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Enterohepatic CirculationBile Acids and SaltsBileCholic AcidsChenodeoxycholic AcidCholic AcidCholestyramine ResinTaurocholic AcidDigitoxinGallbladderCholesterol 7-alpha-HydroxylaseOrganic Anion Transporters, Sodium-DependentBiliary FistulaIntestinal AbsorptionIleumLiverCholecystectomyDeoxycholic AcidCholesterolGlucuronidesBile DuctsIntestinesFecesCholelithiasisLiver CirculationHelicobacterSymportersAdministration, OralChromatography, Thin LayerDuodenumInjections, IntravenousBiotransformationIntestine, SmallTritiumMetabolic Clearance RateHelicobacter hepaticusPhospholipidsChromatography, High Pressure LiquidCarbon IsotopesCarbon RadioisotopesBlood CirculationReceptors, Cytoplasmic and NuclearBiological TransportKineticsModels, BiologicalRats, Inbred Strains

IntestinalLiverUptakeExcretionLymphBilirubinHepaticToxicitySecretionInflammationMetabolismConcentrationAbsorptionCONCLUSIONSDisordersPatientsSevereMorbidityMechanismHyperbilirubinemiaCirrhosisInterfereBile acidInflammatoryDeficiencyMolecular motionBodyExposureGastrointestinalNeurologicalIncreaseAlterLevelsBloodOrganProteinAdministrationFormationRapidResultsAnimalPeople

Intestinal4

• Pancreatic insufficiency, intestinal malabsorption, or intestinal diseases that may alter the concentration of bile acids may also lead to decreased absorption of either of the components of RELYVRIO. (relyvrio-hcp.com)
• Because different enterohepatic circulation, pancreatic, and intestinal disorders have varying degrees of severity, consider consulting with a specialist. (relyvrio-hcp.com)
• Calcium channel blockers verapamil, ni edipine, elodipine beta blockers htn, tachycardia, myocardial ischemia may alter intestinal flora, reducing enterohepatic circulation because they do not benefit from agent. (easternpropane.com)
• In addition to measuring serum cholesterol concentrations, hepatic and intestinal genes involved in enterohepatic circulation of cholesterol and bile acids were analyzed by real-time reverse-transcriptase polymerase chain reaction and Western blot. (hal.science)

Liver6

• Bile acids (BAs) undergo extensive enterohepatic circulation and play important roles in the gut-liver axis. (gutnliver.org)
• In the present study, we posit that ileocecal resection interrupts the delivery of these hepatotoxic substances to the liver by physically disrupting the enterohepatic circulation, thereby shielding the liver from exposure to the aforementioned noxious stimuli. (bvsalud.org)
• Farnesoid X receptor (FXR) and its regulated target networks in both the liver and the intestines are critical in suppressing BA synthesis and promoting BA transport and enterohepatic circulation. (aspetjournals.org)
• Most of this is stored in the liver and is recycled via enterohepatic circulation. (wikidoc.org)
• Colchicine is primarily metabolized by the liver, undergoes significant enterohepatic re-circulation, and is also excreted by the kidneys. (covid19criticalcare.com)
• Fibrosis itself causes no symptoms but can lead to portal hypertension (the scarring distorts blood flow through the liver) or cirrhosis (the scarring results in disruption of normal hepatic architecture and liver dysfunction). (msdmanuals.com)

Uptake1

• Occasionally, cirrhosis can cause unconjugated hyperbilirubinemia, as hepatic fibrosis leads to capillarization of the sinusoids, causing decreased bilirubin uptake by hepatocytes. (medscape.com)

Excretion1

• Lead interferes with the synthesis of heme, resulting in accumulation of ALA in tissues and elevated excretion of ALA in urine, elevation of zinc protoporphyrin in erythrocyte, reductions in blood hemoglobin, and in a hypochromic, normocytic anemia at higher levels of exposure. (cdc.gov)

Lymph2

• In the fast-active state, fat cell tissue may generate friction heat, increase local temperature and remove excess fat and toxin from the body through sweat gland, enterohepatic circulation and lymph and ultimately achieve the effect of dissolving fat. (gizmosupplyco.com)
• Excess fat and toxins are removed from the body through sweat glands, enterohepatic circulation, and lymph, thus achieving the effect of dissolving fat. (rejuvafresh.com)

Bilirubin3

• Albumin delivers the bilirubin into the hepatocytes and goes back to blood circulation. (labpedia.net)
• The percentage of bilirubin production from this mechanism can reach 70% in dyserythropoiesis disorders such as thalassemia major, megaloblastic anemia, congenital erythropoietic porphyria, and lead poisoning. (medscape.com)
• If the production of unconjugated bilirubin is prolonged, it can precipitate bilirubin salts, leading to the formation of gallstones. (medscape.com)

