Leiomyosarcoma for smooth muscle. Medical search. Frequent questions

Leiomyosarcoma is an aggressive soft tissue sarcoma that has significant high unmet medical need, especially for those patients who have relapsed or are refractory to current treatments. (prnewswire.com)
Leiomyosarcoma is a particularly aggressive tumor type that desperately requires new treatment options for patients," said Brian Van Tine , M.D., Ph.D., Sarcoma Program, Washington University and lead clinical investigator. (prnewswire.com)
The origin of the word is from leio- + myo- + sarcoma which means malignant smooth muscle tumor. (wikipedia.org)
Although leiomyosarcomas are rare, they belong to of the more common types of soft-tissue sarcoma, representing 10 to 20% of new cases. (wikipedia.org)
When there is an infiltrative border, the nodule most likely represents adenomyosis (which may simulate a mass) or a sarcoma (ie, leiomyosarcoma or endometrial stromal sarcoma). (medscape.com)
Leiomyosarcoma is a smooth muscle soft tissue sarcoma that can arise from almost any site in the body. (dana-farber.org)
Although necrosis has been described in 30% or more of inflammatory myofibroblastic tumors, the presence of necrosis at the tumor-detrusor muscle interface in muscle-invasive cases was one criterion present in sarcoma that distinguished it from inflammatory pseudotumor (see Image 3 in the figure below). (medscape.com)
There are many lesions like rhabdomyosarcoma, fibrosarcoma, liposarcoma, multiple peripheral nerve sheath tumour, angiosarcomas, melanomas, kaposi sarcoma, solitary fibrous tumors, etc., which mimic leiomyosarcoma clinically and histopathologically and therefore immunohistochemical staining with specific markers plays a vital role in arriving at a conclusive diagnosis. (oldcitypublishing.com)
Soft tissue sarcoma broadly defines cancers that develop in the body's soft tissues (i.e. muscles, tendons, fat, lymph vessels, blood vessels, and nerves). (curesarcoma.org)
This type of sarcoma usually begins in the muscles attached to bones and in the muscles that help the body to move. (curesarcoma.org)
This type of sarcoma derives from the smooth muscle of the body wherever it is found, such as the walls of blood vessels, the uterine wall, and other sites. (curesarcoma.org)
A rare soft tissue sarcoma characterized by a malignant space-occupying lesion most commonly located in the retroperitoneum or the inferior vena cava, but also other soft tissues, and composed of cells showing distinct features of smooth muscle cells. (orpha.net)
Primary pulmonary leiomyosarcomas is a subtype of pulmonary sarcoma, accounting for less than 0.5% of all malignant pulmonary neoplasms. (panafrican-med-journal.com)
According to the NHS , Leiomyosarcoma (LMS) is a type of soft tissue sarcoma that grows in the smooth muscles that line organs like the stomach, bladder, and intestines. (yahoo.com)
While there are several different types of soft tissue sarcoma, leiomyosarcomas are one of the more common types of sarcoma to develop in adults. (yahoo.com)
1] It is a type of spindle cell sarcoma, which is a soft tissue tumor, originating from smooth muscle. (faoj.org)
GIST was never mentioned because before the year 2000, GISTs were previously misclassified as other types of soft tissue sarcoma (STS), including tumors of smooth-muscle origin (most commonly leiomyosarcoma, and also leiomyoma or leiomyoblastoma). (liferaftgroup.org)
Subtypes of sarcoma can develop and affect parts of bone, connective tissue, and areas such as blood vessels, nerves, muscle, and fat, including tissues around bones and joints. (gleneagles.com.sg)
Leiomyosarcoma is a type of soft tissue sarcoma. (drallison.org)
As with all forms of sarcoma, leiomyosarcomas can develop anywhere in the body, and the treatment options vary depending on where the tumors are located, the grade and stage, and the patient's overall health profile, among other factors. (drallison.org)
A sarcoma is a type of cancer that usually develops from certain tissues like, within the bone or muscle. (suratoncologycentre.in)

A leiomyosarcoma, also known as LMS, is a rare malignant (cancerous) smooth muscle tumor. (wikipedia.org)
The myometrial tumor interface of a myxoid leiomyosarcoma. (medscape.com)
Leiomyosarcoma is a malignant non-epithelial smooth muscle tumor that can occur anywhere in the body. (nepjol.info)
Primary hepatic leiomyosarcoma (PHL) is a rare malignant tumor, which originates from smooth muscles. (koreamed.org)
Epstein-Barr virus-associated smooth muscle tumor is an uncommon neoplasm associated with immunodeficiency. (allenpress.com)
Different anatomic sites can be involved by Epstein-Barr virus-associated smooth muscle tumor, and even multiple locations can contain these unique lesions within the same patient. (allenpress.com)
Epstein-Barr virus (EBV)-associated smooth muscle tumor (SMT) is an uncommon neoplasm typically manifesting in immunodeficient individuals. (allenpress.com)
A leiomyoma is a relatively harmless and non-spreading tumor that arises from the smooth muscle of the stomach and intestinal tract. (petmd.com)
Leiomyosarcoma, tumor of the foot, smooth muscle cell tumor. (faoj.org)

