Lean and obese mice. Medical search. Frequent questions

Within the academia and the pharmaceutical industry alike, the ob/ob mouse model is widely used for studies on initial aspects of metabolic disturbances leading to type 2 diabetes, including insulin resistance and obesity 11 . (nature.com)
Finally, lipopolysaccharide administration induced a long-lasting expression of IL-1Ra in mouse WAT, suggesting that adipose tissue is an important source of IL-1Ra in both obesity and inflammation. (diabetesjournals.org)
We also examined mid-gestation placental lipid composition and metabolism in mice fed high fat/high sugar diet to induce obesity. (unl.edu)
One clue came from a 2010 Genome Biology study (doi:10.1186/gb-2010-11-11-r111) showing that genetically identical mice sharing a mutation in a protein called Trim28 exhibit high variability in their body mass, suggesting that this protein might trigger epigenetic changes that contribute to individual variation in obesity. (eurekalert.org)
To learn more about the link between obesity and breast cancer, researchers studied the breast tissues of lean and obese breast cancer patients, as well as tissues belonging to obese mice. (theverge.com)
We identified several SM-encoding biosynthetic gene clusters (BGCs) from the metagenomic data of lean and obese individuals and found significant association between some BGCs, including those that produce hitherto unknown SM, and obesity. (hindawi.com)
In addition, the mean abundance of BGCs was positively correlated with obesity, consistent with the lower taxonomic diversity in the gut microbiota of obese individuals. (hindawi.com)
For example, some studies report an increased Firmicutes to Bacteroidetes ratio in obese patients [ 6 , 7 ], whereas others found no association between the above phyla and obesity [ 8 , 9 ]. (hindawi.com)
In this study, we analyzed the differences in the BGCs of nonobese and obese individuals using human fecal metagenomic data, in order to identify obesity-associated BGCs. (hindawi.com)
In comparing the immune response of lean and obese female mice, the study authors write in the study that they hoped to find out how obesity affects the immune response of the genital mucosa. (the-scientist.com)
Weight loss following diet-induced obesity does not alter colon tumorigenesis in the AOM mouse model. (ajmc.com)
A possible link to gut flora and obesity was first discovered by comparing intestinal bacteria in obese and lean individuals and there were significant differences. (doctormurray.com)
Oligofructose, a nondigestible prebiotic fiber, can restore a lean gut microbial community profile in the context of obesity, suggesting a potentially novel approach to treat the OA of obesity. (jci.org)
Here, we report that - compared with the lean murine gut - obesity is associated with loss of beneficial Bifidobacteria, while key proinflammatory species gain in abundance. (jci.org)
Other studies have evaluated alternative proteins for obesity weight management in mice, but most have used genetically altered mice designed to stay obese no matter what. (illinois.edu)
Changing the mix of gut bacteria in mice prevented those destined for obesity from gaining weight and fat or developing related metabolic problems linked to insulin resistance - but only if the mice ate a healthy diet - a new study from Washington University School of Medicine in St. Louis has found. (ausfoodnews.com.au)
These experiments demonstrate that human gut microbes "transmitted" to mice can shape physical traits such as obesity and leanness in the mice. (harvard.edu)
Kravitz has a background in studying Parkinson's disease, and when he began conducting obesity research a few years ago, he was struck by similarities in behavior between obese mice and Parkinsonian mice. (psypost.org)
Carbonyl reductase 1 (Cbr1), a recently discovered contributor to tissue glucocorticoid metabolism converting corticosterone to 20ß-dihydrocorticosterone (20ß-DHB), is upregulated in adipose tissue of obese humans and mice and may contribute to cardiometabolic complications of obesity . (bvsalud.org)
Mice lacking one Cbr1 allele and mice overexpressing Cbr1 in their adipose tissue underwent metabolic phenotyping before and after induction of obesity with high-fat feeding . (bvsalud.org)
Yifei Kang et al, Yellow Mealworm (Tenebrio molitor) and Lesser Mealworm (Alphitobius diaperinus) Proteins Slowed Weight Gain and Improved Metabolism of Diet-Induced Obesity Mice, The Journal of Nutrition (2023). (medtelligence.net)
For example, obesity can be transferred to germ-free mice with fecal microbiota from obese subjects, but not from lean twins. (medscape.com)
lion adults are obese and 2.1 bil ion attributed to obesity. (who.int)

