• Leakage is the most significant complication of gastrointestinal surgery and advanced endoscopic procedures. (omicsonline.org)
  • Background: Leakage is the most significant complication of gastrointestinal surgery and advanced endoscopic procedures. (omicsonline.org)
  • Anastomotic leak is the most frequently encountered complication. (wikipedia.org)
  • For severe complication between the two groups (anastomotic leakage and stenosis), they showed no difference. (researchsquare.com)
  • Anastomotic leak (AL) is an uncommon but potentially devastating complication after rectal resection. (coloproctol.org)
  • Anastomotic leak is an uncommon but potentially devastating complication after total mesorectal excision (TME) of rectal cancer, occurring in 2% to 19% of patients [ 1 ]. (coloproctol.org)
  • Anastomotic leakage is still the most undesirable complication of colorectal surgery. (unpad.ac.id)
  • hence, this complication should be prevented as much as possible.Several studies have shown a correlation between low albumin levels and increased anastomotic leakage.The Colon Leakage Score (CLS) is a standard score for predicting anastomotic leakage, but this score does not include the albumin level as a parameter of anastomotic leakage despite the importance of the albumin level's contribution on the anastomotic leakage. (unpad.ac.id)
  • Gastric leak is estimated to be the most serious complication of this procedure due to difficult healing processes not to mention the fact that it may also be responsible for local or general severe septic complications. (ommegaonline.org)
  • Staple line dehiscence and subsequent leaks following sleeve gastrectomy are not very frequent but are a difficult complication that can also become chronic. (ommegaonline.org)
  • Main aim of this paper is to provide an overview of the pathogenic and promoting factors of staple line leak following LSG on the basis of recent literature review and to report the evidence based preventive measures and treatment solutions of this life-threatening complication. (ommegaonline.org)
  • However, anastomotic leakage remains a serious complication in colorectal surgery and continues to be a concern for colorectal surgeons. (biomedcentral.com)
  • Post-operative anastomotic leakage (AL) is a common and severe complication following colorectal surgery that leads to high morbidity and mortality. (suntextreviews.org)
  • Anastomotic leakage, a known major postoperative complication, potentially leads to readmission, reoperation, and increased mortality rates in patients, such as rectal cancer patients following a low anterior resection (LAR). (coloproctol.org)
  • The mean delay time from the day of operation to the diagnosis of anastomotic leakage was 61.0±80.4 days while the mean time for leakage closure was 117.6±68.3 days. (coloproctol.org)
  • This analysis of colorectal anastomoses at a tertiary institution in Jamaica demonstrates acceptable leak and mortality rates. (uwi.edu)
  • Anastomotic failure causes morbidity and mortality even in technically correct anastomoses. (biomedcentral.com)
  • We isolated fecal content and small intestinal leukocytes from murine, Roux-en-Y and end-to-end anastomoses, to identify microbiome changes and subsequent alterations in the regulatory and pro-inflammatory immune cells 3 days post-operative. (biomedcentral.com)
  • When using the indocyanine green, the intensity of the fluorescence signal detected in the tissue can be used as a marker of tissue perfusion, to assess the state of intes- tinal perfusion, intestinal anastomoses, anastomotic leaks, and the presence of affected lymph nodes. (surgchronicles.gr)
  • Benefits of the new surgical technique are total absence of Roux-en-Y related intestinal complications. (scirp.org)
  • This study was a cross-sectional retrospective analytical study on medical records of CRC patients over the age of 18 who underwent intestinal anastomotic resection surgery between 2016-2020. (unpad.ac.id)
  • Anastomotic failure is one of the most serious complications of intestinal surgery [ 24 ]. (biomedcentral.com)
  • Complications after intestinal resection and anastomosis include bleeding, stricture, and anastomotic leakage [2]. (suntextreviews.org)
  • RESULTS: All animals survived, and no leakage, intestinal obstruction, or wound infection was observed during the experiment. (bvsalud.org)
