FattyGenetically obeseNoted in obeseTissuesSecretionLipidsConcentrationsDiabetic ratsSerumMaleObese individualsSkeletal muscleLittermatesMetabolismObesityGlucose homeostasisReceptors0.05IntakeExperimentalControlProteinCounterpartsResponsesLiversHistologyNIDDMFemaleModelVoluntaryDiabetesLevelsStudyKidneyMechanismsFoldRegulationSimilarAdministrationIncreasesLowerContrastHypothalamusAnimalTimeControls
Fatty9
- The Zucker diabetic fatty rat offered such a model system. (jci.org)
- Meanwhile, the naturally-lean people released lots of fatty acids and burned them for fuel soon after they stopped eating - including that twenty-five year-old woman who couldn't gain weight in spite of her "excellent" appetite. (fathead-movie.com)
- Furthermore, in response to several different classes of antidiabetic peroxisome proliferator-activated receptor gamma agonists, adipose tissue resistin expression is increased in both ob/ob mice and Zucker diabetic fatty rats. (nih.gov)
- To determine if the CB1 receptor antagonist Rimonabant affected basal or activated insulin secretion we researched isolated islets from low fat siblings and obese Zucker (ZF) and Zucker Diabetic Fatty (ZDF) rats that were Drospirenone incubated for 24 h and exposed to 11 mmol/l glucose plus 0.3 mmol/l palmitate (GL) with or without Rimonabant. (bioskinrevive.com)
- The abbreviations used for the Zucker RICTOR obese (312-415 g) Drospirenone and Zucker Diabetic Fatty (260-340 g) rats are ZF and ZDF respectively. (bioskinrevive.com)
- At 6weeks of age, Zucker lean control (ZLC) and Zucker diabetic fatty (ZDF) rats were put on a treadmill with or without running for 1h/session/day for 5weeks. (mcmaster.ca)
- We investigated the changes in serum levels of trace elements and inflammation markers in fatty livers using two rat models of NAFLD, the methionine and choline deficient (MCD) diet model and Obese-Zucker rats. (unipv.it)
- Melatonin administration ameliorates glucose homeostasis in Zucker diabetic fatty (ZDF) rats. (uaeu.ac.ae)
- The objective of this study was to investigate the effects of melatonin in diabetes in relation to the levels and regulation of plasma chromium (Cr), vanadium (V), and magnesium (Mg) in Zucker diabetic fatty (ZDF) and Zucker lean (ZL) rats. (uaeu.ac.ae)
Genetically obese5
- We studied the content of GABA (gamma-aminobutyric acid) and the activity of both GABA aminotransferase (GABA-t) and glutamate decarboxylase (GAD) in the brainstem and pancreas of either 11 weeks old genetically obese rats and their age matched lean control rats. (unime.it)
- In order to investigate whether the impaired GH secretion associated with obesity is due to a pituitary disorder we studied GH mRNA levels by in situ hybridization in genetically obese and lean Zucker rats. (omeka.net)
- The genetically obese Zucker rat is a widely used model of early-onset obesity. (omeka.net)
- These results show that despite low GH secretion, genetically obese Zucker rats have 1) normal linear (nasoanal) growth, 2) normal or increased circulating levels of IGF-I and IGFBP-3, and 3) increased plasma IGF-I responses to exogenous GH. (omeka.net)
- Hearts from 50 wk-old genetically obese female Zucker rats (624 ± 13 g) and their lean littermate controls (275 ± 5 g) were isolated during ether anesthesia, supported metabolically by retrograde aortic perfusion (6 ml/min, 35° C) with physiological solution containing suspended canine erythrocytes (hematocrit, 20%), and the ventricles were paced at 180 beats/min. (edu.au)
Noted in obese2
- These rats exhibit hepatic steatosis in adulthood similar to those noted in obese individuals. (uwaterloo.ca)
- Contraction increased AMPKα1 activity 2.3-fold in lean rats, whereas no effect was noted in obese rats. (diabetesjournals.org)
Tissues3
- IκB-α level was significantly higher in the obese liver tissues and nuclei than their lean counterparts. (uwaterloo.ca)
- The purpose of this study was to compare the effects of two training modalities (moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT)) on the pro/antioxidant status of different tissues in obese Zucker rats. (hindawi.com)
- Intake of Baked Cod Fillet Resulted in Lower Serum Cholesterol and Higher Long Chain n -3 PUFA Concentrations in Serum and Tissues in Hypercholesterolemic Obese Zucker fa/fa Rats. (uib.no)