The stomach, bladder, uterus, blood vessels, and intestines are examples of hollow organs made up of smooth muscles where LMS can be located, however the uterus or abdomen are the most common sites. (wikipedia.org)
Smooth muscle cells make up the involuntary muscles, which are found in most parts of the body, including the uterus, stomach and intestines, the walls of all blood vessels, and the skin. (wikipedia.org)
Uterine leiomyosarcomas come from the smooth muscle in the muscle layer of the uterus. (wikipedia.org)
It would be advisable to perform this stain in all epithelioid smooth muscle tumors of the uterus. (nih.gov)
In appearance, leiomyosarcomas of the uterus have features that range from those similar to leiomyoma (rare) to overtly malignant, gross features similar to those of high-grade sarcomas that may occur anywhere in the body, with infiltrative edges, necrosis, hemorrhage, and a variegated cut surface. (medscape.com)
In 2021, further testing revealed she had stage 4 uterine leiomyosarcoma, a rare cancer of the smooth muscles in the uterus. (yahoo.com)
Though LMS may arise from any site in the body containing a smooth muscle layer, they most often occur in the uterus, the retroperitoneum, and the extremities [ 5 , 6 ]. (oncotarget.com)
Leiomyosarcomas are sporadic malignant tumors that frequently arise from soft tissues, smooth muscles of the uterus, or gastrointestinal tract. (panafrican-med-journal.com)
Atypical leiomyomas of the uterus are well-defined neoplasms with smooth muscle cells. (uwi.edu)
Rhabdomyosarcoma (RMS) is a rare cancer that forms in soft tissue - specifically skeletal muscle tissue or sometimes in hollow organs such as the bladder or uterus. (suratoncologycentre.in)

[ 1 ] Intestinal leiomyosarcomas are mesenchymal tumors of smooth muscle origin. (medscape.com)

Leiomyomas are benign smooth muscle tumors that have overlapping features with leiomyosarcomas. (wikipedia.org)
Although both originate from smooth muscle, it is important to note that leiomyomas do not mature to become leiomyosarcomas. (wikipedia.org)
Leiomyomas are seen in pre-menopausal women and are symptomatic 20-50% of the time, while leiomyosarcomas, the most common uterine sarcomas, are seen in older post-menopausal women with 40-60 being the peak age incidence. (wikipedia.org)
they range from benign leiomyomas to low-grade and high-grade leiomyosarcomas . (medscape.com)
Leiomyomas and leiomyosarcomas are believed to develop independently and are not progressive. (medscape.com)
Uterine atypical leiomyomas (ALs) are extremely rare and occur in an age group almost one decade earlier than that for leiomyosarcomas. (uwi.edu)
There were 49 cases of smooth muscle tumors: 27 leiomyomas and 22 leiomyosarcomas. (bvsalud.org)

Leiomyosarcoma (LMS) are 15% of adult sarcomas and remain seldom curable in metastatic phase. (nature.com)
Leiomyosarcomas are rare, comprising fewer than 5% of all gynecologic malignancies and 30% of all uterine sarcomas. (medscape.com)
Approximately 1%-2% of solid tumors are soft-tissue sarcomas, and leiomyosarcomas comprise roughly 2%-9% of these sarcomas. (medscape.com)
Sarcomas comprise less than 1% of all primary breast neoplasms and only a minority of these are leiomyosarcomas. (scirp.org)
According to literature data, primary leiomyosarcoma is characterized by a better prognosis compared with other breast sarcomas, To date, the factors that are predictive of patient prognosis have not been identified. (scirp.org)
Leiomyosarcomas (LMS) are sarcomas that comprise spindle-cell neoplasms that develop from smooth muscle tissue and affect approximately 1 out of 100,000 Americans per year [ 2 - 4 ]. (oncotarget.com)
Approximately 350 spindle cell sarcomas are diagnosed each year and of these only eight percent are leiomyosarcomas. (faoj.org)
Sarcomas are cancers that develop in the soft/connective tissue found throughout the body - fat, bone (known as osteosarcoma), blood cells, cartilage, and muscle. (drallison.org)
With so many muscles and networks of connective tissue spread out across the body, there are dozens of different types of sarcomas. (drallison.org)
Soft tissue sarcomas are a group of cancers that grow in parts of your body such as your muscles, bones, deep layers of skin, or in fat. (suratoncologycentre.in)
Retroperitoneal sarcomas (RPS), such as pleomorphic leiomyosarcoma, often invade or displace vital organs in the abdominal cavity and exhibit an aggressive clinical course. (biomedcentral.com)
Soft tissue sarcomas (STS) are malignant tumors that arise from mesoderm-derived tissues, such as fat, muscle, and connective tissue. (biomedcentral.com)