When scientists transferred gut microbiome cells from obese mice into lean ones, the recipients gained weight. (reachmd.com)
Performing a similar analysis on the greater vaginal microbiome, the team found that administering antibiotics to remove commensal vaginal microbiota also significantly decreased obese mice's survival. (the-scientist.com)
Oligofructose supplementation restores the lean gut microbiome in obese mice, in part, by supporting key commensal microflora, particularly Bifidobacterium pseudolongum. (jci.org)
To circumvent this potential interpretational problem, we aimed at providing an overview about whether and how dietary supplementation of different complex carbohydrates changes the gut microbiome in healthy non-obese individuals. (frontiersin.org)
He has another paper in the works to characterize the effects of mealworms on the mouse microbiome. (illinois.edu)
An Integrated Systems Biology Approach to Identify Opioid-Induced Shifts in Function of the Gut Microbiome among Lean and Obese Mice Undergoing Systemic Opioid Treatment. (utk.edu)

The microbiota of obese mice differed from that of the lean mice, with a higher level of gut-derived bacteria such as E. coli . (the-scientist.com)

So, people who are obese would reduce their cancer risk by losing weight, right? (ajmc.com)
There are hundreds of millions of people who are obese but not yet diabetic even though they have the hallmarks that they're going to get diabetes. (medpagetoday.com)

We used loss- and gain-of-function approaches including genetic manipulation of the lipolytic enzyme Pnpla2 , change in environmental temperature, and lifestyle interventions to comprehensively test the premise that a thermogenic-like BAT phenotype is coupled with enhanced glucose tolerance in female mice. (diabetesjournals.org)
Thermoneutral housing (30 °C vs. 22 °C) of mice induces an obese phenotype without dietary changes. (unl.edu)
Male C57BL/6j (lean) and ob/ob mice (leptin-deficient mice exhibiting obese phenotype) were subjected to SF or control conditions for 24 h using an automated SF chamber. (peerj.com)
Serum leptin levels are directly related to adipose tissue mass, which leads to increased leptin levels associated with the obese (OB) phenotype ( Al Maskari & Alnaqdy, 2006 ). (peerj.com)
Loss of the PPM1H phosphatase that is specific for LRRK2-phosphorylated Rab GTPases yields the same cilia loss phenotype seen in mice expressing pathogenic LRRK2 kinase, strongly supporting a connection between Rab GTPase phosphorylation and cilia loss. (elifesciences.org)

By comparing the BGCs of known SM between obese and nonobese samples, we found that menaquinone produced by Enterobacter cloacae showed the highest correlation with BMI, in agreement with a recent study on human adipose tissue composition. (hindawi.com)
Here we used a fate-mapping approach in mouse models to determine the developmental origins and the differential turnover kinetics of ATMs in lean and obese adipose tissue. (ntu.edu.sg)
Carbonyl reductase 1 amplifies glucocorticoid action in adipose tissue and impairs glucose tolerance in lean mice. (bvsalud.org)
This study tested the hypothesis that Cbr1-mediated glucocorticoid metabolism influences glucocorticoid and mineralocorticoid receptor activation in adipose tissue and impacts glucose homeostasis in lean and obese states. (bvsalud.org)
20ß-DHB activated both the glucocorticoid and mineralocorticoid receptor in adipose tissue and systemic administration to wild-type mice induced glucose intolerance , an effect that was ameliorated by both glucocorticoid and mineralocorticoid receptor antagonism. (bvsalud.org)
Cbr1 haploinsufficient lean male mice had lower fasting glucose and improved glucose tolerance compared with littermate controls, a difference that was abolished by administration of 20ß-DHB and absent in female mice with higher baseline adipose 20ß-DHB concentrations than male mice . (bvsalud.org)
Conversely, overexpression of Cbr1 in adipose tissue resulted in worsened glucose tolerance and higher fasting glucose in lean male and female mice . (bvsalud.org)
Carbonyl reductase 1 is a novel regulator of glucocorticoid and mineralocorticoid receptor activation in adipose tissue that influences glucose homeostasis in lean mice . (bvsalud.org)