Secretion5
- Needlessly to say basal secretion was considerably raised in islets from obese or GL-treated low fat rats whereas the collapse upsurge in GSIS was reduced. (bioskinrevive.com)
- Nonetheless it reduced GSIS in islets from low fat rats without influencing basal secretion. (bioskinrevive.com)
- In contrast it appears to decrease stimulated secretion in islets from lean animals but not in obese or GL-exposed islets. (bioskinrevive.com)
- As expected basal secretion was significantly elevated in islets from obese or GL-treated lean rats whereas the fold increase in GSIS was diminished. (bioskinrevive.com)
- Like obese children, these obese rats are hyperinsulinemic and have low GH secretion. (omeka.net)
Lipids3
- Liver histology and the level of total lipids confirmed that Zucker obese rats had hepatic steatosis, which was further augmented by piroxicam treatment. (uwaterloo.ca)
- Polar lipids and other metabolites extracted from plasma from lean, diabetic, and obese Zucker rats were analyzed by flow injection using high resolution time of flight mass spectrometry. (chromatographyonline.com)
- Based on other interdisciplinary investigations on the lipid depots of diabetes 2 muscles made us to propose these accumulated contrasted contents to be made of peculiar lipids, including acyl-ceramides, as those were only found while diabetes 2 progresses in aging obese rats. (northumbria.ac.uk)
Concentrations2
- Conclusions The serum concentrations of trace elements change significantly only in MCD rats, which spontaneously progress to NASH. (unipv.it)
- Melatonin administration ameliorates the diabetic status of ZDF rats by enhancing plasma Cr and V concentrations. (uaeu.ac.ae)
Diabetic rats1
- METHODS AND PROCEDURES Animals Islets were isolated from 7- to 11-week-old male ZF and Zucker diabetic rats and their lean siblings. (bioskinrevive.com)
Serum4
- Results In MCD rats, a serum increase in Cl, Mg and Na and a decrease in Ca2+, Zn were detected in comparison with control rats. (unipv.it)
- An increase in only serum Ca2+ was found in Obese-Zucker rats. (unipv.it)
- The serum level of IGF-binding protein-3 (IGFBP-3) measured by Western ligand blotting was not significantly different in lean vs, obese rats. (omeka.net)
- The Effect of Lean-Seafood and Non-Seafood Diets on Fasting and Postprandial Serum Metabolites and Lipid Species: Results from a Randomized Crossover Intervention Study in Healthy Adults. (uib.no)
Male6
- Postnatal development of the gastrin-releasing peptide system in the lumbosacral spinal cord controlling male reproductive function in rats. (genscript.com)
- These results suggest that androgen surge during male puberty plays an important role in the development and maintenance of the male-specific GRP function in the rat spinal cord. (genscript.com)
- Material and methods NAFLD was induced in male Wistar rats by 3-week MCD diet administration, after which, blood samples were collected. (unipv.it)
- 12-week old Obese (fa/fa) and Lean (fa/-) male Zucker rats were also used. (unipv.it)
- A total of 80 male albino rats(Wistar strain) were used in this study. (edu.pk)
- In the present study, we investigated linear growth and its hormonal control in Zucker rats (male and female) from 4-20 weeks of age. (omeka.net)
Obese individuals1
Skeletal muscle3
- We determined the effects of insulin and muscle contraction/hypoxia on PI 3-kinase, AMPK, and glucose transport activity in epitrochlearis skeletal muscle from insulin-resistant Zucker ( fa/ fa ) rats. (diabetesjournals.org)
- Insulin-stimulated glucose transport in isolated skeletal muscle was reduced 47% in obese versus lean rats, with a parallel 42% reduction in tyrosine-associated PI 3-kinase activity. (diabetesjournals.org)
- Contraction and hypoxia elicited normal responses for glucose transport in skeletal muscle from insulin-resistant obese rats. (diabetesjournals.org)
Littermates1
- In the obese animals, compared to their lean littermates, the naso-anal length was normal or slightly greater, whereas the tails and femurs were shorter. (omeka.net)
Metabolism1
- Effects of legume protein hydrolyzates on lipid metabolism in an obese rat experimental model. (ugr.es)
Obesity2