  • Utility of colon leakage score in left-sided colorectal surgery. (unpad.ac.id)
  • Predicting the risk of anastomotic leakage in left-sided colorectal surgery using a colon leakage score. (unpad.ac.id)
  • The aim of this study was to compare the incidence of anastomotic leakage between a conventional manual circular stapler (MCS) and the ECHELON CIRCULAR™ Powered Stapler (ECPS) in patients with left-sided colorectal cancer who underwent anastomosis with the double stapling technique. (biomedcentral.com)
  • The ECPS has the potential to help reduce the rate of anastomotic leakage in left-sided colorectal surgery. (biomedcentral.com)
  • Successful treatment of anastomotic leakage with covered self-expanding metallic stents (stent) has recently been reported. (e-ce.org)
  • The main aim of this study was to introduce a novel method for creating a vacuum-assisted drain for the treatment of anastomotic leakage after LAR. (coloproctol.org)
  • The significance lies in the resultant abdominal sepsis, related morbidity and mortality, risk of anastomotic loss, permanent stoma creation and the effect on local recurrence and overall patient survival in colorectal cancer cases. (uwi.edu)
  • Patients that have an anastomotic leak after colorectal surgery have a greater hospital length of stay, morbidity, mortality, permanent stoma rate, and even poorer oncological outcomes [ 8 , 9 ]. (coloproctol.org)
  • A. Shimotakahara, A. Yamataka, T. Yanai, H. Kobayashi, T. Okazaki, G. J. Lane and T. Miyano, "Roux-en-Y Hepa tico-Jejunostomy for Biliary Reconstruction during the Surgical Treatment of Choledochal Cyst: Which Is Better? (scirp.org)
  • Anastomotic leakage remains a concern in general surgical practice. (uwi.edu)
  • Breakdown of the connection and subsequent leakage of effluent (fluids, secretions, air) from a SURGICAL ANASTOMOSIS of the digestive, respiratory, genitourinary, and cardiovascular systems. (bvsalud.org)
  • The company has created a patent-pending implantable biodegradable wireless sensor designed to continuously monitor the GI tract near the surgical site, alerting physicians to potential anastomotic leakage post-operation and also enabling early patient discharge by identifying proper tissue healing. (hhmglobal.com)
  • Conclusions: SFM did not seem to influence the risk of anastomotic leakage after anterior resection for rectal cancer, regardless of type of mesorectal excision, use of minimally invasive surgery, or high vascular ligation. (lu.se)
  • Therefore, this study sought to analyze the correlation between the albumin level, CLS, and the incidence of anastomotic leakage after anastomotic resection surgery in colorectal cancer (CRC) patients at Dr. Hasan Sadikin General Hospital Bandung, Indonesia. (unpad.ac.id)
  • An V, Chandra R, Lawrence M. Anastomotic failure in colorectal surgery: where are we at? (unpad.ac.id)
  • Zarnescu EC, Zarnescu NO, Costea R. Updates of risk factors for anastomotic leakage after colorectal surgery. (unpad.ac.id)
  • Exero Medical, developer of a wireless sensor for early detection of anastomotic leaks following GI surgery, announced it has completed the first human implantation of its sensor. (hhmglobal.com)
  • At the 3rd day after surgery, anastomotic leakage was found by an upper gastrointestinal series (UGI). (e-ce.org)
  • CT scan for early diagnosis of anastomotic leak after colorectal surgery: is rectal contrast useful? (canceropole-est.org)
  • No radiologic or clinical leaks were observed after surgery. (ox.ac.uk)
  • The aim of the study was to assess the predictive value of haematological and biochemical markers for anastomotic leakage after colorectal surgery. (suntextreviews.org)
  • Its use for the prevention of anastomotic leaks (AL) has been gaining popularity, with accumulating data on lower leak rates with (ICG) fluorescence guided surgery. (diagnosticgreen.com)
  • WP31: Does the use of intraoperative fluorescence imaging with indocyanin green (ICG) reduce the rate of anastomotic leakage after colorectal surgery? (eu.com)
  • All 10 patients, who underwent LAR surgery from 2018 to 2019, were diagnosed with anastomotic leakage and had received neoadjuvant chemotherapy prior to surgery. (coloproctol.org)
