• Nevertheless, both FH and the LDL receptor continue to be in the interest of atherosclerosis research. (eas-society.org)
  • The August and September issues of Atherosclerosis contain several articles describing diagnostic criteria and clinical consequences of FH, evaluating soluble versions of an LDL receptor related protein towards its relevance as a biomarker or exploiting the knock out of the LDL-receptor as a model for atherosclerosis research in mice. (eas-society.org)
  • In hSkMCs and AML12 hepatocytes, recombinant WISP1 impaired insulin action by inhibiting phosphorylation of insulin receptor, Akt and its substrates glycogen synthase kinase 3β, FOXO1 and p70S6 kinase, and inhibiting insulin-stimulated glycogen synthesis and suppression of gluconeogenic genes. (springer.com)
  • 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs" . (wikipedia.org)
  • Clearance of Alzheimer's amyloid-ss(1-40) peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. (nih.gov)
  • In the circulation, CSF, and brain interstitial fluid (ISF), soluble Aβ may exist as a free peptide or be associated with different transport binding proteins such as apolipoproteins J (apoJ) ( 17 - 18 ) and E (apoE) ( 19 ), transthyretin ( 20 ), lipoproteins ( 21 ), albumin ( 22 ), and α 2 -macroglobulin (α 2 M) ( 23 ). (pubmedcentralcanada.ca)
  • What is the function of cholesteryl ester transfer protein (CETP)? (brainscape.com)
  • Impaired maturation of HDL in CRF is primarily due to down regulation of lecithin-cholesterol-acyltransferase and, to a lesser extent, increased plasma cholesteryl ester transfer protein (CETP). (ifcc.org)
  • Marian Blanca Ramírez from the CSIC in Spain has been studying the effects of LRRK2, a protein associated with Parkinson's disease, on cell motility. (biologists.org)
  • Ass(1-40) clearance was substantially inhibited by the receptor-associated protein, and by antibodies against LDL receptor-related protein-1 (LRP-1) and alpha(2)-macroglobulin (alpha(2)M). As compared to adult wild-type mice, clearance was significantly reduced in young and old apolipoprotein E (apoE) knockout mice, and in old wild-type mice. (nih.gov)
  • In developing white matter, decreased total β-catenin, activated β-catenin, and cyclin D1 levels coincided with the peak of Sox17 expression, and immunoprecipitates showed a developmentally regulated interaction among Sox17, T-cell transcription factor 4, and β-catenin proteins. (jneurosci.org)
  • 1997). "Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action" . (wikipedia.org)
  • the interaction is transient and coincides with a reduction of ligand binding by the receptor (PubMed:1712782, PubMed:1400426, PubMed:7774585, PubMed:16938309, PubMed:16678114). (genecards.org)
  • Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. (nih.gov)
  • High-mobility group (HMG) proteins are involved in oligodendrocyte lineage specification and cell maturation ( Wegner, 2000 , 2001 ). (jneurosci.org)
  • Use of these proteins provides another example of apoptotic cell clearance mediated by pattern recognition molecules of the innate immune system. (rupress.org)
  • As C1q has been shown to recognize and bind to surface blebs on apoptotic keratinocytes ( 16 ), and apoptotic vascular endothelial cells ( 17 ), we questioned the potential role of C1q and the related protein MBL as mediators of apoptotic cell recognition and clearance and have begun to examine mechanisms of this engulfment. (rupress.org)
  • This latter function is thought to reflect high-affinity, cell surface chaperone receptors on APCs, which direct GRP94 into the MHC class I re-presentation pathway. (jimmunol.org)
  • The conclusion that CD91 functions as the GRP94 receptor stems from the observation that α 2 M, the active form (α 2 M*) of which is an established, endogenous ligand for CD91, abrogates GRP94-mediated, APC-dependent T cell stimulation ( 12 ). (jimmunol.org)
  • We report in this work that the binding of GRP94 to APC cell surface receptors was RAP and α 2 M*-insensitive. (jimmunol.org)
  • Furthermore, CD91 and its ligand, Pseudomonas exotoxin, segregated from receptor-internalized GRP94 in early compartments of the endocytic pathway. (jimmunol.org)
  • The outcome of the most intensively studied Wnt pathway - the canonical Wnt/β-catenin signaling pathway - relies to a large extent on the regulation of the stability/abundance of the β-catenin protein ( Fig. 1 ). (biologists.org)
  • In OPCs, the expression pattern of Sox17, cyclin D1, and secreted Frizzled-related protein-1 in the presence of platelet-derived growth factor (PDGF) was coordinately accelerated by addition of thyroid hormone, indicating differentiation-induced regulation of Sox17 targets. (jneurosci.org)
  • Analysizing the absence of the normal protein was done with immunoblot for affected individuals having LRPAP1 mutations revealing the mutations in LRPAP1 probability of loss-of-function mutations. (wikipedia.org)