- In the present research, Zucker obese rats were used as a model of human obesity and insulin resistant state. (uwaterloo.ca)
- In this report we show that resistin expression is significantly decreased in the white adipose tissue of several different models of obesity including the ob/ob, db/db, tub/tub, and KKA(y) mice compared with their lean counterparts. (nih.gov)
Glucose homeostasis1
- 2014). Loss of ovarian estrogens causes only mild deterioration of glucose homeostasis in female ZDF rats preventable by voluntary running exercise. (umontreal.ca)
Receptors1
- Cannabinoid CB1 and CB2 receptors have been identified in isolated mouse rat and human pancreatic islets with CB1 receptors mainly expressed in non-β-cells and CB2 receptors expressed in both β- and non-β cells (24-27). (bioskinrevive.com)
0.052
- 0.05) in the obese livers than in the lean livers, the difference between obese and lean groups was not as significant as that noted for the level of NF-κB assessed by western blot. (uwaterloo.ca)
- 0.05) in obese rats, while the same therapeutic approach did not affect this parameter in lean rats. (unime.it)
Intake1
- all forms of GRP reduce food intake in obese and lean adult Zucker rats similar to Bn in weanling rats. (genscript.com)
Experimental1
- Interaction with aerobic physical exercise/efectos de hidrolizados proteicos vegetales procedentes de leguminosas sobre el metabolismo lipídico en un modelo experimental de rata obesa. (ugr.es)
Control4
- Title: The stomach and/or upper duodenum contain sites of action that control meal size and intermeal interval length by exogenous rat gastrin releasing peptide. (genscript.com)
- Zucker lean counterparts served as control. (uwaterloo.ca)
- Moreover Zucker rats showed increased plasma levels of insulin and a greater body weight when compared to their lean control rats. (unime.it)
- They also develop sympathetically-driven hypertension with diminished baroreflex control of sympathetic nerve activity (SNA) and heart rate (HR) compared to lean Zucker rats. (unthsc.edu)
Protein7
- Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: an alteration not due to hyperglycemia. (jci.org)
- Normalization of circulating glucose in the rat model by either insulin or phlorizin treatment did not result in a reduction in membrane PKC isozyme protein or kinase activity. (jci.org)
- The obese nuclei contained two to three fold higher levels of NF-κB protein than the lean liver nuclei. (uwaterloo.ca)
- In accordance, the phosphorylation levels of cardiac troponin I (cTnI) and myosin binding protein-C (cMyBP-C) were lower in LV (but not in RV) cardiomyocytes of ZDF animals than in their counterparts of the Lean or Lean + Vard groups. (unideb.hu)
- Our data illustrate partially overlapping myofilament protein alterations for LV and RV cardiomyocytes in diabetic rat hearts upon long-term PDE-5A inhibition. (unideb.hu)
- In this study, the effect of protein malnutrition and its reversal was observed in rats. (edu.pk)
- It was observed that protein malnutrition had an adverse though reversibleeffect on the thyroid follicular cell size of the albino rats. (edu.pk)
Counterparts1
- Ca2+-sensitivity of isometric force production (pCa50) was significantly higher in LV (but not in RV) cardiomyocytes of ZDF rats than in their counterparts in the Lean or Lean + Vard groups. (unideb.hu)
Responses1
- Sequence analysis and feeding responses evoked by the large molecular form of gastrin releasing peptide (GRP) in the rat GRP-29. (genscript.com)
Livers3
- Piroxicam treatment lowered the level of NF-κB in obese and lean livers. (uwaterloo.ca)
- IκB-α was higher in obese livers than in lean livers. (uwaterloo.ca)
- Lipid raft was extracted and identified successfully from obese and lean livers. (uwaterloo.ca)
Histology1
- Haverbeke G. "Quantitative Histology of Rat Thyroid. (edu.pk)
NIDDM1
- There was a significant increase in immunodetectable PKC-alpha (twofold), -epsilon (threefold), and -zeta (twofold) in the membrane fraction isolated from obese subjects with NIDDM compared with the lean controls. (jci.org)
Female2
- Female Zucker obese and lean rats (5 weeks old) were fed a semisynthetic diet with or without piroxicam (150 ppm). (uwaterloo.ca)
