• 55%) left ventricular ejection fraction (EF). (medscape.com)
  • A transthoracic echocardiogram demonstrated a moderately dilated left ventricle, eccentric left ventricular hypertrophy, and a severely reduced left ventricular systolic function with an ejection fraction of 20-25% as well as global left ventricular hypokinesis. (hindawi.com)
  • For purposes of this measure, LVSD is defined as chart documentation of a left ventricular ejection fraction (LVEF) less than 40% or a narrative description of left ventricular systolic (LVS) function consistent with moderate or severe systolic dysfunction. (acponline.org)
  • Heterozygotes demonstrated mildly lower left ventricular ejection fractions (LVEFs) at rest compared with controls (0.56 + or - 0.10 vs 0.62 + or - 0.07, P = .02). (nih.gov)
  • We enrolled 10 917 eligible patients who had coronary artery disease and a left-ventricular ejection fraction of less than 40% in a randomised, double-blind, placebo-controlled, parallel-group trial. (nih.gov)
  • Thus, the overall clinical result of omecamtiv mecarbil is an increase in left ventricular systolic ejection time and ejection fraction. (wikipedia.org)
  • Thus omecamtiv mecarbil improves systolic function by increasing the systolic ejection duration and stroke volume, without consuming more ATP energy, oxygen or altering intracellular calcium levels causing an overall improvement in cardiac efficiency. (wikipedia.org)
  • Current clinical studies on humans have shown there is a direct linear relationship between dose and systolic ejection time. (wikipedia.org)
  • Adverse effects, such as ischemia, were only seen at doses beyond this level, due to extreme lengthening of systolic ejection time. (wikipedia.org)
  • In this regard, left ventricular ejection fraction (LVEF) is preserved in the majority of CKD patients who develop HF[ 1 ]. (medsci.org)
  • Objectives To evaluate the feasibility and reliability of hand-held ultrasound (HUD) examinations with real-time automatic decision-making software for ejection fraction (autoEF) and mitral annular plane systolic excursion (autoMAPSE) by novices (general practitioners), intermediate users (registered cardiac nurses) and expert users (cardiologists), respectively, compared to reference echocardiography by cardiologists in an outpatient cohort with suspected heart failure (HF). (bmj.com)
  • In cardio-oncology, research and clinical monitoring of cardiotoxicity with anthracycline and trastuzumab treatment has focused primarily on asymptomatic reductions in left ventricular ejection fraction (LVEF), so-called "cancer therapy-related cardiac dysfunction," or heart failure with reduced ejection fraction (HFrEF). (acc.org)
  • GLS and WMAI difference at baseline and follow-up shows a positive correlation with left ventricular ejection fraction (LVEF) changes at baseline and follow-up (p (scirp.org)
  • We investigated the prognostic importance of anaemia in patients with acute myocardial infarction (AMI) and left ventricular systolic dysfunction (LVSD) with and without HF. (ku.dk)
  • Cardiotoxicity was defined as left ventricular systolic dysfunction (LVSD) of grade ≥2. (medpagetoday.com)
  • Left ventricular systolic dysfunction (LVSD) is often diagnosed only after patients develop symptoms. (managedhealthcareexecutive.com)
  • This causes peripheral edema (blood pooling), which the sympathetic nervous system tries to correct by overstimulating the cardiac myocytes, leading to left ventricular hypertrophy, another characteristic of chronic heart failure. (wikipedia.org)
  • 2009 . Clinical impact of left ventricular hypertrophy and implications for regression. (nih.gov)
  • 9. Cortisol Excess in Patients With Primary Aldosteronism Impacts Left Ventricular Hypertrophy. (nih.gov)
  • 10. Long-term effects of adrenalectomy or spironolactone on blood pressure control and regression of left ventricle hypertrophy in patients with primary aldosteronism. (nih.gov)
  • 14. Role of aldosterone in left ventricular hypertrophy in hypertension. (nih.gov)
  • Hypertrophic Cardiomyopathy Hypertrophic cardiomyopathy is a congenital or acquired disorder characterized by marked ventricular hypertrophy with diastolic dysfunction (eg, due to valvular aortic stenosis, coarctation. (msdmanuals.com)
  • The right ventricular function was mildly to moderately reduced. (hindawi.com)
  • The right ventricular systolic pressure was elevated at 50-60 mmHg and there was a moderate degree of pulmonary hypertension. (hindawi.com)
  • Right ventricular (RV) dysfunction has adverse effects on long-term outcome in patients with repaired tetralogy of Fallot (TOF). (nih.gov)
