Lectin family receptor. Medical search. Frequent questions

CD161 is encoded by the KLRB1 (Killer cell lectin-like receptor subfamily B member 1) gene. (bdbiosciences.com)
NK1.1 (Killer cell lectin-like receptor subfamily B, member 1, KLRB1, NKR-P1A, CD161, cluster of differentiation 161), refers to Natural Killer (NK) cells, lymphocytes that mediate cytotoxicity and secrete cytokines after immune stimulation. (thermofisher.com)

[ 5 ] C1q is a member of the collectin family, which also includes surfactant A, surfactant D, and mannose-binding lectin (MBL). (medscape.com)
The mouse Macrophage Mannose Receptor (MMR), also known as CD206 and MRC1 (mannose receptor C, type 1), is a 175 kDa scavenger receptor that is expressed on tissue macrophages, myeloid dendritic cells, and liver and lymphatic endothelial cells (1). (rndsystems.com)
Description: This MR6F3 antibody recognizes mouse CD206 also known as Macrophage Mannose Receptor (MMR) or Mannose Receptor C, Type 1 (MRC1). (fishersci.com)
DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
Here we describe the 3.2 Å cryo-EM structure of human DEC-205, thereby illuminating the structure of the mannose receptor protein family. (uci.edu)
We have previously shown that hemocyanins are internalized by APCs through receptor-mediated endocytosis with proteins that contain C-type lectin domains, such as mannose receptor (MR). However, the contribution of other innate immune receptors to the proinflammatory signaling pathway triggered by hemocyanins is unknown. (exeter.ac.uk)
Some of the major genes identified by this approach and validated in several populations including our work, include the chemokine (C-C motif) ligand 2 ( CCL2 ), human leukocyte antigen ( HLA ), interferon-γ ( IFNG ), mannose-binding lectin ( MBL ), nitric oxide synthase 2, inducible ( NOS2A ), solute carrier family 11A member 1 ( SLC11A1 ), SP110 , and the toll-like receptor ( TLR ) genes. (sun.ac.za)
200 kDa C-type lectin transmembrane protein of the MMR (macrophage mannose receptor) family, expressed at high levels on dendritic cells and thymic epithelial cells, and at low levels on lymphocytes, NK cells and monocytes. (exbio.cz)
CD205, also known as DEC-205, is an endocytic receptor of macrophage mannose receptor family. (exbio.cz)
MBL = mannose-binding lectin. (msdmanuals.com)

Homologous paired receptors often, but not always, have a shared ligand in common. (wikipedia.org)
More broadly, pairs of receptors have been identified that exhibit paired functional behavior - responding to a shared ligand with opposing intracellular signals - but are not closely homologous or co-located in the genome. (wikipedia.org)
After ligand binding to the receptor, the resulting complex is internalized and transported to a sorting organelle, where receptor and ligand are disassociated. (joplink.net)
Upon ligand recognition, Mincle interacts with the Fc receptor common γ-chain (FcRγ), which triggers intracellular signaling through Syk leading to CARD9-dependent NF-κB activation. (invivogen.com)
NKR-P1A, the receptor encoded by the KLRB1 gene, recognizes Lectin Like Transcript-1 (LLT1) as a functional ligand. (thermofisher.com)
Binding of the CD94/NKG2A receptor by its ligand (Qa-1(b)) did not significantly inhibit CD8(+) T cell effector functions. (duke.edu)
The carbohydrate-recognition domain (CRD) and the neck/repeat region represent the key features of CD209L family proteins that are also central to facilitating cellular ligand interactions and pathogen recognition. (preprints.org)
This unique pathway of receptor-mediated uptake proves to be necessary for presentation of antigenic peptides at low doses of ligand. (exbio.cz)

