Ldl receptor or lipoprotein receptor. Medical search. Frequent questions

It is a cell-surface receptor that recognizes apolipoprotein B100 (ApoB100), which is embedded in the outer phospholipid layer of very low-density lipoprotein (VLDL), their remnants-i.e. intermediate-density lipoprotein (IDL), and LDL particles. (wikipedia.org)
VLDL = very low-density lipoprotein. (medscape.com)
Rosuvastatin also inhibits hepatic synthesis of very low-density lipoprotein (VLDL). (pediatriconcall.com)
The overall effect is a decrease in plasma LDL and VLDL. (pediatriconcall.com)
LDL is formed from very low-density lipoprotein (VLDL) and is catabolized predominantly by the high affinity LDL receptor. (nih.gov)
The mechanism of the LDL-lowering effect of lovastatin may involve both reduction of VLDL-C concentration, and induction of the LDL receptor, leading to reduced production and/or increased catabolism of LDL-C. Apolipoprotein B also falls during treatment with lovastatin. (nih.gov)
2 In the blood, APOE protein could interact with lipids, resulting in lipoproteins, including very-low-density lipoproteins (VLDL). (dovepress.com)
APOE is also involved in the formation of chylomicrons and VLDL and affects the activity of other lipid metabolism-associated proteins and enzymes, such as hepatic lipase and lipoprotein lipase. (dovepress.com)
APOE is a 299 amino acid plasma glycoprotein associated with LDL, VLDL, and high-density lipoproteins (HDL). (dovepress.com)
Apolipoprotein B binds to specific receptors on cell membranes and is involved in removal of LDL and very low density lipoprotein (VLDL) cholesterol from circulation. (thermofisher.com)
Very-low-density lipoproteins (VLDL) contain apoprotein B-100 (apo B), are synthesized in the liver, and transport TGs and cholesterol to peripheral tissues. (msdmanuals.com)
Most of the circulating cholesterol is found in three major lipoprotein fractions: very low-density lipoproteins (VLDL), low-density lipoproteins (LDL), and high-density lipoproteins (HDL). (cdc.gov)
These fatty acids are transported to the liver, where they are used for triglyceride synthesis and are exported as very-low-density lipoprotein (VLDL), which is elevated in these patients. (medscape.com)

The receptor also recognizes apolipoprotein E (ApoE) which is found in chylomicron remnants and IDL. (wikipedia.org)
Hyperlipidemia comprises a heterogeneous group of disorders, characterized by high levels in one or more lipids and/or lipoproteins [atherogenic free fatty acids (FA), triglycerides (TG) (hypertriglyceridemia), small dense low-density lipoprotein cholesterol (LDL-C) (hypercholesterolemia), and apolipoprotein (apo) B], and/or low level in antiatherogenic high density lipoprotein cholesterol (HDL-C), in the circulation [ 1 - 3 ]. (hindawi.com)
The second is an apolipoprotein(a) which is bound to the LDL-like molecule at the ApoB receptor with a disulfide bond. (medscape.com)
Hepatic LDL-receptor mRNA concentrations were significantly decreased in animals fed on TP, while apolipoprotein B mRNA concentrations were significantly increased. (cambridge.org)
These effects on lipoprotein metabolism may be exerted through specific modulation of the expression of the LDL receptor and apolipoprotein B genes. (cambridge.org)
Lomitapide inhibits microsomal triglyceride transfer protein, which plays a key role in apolipoprotein B-containing lipoprotein assembly and secretion in the liver and intestines. (medscape.com)
Serum lipids profiles, including total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), triglyceride (TG), apolipoprotein A-Ⅰ (apoA-Ⅰ), apolipoprotein B (apoB) and clinicopathologic data were analyzed. (researchsquare.com)
Jenny Kanter and Karin Bornfeldt of the University of Washington School of Medicine have shown previously that the low insulin levels characteristic of diabetes lead to increased levels of apolipoprotein C3, or APOC3, and triglyceride-rich lipoproteins, or TRLs, as well as accelerated atherosclerosis. (asbmb.org)
Pitavastatin is indicated as an adjunctive therapy to diet to reduce elevated total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), apolipoprotein B (Apo B), triglycerides (TG), and to increase HDL-C in adult patients with primary hyperlipidemia or mixed dyslipidemia. (wikidoc.org)
Apolipoprotein B (apo B) in human plasma is a major protein of low density lipoproteins (LDL) with a molecular mass of approximately 260-500 kDa. (thermofisher.com)
Apolipoprotein B is mostly synthesized in the liver, and is a major apolipoprotein of very low density, intermediate density and low density lipoproteins (LDL) as well as being a major component of lipoprotein (a). (thermofisher.com)
Apolipoprotein B is a ligand for the LDL receptor and elevated levels are associated with premature atherosclerosis. (thermofisher.com)
High triglycerides are associated with increased risk for CAD in patients with other risk factors, such as low HDL-cholesterol, some patient groups with elevated apolipoprotein B concentrations, and patients with forms of LDL that may be particularly atherogenic. (cdc.gov)
Apolipoprotein B is the main protein component of LDL and accounts for approximately 95% of the total protein content of LDL. (cdc.gov)