To test whether these findings extend to humans, the researchers examined fat tissue samples from 22 lean and 18 obese pre-pubertal children who entered the clinic for elective surgery. (eurekalert.org)
The researchers next analyzed publicly available datasets from genetically identical twin pairs, each comprising one obese and one lean individual. (eurekalert.org)
Treating obese mice with catestatin (CST), a peptide naturally occurring in the body, showed significant improvement in glucose and insulin tolerance and reduced body weight, report researchers. (sciencedaily.com)
To test the effect of the amino acid arginine, researchers subjected lean and obese animal models to a so-called glucose tolerance test, which measures the body's ability to remove glucose from the blood over time. (nutraingredients-usa.com)
The researchers used electron microscopy and other imaging techniques to view thousands of cells from the liver tissue of lean and obese mice. (harvard.edu)
In an elegant proof-of-principle approach, the researchers used synthetic molecules to decrease the physical distance between the ER and mitochondria in cells and in liver tissue and found that this intervention impaired mitochondrial function and made mice more sensitive to high fat diet-induced insulin resistance and diabetes. (harvard.edu)
The researchers also demonstrated that by disrupting the ER-mitochondrial interactions and calcium transfer, they could markedly improve the metabolic health of obese diabetic mice - pointing the way to a potential treatment target in humans. (harvard.edu)
Researchers found that precancerous cells grown in obese fat tissues are more likely to turn into malignant tumors than cells grown in lean fat tissues. (theverge.com)
by putting obese mice on a diet, the researchers showed that some of the changes that took place in the fatty tissues were reversible. (theverge.com)
In a study published November 8 in Cell Reports , researchers found that thanks to differences in their vaginal microbiomes compared with lean mice, obese mice fed a high-fat diet had stronger immune responses against HSV-2, which causes genital herpes in humans. (the-scientist.com)
The researchers gave some of the mice standard food and fed others a high-fat diet. (the-scientist.com)
When the researchers used an antibody to inhibit receptors for γδ T-cells, it significantly reduced the ability of obese mice to combat HSV-2, whereas it had no effect on lean mice, indicating that γδ T-cells played a role in the obese mice's immunity. (the-scientist.com)
When the researchers introduced E. coli into the vaginal microbiomes of lean mice, they found that it promoted viral clearance and prevented HSV-2 symptoms compared to controls. (the-scientist.com)
In a series of experiments in mice, researchers found that inhibition of the kinase CaMKII -- or even some of its downstream components -- lowered blood glucose and insulin levels, Ira Tabas, MD, PhD , of Columbia University Medical Center in New York City, and colleagues reported online in Cell Metabolism . (medpagetoday.com)
In further analyses, the researchers discovered deleting or inhibiting any of these three elements ultimately improved insulin-induced Akt-phosphorylation in obese mice -- an important part of improving insulin sensitivity. (medpagetoday.com)
Researchers used identical and fraternal female human twin pairs, ranging in age from 21 to 32, in which one twin was obese and the other lean - a weight disparity that occurs in about 6 per cent of twins. (ausfoodnews.com.au)
Researchers showed that by transplanting entire collections of human microbes into different groups of mice, they could mimic the body composition of each twin. (ausfoodnews.com.au)
Because mice naturally eat one another's feces, the researchers said they were able to observe what happened when a mouse carrying a collection of gut microbes from an obese twin was housed with another mouse carrying gut microbes from the lean twin. (ausfoodnews.com.au)
The researchers showed that weight gain, accumulation of fat and development of metabolic problems were only prevented in mice that had "obese" microbes if they ate healthy diets. (ausfoodnews.com.au)
Researchers are collecting fecal samples from lean, healthy donors, freeze-drying their stool and packaging a few grams of it into capsules, which are then given to 20 obese patients. (harvard.edu)
Researchers have shown that in mice prebiotics, particularly oligofructose, can reverse certain gastric problems. (trilinkbiotech.com)
The researchers also plan to look at how quickly the mice recover to normal activity levels once they begin eating a healthy diet and losing weight. (psypost.org)

Gut microbes (captured from fecal samples) from the twins' guts were transferred into mice that had been raised in a previously microbe-free environment. (ausfoodnews.com.au)

