• Increasing attention is now being directed at the network of signaling pathways that effect the EMT in lens epithelial cells, with the aim of identifying potential therapeutic targets to inhibit cataract, particularly PCO, which remains a significant clinical problem in ophthalmology. (nih.gov)
  • Western blot analysis and in situ hybridization confirmed the presence of AND-34 RNA and protein in lens epithelial cells, particularly at the lens equator. (molvis.org)
  • While Akt Ser 473 phosphorylation was readily detectable in AND-34 +/+ lens epithelial cells, it was markedly reduced in the AND-34 −/− lens epithelium. (molvis.org)
  • These results demonstrate the loss of AND-34 dysregulates focal adhesion complex signaling in lens epithelial cells and suggest that AND-34-mediated signaling is required for maintenance of the structural integrity of the adult ocular lens. (molvis.org)
  • Animals -872 Jack Russell Terriers from which buccal epithelial cells were collected and phenotypes for cataracts and lens luxation were determined and an additional 1,898 Jack Russell Terriers without phenotypic information used to complete pedigree relationships and that were included in the analyses. (avma.org)
  • Highly expressed in the mammalian lens, the α-crystallins have been postulated to play a critical role in the maintenance of lens optical properties by sequestering age-damaged proteins prone to aggregation as well as through a multitude of roles in lens epithelial cells. (nih.gov)
  • In the presence or absence of TLR3, human lens epithelial cell line SRA01/04 are treated with TGF-β2. (researchsquare.com)
  • Lens epithelial cells are distributed under the anterior capsule of the lens and under the capsule of the equator of the lens. (researchsquare.com)
  • The lens epithelial cells proliferate, differentiate and migrate inward to form lens fibers. (researchsquare.com)
  • Excessive proliferation and migration of lens epithelial cells and transformation into mesenchymal cells (ie EMT) are common causes of cataracts. (researchsquare.com)
  • This study of epithelial-mesenchymal transformation and epithelial cell polarity in vitro reveals that environmental conditions can have a profound effect on the epithelial phenotype, cell shape, and polarity as expressed by the presence of apical and basal surfaces. (rupress.org)
  • Epithelial cells from adult and embryonic anterior lens were studied in detail. (rupress.org)
  • Fibrotic changes involve hyperproliferation, transdifferentiation from an epithelial to a myofibroblast phenotype, matrix deposition and matrix contraction. (uea.ac.uk)
  • Procedures -Narrow-sense heritabilities and genetic correlation for cataracts and lens luxation were modeled by use of threshold analysis, whereas complex segregation analysis was used to characterize mode of inheritance. (avma.org)
  • The purpose of this study was to identify the genetic cause and describe the clinical phenotype of Schnyder corneal dystrophy (SCD) in six unrelated probands. (biomedcentral.com)
  • Although large population studies can identify associations between genotypes and phenotypes, resulting associations have limited capacity to predict phenotype in individuals, which is the ultimate goal of precision medicine. (cdc.gov)
  • 6 years old, unless confirmed as having cataracts or lens luxation, were classified as an unknown phenotype. (avma.org)
  • Results -Cataracts and primary lens luxation were highly heritable and genetically correlated, and neither was controlled by a single gene. (avma.org)
  • Conclusions and Clinical Relevance -Analysis of the data indicated that concerted selection against both cataracts and primary lens luxation when choosing breeding animals can be used to improve ocular health in Jack Russell Terriers. (avma.org)
  • These findings demonstrate that the role of α-crystallins in lens development is conserved from mammals to zebrafish and set the stage for using the embryonic lens as a model system to test mechanistic aspects of α-crystallin chaperone activity and to develop strategies to fine-tune protein-protein interactions in aging and cataracts. (nih.gov)
  • For this purpose, we have carried out morpholino-mediated knockdown of αA-, αBa- and αBb-crystallin and characterized the gross morphology of the lens. (nih.gov)
  • We recently reported the usefulness of applying mathematical models ( i.e. principal component and cluster analyses) to multiple variables for the identification of clinical phenotypes in a cohort of COPD subjects [ 4 ]. (ersjournals.com)
  • These original analyses allowed the description of four COPD groups, which we called "clinical COPD phenotypes" [ 4 ]. (ersjournals.com)