Hepatic1

• Enterohepatic signaling and nonsense-mediated ribonucleic acid (RNA) decay were evaluated and correlated with hepatic injury. (bvsalud.org)

Toxicity1

• Oral studies in animals support the human evidence regarding neurobehavioral toxicity of lead to infants and children from prenatal and postnatal exposure. (cdc.gov)

Secretion3

• The homeostasis of bile acids is maintained through a tightly regulated enterohepatic circulation and canalicular secretion of bile acids via bile salt export pump (BSEP) is the rate-limiting step in the circulation. (uri.edu)
• They form when there's excessive cholesterol secretion into the bile, leading to cholesterol crystallization into solid particles. (rupahealth.com)
• Both obesity and rapid weight loss can lead to excess cholesterol secretion into bile. (rupahealth.com)

Inflammation1

• See clinical presentation of ra leads to inflammation of the criteria and are therefore not be administered once daily dosing is reasonable for eligible patients. (easternpropane.com)

Metabolism2

• CONCLUSIONS: In summary, interruption of enterohepatic circulation via ileocecal resection abrogates the liver's exposure to toxic and inflammatory mediators while promoting physiological adaptations in bile acid metabolism and maintaining existing homeostatic pathways. (bvsalud.org)
• The gut microbiota influences cholesterol metabolism and the enterohepatic circulation of bile acids. (rupahealth.com)

Concentration1

• Oral administration generally leads to two peaks of concentration, due to enterohepatic circulation. (wikipedia.org)

Absorption8

• Gastrointestinal absorption of soluble lead salts in adult humans can be high during fasting (40-50%), but is about 3-15% when ingested with food. (cdc.gov)
• On the basis of dietary balance studies, gastrointestinal absorption of lead in children appears to be higher and may account for 40-50% of the ingested dose. (cdc.gov)
• Studies in animals also provide evidence that gastrointestinal absorption of lead is much higher in younger organisms. (cdc.gov)
• Absorption is strongly affected by nutritional status, with higher absorption of lead in children who are iron deficient. (cdc.gov)
• Calcium deficiency also may increase lead absorption, based on studies in children. (cdc.gov)
• Coadministration of calcium with lead decreases lead absorption in adults, and in animal studies. (cdc.gov)
• Vitamin D administration has been shown to enhance lead absorption in animal studies. (cdc.gov)
• Thus, the effects are very obvious: Enhance blood circulation, accelerate the decomposition of fat, take away wastes, enhance the effect of removing cellulite, effectively improve the state of areola tissue, remove stubborn fat and improve the sufficient absorption condition of diet products. (gizmosupplyco.com)

CONCLUSIONS1

• Conclusions: These results indicate that formula feeding leads to increased CYP7A1 protein expression and fecal bile acid loss in neonatal piglets, and this outcome is linked to reduced efficacy in inhibiting CYP7A1 expression through FGF19 and SHP transcriptional repression mechanisms. (hal.science)

Disorders1

• In patients with disorders that interfere with bile acid circulation, there may be an increased risk for worsening diarrhea, and patients should be monitored appropriately for this adverse reaction. (relyvrio-hcp.com)

Patients1

• Within the MicroGO cohort, patients with high serum LBP levels also showed higher levels of zonulin and TLR5 and TLR9 ligands in their circulation. (frontiersin.org)

Severe1

• Aspiration from emesis and misplaced nasogastric tubes for activated charcoal administration can lead to severe respiratory compromise and even death. (answerlib.org)

Morbidity2

• MS has been proven to be associated with an increased incidence of cardiovascular diseases and type 2 diabetes mellitus, leading to morbidity and mortality. (biomedcentral.com)
• Serious' effects are those that evoke failure in a biological system and can lead to morbidity or mortality (e.g., acute respiratory distress or death). (cdc.gov)

Mechanism1

• As a secondary decontamination mechanism, it interrupts a potential enterohepatic and/or enteroenteric circulation (8, 15, 16). (answerlib.org)

Hyperbilirubinemia1

• Excessive hyperbilirubinemia can lead to permanent brain damage. (biomedcentral.com)

Cirrhosis1

• and (iv) as inhibitors of the transformation of stellate hepatocytes into myofibroblasts, the process responsible for the deposition of collagen fibres leading to cirrhosis. (springer.com)

Interfere1

• In its binding with sulfhydryl groups, lead may interfere with the activity of zinc metalloenzymes, as zinc binds to a sulfhydryl group at the active site. (cdc.gov)

Bile acid1

• Impairment of BSEP expression by xenobiotics such as diabetic drug troglitazone and endobiotics such as estrogens leads to an increase in intrahepatic as well as systemic bile acid levels, a hallmark for intrahepatic cholestasis. (uri.edu)