The extracellular region may contain multiple repeating protein domains and may be members of either the immunoglobulin or C-type lectin families. (wikipedia.org)
Activating receptors have a truncated cytoplasmic sequence compared to their corresponding inhibitory receptor and feature a positively charged amino acid residue in their transmembrane domain, enabling protein-protein interaction with an adaptor protein that possesses a immunoreceptor tyrosine-based activation motif (ITAM). (wikipedia.org)
It belongs to a family of receptors sharing similar protein structure that also includes DEC205, phospholipase A2 receptor, and Endo180 (2, 3). (rndsystems.com)
G-protein coupled receptors (GPCRs) are ancient, ubiquitous, constitute the largest family of transducing cell surface proteins, and are integral to cell communication via an array of ligands/neuropeptides. (biomedcentral.com)
Artemin, a neuronal survival factor in the glial cell line-derived neurotrophic factor family, binds the glycosylphosphatidylinositol-anchored protein GFRα3 and the receptor tyrosine kinase Ret. (jneurosci.org)
The KLRB1 protein contains an extracellular domain with several motifs characteristic of C-type lectins, a transmembrane domain, and a cytoplasmic domain. (thermofisher.com)
CD62E (also known as E-selectin, ELAM-1, and LECAM-1) is a 115 kD type I membrane protein and a member of the selectin family. (biolegend.com)
This 205 kDa C-type lectin transmembrane protein mediates adsorptive uptake and its intracellular domain contains coated pit localization sequence and distal acidic motif, which is required for recycling beyond early endosomes through deeper MHC II+ late endosomes and lysosomes. (exbio.cz)
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human G Protein Coupled Receptor, Family C, Group 5, Member A (GPRC5A) in Tissue homogenates, cell lysates and other biological fluids. (worldcarecouncil.org)
Several groups have reported that protein tyrosine phosphatase receptor type Z (PTPRZ) is highly expressed in glioblastoma, and that targeting PTPRZ attenuates tumor growth in mice. (bvsalud.org)
Moreover, we generated a signature of 8 genes co-expressed with ACVRL1 across different tumor types and characterized the c-type lectin domain containing protein (CLEC)14A as a potential downstream target of ACVRL1. (lu.se)

CD161 is a member of the C-type lectin superfamily and is also referred to as C-type lectin domain family 5 member B (CLEC5B). (bdbiosciences.com)
Several genes of the C-type lectin superfamily, including the rodent NKRP1 family of glycoproteins, are expressed by NK cells and may be involved in the regulation of NK cell function. (thermofisher.com)
In the Brown Group, we are interested in a superfamily of receptors called C-type lectin receptors (CLRs). (exeter.ac.uk)
It is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. (shu.edu)
Inadequate efficacy similarly halted the development of agents impinging on the activity of the activin receptor-like kinase (ALK)1, a member of the transforming growth factor-β superfamily. (lu.se)

Paired receptors are pairs or clusters of receptor proteins that bind to extracellular ligands but have opposing activating and inhibitory signaling effects. (wikipedia.org)
The extracellular domains of homologous paired receptors are typically very similar in sequence but have different binding affinity for their shared ligands, with the inhibitory member of the pair binding more tightly. (wikipedia.org)
Inhibitory receptors have a cytoplasmic sequence typically containing at least one immunoreceptor tyrosine-based inhibitory motif (ITIM). (wikipedia.org)
Sequence features such as the presence of an ITIM-like sequence in the 3' untranslated region of some activating receptors imply that the activating members of the pair likely evolved from the inhibitory members. (wikipedia.org)
Including non-paired examples, over 300 potential immune inhibitory receptors have been identified in the human genome. (wikipedia.org)
Canonically, inhibitory receptors recruit phosphatases through their ITIM motifs, inhibiting the function of cells in which they are expressed. (wikipedia.org)
NK cell activation and the triggering of effector functions is governed by a complex set of activating and inhibitory receptors. (frontiersin.org)
Here, we review tumor-NK cell interactions, discuss the mechanisms by which NK cells generate an antitumor immune response, and discuss NK cell-based therapeutic strategies targeting activating, inhibitory, and co-stimulatory receptors. (frontiersin.org)
These inhibitory receptors recognize MHC class I alleles , which could explain why NK cells kill cells possessing low levels of MHC class I molecules. (wikidoc.org)
Siglecs (sialic acid-binding immunoglobulin-like lectins) are single-pass cell surface receptors that have inhibitory activities on immune cells. (mdpi.com)
It is also known as Myeloid Inhibitory C-Type Lectin-Like Receptor and Dendritic Cell-Associated Lectin. (shu.edu)

Paired receptors are membrane proteins with extracellular domains that interact with extracellular ligands. (wikipedia.org)
At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
C-type lectin CD209/DC-SIGN and CD209L/L-SIGN proteins are distinct cell adhesion and pathogen recognition receptors that mediate cellular interactions and recognize a wide range of pathogens including, viruses such as SARS, SARS-CoV-2, bacteria, fungi and parasites. (preprints.org)
Pathogens exploit CD209L family proteins to promote infection and evade the immune recognition system. (preprints.org)

Paired receptors transduce extracellular signals through opposing intracellular signaling pathways. (wikipedia.org)
Intracellular lectins and glycan-modifying enzymes mediate autophagy and control host immunity and inflammation. (nature.com)
To determine how the profile of NK receptor expression changes in murine CD8(+) T cells as they respond to intracellular pathogens, we used class I tetramer reagents to directly examine Ag-specific T cells during lymphocytic choriomeningitis virus and Listeria monocytogenes infections. (duke.edu)