  • Overall, we treated 10 patients with complicated anastomotic sinus cavities following LAR surgery using these handmade devices. (coloproctol.org)
  • In this study, a total of 10 patients, which were diagnosed with an anastomotic leakage or defect in the anastomotic line following LAR surgery due to rectal cancer, were included prospectively from 2018 to 2019. (coloproctol.org)
  • BACKGROUND AND AIMS: The use of sutures to strengthen the anastomosis after rectal cancer surgery to reduce the possibility of anastomotic leakage has been debated. (bvsalud.org)
  • The aim of this systematic review and meta-analysis was to investigate the influence of intraoperative anastomotic reinforcing sutures on anastomotic leakage of double-stapling anastomosis for laparoscopic rectal cancer surgery. (bvsalud.org)
  • METHODS: A systematic search of PubMed, Embase, Web of Science, and Cochrane databases was performed to identify literature examining anastomotic leak as the primary outcome to compare studies of laparoscopic surgery for rectal cancer using the double-stapling anastomosis technique with or without intraoperative anastomotic reinforcement with sutures. (bvsalud.org)
  • The circular stapling device as a risk factor for anastomotic leakage in rectal cancer surgery. (cancercentrum.se)
  • Risk factors for anastomotic leakage after rectal cancer surgery: a case-control study. (cancercentrum.se)
  • Zhuo ZG, Shen X, Song TN et al (2020) The efficacy of ischemic conditioning in the prevention of gastroesophageal anastomotic complications: a meta-analysis. (springer.com)
  • Leakages in the upper gastrointestinal tract are associated with numerous and most serious complications. (uni-wuerzburg.de)
  • Due to lack of studies Leakages in the upper gastrointestinal tract are associated with numerous and most serious complications. (uni-wuerzburg.de)
  • Staple line leaks, bleeding, strictures and postoperative increased rate of gastroesophageal reflux disease (GERD) (described as either de novo or as being caused by aggravation of preexisting symptoms) are the commonly reported complications following LSG. (ommegaonline.org)
  • At the 11th week after stent insertion, the stent was removed without complications and the leakage was completely closed. (e-ce.org)
  • Anastomotic leakage is one of the major complications following colorectal surgeries. (coloproctol.org)
  • The incidence of anastomotic leakage in the ECPS group was significantly lower than that in the MCS group (4.4% versus 14.3%, p = 0.048). (biomedcentral.com)
  • Furthermore, even after propensity score matching, an association was found between the use of the ECPS and a reduced incidence of anastomotic leakage. (biomedcentral.com)
  • The incidence of leakage in this operation has been reported up to 36% with a mortality of 6% to 22% [ 1 ]. (coloproctol.org)
  • CONCLUSIONS: Intraoperative anastomotic reinforcement with sutures may be associated with a lower incidence of anastomotic leakage. (bvsalud.org)
  • Anastomotic leakage occurred in 83 (21.8%) and 123 (20.3%) patients operated with and without SFM, respectively. (lu.se)
  • There were thirty-two patients with colorectal cancer underwent anastomotic resection during the study period, with two patients experienced anastomotic leakage. (unpad.ac.id)
  • Risk factors for anastomotic leak after colon resection for cancer: multivariate analysis and nomogram from a multicentric, prospective, national study with 3193 Patients. (unpad.ac.id)
  • The management of patients who develop leakages requires a multidisciplinary team. (ommegaonline.org)
  • Pancreatic anastomotic leakage after pancreaticoduodenectomy in 1,507 patients: a report from the Pancreatic Anastomotic Leak Study Group. (edu.pl)
  • C-reactive protein identifies patients at low risk of anastomotic leak after esophagectomy. (canceropole-est.org)
  • Patients with anastomotic leakage (AL) had significantly greater mean WBC and neutrophil values but lower mean lymphocyte values on the 4th POD [15-19]. (suntextreviews.org)
  • NIR ICG assessment change in site of bowel division 29 patients (5.8%) no subsequent leak rates in these patients. (diagnosticgreen.com)
  • Therefore, patients were treated with a handmade vacuum-assisted drain and were revisited every 5 to 7 days for further evaluations and drain replacement until leakage resolution. (coloproctol.org)