The aim of this study is to analyse and compare the clinical features of leiomyoma and leiomyosarcoma, because they help in the differential diagnosis. (bvsalud.org)

In uterine smooth muscle tumors, some epithelioid cells most likely undergo clear cell changes and become positive for HMB-45. (nih.gov)
The majority of uterine smooth muscle tumors occur in the corpus, but the cervix, vaginal canal, broad ligament, and ovaries may also be involved. (medscape.com)

At most other primary sites-retroperitoneal extremity (in the abdomen, behind the intestines), truncal, abdominal organs, etc.-leiomyosarcomas appear to grow from the muscle layer of a blood vessel (the tunica media). (wikipedia.org)
Thus, a leiomyosarcoma can have a primary site of origin anywhere in the body from a blood vessel. (wikipedia.org)
Primary leiomyogenic tumours have been reported in unusual locations where smooth muscle cells are usually absent, such as the sinonasal cavity. (bmj.com)
When considering all the primary malignancies of the small bowel, adenocarcinomas tend to occur more proximally, whereas carcinoids , lymphomas, and leiomyosarcomas occur more distally. (medscape.com)
Depending on the study reviewed, the primary sites of occurrence of leiomyosarcomas are divided equally between the stomach and the small intestine. (medscape.com)
Waterwarth described the first instance of primary leiomyosarcoma breast (PLB) in 1968. (nepjol.info)
We discuss the case of a 41-year-old female who presented with a breast lump that was subsequently confirmed as Primary leiomyosarcoma and was treated with wide local excision with margins. (nepjol.info)
We report a case of primary leiomyosarcoma of the breast occurring in young female patient which was successfully treated by surgery and radiotherapy. (scirp.org)
2003) Primary leiomyosarcoma of the breast: A case report with review of the literature, The Breast Journal, 9, 494-496. (scirp.org)
Coexisting primary pulmonary leiomyosarcoma (PPL) with pulmonary Aspergillosis in immunocompetent patients is a rare occurrence. (panafrican-med-journal.com)
Primary pulmonary leiomyosarcomas (PPLs) are uncommon, with few reported cases in the literature [ 1 ]. (panafrican-med-journal.com)
Here, we report a case of subcutaneous leiomyosarcoma, which was initially diagnosed as a ganglionic cyst and was referred to podiatry by a primary care physician for evaluation. (faoj.org)
The primary antibody anti-alpha-Smooth Muscle Actin mouse monoclonal, 1A4/ASM-1 (Cat. (progen.com)

Oct. 23, 2015 /PRNewswire/ -- Janssen Biotech, Inc. today announced the U.S. Food and Drug Administration (FDA) has approved YONDELIS ® (trabectedin) for the treatment of patients with unresectable (unable to be removed with surgery) or metastatic liposarcoma (LPS) or leiomyosarcoma (LMS) who received a prior anthracycline-containing regimen. (prnewswire.com)
Liposarcoma can occur in fat cells in any part of the body, but most cases occur in the muscles of the limbs or in the abdomen. (suratoncologycentre.in)

Leiomyosarcomas are rare mesenchymal neoplasms characterized by a smooth muscle differentiation pattern. (oncotarget.com)

If cancer has already spread (metastasized) to other parts of the body at the time a leiomyosarcoma is found, then chemotherapy may lead to slightly longer survival. (msdmanuals.com)
The chemotherapy drug imatinib has been found to be effective in treating leiomyosarcoma that cannot be treated with surgery. (msdmanuals.com)
This report describes a case of rapidly progressive retroperitoneal pleomorphic leiomyosarcoma that was favorably controlled by debulking surgery followed by combination chemotherapy and radiotherapy. (biomedcentral.com)
Multimodal therapy with debulking surgery, combination chemotherapy and radiotherapy controlled a rapidly progressive retroperitoneal pleomorphic leiomyosarcoma. (biomedcentral.com)