NK-cells, along with macrophages and several other cell types, express the FcR molecule, an activating biochemical receptor that binds the Fc portion of antibodies . (wikidoc.org)
We used newly generated anti-CLECSF8 monoclonal antibodies (mAB) to assess receptor expression in the mouse by flow cytometry. (biomedcentral.com)

Once internalized, ligands are released following acidification of phagosomes or endosomes, and the receptor recycles to the cell surface (3, 8). (rndsystems.com)
These receptors bind to various ligands on target cells, both endogenous and exogenous, and have an important role in regulating the NK-cell response. (wikidoc.org)
GDNF family ligands (GFLs) activate the Ret receptor tyrosine kinase through binding of glycosylphosphatidylinositol-anchored GDNF family receptor α coreceptors (GFRα1-4) ( Sariola and Saarma, 2003 ). (jneurosci.org)
C-type lectin-like receptors (CTLRs) play critical roles in immunity and homeostasis by recognising a great variety of microbial or endogenous ligands [ 1 ]. (biomedcentral.com)
The requirement for tumor angiogenesis has been therapeutically exploited in the clinical setting mainly by means of inhibition of the vascular endothelial growth factor family of ligands and receptors. (lu.se)

Two decades later, pioneering studies suggested that lectin-like molecules constitutively expressed on the surface of macrophages can selectively recognize changes on glycans decorating the surface of apoptotic thymocytes, 4 , 5 although these studies likewise did not provide substantial insight into the mechanisms by which lectin-glycan interactions regulate cell death. (nature.com)
CD206 is a 175-kDa, type 1 integral membrane glycoprotein receptor that is present in macrophages, some dendritic cells, as well as liver and lymphoid endothelial cells. (fishersci.com)
Thus, we studied the roles of Dectin-1, Dectin-2, and Toll-like receptor 4 (TLR4) in the hemocyanin activation of murine APCs, both in dendritic cells (DCs) and macrophages, using hemocyanins from Megathura crenulata (KLH), Concholepas concholepas (CCH) and Fissurella latimarginata (FLH). (exeter.ac.uk)

CLEC12 is a cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. (shu.edu)

NK-cells are defined as large granular lymphocytes that do not express T-cell antigen receptors (TCR) or Pan T marker CD3 or surface immunoglobulins (Ig) B cell receptor but that usually express the surface markers CD16 (FcγRIII) and CD56 in humans, and NK1.1/NK1.2 in certain strains of mice. (wikidoc.org)

The cryo-EM structure of the endocytic receptor DEC-205. (uci.edu)
Gurer C, Strowig T, Brilot F, Pack M, Trumpfheller C, Arrey F, Park CG, Steinman RM, Münz C: Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses. (exbio.cz)
A member of a family of endocytic receptors. (bvsalud.org)

Homologous paired receptors have characteristic differences in their transmembrane and cytoplasmic regions that distinguish the activating and inhibiting members of the pair. (wikipedia.org)

The immune system utilizes sensors on immune cells named pattern recognition receptors to recognize invading pathogens and foreign substances. (exeter.ac.uk)

KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al. (nih.gov)
Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy. (nih.gov)
However, CD56 dim NK cells can produce cytokines, specifically IFN-γ, after cell triggering via NKp46 of NKp30 activating receptors or after stimulation with combinations of IL-2, IL-12, and IL-15 ( 7 ). (frontiersin.org)
C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. (invivogen.com)
Mincle is an ITAM-coupled activating receptor that senses damaged cells. (invivogen.com)

Of the 8 plasma membrane receptors for complement, only deficiencies of CR3 and CR4 due to CD18 deficiency have been described, known as leukocyte adhesion deficiency (LAD) type 1 . (medscape.com)
The receptor then returns to the cell membrane surface. (joplink.net)
2018 ). Here, we will solely focus on the less recognized globosides and in particular the globoside Gb 3 , which is the membrane receptor for vero toxins. (springer.com)

Evidence suggests that C1q binds a receptor present on phagocytic cells, termed C1qRP. (medscape.com)
The C3a receptor binds C3a and C4a. (medscape.com)

Traditionally, paired receptors are defined as homologous pairs with similar extracellular domains and different cytoplasmic regions, whose genes are located together in the genome as part of the same gene cluster and which evolved through gene duplication. (wikipedia.org)
Its extracellular region is composed of an N-terminal cysteine-rich domain, followed by a single fibronectin type II repeat, and eight C-type lectin carbohydrate recognition domains (CRD) (3‑5). (rndsystems.com)