Serum oxLDL levels are decreased in both lean and obese diabetic animals treated with TZDs. (jci.org)
One of the areas we're most excited about in potential clinical use is in obese people before they get diabetic," Tabas told MedPage Today . (medpagetoday.com)

They then populated the guts of these mice either with human intestinal microbes from an obese woman or from her lean twin sister. (harvard.edu)
Specifically, she's asking whether transferring intestinal microbes from a slim person may help an obese person lose weight. (harvard.edu)

As expected, this diet made the mice overweight and they started to show signs of pre-diabetes-like metabolic problems, such as insulin resistance and elevated fasting blood sugar levels. (nih.gov)
By 2013 approximately 29% of the world population was said to be overweight or obese. (trilinkbiotech.com)
Increased consumption of dairy foods and protein during diet- and exercise-induced weight loss promotes fat mass loss and lean mass gain in overweight and obese pre-menopausal women. (bodybuilding.com)
Consider a study that placed 90 overweight and obese adult women on either a low-dairy diet following the RDA for protein (15% of total calories as protein , and less than 2% of total calories from dairy products, respectively), an RDA protein level and moderate-dairy diet (7.5% of calories from dairy), or a high-protein (30%) and high-dairy diet (15%), in combination with daily exercise for 16 weeks. (bodybuilding.com)

Strikingly, obese children with Trim28-deficient tissue samples showed the same epigenetic changes observed in Trim28-deficient obese mice. (eurekalert.org)
To study insulin resistance, Harrison is currently comparing Rac1 activity in skeletal muscle cells and skeletal muscle tissue of lean and obese mice. (oregonstate.edu)
A healthy person, in a food shortage situation, would burn mostly fat initially before tearing down lean tissue. (180degreehealth.com)

The prevention of problems was associated with an invasion of a group of bacteria called Bacteroidetes from mice with "lean" microbes into the guts of mice with "obese" microbes. (ausfoodnews.com.au)

Mice fed low-fat mouse food and given gut microbes from an obese twin gained weight and fat and took on the metabolic dysfunction of the donor, while mice given gut microbes from a lean twin stayed lean. (ausfoodnews.com.au)
In a further set of experiments for the study, the twins' microbes were again transplanted into germ-free mice. (ausfoodnews.com.au)
In this round, mice with microbes from a lean twin were put in cages with mice carrying microbes form an obese twin. (ausfoodnews.com.au)
When the animals were fed a typical "unhealthy" diet - high in saturated fat and low in fruits and vegetables - there was no colonisation of "lean" microbes into the guts of mice carrying microbes from an "obese" twin. (ausfoodnews.com.au)
If the animals ate a healthy diet low in saturate fat and high in fruits and vegetables, microbes from the lean twin invaded the gut of the mouse with the obese twin's microbes, preventing weight gain and the development of metabolic problems associated with insulin resistance. (ausfoodnews.com.au)
In 2009, a study by Dr Gordon and his colleagues indicated that the collections of microbes in the guts of obese people lacked the "diversity and richness" of people who were lean. (ausfoodnews.com.au)

We previously showed that this cytokine antagonist is upregulated in the serum of obese patients, correlating with BMI and insulin resistance. (diabetesjournals.org)

We have shown that an endogenous peptide, catestatin, can directly suppress glucose production from hepatocytes and can indirectly suppress lipid accumulation in liver as well as macrophage-mediated inflammation in obese mice," said Sushil K. Mahata, PhD, professor of medicine at UC San Diego School of Medicine. (sciencedaily.com)
Treating obese mice with CST inhibited the recruitment of monocyte-derived macrophages to the liver and decreased inflammation, suggesting CST is an anti-inflammatory peptide. (sciencedaily.com)
Research published this week in the American Journal of Gastrointestinal and Liver Physiology finds that losing large amounts of weight may not offer protection against colon and liver cancer, based on experiments with mice. (ajmc.com)
Body weight loss and excess fat reduction did not protect mice from colon cancer progression and liver dysplastic lesion," the authors said in their abstract, "even though these mice had improved blood glucose and leptin levels. (ajmc.com)
Ob/ob mice exhibited elevated cytokine gene expression in liver (TNF-α, TGF-β1), heart (TGF-β1), fat (TNF-α), and brain (hippocampus, hypothalamus, prefrontal cortex: IL-1β, TNF-α) compared with wild-type mice. (peerj.com)
Thus liver p38 and MK2, like CaMKII, play an important role in the development of hyperglycemia and hyperinsulinemia in obese mice," they wrote. (medpagetoday.com)
In addition, induction of adiponectin, a hormone secreted by adipocytes, has been implicated in the protective action of saturated fat against the development of alcoholic fatty liver in mice. (medscape.com)
The role of the early growth response-1 (EGr-1) transcription factor is thought to be essential for ethanol-induced fatty liver injury in mice. (medscape.com)
Hepatocyte death by apoptosis occurs in alcoholic fatty liver and has been demonstrated in rats and mice after ethanol feeding. (medscape.com)
This may be related to mitochondrial proteins that regulate apoptosis and necrosis and that are shown to be induced in mouse fatty liver models. (medscape.com)