  • Endoscopic vacuum-assisted closure of anastomotic leakage following anterior resection of the rectum: a new method. (bbraun.com)
  • Sealants applied over the closure lines may help in the prevention of leakage by reinforcing the anastomosis during the initial susceptible healing period, allowing the natural healing process additional time by mechanically supporting the bowel edges. (omicsonline.org)
  • Anastomotic leakage is defined as the presence of pus or enteric contents within the drains, presence of abdominal or pelvic collections in the area of anastomosis on postoperative imaging, leakage of contrast through the anastomosis during an enema or evident anastomotic dehiscence at reoperation for postoperative peritonitis [3]. (suntextreviews.org)
  • Due to lack of studies concerning therapeutic options in the event of a leakage in the upper gastrointestinal tract, the treatments are not based on evidence, but rely on empirical decisions and the experience of the treating physician. (uni-wuerzburg.de)
  • The primary goal of the study was to describe the endoscopic vacuum therapy as a treatment option for leaks in the upper gastrointestinal tract, to evaluate results and comparing the results with current studies in the literature. (uni-wuerzburg.de)
  • Clinical studies are required in order to evaluate its efficacy in reducing the rate of gastrointestinal anastomotic leakage. (omicsonline.org)
  • This minimally invasive method was especially designed for anastomotic leakage treatment in upper and lower gastrointestinal tract and colorectal area. (bbraun.com)
  • Most common leakages are from the breakdown of suture lines in gastrointestinal or bowel anastomosis. (bvsalud.org)
  • Founded in 2018 by the MEDX Xelerator, an Israeli Innovation Authority incubator and Clalit HMO, the largest HMO in Israel, Exero Medical goal is to save lives through early detection of anastomotic leaks following gastrointestinal (GI) surgeries, addressing a $2 billion market with its sensor technology. (hhmglobal.com)
  • Currently, vacuum-assisted closure, as featured by B-Braun (B-Braun Medical B.V.), is already being used for the treatment of gastrointestinal leakages and fistulas. (coloproctol.org)
  • Vacuum-assisted closure (VAC) has been used for gastrointestinal leakages and fistulas [ 2 - 4 ], thus, allowing sepsis control and facilitation of the healing process. (coloproctol.org)
  • Li SJ, Wang ZQ, Li YJ et al (2017) Diabetes mellitus and risk of anastomotic leakage after esophagectomy: a systematic review and meta-analysis. (springer.com)
  • At the 12th day after the primary repair, the leakage was successfully managed by stent insertion and the patient improved thereafter. (e-ce.org)
  • We report here on a case of anastomotic leakage after gastrectomy, and this was completely managed by stent insertion. (e-ce.org)
  • External drainage of pancreatic duct with a stent to reduce leakage rate of pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial. (edu.pl)
  • Gao C, Xu G, Wang C et al (2019) Evaluation of preoperative risk factors and postoperative indicators for anastomotic leak of minimally invasive mckeown esophagectomy: a single-center retrospective analysis. (springer.com)
  • Frequency of anastomotic leakage after colorectal surgeries. (who.int)
  • Manghelli JL, Ceppa DP, Greenberg JW et al (2019) Management of anastomotic leaks following esophagectomy: when to intervene. (springer.com)
  • Verstegen MA-OX, Bouwense SAW, van Workum F et al (2019) Management of intrathoracic and cervical anastomotic leakage after esophagectomy for esophageal cancer: a systematic review. (springer.com)
  • An early leak within the first to second postoperative days occurs most often because of technical reasons, whereas a latent leak occurring by the end of the first postoperative week is most often attributed to a failure in the normal healing mechanisms [ 43 ]. (biomedcentral.com)
  • We have assessed the feasibility of a new intraluminal biodegradable bypass device that we designed to avoid anastomotic leakage and the necessity of a temporary stoma. (ox.ac.uk)
  • Conclusions Great caution must be taken when prescribing NSAIDs following colonic or rectal anastomotic creation. (mun.ca)