  • Recently, a panel of experts proposed the following modified definition for clinical COPD phenotypes: "a single or combination of disease attributes that describes differences between individuals with COPD as they relate to clinically meaningful outcomes (symptoms, exacerbations, response to therapy, rate of disease progression, or death)" [ 2 , 3 ]. (ersjournals.com)
  • These authors suggested that, before being referred to as clinical phenotypes, clusters of related patients require longitudinal validation to determine how they differ with respect to important clinical outcomes [ 2 ]. (ersjournals.com)
  • The clinical phenotype of ADAMTSL4 -associated ectopia lentis was summarized and expanded. (molvis.org)
  • Severe myopia is the first sign of ectopia lentis and may precede lens dislocation by several months to a year or even longer. (medscape.com)
  • ADAMTSL4- associated ectopia lentis is a rare autosomal recessive condition that is primarily associated with crystalline lens displacement. (molvis.org)
  • The laboratory's focus is on the development of the lens and the retina. (uclahealth.org)
  • Tissue-wise, these studies encompass differentiating ocular lens fiber cells, the retina, the brain and the heart. (uclahealth.org)
  • We found that Ipo13 was expressed in the cornea, sclera, lens, and retina in mice. (altmetric.com)
  • Basal levels of p130Cas phosphorylation were higher in AND-34 +/+ than in AND-34 −/− lens epithelium. (molvis.org)
  • As technology improves, "I expect we will see even more insights like this that can help us translate from genome sequence to the actual phenotype of an extinct animal", says Beth Shapiro at University of California Santa Cruz. (newscientist.com)
  • In the 3D Lab we deal with different technologies for quantifying, analysing and visualising 3D complex phenotypes of both extant and extinct (fossils) organisms. (lu.se)
  • Female carriers manifest characteristic lens opacities, but they typically have normal renal and neurologic function. (medscape.com)
  • This terminology was based on the classical definition of "phenotype", referring to the observable characteristics (including respiratory manifestations and comorbidities) of patients. (ersjournals.com)
  • Due to its unique biological characteristics, the lens has become an ideal biological tool for the study of fibrosis. (researchsquare.com)
  • Using UAV-Based Imagery to Determine Volume, Groundcover, and Growth Rate Characteristics of Lentil (Lens culinaris Medik. (usask.ca)
  • Phenotypes of conjunctival inflammatory cells in sarcoidosis. (bmj.com)
  • Here, we have examined the role of α-crystallins in the development of the vertebrate zebrafish lens. (nih.gov)
  • These abnormalities were less frequent in transgenic zebrafish embryos expressing rat αA-crystallin suggesting a specific role of α-crystallins in embryonic lens development. (nih.gov)
  • Morpholino-oligonucleotide-induced knockdown of ipo13 in zebrafish caused dose-dependent microphthalmia and coloboma, which is highly similar to the ocular phenotypes in the patient. (altmetric.com)
  • Notably, these ocular phenotypes in ipo13-deficient zebrafish could be rescued remarkably by full-length ipo13 mRNA, suggesting that the phenotypes observed in zebrafish were due to insufficient ipo13 function. (altmetric.com)
  • The penetrance of the lens phenotype was reduced by transgenic expression of rat αA-crystallin and its severity was attenuated by maternal αA-crystallin expression. (nih.gov)
  • Purpose: To assess the performance of a deep learning (DL) algorithm for evaluating and supervising cataract extraction using phacoemulsification with intraocular lens (IOL) implantation based on cataract surgery (CS) videos. (researchgate.net)
  • A comparison of 141 polymacon (Iogel) and 140 poly(methyl methacrylate) intraocular lens implants. (bmj.com)
  • Homozygous null mice exhibit male infertility and eye abnormalities including microphthalmia, absent vitreous body, abnormal ciliary body, retinal layers, and lenses. (jax.org)
  • We observed lens abnormalities, including increased reflectance intensity, as a consequence of the interference with expression of these proteins. (nih.gov)
  • or other lens abnormalities. (medlineplus.gov)
  • It yields a typical uncertainty on the mean redshift in each of five tomographic bins for an idealized simulation of the DES Year 3 weak-lensing tomographic analysis of σΔz = 0.007, which is a 60 per cent improvement compared to the Year 1 analysis. (osti.gov)