A primary hepatocyte from an obese mouse, showing close interaction between the endoplasmic reticulum (red) and the mitochondria (green). (harvard.edu)

Due to the discovery of leptin, she analyzed leptin concentrations of the mice in the parabiotic experiments. (wikipedia.org)
The scientists used flow cytometry to figure out the relative abundances of different cells in the mucosa, then compared concentrations between obese and lean mice. (the-scientist.com)

describing how dysregulation of an imprinted gene network leads to both lean and obese phenotypes in individuals with the identical genotype. (eurekalert.org)

In WAT of obese humans, IL-1Ra was also markedly increased. (diabetesjournals.org)
Moreover, it can be speculated that IL-1Ra, whose production is markedly increased in WAT in obese individuals, contributes further to weight gain because of its endocrine and paracrine effects on the hypothalamus and adipocytes, respectively. (diabetesjournals.org)

After injecting leptin into each pair's obese mouse, she found that leptin circulated between the conjoined animals, but the circulation of leptin took some time to reach equilibrium. (wikipedia.org)
Harris concluded that leptin levels are increased in obese animals, but other factors could also affect them. (wikipedia.org)
Also, leptin was determined to decrease fat storage in both obese and thin animals. (wikipedia.org)

"Mice without GLP-1 receptors are not affected to the same extent by arginine," he added. (nutraingredients-usa.com)
The investigators found that in obese mice, physical inactivity results from altered dopamine receptors rather than excess body weight. (psypost.org)

We conclude that supplemental complex carbohydrates that increase Bifidobacteria and Lactobacilli, without increasing the deleterious Bacteroides , are most likely promoting cardiometabolic and immunological health in obese subjects. (frontiersin.org)

And mice injected with gut bacteria from marathon runners ran longer distances. (reachmd.com)
In other words, when skinny mice were inoculated with the bacteria flora of the fat mice, they became fat mice themselves and vice versa. (doctormurray.com)

The study shows that supplementation with the amino acid significantly improves glucose metabolism in both insulin-sensitive and insulin-resistant mice. (nutraingredients-usa.com)
They found that arginine improves glucose metabolism significantly in both lean (insulin-sensitive) and obese (insulin-resistant) mice. (nutraingredients-usa.com)
SF significantly increased IL-1β and TNF-α gene expression in fat and TGF-β1 expression in spleen relative to controls, but only in wild-type mice. (peerj.com)
Specifically, the high-protein and high-dairy diet significantly decreased fat mass and increased lean body mass better than the other groups. (bodybuilding.com)
Conversely, Tim-4+ MHCII+ ATMs are quickly replaced in a CCR2-dependent manner by bone marrow-derived Tim-4- MHCII+ ATMs that have significantly higher turnover rates than those in lean mice. (ntu.edu.sg)

We found that energy expenditure was equivalent between germ-free (GF) and specific-opportunistic-pathogen free line (SPF) mice, and we extend this observation to the OligoMM12 microbiota (12 species across 5 phyla that are naturally abundant in a murine gut microbiota). (biorxiv.org)
We found that in lean, murine VAT the majority of ATMs express T cell immunoglobulin and mucin domain containing 4 receptor (Tim-4), lack the expression of CCR2 and can be further subdivided based on their expression of MHC class II and CD11c. (ntu.edu.sg)