Inflammatory1

• The subsequent translocation of bacterial compounds to the systemic circulation may aggravate inflammatory processes within the orbital tissue and, as a consequence, augment the proportion of activated myofibroblasts, which actively secrete extracellular matrix leading to retro-orbital tissue expansion. (frontiersin.org)

Deficiency2

• Prolonged B-12 deficiency can lead to nerve degeneration and irreversible neurological damage. (lifesourcevitamins.com)
• I would strongly recommend that you do something to remedy the situation, as this deficiency can eventually lead to death if left unchecked. (vibrancyuk.com)

Molecular motion3

• Micropore introverted blast inside and outside cell may lead to enhanced molecular motion and a higher energy level and this will finally cause fat cell rupture and there achieve the effects of body building and losing weight. (gizmosupplyco.com)
• The strong impact on fat cells creates an introverted explosions, leading to enhanced molecular motion and higher energy levels. (rejuvafresh.com)
• Micropore introverted blast inside and outside cell may lead to enhanced molecular motion and a higher energy level. (thebeautyequipment.com)

Body4

• Lead accumulates in blood, such that bone lead accounts for approximately 73% of the body burden in children, increasing to 94% in adults. (cdc.gov)
• Lead has been shown to affect virtually every organ and system in the body in both humans and animals. (cdc.gov)
• Lead can affect virtually every organ or system in the body through mechanisms that involve fundamental biochemical processes. (cdc.gov)
• IMD's actions enhance Phase III Detoxification-the system of transporters leading out of the body. (drjillhealth.com)

Exposure5

• The distribution of lead appears similar across routes of exposure. (cdc.gov)
• The effects of lead are similar across inhalation and oral routes of exposure. (cdc.gov)
• Epidemiological studies provide evidence for an association between prenatal and postnatal exposure to lead and adverse effects on neurodevelopment in infants and young children, and support the use of PbB as an index of toxicological effect. (cdc.gov)
• Animal data demonstrate that oral exposure to lead increases blood pressure. (cdc.gov)
• At higher levels of exposure in humans, lead produces cardiac lesions and electrocardiographic abnormalities. (cdc.gov)

Gastrointestinal2

• A plethora of microorganisms have colonized the gastrointestinal (GI) tract by the time that we are born, and they play a crucial role in building our future physiology and immunity, leading to homeostasis of the internal environment. (biomedcentral.com)
• delayed gastrointestinal manifestations of intoxication leading to dehydration and hepatotoxicity. (cdc.gov)

Neurological1

• The most sensitive effects of lead appear to be neurological (particularly in children), hematological, and cardiovascular. (cdc.gov)

Increase1

• A reduction in soluble fibre will cause an increase in the amount of toxic bile reabsorbed in the enterohepatic circulation cycle. (ggenereux.blog)

Alter1

• In animals, lead has been shown to alter a number of neurotransmitter systems including dopamine, norepinephrine, serotonin, and gamma- aminobutyric acid systems (ATSDR 1999). (cdc.gov)

Levels1

• Leads to lowering of blood mercury levels, allowing organ- and tissue-bound mercury safely to drain into the blood at a natural rate. (drjillhealth.com)

Blood1

• Initially, lead is distributed to the blood plasma and soft tissues, but under steady state conditions 99% of the lead in blood is found in the erythrocyte, where much of it is bound to hemoglobin. (cdc.gov)

Organ1

• The culmination of these mechanisms leads to multi-organ dysfunction and failure. (covid19criticalcare.com)

Protein1

• Lead also binds to metallothionein, a sulfhydryl-rich protein, but does not appear to displace cadmium or zinc. (cdc.gov)

Administration2

• Administration in rhino may lead to hypoventilation, hypoxaemia and metabolic acidosis. (wildpharm.co.za)
• Criteria for admission to the venous circulation, d propagate into more serious rhythm and sudden weight changes sos cyclophosphamide electrocardiography during iv administration, rbcs in the anteriorposterior position. (easternpropane.com)

Formation1

• O2 molecule is added, which will lead to CO formation, which is exhaled through the lungs. (labpedia.net)

Rapid1

• Our lifestyle and dietary structure have significantly changed due to rapid economic development and improvements in quality of life, leading to the rapid occurrence of MS in recent years. (biomedcentral.com)

Results1

• Avoid shaking the tube, which may lead to inaccurate results. (labpedia.net)

Animal1

• Re-cycling of etorphine via enterohepatic circulation or redistribution from adipose depots may lead to re-narcotization of the animal. (wildpharm.co.za)

People1

• Some people already have compromised / partially obstructed bile ducts leading to cholestasis. (ggenereux.blog)