Living with a rare, aggressive cancer like leiomyosarcoma means dealing with a shocking lack of effective treatment options, and, too often, a dismal prognosis. (dana-farber.org)
The best prognosis is cutaneous leiomyosarcoma and arises from the small muscles in the hair follicles. (faoj.org)
The prognosis for patients with purely cutaneous leiomyosarcoma is an unusually good 90% survival. (faoj.org)

Gastrointestinal leiomyosarcomas might come from smooth muscle in the GI tract, or alternatively, from a blood vessel. (wikipedia.org)

Cutaneous leiomyosarcomas derive from the pilo-erector muscles in the skin. (wikipedia.org)

It shows skeletal muscle differentiation. (curesarcoma.org)
Immunohistochemical study showed positivity for c-kit (CD117) and S-100 with neural and muscle differentiation present. (scirp.org)
The differentiation of ALs from leiomyosarcomas is crucial. (uwi.edu)

In the past, GI stromal tumors ( GISTs ) were misdiagnosed as leiomyosarcomas. (medscape.com)
GISTs, however, have been shown to lack characteristics of smooth muscle tumors on histologic examination. (medscape.com)

Of this uncommon group of highly malignant neoplasms, the leiomyosarcoma is the most common histiotype. (medscape.com)

Leiomyosarcoma (LMS) is a rare and aggressive cancer found in smooth muscle tissue. (prnewswire.com)
The most serious risks associated with YONDELIS are neutropenic sepsis (severe infections due to decreased white blood cells), rhabdomyolysis (severe muscle problems), cardiomyopathy (heart muscle problems, including heart failure), hepatotoxicity (liver problems, including liver failure), anaphylaxis, and extravasation (leakage of YONDELIS out of the vein during infusion) leading to tissue necrosis (tissue cell damage or death) and embryofetal toxicity. (prnewswire.com)
They start from cells in a type of muscle tissue called smooth muscle. (yahoo.com)
Leiomyosarcoma accounts for approximately 10% of all diagnoses for this form of cancer, making it the third most common form (overall, soft tissue cancer is very rare). (drallison.org)
Leiomyosarcoma is a rare type of cancer that affects smooth muscle tissue. (suratoncologycentre.in)

Treatment for subcutaneous leiomyosarcoma is resection and some authors suggest postoperative radiotherapy. (faoj.org)

pazopanib is the targeted therapy used in metastatic leiomyosarcoma as second line and is well tolerated. (wikipedia.org)

Count Me In, a non-profit cancer research initiative, is inviting patients living with a rare cancer called leiomyosarcoma to share their data and become partners in research in order to drive new discoveries and improve understanding of this cancer. (dana-farber.org)
The new Leiomyosarcoma Project (LMS) joins another such patient-partnered rare cancer research initiative offered through Count Me In, the Osteosarcoma Project (OS), which also aims to accelerate the pace of cancer research by allowing patients to easily share their unique health data. (dana-farber.org)
Other women stepped forward after hearing about the Boston-area woman's death from a smooth-muscle cancer called leiomyosarcoma. (drugwatch.com)
A year ago and a half ago, Jill was diagnosed with leiomyosarcoma, a rare cancer that affects smooth muscle cells. (cancer-services.org)
The immune suppression drugs raise the risk of cancer, and he developed a rare type leiomyosarcoma. (dailysabah.com)
Leiomyosarcoma (cancer of smooth muscle cells) can develop in the wall of the stomach. (msdmanuals.com)
Stephanie Coles, 39, was diagnosed with leiomyosarcoma after noticing a lump that turned out to be cancer. (yahoo.com)
But after visiting her doctors the mum-of-three went on to be diagnosed with leiomyosarcoma, a rare form of cancer and is now awaiting surgery to remover the 8kg tumour. (yahoo.com)

The drug appears to work particularly well in leiomyosarcoma, a common subtype. (mskcc.org)

Of the leiomyosarcomas, 20% are found in the GI tract, with sites of occurrence evenly divided between the stomach and the small intestine. (medscape.com)

The new Leiomyosarcoma Project joins an existing effort, Count Me In's Osteosarcoma Project, to partner with patients and accelerate scientific discovery in rare cancers. (dana-farber.org)
The availability of patient data is especially crucial in rare cancers such as leiomyosarcoma and osteosarcoma as current therapies tend to be limited. (dana-farber.org)
Approximately 3,000 new patients are diagnosed with osteosarcoma or leiomyosarcoma in the United States each year. (dana-farber.org)
Now osteosarcoma and leiomyosarcoma participants have the opportunity to directly receive information about what researchers have learned from studying their individual samples. (dana-farber.org)