Next, the scientists divided these mice into four groups to be fed four different diets for an additional 12 weeks: a standard diet alone, a high-fat diet alone, a high-fat diet with a low amount of disulfiram, or a high-fat diet with a higher amount of disulfiram. (nih.gov)
Both were fed diets to make them obese, but then 1 group was put on a diet until the mice lost weight and became lean. (ajmc.com)
A new study in mice from the University of Illinois Urbana-Champaign suggests replacing traditional protein sources with mealworms in high-fat diets could slow weight gain, improve immune response, reduce inflammation, enhance energy metabolism, and beneficially alter the ratio of good to bad cholesterol. (illinois.edu)
Mealworm protein didn't cause obese mice to lose weight, but their rate of weight gain slowed relative to mice consuming high-fat diets with casein. (illinois.edu)
High-protein, high-dairy diets - when combined with daily exercise - produce better results than low-protein, low-dairy diets for losing body fat and increasing lean muscle mass. (bodybuilding.com)

There were no differences in embryo development rate or size, but thermoneutral mice had decreased trophectoderm outgrowth, which will become the placenta, and decreased circulating estrogen, which is important for uterine receptivity. (unl.edu)
These mice segregated into two distinct populations that showed striking differences in body mass. (eurekalert.org)
There were no significant differences in the polyp number, polyp size, or grade of dysplasia," in the obese and lean groups, the team wrote. (ajmc.com)

An off-label experiment in mice using disulfiram, which has been used to treat alcohol use disorder for more than 50 years, consistently normalized body weight and reversed metabolic damage in obese middle-aged mice of both sexes. (nih.gov)
In one experiment in obese mice, they found that no matter how CaMKII was knocked out, it led to lower blood glucose levels and lower fasting plasma insulin levels in response to a glucose challenge. (medpagetoday.com)
Another group, the control, consumed a lean diet with casein throughout the experiment. (illinois.edu)

Compared with their lean counterparts, obese twins tended to show lower TRIM28 levels, as well as a reduction in the activity of imprinted genes that control weight. (eurekalert.org)

The investigators looked at six different components in the dopamine signaling pathway and found that the obese, inactive mice had deficits in the D2 dopamine receptor. (psypost.org)

Starting in 1977, Ruth B.S. Harris, a graduate student under Hervey, repeated previous studies about parabiosis in rats and mice. (wikipedia.org)

Furthermore, Gordon and his colleagues showed that the microbial community from a lean human could infiltrate and displace that from an obese person, preventing mice from gaining weight as long as they were on a healthy diet. (harvard.edu)

DeWeerdt quotes Patrice Cani, a researcher of metabolism and nutrition at the Catholic University of Louvain in Belgium as saying 'We found that mice fed with oligofructose had an improved gut barrier function . (trilinkbiotech.com)

To their surprise, they found that while all the lean mice died in the first two weeks, half of the obese mice survived the three-week period. (the-scientist.com)
They found that the vaginal mucosa of obese mice contained a higher level of cytotoxic gamma-delta (γδ) T-cells, a type of white blood cell typically rare in the body. (the-scientist.com)
That led to studies in animals that found that switching the bacterial flora from the colons between fat and skinny mice would reverse their condition. (doctormurray.com)
Consider what Liping Zhao, a microbiologist at Shanghai Jiao Tong University in China, found after he put a severely obese man on a strict diet. (trilinkbiotech.com)
By studying lean mice that were engineered to have the same defect in the D2 receptor, they found that those mice did not gain weight more readily on a high-fat diet, despite their lack of inactivity, suggesting that weight gain was compounded once the mice start moving less. (psypost.org)

our data support a model in which LRRK2 and PPM1H mutant mice show altered responses to critical Hedgehog signals in the nigrostriatal pathway. (elifesciences.org)

The mice that were given prebiotics also had improved metabolic markers, reduced fat mass and reduced inflammation,' Cani added. (trilinkbiotech.com)

Mice in either disulfiram dose diet group became leaner and showed significant improvement in blood glucose levels on par with the mice who were returned to standard diet. (nih.gov)