- Although female rats may develop salt-induced sensitization of the RVLM, we hypothesize estrogen enhances NTS function to combat impairment of sympatho-inhibitory reflexes in early stages of metabolic syndrome. (unthsc.edu)
Model1
- Plasma Mg levels were significantly lower in C-ZDF vs. C-ZL rats, demonstrating the presence of hypomagnesemia in this diabetes mellitus model. (uaeu.ac.ae)
Voluntary1
- Voluntary resistance exercise training with obese and lean Zucker rats. (cdc.gov)
Diabetes1
- 2006). PPARg Agonism Prevents the Onset of Type 2 Diabetes in ZDF Rats : A Comparison to PPARaAgonism. (umontreal.ca)
Levels2
- Vardenafil treatment increased cyclic guanosine monophosphate (cGMP) levels and decreased 3-nitrotyrosine (3-NT) levels in the left and right ventricles of ZDF animals, but not in Lean animals. (unideb.hu)
- Plasma V and Cr levels were significantly higher in M-ZDF vs. C-ZDF rats. (uaeu.ac.ae)
Study3
- In this study, we observed the effects of a physical exercise on COX-2 immunoreactivity in the hippocampus using immunohistochemistry in rats. (mcmaster.ca)
- This study strongly supports the idea that a decreased brainstem GABA content may be responsible for hyperinsulinemia in obese Zucker rats. (unime.it)
- The Effect of Lean-Seafood and Non-Seafood Diets on Fecal Metabolites and Gut Microbiome: Results From a Randomized Crossover Intervention Study. (uib.no)
Kidney1
- However, LYPLAL1, TFAP2B, SEC16B and FAIM2 were significantly lower expressed in the kidney fat of ZDF than ZL rats. (uni-regensburg.de)
Mechanisms1
- This project uses obese Zucker rats (OZR) to determine cellular and systemic mechanisms that produce altered autonomic reflexes in the setting of metabolic syndrome. (unthsc.edu)
Fold1
- Rimonabant reduced basal hypersecretion in islets from obese rats and GL-treated low fat rats without reducing the fold upsurge in GSIS. (bioskinrevive.com)
Regulation3
- The site of action of rat gastrin releasing peptide, in regulation of meal size and intermeal interval, is most likely the stomach and/or the duodenum. (genscript.com)
- GRP regulation of meal size and intermeal interval occurs at different sites in the rat. (genscript.com)
- This appears to be the first report of a beneficial effect of melatonin treatment on plasma Cr and V regulation in ZDF rats. (uaeu.ac.ae)
Similar2
- Hypoxia increased AMPKα1 activity to a similar extent (more than sixfold) in lean and obese rats. (diabetesjournals.org)
- The obese and lean end-diastolic PV curves were not different, and therefore the obese and lean LV chamber compliances were similar. (edu.au)
Administration2
- Obese and lean Zucker rats respond similarly to intraperitoneal administration of gastrin-releasing peptides. (genscript.com)
- On the other hand, the repeated oral administration of celecoxib to 4-week-old ZDF rats significantly decreased the neuroblasts in the subgranular zone of the dentate gyrus. (mcmaster.ca)
Increases1
- Results show that both site-specific upregulation (pharmacological or chemogenetic) and chronic downregulation (RNA interference) of MCH communication to the vHP increases impulsive responding in rats, indicating that perturbing this system in either direction elevates impulsivity. (nature.com)
Lower2
- NEGR1 was even lower expressed in subcutaneous and mesenterial fat, while MTCH2 was higher expressed in the subcutaneous and mesenterial fat of ZDF rats. (uni-regensburg.de)
- Gaba content and GAD activity in the brainstem of 11 weeks old obese rats were lower than in age matched lean controls. (unime.it)
Contrast1
- By contrast no difference was observed between obese and lean rats in the GABAergic system of pancreas. (unime.it)
Hypothalamus1
- Interestingly, the expression pattern in the hypothalamus showed no differences between obese ZDF and lean ZL rats. (uni-regensburg.de)
Animal1
- After 8 weeks of feeding, rats were euthanized and liver from each animal was collected. (uwaterloo.ca)
Time2
- The animals were fed normal rat chow and water until time of sacrifice. (bioskinrevive.com)
- It is time for right-leaning Jews to recognize - and oppose - the anti-Semitism among their conservative gentile allies. (theyeshivaworld.com)
Controls1
- Immunodetectable membrane PKC-alpha, -beta, -epsilon, and -zeta were significantly increased when compared with both the lean and obese controls. (jci.org)