These are involuntary muscles that we have no control over. (yahoo.com)

Leiomyosarcomas spread to the liver and peritoneum first. (medscape.com)

It can originate from the smooth muscles of pulmonary parenchyma, interstitium, or pulmonary vasculatures [ 1 , 2 ]. (panafrican-med-journal.com)

Often, as the size of the leiomyosarcoma increases, necrosis and bleeding follow. (medscape.com)

Smooth muscle actin and desmin were positive in all cases. (nih.gov)
Immunohistochemical analysis revealed high-grade malignant cells strongly positive for h-caldesmon and positive for α-smooth muscle actin, desmin, and calponin, resulting in a diagnosis of PLS. (biomedcentral.com)
IHC analysis of human colon using anti-alpha-Smooth Muscle Actin antibody. (progen.com)
Western blot analysis of human HeLa cell lysate with anti-alpha-Smooth Muscle Actin antibody. (progen.com)
IHC analysis of head and neck squamous cell carcinoma using anti-alpha-Smooth Muscle Actin antibody. (progen.com)

Intestinal leiomyosarcomas are fairly rare, with a frequency of around 1.4 cases per 100,000 patients. (medscape.com)

Most leiomyosarcomas metastasize within 2 years of diagnosis. (medscape.com)
To clarify the nature of leiomyosarcoma of the breast, and also to establish the proper treatment strategy, we report this case We report this case while discussing The Clinical presentation, diagnosis, therapy and pathologic feature. (scirp.org)
The immunohistochemical diagnosis was pleomorphic leiomyosarcoma with high-grade malignancy and aggressive proliferative features. (biomedcentral.com)

[2] LMS is an aggressive type of STS where smooth muscle cells become cancerous. (prnewswire.com)

While many people with early leiomyosarcoma often remain symptom-free, some leiomyosarcomas are diagnosed after a person develops symptoms. (yahoo.com)

From 12 epithelioid leiomyosarcomas, we selected 5 that had: 1) clear cell areas and 2) spindle cell areas that were at least focally positive for desmin and caldesmon. (nih.gov)

4, 11, 12, 13] The ALK-1 reactivity correlates with local recurrence[13] and muscle invasion. (medscape.com)

Additional studies are required to explore potential therapeutic applications and mechanisms for leiomyosarcoma treatment. (oncotarget.com)

De la Pena, J, Wapnir, I. (2008) Leiomyosarcoma of the breast in a patient with a 10-year-history of cyclo-phosphamide exposure: A case report. (scirp.org)
2004) Primitive leiomyosarcoma of the breast: case report and review of the literature. (scirp.org)
The authors present a case report of a rare leiomyosarcoma. (faoj.org)

PTCT ) today announced encouraging preliminary safety and efficacy results from its Phase 1B study of unesbulin (PTC596) in advanced leiomyosarcoma (LMS) patients. (prnewswire.com)
The preliminary results demonstrate promising early efficacy in patients with advanced leiomyosarcoma. (prnewswire.com)
Leiomyosarcoma patients with high expression of GAS6 or PROS1 present a significantly worse PFS. (nature.com)
Leiomyosarcoma patients, especially those whom develop metastasis, express higher levels of TYRO3 and GAS6. (nature.com)
Leiomyosarcoma was more frequent in patients up to 50 years and the jaws were the most affected sites. (bvsalud.org)

2004) Leiomyosarcoma of the breast: A pathologic and comparative genomic hybridization study of two cases. (scirp.org)
Only 21 cases of leiomyosarcoma in both the foot and ankle have been reported in the literature since 1936. (faoj.org)
Cases of smooth muscle tumors of the oral cavity were also compiled from 1970 to 2010. (bvsalud.org)

Anatomy17

Organisms3

Diseases17

Chemicals and Drugs5

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes4

Disciplines and Occupations1

Sarcoma21

Tumor9

Uterus10

Tumors of smooth muscle origin1

Leiomyomas7

Sarcomas12

Leiomyoma and leiomyosarcoma1

Uterine smooth muscle tumors2

Primary13

Liposarcoma2

Mesenchymal1

Chemotherapy4

Prognosis3

Gastrointestinal1

Cutaneous1

Differentiation3

GISTs2

Uncommon1

Tissue5

Resection1

Metastatic1

Cancer8

Subtype1

Stomach1

Osteosarcoma4

Involuntary muscles1

Liver1

Originate1

Necrosis1

Actin5

Intestinal1

Diagnosis3

Cancerous1

Symptoms1

Spindle-cell1

Recurrence1

Therapeutic1

Case report3

Patients5

Cases3