  • This study was designed to identify the pathogenic mutation in a Chinese family with arrhythmogenic right ventricular cardiomyopathy /dysplasia (ARVC/D) using whole genome sequencing (WGS). (karger.com)
  • Pulmonary arterial hypertension (PAH) is a progressive disease characterized by increased pulmonary artery pressure leading to right ventricular (RV) failure. (frontiersin.org)
  • Prevalence of echocardiographic left-atrial enlargement in hypertension: a systematic review of recent clinical studies. (nih.gov)
  • 2011 . Association of obesity and hypertension with left ventricular geometry and function in children and adolescents. (nih.gov)
  • 140 mmHg systolic hypertension accounted for 18% of and Yemen). (who.int)
  • 7. Plasma aldosterone and left ventricular diastolic function in treatment-naïve patients with hypertension: tissue-Doppler imaging study. (nih.gov)
  • 11. Left ventricular systolic function in primary aldosteronism and hypertension. (nih.gov)
  • 17. Comparison of left ventricular structure and function in primary aldosteronism and essential hypertension by echocardiography. (nih.gov)
  • We retrospectively analyzed consecutive patients with significant MR and LV systolic dysfunction on echocardiography between 1995 and 2002. (nih.gov)
  • ECG gated Echocardiography with measurement of atrial electromechanical coupling (PA), left atrial intra-AEMD over a period of 1 year from July 2017 to July 2018 in Mansoura specialized medical hospital. (scirp.org)
  • The whole patients were assessed by way of thorough records taking, medical examination, twelve lead surface (ECG), ECG gated echocardiography with assessment of atrial electromechanical coupling (PA), left atrial intra-AEMD over a period of 1 year from July 2017 to July 2018 in department of cardiovascular medicine, Faculty of Medicine, Mansoura University. (scirp.org)
  • They found that among patients with no prior history of heart disease, 47 (26%) showed signs of "significant" coronary artery disease (CAD), valvular disease, or left ventricular systolic dysfunction with screening echocardiography done at least five years and an average of 15 years after finishing radiation therapy. (lymphomainfo.net)
  • Mitral inflow pattern and tissue doppler were indicative of grade 3 diastolic dysfunction. (hindawi.com)
  • This study was designed to assess effects of mitral valve annuloplasty (MVA) on mortality in patients with mitral regurgitation (MR) and left ventricular (LV) systolic dysfunction. (nih.gov)
  • 65, sex, prior history of Afib, prior antiarrhythmic drugs, presence of ischemic heart disease, presence of left atrial (LA) dilatation, presence of right atrial (RA) dilatation, and the creation of bidirectional block. (medscape.com)
  • However, if often causes disease of the myocardium, such as heart failure, linked to the severity of DMR, and ventricular or atrial dysfunction or arrhythmia. (nih.gov)
  • PA lateral, PA septal and left atrium EMD are prolonged in postprandial condition than during fasting and it may be predictor of occurrence of postprandial palpitation and hidden atrial fibrillation. (scirp.org)
  • Prolonged Atrial electromechanical delay reflects the electrical remodeling of the left atrium, which is important for maintenance of AF [2]. (scirp.org)
  • Single centre experience in a large cohort of patients undergoing epicardial ventricular tachycardia ablation. (ksw.ch)
  • We aimed to test whether lowering the heart rate with ivabradine reduces cardiovascular death and morbidity in patients with coronary artery disease and left-ventricular systolic dysfunction. (nih.gov)
  • 8 patients had ventricular). (nih.gov)
  • RV systolic function during exercise in these 15 patients was significantly impaired before and returned to similar levels after surgery, compared with the rest of the patients. (nih.gov)
  • Omecamtiv mecarbil effectively relieves symptoms and enhances the quality of life of systolic heart failure patients. (wikipedia.org)
  • However, the rate of attenuation has not been investigated well in patients with varying degrees of systolic dysfunction. (karger.com)
  • Chez les patients hypertendus, le taux de mortalité était plus élevé uniquement chez les patients admis pour un infarctus du myocarde avec sus-décalage du segment ST. Après ajustement des résultats en fonction des variables de référence, l'hypertension s'est révélé être un facteur prédictif indépendant de l'insuffisance cardiaque (OR = 1,31) et de l'accident vasculaire cérébral (OR = 2,47). (who.int)