In humans, the LDL receptor protein is encoded by the LDLR gene on chromosome 19. (wikipedia.org)
Individuals with disruptive mutations (defined as nonsense, splice site, or indel frameshift) in LDLR have an average LDL-cholesterol of 279 mg/dL, compared with 135 mg/dL for individuals with neither disruptive nor deleterious mutations. (wikipedia.org)
This protein belongs to the LDLR family and is made up of a number of functionally distinct domains, including 3 EGF-like domains, 7 LDL-R class A domains, and 6 LDL-R class B repeats. (wikipedia.org)
These modules include a putative signal peptide for protein export, four epidermal growth factor (EGF) repeats with associated spacer domains, three LDL-receptor (LDLR) repeats, a single transmembrane spanning domain, and a cytoplasmic domain. (nih.gov)
Ng lipoproteins are taken up by two functionally significant low-density lipoprotein (LDL) receptors: the prototypic LDL receptor (LDLR) along with the LDL receptor-related protein 1 (LRP1). (nicotinic-receptor.com)
The low-density lipoprotein receptor (LDLR) is the major cholesterol-carrying lipoprotein of plasma, acting to regulate cholesterol homeostasis in mammalian cells. (embl.de)
Scientists from the University of Nottingham and Duke University have discovered that many of the blood vessels that feed high grade glioma brain tumours have high levels of Low-Density Lipoprotein (LDL) receptors (LDLR) on them. (nottingham.ac.uk)
The purpose of the present study was to test the hypothesis that lecithin:cholesterol acyltransferase (LCAT) deficiency would accelerate atherosclerosis development in low density lipoprotein (LDL) receptor (LDLr-/-) and apoE (apoE-/-) knockout mice. (eurekamag.com)
After 16 weeks of atherogenic diet (0.1% cholesterol, 10% calories from palm oil) consumption, LDLr-/- LCAT-/- double knockout mice, compared with LDLr-/- mice, had similar plasma concentrations of free (FC), esterified (EC), and apoB lipoprotein cholesterol, increased plasma concentrations of phospholipid and triglyceride, decreased HDL cholesterol, and 2-fold more aortic FC (142 +/- 28 versus 61 +/- 20 mg/g protein) and EC (102 +/- 27 versus 61+/- 27 mg/g). (eurekamag.com)
LCAT deficiency resulted in a 12-fold increase in the ratio of saturated + monounsaturated to polyunsaturated cholesteryl esters in apoB lipoproteins in LDLr-/- mice and a 3-fold increase in the apoE-/- mice compared with their counterparts with active LCAT. (eurekamag.com)
We conclude that LCAT deficiency in LDLr-/- and apoE-/- mice fed an atherogenic diet resulted in increased aortic cholesterol deposition, likely due to a reduction in plasma HDL, an increased saturation of cholesteryl esters in apoB lipoproteins and, in the apoE-/- background, an increased plasma concentration of apoB lipoproteins. (eurekamag.com)