Mincle is a C-type lectin receptor that has emerged as an important player in innate immunity. (invivogen.com)
Mincle is a member of the C-type lectin receptor (CLR) family. (invivogen.com)
Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. (invivogen.com)
CLECSF8 is a predominantly monocyte/macrophage and neutrophil expressed receptor, showing significant interdependence with Mincle, but not Dectin-2. (biomedcentral.com)
Now, the identification of the monocyte-inducible C-type lectin (Mincle) as an essential receptor for TDM provides new insight into the formation of the characteristic granulomas in tuberculosis and an avenue for rational adjuvant design. (silverchair.com)

The receptor recognizes terminal galactose and N-acetylgalactosamine units. (joplink.net)
This receptor recognizes a variety of exogenous and endogenous stimuli, such as mycobacteria, some fungi, and necrotic cells [1, 2]. (invivogen.com)

The prototypic member of this family, Dectin-1, identified by Prof. Gordon Brown, plays a central role in mounting a protective innate immune response against fungal infections. (exeter.ac.uk)
We have recently identified a novel family of CLRs and my research is aimed at better understanding the roles and functions of these receptors and how they influence innate and adaptive immunity during fungal infection. (exeter.ac.uk)
20 yr later, the role of innate receptors in licensing adaptive responses is no longer a secret, but Freund's adjuvant remains dirty. (silverchair.com)

Mahnke K, Guo M, Lee S, Sepulveda H, Swain SL, Nussenzweig M, Steinman RM: The dendritic cell receptor for endocytosis, DEC-205, can recycle and enhance antigen presentation via major histocompatibility complex class II-positive lysosomal compartments. (exbio.cz)

Homologous paired receptors are located in the same gene cluster and are thought to have evolved through gene duplication. (wikipedia.org)
Importantly, multiple genomic innovations including gene losses, independent contraction and expansion of specific gene families and their associated regulatory networks likely moulded the evolution of the nautilus pinhole eye. (nature.com)
Several genes were present as members of gene families, as has also been observed in other insect species. (biomedcentral.com)

Expression of the GFRα3 receptor is primarily restricted to the peripheral nervous system and is found in a subpopulation of nociceptive sensory neurons of the dorsal root ganglia (DRGs) that coexpress the Ret and TrkA receptor tyrosine kinases and the thermosensitive channel TRPV1. (jneurosci.org)

Endogenous lectins and glycans are critical signals in the resolution of cell death. (nature.com)

Paired receptors are highly expressed in the cells of the immune system, especially natural killer (NK) and myeloid cells, and are involved in immune regulation. (wikipedia.org)
Although paired receptors are best characterized as part of the human and mouse immune systems, they have also been studied in other organisms. (wikipedia.org)
The adaptive immune system is unique to jawed vertebrates, but an example of a paired receptor family has been identified in a jawless vertebrate, termed agnathan paired receptors resembling Ag receptors (APAR) in the hagfish. (wikipedia.org)
Some paired receptors are expressed outside the immune system, for example in neurons, endothelium, and epithelium but in many examples, wide tissue distribution can be observed. (wikipedia.org)
These receptors trigger a plethora of immune responses that confer protection against infection and could also contribute to unwanted exacerbated immune responses. (exeter.ac.uk)
However, we know very little of how these receptors, in particular Dectin-1, influences adaptive immune responses to fungi. (exeter.ac.uk)

From these critical studies, putative NV receptors were identified, and thus it was hypothesized that a successful in vitro cell culture system would most likely possess these receptors to support NV replication. (cdc.gov)

Understanding the function of lectin-glycan recognition systems in cell death will facilitate the implementation of novel therapeutic strategies aimed at controlling unbalanced cell proliferation and survival in several pathologic conditions. (nature.com)
Recognition of Tumor Nidogen-1 by Neutrophil C-Type Lectin Receptors. (invivogen.com)
NK cells express several families of receptors that play central roles in target cell recognition. (duke.edu)

Expression of paired receptors is common in many types of leukocytes, especially myeloid cells and natural killer (NK) cells. (wikipedia.org)
Expression in NK cells can be stochastic, resulting in unique variations in receptor repertoire. (wikipedia.org)
Three GPCRs clustered with recently identified putative CHH receptors (CHHRs), and differential expression over the molt cycle suggests that they are associated with ecdysteroidogenesis regulation. (biomedcentral.com)
Two putative Corazonin receptors showed much higher expression in the YOs compared with all other GPCRs, suggesting an important role in molt regulation. (biomedcentral.com)
heterodimers) - a C-type lectin family receptor, conserved in both rodents and primates and identifies non-classical (also non-polymorphic) MHC I molecules like HLA E . Though indirect, this is a way to survey the levels of classical (polymorphic) HLA molecules, however, because expression of HLA-E at the cell surface is dependent upon the presence of classical MHC class I leader peptides. (wikidoc.org)
Scholars@Duke publication: Viral and bacterial infections induce expression of multiple NK cell receptors in responding CD8(+) T cells. (duke.edu)
The expression profile of PTN and its receptors was analyzed using an immunohistochemical method. (bvsalud.org)