In genetically identical mice and human twin pairs, epigenetic marks altered the activity of weight-control genes to produce distinct subpopulations of lean and obese individuals. (eurekalert.org)
The Trim28-deficient obese mice showed impaired expression of epigenetically regulated "imprinted" genes, such as Nnat and Peg3, which alter growth and body weight. (eurekalert.org)
These mice ate more and were heavier but lost weight when treated with CST. (sciencedaily.com)
The prognosis for breast cancer patients who are obese tends to be worse than that of women whose weight falls within the normal range. (theverge.com)
In the meantime, however, the study hints that, in some cases, losing weight might be able to improve health outcomes for breast cancer patients who are obese. (theverge.com)
As expected, the mice who stayed on the high-fat diet alone continued to gain weight and show metabolic problems. (nih.gov)
Mice who switched to standard diet alone gradually saw their body weight, fat composition and blood sugar levels return to normal. (nih.gov)
The mice in the remaining two groups, with either a low or high dose of disulfiram added to their still-fatty food, showed a dramatic decrease in their weight and related metabolic damage. (nih.gov)
Mice on the high disulfiram dose lost as much as 40% of their body weight in just four weeks, effectively normalizing their weight to that of obese mice who were switched back to standard diet. (nih.gov)
When we first went down this path, we did not know what to expect, but once we started to see data showing dramatic weight loss and leaner body mass in the mice, we turned to each other and couldn't quite believe our eyes," Bernier said. (nih.gov)
According to study's research team, the key to the positive results seem to stem from disulfiram's anti-inflammatory properties, which helped the mice avoid imbalances in fasting glucose and protected them from the damage of fatty diet and weight gain while improving metabolic efficiency. (nih.gov)
Swanson's team intentionally used "wild type" mice so they would gain weight the same way many humans do: through diet. (illinois.edu)
These mice gained weight and fat and developed metabolic problems. (ausfoodnews.com.au)
There's a common belief that obese animals don't move as much because carrying extra body weight is physically disabling. (psypost.org)
Beginning in the second week, the mice on the unhealthy diet had higher body weight. (psypost.org)
Surprisingly, the mice on high-fat diet moved less before they gained the majority of the weight, suggesting that the excess weight alone was not responsible for the reduced movements. (psypost.org)
A similar transplant of the microbiota from Malawian children with kwashiorkor with a Malawian diet, however, produces weight loss in mice, accompanied by alterations in amino acid, carbohydrate and intermediate metabolism. (medscape.com)

The gut metagenomic data was extracted from the European Bioinformatics Institute-Sequence Read Archive database using the accession number ERP003612, which initially was used to analyze the correlation between the colonic microbiota and metabolic disorders in a Danish cohort of 123 nonobese and 169 obese individuals [ 15 ]. (hindawi.com)

University of Washington translational immunologist David Koelle , who didn't work on the study, agrees this is a fascinating study, but is "not sure how relevant [it] is to humans," because HSV-2 interacts with the mouse body differently than it does humans. (the-scientist.com)
Notably, only the high-protein and high-dairy group realized an increase in lean body mass, whereas the moderate-dairy and low-protein/low-dairy groups actually had no change or a significant reduction in lean mass. (bodybuilding.com)
In a group of obese school children from South Korea, 30% had antibodies to Adv 36, and infected children had higher body mass index z-scores than uninfected children ( 5 ). (cdc.gov)

The findings could also have an impact on breast reconstruction surgeries that involve the implantation of obese fat tissues, says Claudia Fishbach, a biomedical engineer at Cornell University and one of the co-authors of the study. (theverge.com)

Supplementation with the amino acid arginine could help to improve glucose metabolism by as much as 40%, according to new research in mice. (nutraingredients-usa.com)

The study from the University of South Carolina involved 2 groups of mice. (ajmc.com)
Then, both groups of mice were exposed to a carcinogen, along with mice from a control group. (ajmc.com)

Clinicians should be aware of the potential for severe complications of novel influenza A (H1N1) virus infection, particularly in extremely obese patients. (cdc.gov)
Tabas also said the drug may be valuable in treating prediabetes, since early data have suggested that CaMKII is generally overactive in obese patients who have not yet progressed to full blown diabetes but is not overactive in lean people. (medpagetoday.com)
Why would poop-packaged pills help obese patients? (harvard.edu)