  • Furusawa K, Takeshita K, Suzuki S, Tatami Y, Morimoto R, Okumura T, Yasuda Y, Murohara T. Assessment of abdominal aortic calcification by computed tomography for prediction of latent left ventricular stiffness and future cardiovascular risk in pre-dialysis patients with chronic kidney disease: A single center cross-sectional study. (medsci.org)
  • There is general interest in finding clinical markers for left ventricular diastolic dysfunction (LVDD), a major cause of cardiorenal syndrome leading to heart failure in chronic kidney disease (CKD) patients. (medsci.org)
  • 1. Left Ventricular Dysfunction in Patients With Primary Aldosteronism: A Propensity Score-Matching Follow-Up Study With Tissue Doppler Imaging. (nih.gov)
  • 15. The association of serum potassium level with left ventricular mass in patients with primary aldosteronism. (nih.gov)
  • 2,3 In a single-center study, the development of diastolic dysfunction has been reported in over 50% of patients treated with anthracycline chemotherapy within the first year of treatment. (acc.org)
  • Fish oil improves tubular dysfunction, lipid profiles and oxidative stress in patients with IgA nephropathy . (greenmedinfo.com)
  • Omega-3 fatty acid reduce the total mortality and sudden death in patients with left ventricular systolic dysfunction. (greenmedinfo.com)
  • The aim of this study is to evaluate the role of 2D speckle tracking in evaluation of the left ventricular (LV) systolic function in chronic total occlusion (CTO) patients before and at 1 day as well as 3 months after percutaneous coronary intervention (PCI). (scirp.org)
  • In this study we aimed to evaluate the role of 2D speckle tracking in evaluation of the LV systolic function in CTO patients at 1 day as well as 3 months after percutaneous coronary intervention. (scirp.org)
  • The current study was designed to evaluate left ventricular function during one-repetition-maximum (1-RM) strength testing and resistance exercise in cardiac patients with moderate left ventricular dysfunction. (nursingcenter.com)
  • The echocardiographic evaluation showed mild left ventricular dilatation, hypokinesia, and systolic dysfunction. (psychiatrist.com)
  • Importantly, current management guidelines do not recommend routine monitoring for ventricular arrhythmia, define criteria for clinical and imaging follow-up, or provide indications for an implantable cardioverter defibrillator (ICD) for primary prevention in MVP. (nih.gov)
  • However, vascular inflammation, thrombosis, and ventricular arrhythmia may be mediated more directly by excessive actions of n-6 eicosanoids than by blood lipoproteins. (nih.gov)
  • Anthracyclines are associated with increased aortic stiffness 1 and diastolic dysfunction, 2 suggesting that anthracycline therapy may also increase the risk of HFpEF. (acc.org)
  • We employed serial radionuclide angiography (RNA) to examine RV and left ventricular (LV) systolic function in adults late after TOF repair and its relation to clinical outcome. (nih.gov)
  • This group of closely followed adults with TOF remained well over 10 years with a low incidence of sudden death and stable RV and LV systolic function, despite a relatively large number of RV outflow reoperations. (nih.gov)
  • Preserved ventricular function may herald a favorable long-term outlook in this group. (nih.gov)
  • However, although it was once felt to be a sufficient explanation for decreased overall functional capacity in people with heart failure, it is now recognized that pumping action, at least as measured as left ventricular systolic function, is poorly related to exercise capacity (2). (nih.gov)
  • Primary outcome measure The feasibility of automatic decision-making software for quantification of left ventricular function. (bmj.com)
  • As the myocardium becomes ischemic, coronary sinus blood pH falls, cellular potassium is lost, lactate accumulates, ECG abnormalities appear, and ventricular function (both systolic and diastolic) deteriorates. (msdmanuals.com)
  • The recanalization of a chronic total coronary occlusion is the possible way to improve left ventricular (LV) function through the recovery of hibernating myocardium. (scirp.org)
  • PURPOSE: Deterioration in left ventricular function is a more sensitive marker of myocardial ischemia during exercise than ST segment depression. (nursingcenter.com)
  • Measurements were performed during 1-RM testing and resistance exercise (20%, 40%, and 60% of 1-RM using 10 to 15 repetitions) on the one-arm biceps curl (BIC) and bilateral knee extension exercises and compared with measurements of left ventricular function during the symptom-limited graded exercise test (SL-GXT). (nursingcenter.com)