  • Mutations in this gene have been associated with adult i blood group phenotype. (nih.gov)
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • Clinicians should be aware of the varied ocular phenotype and the risks of retinal detachment, ocular hypertension, and glaucoma in the diagnosis and management of this condition. (molvis.org)
  • Periocular migration of hard contact lenses. (bmj.com)
  • CORE's multidisciplinary biosciences team works together to investigate fundamental research questions relating to the ocular surface and biomaterials, particularly contact lenses. (uwaterloo.ca)
  • it produces aqueous humor, facilitates trabecular outflow, intervenes in alteration of the shape of the crystalline lens during accommodation, and secretes hyaluronic acid into the vitreous. (medscape.com)
  • A small percentage of AND-34 −/− mice show distinctive small white eye lesions resulting from the migration of ruptured cortical lens tissue into the anterior chamber. (molvis.org)
  • Following initial vacuolization and liquefaction of the lens cortex first observed at postnatal day three, posterior lens rupture occurs in all AND-34 −/− mice, beginning as early as three weeks and seen in all mice at three months. (molvis.org)
  • The role of macrophage phenotypes in tumour progression has been extensively reviewed 6 - 10 . (ersjournals.com)
  • These findings indicate that TLR3 prevents the progression of lens fibrosis by targeting the Jagged-1/Notch signaling pathway to regulate LEC proliferation, migration, invasion and TGF-β2-induced EMT. (researchsquare.com)
  • A more consistent and severe lens phenotype was evident in maternal/zygotic αA-crystallin mutants compared to those observed by morpholino knockdown. (nih.gov)
  • There are benign and severe phenotypes. (msdmanuals.com)
  • However, this trend did not reach statistical significance, probably due to the limited numbers of patients within these phenotypes. (ersjournals.com)
  • CD68 + macrophages expressing markers of a cytotoxic M1 phenotype or a noncytotoxic M2 phenotype were identified in the islets and stroma of surgically resected tumours from 20 patients with extended survival (median 92.7 months) and 20 with poor survival (median 7.7 months), using immunohistochemistry. (ersjournals.com)
  • Macrophages infiltrating the tumour islets in nonsmall cell lung cancer were predominantly of the M1 phenotype in patients with extended survival. (ersjournals.com)
  • These patients often exhibit the characteristic facial appearance of frontal bossing, deep set eyes, and full cheeks, although the characteristic phenotype is often difficult to identify in neonates. (medscape.com)
  • Patients with the Duarte variant have a much milder phenotype. (msdmanuals.com)
  • Two interrelated paradigms currently under investigation are: 1) Molecular basis of the differential expression of the gene for the small heat shock protein Alpha B-crystallin, a protein associated with with vision (e.g. in the ocular lens), oncogenesis (e.g. in breast cancer) and neural degeneration (e.g. in Alzheimer's disease). (uclahealth.org)
  • These studies entail attempts at relating gene activity to the functional phenotype of vision. (uclahealth.org)
  • Several years after the best-selling book, The Selfish Gene, which was the topic of our first episode, Richard Dawkins published The Extended Phenotype. (freshlenspodcast.com)
  • Based on these findings, we analysed mortality risks among phenotypes using Cox models (both unadjusted and adjusted for age) ( fig. 2 ). (ersjournals.com)
  • The vertebrate lens has a distinct polarity and structure that are regulated by growth factors resident in the ocular media. (nih.gov)
  • As a consequence of racial intermixture during the colonial era, phenotype in the contemporary Mexican-origin population ranges on a continuum from those who appear white to those who have dark skin, indigenous facial features, and shorter height than average. (encyclopedia.com)
  • Lentil (Lens culinaris) has been late to enter the world of high throughput molecular analysis due to a general lack of genomic resources. (usda.gov)
  • Although fibrotic diseases can affect many organs, such as liver fibrosis, kidney fibrosis, lung fibrosis and lens fibrosis, there are still some potential common pathogenesis mechanisms for fibrosis in different organs. (researchsquare.com)
  • However, if this integrity is breached through an altered ocular environment or physical disruption, such as cataract surgery, then fibrotic modifications to the lens can occur that are ultimately detrimental to vision. (uea.ac.uk)
