in genetic disease. (cdc.gov)
As of first of January 2022, StemTherapy and MultiPark have decided to merge the former iPSC, CRISPR and vector platforms into the new Cell and Gene Therapy Core . (lu.se)

All the tumors, irrespective of the site of lentiviral vector injection (the initiating population), shared common features of high expression of stem or progenitor markers and low expression of differentiation markers. (cellimagelibrary.org)

Agilent vectors, for example, are suitable and compatible with generation-four packaging systems (i.e., the latest version of packaging systems). (biopharminternational.com)
Here, we sought to develop a forward genetic screening approach suitable for the elucidation of endogenous genomic substrates of human DNA transposases and recombinases. (biomedcentral.com)

The primary objective of these viral vector systems is to achieve the highest possible titers without forming replication-competent variants. (biopharminternational.com)
The vectors can be produced at very high titers and used directly for in vivo injections. (lu.se)

For all practical purposes, a viral vector is a genetic element wrapped in its own transfection reagent, which makes transfection titrations possible (e.g., dosage responses) and highly effective. (biopharminternational.com)

Genetic testing can now identify specific mutations associated with these conditions, enabling precise diagnosis and facilitating genetic counseling for affected individuals and their families. (alliedacademies.org)
The complex nature of these conditions, the variability in disease presentation, and the identification of rare genetic mutations pose hurdles in diagnosis and treatment. (alliedacademies.org)
This framework identified multiple eligible mutations among 235 people with the genetic disorder ataxia-telangiectasia. (cdc.gov)

The virus contains a reverse transcriptase molecule found to perform transcription of the viral genetic material upon entering the cell. (wikipedia.org)
Moreover, in each entry mode, fusion of the viral and the cellular membranes, which is the plasma membrane in A and the endosomal membrane in B, is required to release the genetic information into the cell. (hstalks.com)
Use a primary and secondary reporter vector transiently transfected into your favorite mammalian cell line. (promegaconnections.com)

Based on these results we have developed a new all-in-one lentiviral vector (CEST) driving the expression of TetR through the SFFV promoter and the expression of eGFP through the doxycycline-responsive CMV-TetO operon. (nih.gov)
However, it is difficult to capture the complexity of transcript isoform variance using these libraries, and large cDNA sequences are often difficult to clone into size-limited viral expression vectors. (cdc.gov)

We will first focus on ex vivo applications and then go through some examples of in vivo administrations of the targeted vectors. (hstalks.com)

Carstens cautions, however, that biomanufacturers need to be aware that such modifications are properties of the packaging system, not the viral vector. (biopharminternational.com)

The virus-driven delivery tools are called "viral vectors. (health.am)

The researchers tested the device mice in a genetic line commonly used to simulate Alzheimer's disease over a course of 39 weeks, showing dramatic reduction of amyloid beta plaque load in the brain. (pharmaceuticalintelligence.com)

Advances in genetic testing technologies have revolutionized the diagnosis of neuromuscular disorders. (alliedacademies.org)

Several reports have demonstrated that a single immunization with integration-defective lentiviral vectors (IDLVs) delivering viral or tumor model antigens in mice was able to elicit broad and long-lasting specific immune responses in the absence of vector integration. (duke.edu)

Arts and colleagues named the genetic element, Genomic RNA Packaging Enhancer element (or GRPE). (health.am)

Anatomy36

Organisms50

Diseases12

Chemicals and Drugs58

Analytical, Diagnostic and Therapeutic Techniques and Equipment39

Phenomena and Processes53

Disciplines and Occupations1

Information Science4

Health Care7

Lentivirus2

Retroviral and lentiviral4

Gamma-retroviral1

Transduction4

Genetically modified2

Proteins7

Genes14

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Adenovirus3

Therapeutic6

Gene delivery2

Adenoviruses1

Particles4

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Vitro5

Patient's4

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Specificity1

Therapies6

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CAS94

Cells20

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Successfully3

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