  • It is often preceded by diastolic dysfunction, which is characterized by impaired active relaxation and increased stiffness. (nih.gov)
  • 0.05), indicating increased left ventricular chamber stiffness. (nih.gov)
  • Effect of bipolar electrode spacing on phrenic nerve stimulation and left ventricular pacing thresholds: an acute canine study. (medtronic.com)
  • In this analysis, there is no clearly demonstrable mortality benefit conferred by MVA for significant MR with severe LV dysfunction. (nih.gov)
  • Coronary angiography images showed severe stenosis of the left anterior descending coronary artery, which was dilated by percutaneous transluminal coronary angioplasty. (medscape.com)
  • They may also include basic investigations of ventricular dysfunction, inflammation, and fibrosis, and correlation of small- and large-animal models with clinical data. (nih.gov)
  • Experimental and clinical evidence suggests that mechanical stress leads to myocardial inflammation, fibrosis, and remodeling that creates the electrophysiological substrate responsible for SCA/SCD and other serious ventricular arrhythmias. (nih.gov)
  • Fish oil, but not flaxseed oil, decreases inflammation and prevents pressure overload-induced cardiac dysfunction . (greenmedinfo.com)
  • 1995 . Indexing left ventricular mass to account for differences in body size in children and adolescents without cardiovascular disease. (nih.gov)
  • Systolic heart failure involves a loss of effective actin-myosin cross bridges in the myocytes (heart muscle cells) of the left ventricle, which leads to a decreased ability of the heart to move blood through the body. (wikipedia.org)
  • 18. Remodeling of the left ventricle in primary aldosteronism due to Conn's adenoma. (nih.gov)
  • Distance covered during a six-minute walk test predicts long-term cardiovascular mortality and hospitalisation rates in men with systolic heart failure: an observational study. (springer.com)
  • Myocardial contractile dysfunction of varying degrees can occur without clinical heart failure. (nih.gov)
  • This study aimed to validate the efficacy of NTP42:KVA4 , a novel oral formulation of NTP42 in clinical development, in preclinical models of PAH while also, critically, investigating its direct effects on RV dysfunction. (frontiersin.org)
  • It was found that PA lateral (50.98 ± 8.07 vs. 50.38 ± 7.47 msec, p 0.026), PA Septal (34.87 ± 6.33 vs. 34.16 ± 6.32 msec, p 0.003) and, left intra-AEMD (PA lateral-PA Septal) (16.72 ± 7.34 vs. 16.21 ± 6.57 msec, p 0.01), values were higher in post prandial condition than in fasting state. (scirp.org)
  • Diastolic dysfunction is associated with cardiac fibrosis in the senescence-accelerated mouse. (nih.gov)
  • however, diastolic dysfunction was accompanied by increased fibrosis in the hearts of SAMP8 mice. (nih.gov)
  • Women heterozygous for dystrophinopathy demonstrate significant left ventricular systolic dysfunction, which is unmasked by exercise. (nih.gov)
  • A subset of individuals with MVP will exhibit SCA or SCD, even in the absence of significant MR, and more will exhibit other frequent ventricular arrhythmias. (nih.gov)
  • Significant increases in systolic blood pressure and left ventricular end-systolic volume ratio values ( P (nursingcenter.com)
  • Assen Goudev Introduction: In dilated cardiomyopathy (DCM) left ventricular (LV) strain and twist are significantly decreased. (karger.com)
  • 2. Aldosterone induces left ventricular subclinical systolic dysfunction: a strain imaging study. (nih.gov)
  • While current PAH therapies improve patient outlook, they show limited benefit in attenuating RV dysfunction. (frontiersin.org)
  • Oxidation state shares drastically in vascular dysfunction via lowering Nitric Oxide bioavailability through numerous complex mechanisms. (scirp.org)
  • She complained of a two-week history of progressively worsening orthopnea and shortness of breath that left her unable to perform daily activities. (hindawi.com)
  • I began to experience a shortness of breath in random waves that didn't leave me gasping for air but certainly made me uncomfortable and very worried. (bmj.com)
  • 6-min walk test provides prognostic utility comparable to cardiopulmonary exercise testing in ambulatory outpatients with systolic heart failure. (springer.com)
  • Due to cardiac muscle ischemia, sinus bradycardia and diastole prolongation was revealed, which increased left ventricular end-diastolic volume and eventually caused left ventricular overload. (tsu.ge)
  • There is no integrative approach to evaluate the risk of progression from MVP to DMR and myocardial dysfunction. (nih.gov)