  • The technique for a real transanal end-to-end anastomosis reduces the risk of leakages and stenosis. (bbraun.com)
  • Making the anastomosis in this area would increase the risk of anastomotic leakage (AL). (springer.com)
  • The multivariate logistic regression proved that RGL-G less than 1.3 was a risk factor for cervical anastomotic leakage ( p = 0.012). (springer.com)
  • To avoid the risk of postoperative ischemic necrosis, anastomotic leakage, colitis, and delayed stricture, it is desirable to ligate proximal to Sudeck's point, for those cases with anastomosis might be absent or present insufficiently [5]. (researchsquare.com)
  • No modifiable risk factors were identified as contributing to anastomotic leaks. (uwi.edu)
  • Colic anastomotic leakage risk factors. (unpad.ac.id)
  • The powered circular stapler, which was developed with the aim of providing reliable and reproducible anastomosis, provides complete anastomosis, resulting in a reduced risk of anastomotic leakage. (biomedcentral.com)
  • The use of this new device provides complete anastomosis, resulting in a reduced risk of anastomotic leakage. (biomedcentral.com)
  • Meta-analysis was performed to assess for overall risk of anastomotic leak with NSAID use, as well as sub-group analysis to compare selective vs non-selective NSAIDs and drug-specific NSAID safety profiles. (mun.ca)
  • Use of an NSAID post-operatively was associated with an overall increased risk of anastomotic leakage [OR 1.58 (1.23, 2.03), P = 0.0003]. (mun.ca)
  • The fear of anastomotic leak is the one that keeps GI surgeons up at night and one that represents a true clinical need. (hhmglobal.com)
  • Reported rates of anastomotic leakage vary from 3-6% in experienced colorectal surgeons and 3-25% overall. (diagnosticgreen.com)
  • Exposure was SFM, while anastomotic leakage within a year constituted the outcome. (lu.se)
  • Indocyanine green (ICG) fluorescence imaging has proven to be an effective tool to assess anastomotic perfusion. (diagnosticgreen.com)
  • We look forward to developing a reliable anastomotic leak detection system, that will save lives, reduce suffering and address a challenge currently costing billions of dollars for payers and providers. (hhmglobal.com)
  • Early detection of anastomotic leakage with C-reactive protein increases the chances of anastomotic salvage. (canceropole-est.org)
  • Methods A systematic review was performed for studies investigating anastomotic leak rate following NSAID use versus control after colonic or rectal anastomosis. (mun.ca)
  • Mobilization of the splenic flexure was performed when tension at the anastomotic site was noted. (biomedcentral.com)
  • Results suggest that leaks occur between the tissue and staple legs penetrating through the tissue. (fh-aachen.de)
  • Normal results for a ureterostomy include the successful diversion of the urine pathway away from the bladder, and a tension-free, watertight opening to the abdomen that prevents urinary leakage. (wikipedia.org)
  • Anastomotic leakage was defined as the extravasation observed on radiologic examinations. (biomedcentral.com)
  • There have been very few reports concerning endoscopic stenting for the management of anastomotic leakage. (e-ce.org)
  • In this study, we evaluated the healing process of anastomotic leakage after the usage of a handmade vacuum-assisted sponge drain in a case series method. (coloproctol.org)
  • Gooszen JAH, Goense L, Gisbertz SS et al (2018) Intrathoracic versus cervical anastomosis and predictors of anastomotic leakage after oesophagectomy for cancer. (springer.com)
  • Aoyama T, Kazama K, Atsumi Y et al (2020) Clinical influence of anastomotic leakage on esophageal cancer survival and recurrence. (springer.com)
  • Choosing the proper approach depends on the clinical condition of the patient and the onset time of leak. (ommegaonline.org)
  • Anastomotic leakage can vary in its onset of occurrence. (biomedcentral.com)
  • The present study aims to assess whether postoperative NSAID use is associated with an increased anastomotic leak rate. (mun.ca)
  • Upon clinical symptoms that suggested anastomotic leakage, such as abdominal pain, high fever, pus or fecal discharge from the pelvic drain, or leukocytosis, computed tomography (CT) was performed to confirm the presence of anastomotic leakage. (biomedcentral.com)