Dr. Farre's team demonstrated that intermittent hypoxia on cancer growth is considerably stronger in lean mice than in obese mice. (medicalnewstoday.com)
Because Trim28 deficiency also increases the risk of cancer and anxiety in mice, they will also examine the broader role of this protein in behavior and disease. (eurekalert.org)
Despite this link, few breast cancer treatments specifically target women who are obese. (theverge.com)
Cancer incidence persisted in the newly lean mice, despite other health improvements in this group. (ajmc.com)

Administering CST had no effect on insulin or glucose tolerance in control lean mice, showing that the effect of CST is restricted to obese animals. (sciencedaily.com)
This difference may be explained by the reduced levels of normal CST in obese mice compared to the lean control animals. (sciencedaily.com)
We conclude that IH can cause acute insulin resistance in otherwise lean, healthy animals, and that the response is associated with decreased glucose utilization of oxidative muscle fibers, but that it occurs independently of activation of the ANS. (atsjournals.org)
Infection with human adenovirus 36 (Adv 36) has been reported to cause a large accumulation of fat in 4 animals (chickens, mice, rats, and monkeys) ( 1 - 3 ). (cdc.gov)
Of animals that were infected, 60%-100% became obese compared with uninfected animals ( 1 - 4 ). (cdc.gov)

However, even in a small animal like the mouse, the predominant model system for studies of diabetes and metabolic stress, the ability to obtain a detailed spatial and quantitative view of the pancreatic β-cell mass distribution has been limited. (nature.com)
By the time mealworms were introduced, the high-fat diet group was obese and experiencing metabolic syndrome, a cluster of conditions increasing risk of heart attack, stroke, diabetes, and other health problems. (illinois.edu)

"We have demonstrated that both lean and fat laboratory mice benefit considerably from arginine supplements," said Clemmensen. (nutraingredients-usa.com)

Swanson's team fed mice a high-fat diet (46% calories from fat) with casein, a protein from dairy, for 12 weeks before switching to the alternative proteins. (illinois.edu)

Here we investigated the extent to which a gnotobiotic microbiota can mimic the influence of a complete microbiota on mouse metabolism using an isolator-housed TSE-PhenoMaster® system. (biorxiv.org)

2018). Here, we show that cilia loss is seen as early as 10 weeks of age in these mice and also in two other mouse strains carrying the most common human G2019S LRRK2 mutation. (elifesciences.org)

The islets contain five hormone-producing cell-types of which the insulin producing β-cells is the most prominent type (~80% in humans and mice). (nature.com)
Microbiota composition correlates with host metabolic health in both humans and mice. (biorxiv.org)

However, each group of mice have a distinctive circadian metabolic profile. (biorxiv.org)
Both the obese mice and the group of mice that were previously obese developed tumors at the same rate, which was higher than the control group. (ajmc.com)

Given that the diet part of the study was done on mice and not humans, it's not entirely clear whether the findings can be replicated in women. (theverge.com)
Now a study done in mice is providing clues about one of the reasons why it may be hard for so many people to stick with an exercise program. (psypost.org)
In the study, mice were fed either a standard or a high-fat diet for 18 weeks. (psypost.org)

The scientific team studied groups of 9-month-old lab mice who had been fed a high-fat diet for 12 weeks. (nih.gov)

Anatomy16

Organisms6

Diseases17

Chemicals and Drugs47

Analytical, Diagnostic and Therapeutic Techniques and Equipment19

Psychiatry and Psychology3

Phenomena and Processes34

Technology, Industry, Agriculture3

Health Care2

Obesity23

Microbiome6

Microbiota of obese1

People who are obese2

Phenotype5

Adipose8

Researchers22

Fecal1

Diabetic2

Intestinal2

Overweight4

Tissue3

Bacteroidetes1

Microbes6

Serum1

Liver10

Hepatocyte1

Concentrations2

Imprinted gene1

Markedly2

Leptin3

Receptors2

Cardiometabolic1

Bacteria2

Significantly5

Murine2

Diets5

Differences3

Experiment3

Twins1

Deficits1

Rats and mice1

Microbial community1

Oligofructose1

Found5

Pathway1

Inflammation1

Blood glucose1

Weight17

Individuals1

Body3

Tissues1

Amino acid1

Groups of mice2

Patients3

Cancer4

Animals5

Diabetes2

Considerably1

Protein1

Metabolism1

20181

Humans and mice2

Group2

Study3

High-fat diet1