  • Fibrotic conditions of the lens include anterior subcapsular cataract and posterior capsule opacification, which affect millions. (uea.ac.uk)
  • The segregation and near-exclusion of mutant cells from the nasal epithelium mirrored the behaviour of mutant cells in other developmental contexts, particularly the lens, suggesting that common primary defects may be responsible for diverse Pax6-related phenotypes. (ed.ac.uk)
  • In: Lens Epithelium and Posterior Capsule Opacification. (uea.ac.uk)
  • The adult lens is separated from other tissues and has no nerve and blood vessel distribution, but draws nutrients from aqueous humor and vitreous humor. (researchsquare.com)
  • The link between phenotype and socioeconomic status is also evident within the Mexican-origin population in the United States and Mexico. (encyclopedia.com)
  • AAS DILI is associated with a distinct phenotype, characterised by considerable bilirubin elevations independent of type of damage. (medscape.com)
  • We hypothesized that "autoimmune encephalitides" may result from any brain inflammation concurring with the presence of brain antigen-directed autoantibodies, e.g., against N-methyl-D-aspartate-receptor NR1 (NMDAR1-AB), which are not causal of, but may considerably shape the encephalitis phenotype. (nature.com)
  • Kaplan-Meier analysis of survival by phenotype is presented in figure 1 . (ersjournals.com)
  • Subjects in phenotype 2 (older age, mild-to-moderate airflow obstruction and low rates of comorbidities) had a lower mortality, but no significant survival difference was found between phenotypes 1, 3 and 4. (ersjournals.com)
  • Recent studies implicate other factors [such as fibroblast growth factor (FGFs), hepatocyte growth factor, integrins], present in the lens and ocular environment, in the pathogenesis of ASC and PCO. (nih.gov)
  • Capturing liver disease phenotypes through the broadest possible lens. (metabolon.es)
  • Recent evidence, however, supports a dual role for macrophages in the regulation of tumour proliferation and immune control 10 , 16 , and indicates that the local tissue microenvironment plays a critical role in determining cell phenotypes. (ersjournals.com)
  • Fibroblast growth factors, in concert with other growth factors, are key regulators of lens fiber cell differentiation. (nih.gov)
  • Accordingly, Cx46 is associated with an increase in cancer stem cell phenotype. (bvsalud.org)
  • The M1 phenotype (classically activated) macrophages are thought to be induced by interferon-γ, with or without lipopolysaccharide and tumour necrosis factor (TNF)-α, and exert a cytotoxic effect against cancer cells. (ersjournals.com)
  • This shift in funding may lead to an emerging generation of health scientists who see the world through an individualist lens and may not engage in factors that can improve the health of populations. (cdc.gov)
  • Its metastatic potential depends on the phenotype of the tumor cells, and it frequently disseminates before diagnosis. (medscape.com)
  • The unadjusted model confirmed that phenotypes 1, 3 and 4 had a statistically significant two- to four-fold increase in mortality risk when compared with phenotype 2. (ersjournals.com)
  • His right lens became dislocated into the anterior chamber and had to be removed. (medscape.com)
  • Through her work, Siân aims to highlight the importance of sonic understanding, acoustic ecologies, and how we can navigate experience through a multitude of senses beyond the West's ocular-centric lens. (boldtendencies.com)
  • Data were obtained for 303 (94.1%) out of the 322 subjects and the median (interquartile range) follow-up duration, which was not significantly different across phenotypes (unpublished data) was 3.35 (2.01-4.25) yrs. (ersjournals.com)
  • Digital phenotyping refers to the in-situ quantification of the human phenotype using data from personal digital devices. (bvsalud.org)
  • These overlapping systems of phenotype-based stratification are rooted in the European conquest, colonization, and enslavement of visibly different people from Africa, Asia , and Latin America beginning near the end of the fifteenth century. (encyclopedia.com)
  • Six new phenotypes have been described that can be accurately and efficiently collected from field trials with the use of UAV's or other overhead image-collection systems. (usask.ca)
  • I learned that you can learn a lot about basic neuroscience through the lens of dementia, because it's sort of like the idea of using the destruction of systems to understand what they do and how they function. (lu.se)
  • EMBT asserted that autistic individuals process and experience the world through a dominantly "male" lens. (autism.org)