CD206 belongs to the C-type lectin family. (fishersci.com)

Three putative CHH receptors were identified and could include an MIH receptor whose activation negatively regulates molting. (biomedcentral.com)

How do C-type lectins tailor adaptive immunity following phagocytosis of apoptotic cells? (nature.com)

The classical, lectin, and alternative pathways converge into a final common pathway when C3 convertase (C3 con) cleaves C3 into C3a and C3b. (msdmanuals.com)

Janeway advocated systematically sorting through the components of empirically discovered adjuvants to identify the individual stimulatory molecules and their cellular receptors, especially those that lead to interleukin-1 (IL-1) secretion ( Janeway, 1989 ). (silverchair.com)

Conversely, major histocompatibility complex class I polypeptide-related sequence A (MHC1A) (O.R.=0.6) and natural cytotoxicity triggering receptor 3 (NCR3) (O.R.=0.46) were associated with lower odds. (medrxiv.org)

It is a member of the C-type lectin family, expressed as a disulfide-linked homodimer. (biolegend.com)
Among these, Siglec-8 is a CD33-related family member selectively expressed on human mast cells and eosinophils, and at low levels on basophils. (mdpi.com)
CLECSF8 is a member of the Dectin-2 family of CTLRs. (biomedcentral.com)
CLEC12 ( C-Type Lectin Domain Family 12 Member A ) is negative regulator of granulocyte and monocyte functioning. (shu.edu)

We discuss here the contribution of glycan-lectin interactions to the initiation, execution and resolution of apoptosis and their emerging roles in other cell death programs including autophagy. (nature.com)

Other members of this receptor family include NKG2, NKR-P1 CD94, and Ly49. (biolegend.com)
These subtle effects suggest that CD94/NKG2A-mediated inhibition of T cells may be limited to particular circumstances or may synergize with other receptors that are similarly up-regulated. (duke.edu)

This practice was considered a secret because the co-stimulatory properties of adjuvants were overshadowed by the focus on antigen interactions with T and B cell receptors. (silverchair.com)

Activation of NK cells is a complex regulatory process modulated by a number of different paired receptor families coexpressed in this cell type. (wikipedia.org)

The chicken (Gallus gallus domesticus) genome contains a number of examples including a very large family, the chicken Ig-like receptors (CHIR) with over 100 members. (wikipedia.org)

The CD11/CD18 complex is part of the beta-2 integrin family and is important in adhesion and phagocytosis (see Table 1). (medscape.com)

Orthologs of receptors that were found to be involved in molt regulation in insects were also identified, including LGR3 and Corazonin receptor, the latter of which was expressed at much higher level than all other receptors, suggesting a key role in YO regulation. (biomedcentral.com)
The up-regulation of these receptors was independent of IL-15 and persisted long after clearance of the pathogen. (duke.edu)

Here, we describe an association of the 3′-UTR +1073 C/T polymorphism of the OLR1 (oxidised LDL receptor 1) on chromosome 12 with AD in French sporadic (589 cases and 663 controls) and American familial (230 affected sibs and 143 unaffected sibs) populations. (bmj.com)

Anatomy9

Organisms21

Diseases1

Chemicals and Drugs94

Analytical, Diagnostic and Therapeutic Techniques and Equipment13

Phenomena and Processes28

Disciplines and Occupations3

Technology, Industry, Agriculture4

Information Science4

Killer cell lectin like receptor2

Mannose10

Ligand8

Protein11

Superfamily5

Inhibitory11

Proteins4

Intracellular3

Antibodies2

Ligands5

Macrophages3

Mediates1

Antigen receptors1

Endocytic3

Transmembrane1

Pattern recogniti1

Activating5

Membrane3

Binds2

Extracellular2

Mincle5

Recognizes2

Innate3

Endocytosis1

Gene3

Tyrosine1

Endogenous1

Immune6

Vitro1

Recognition3

Expression7

CD2061

Putative1

Adaptive1

Pathways1

Molecules1

Cytotoxicity1

Member4

Contribution1

CD942

Interactions1

Activation1

Genome1

Phagocytosis1

Regulation2

Polymorphism1