Reducing PCSK9 can help your liver break down more LDL cholesterol and encourage healthy cholesterol levels. (dallasnews.com)
The enzyme proprotein convertase subtilisin/kexin type 9, or PCSK9, regulates cholesterol metabolism by binding and chaperoning the low-density lipoprotein, or LDL, receptor to be degraded. (asbmb.org)
That receptor clears LDL from circulation, making PCSK9 an appealing drug target: Blocking PCSK9 lowers blood LDL concentration, thereby reducing risk for cardiovascular disease. (asbmb.org)
The enzyme PCSK9 protein regulates cholesterol metabolism by degrading the low-density lipoprotein receptor. (asbmb.org)
Furin post-translationally modifies extracellular PCSK9 to form PCSK9_55, which has reduced capacity for LDL receptor degradation. (asbmb.org)
By studying outliers in this population, Dr. Hobbs identified a genetic defect in PCSK9 that is responsible for low plasma LDL levels. (jci.org)
She also discusses the initiation of the Dallas Heart Study and the development of a therapeutic inhibitor of PCSK9 for lowering LDL. (jci.org)
PCSK9 inhibitor persistence in patients with familial hypercholesterolaemia (FH) appears to be very high over time and associated with achievement of low-density lipoprotein cholesterol (LDL-C) goals as well as an improvement in quality-of-life according to an analysis of clinical practice data by Spanish researchers. (hospitalhealthcare.com)
In addition, studies have suggested that the use of a PCSK9 inhibitor led to a 54.9% mean reduction in LDL-C from baseline in those with severe heterozygous FH . (hospitalhealthcare.com)
A recent discovery showed that statin therapy stimulates the production of PCSK9, an enzyme that leads to the destruction of LDL receptors. (acc.org)
The present study tested SAR236553/REGN727, a monoclonal antibody that binds to PCSK9, blocking its effects and preventing the degradation of LDL receptors. (acc.org)
Medicines called PCSK9 inhibitors lower cholesterol-increasing LDL receptors. (cdc.gov)

The researchers found that APOC3 and APOB colocalize in atherosclerotic lesions of the aorta, supporting their hypothesis that the lipoproteins containing APOC3 particles could be these TRLs and RLPs. (asbmb.org)
ApoE-/- LCAT-/- mice fed the atherogenic diet, compared with apoE-/- mice, had higher concentrations of plasma FC, EC, apoB lipoprotein cholesterol, and phospholipid, and significantly more aortic FC (149 +/- 62 versus 109 +/- 33 mg/g) and EC (101 +/- 23 versus 69 +/- 20 mg/g) than did the apoE-/- mice. (eurekamag.com)
LDL receptor analysis can be used to identify the specific LDL receptor defect, and LDL receptor or apoB-100 studies can help distinguish heterozygous FH from the similar syndrome of familial defective apoB-100. (medscape.com)

The low-density lipoprotein receptor (LDL-R) is a mosaic protein of 839 amino acids (after removal of 21-amino acid signal peptide) that mediates the endocytosis of cholesterol-rich low-density lipoprotein (LDL). (wikipedia.org)
e.g. a truncation of the receptor protein at residue number 660 leads to domains 3,4 and 5 of the EGF precursor domain being missing. (wikipedia.org)
This precludes the movement of the receptor from the ER to the Golgi, and leads to degradation of the receptor protein. (wikipedia.org)
The gene, termed low-density lipoprotein receptor related protein 5 (LRP5), encodes a protein of 1615 amino acids that contains conserved modules which are characteristic of the low-density lipoprotein (LDL) receptor family. (nih.gov)
Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. (thermofisher.com)
LDLRAP1, LDL receptor adaptor protein 1 (i.e. (endotext.org)
Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. (embl.de)
These findings are a significant step in understanding the biology of tumours and how they gather energy to grow and spread like from the body's own fat and protein containing lipoprotein particles. (nottingham.ac.uk)
Low-density lipoprotein (LDL) is the carrier protein for cholesterol in the blood. (thermofisher.com)
Autosomal recessive hypercholesterolemia caused by mutations in a putative LDL receptor adaptor protein. (medscape.com)

We've known for 30 years that lowering LDL cholesterol with statins lowers the risk of heart disease and that the more you can lower LDL cholesterol, the greater reduction in that risk," said James McKenney, PharmD, chief executive officer of National Clinical Research, and the study's lead investigator. (acc.org)
Several types of medicines help lower LDL cholesterol. (cdc.gov)
Statin drugs lower LDL cholesterol by slowing down the liver's production of cholesterol. (cdc.gov)
2 These medicines are used in people who have familial hypercholesterolemia (FH) , a genetic condition that causes very high levels of LDL cholesterol and people with clinical ASCVD who require lower LDL cholesterol levels. (cdc.gov)
LDL-cholesterol is measured to assess risk for CHD and to follow the progress of patients being treated to lower LDL-cholesterol concentrations. (cdc.gov)

A new study significantly refines the association between prostate cancer and blood lipids, highlighting genetic risk factors associated with low density lipoprotein (LDL) cholesterol and triglycerides as key players and identifying 17 related gene loci that make risk contributions to levels of these blood lipids and to prostate cancer. (sciencedaily.com)
MANNHEIM, Germany - Lomitapide , which reduces lipoprotein production in the liver, could help manage pediatric homozygous familial hypercholesterolemia (HoFH), suggest results of a trial that showed large reductions in circulating lipids . (medscape.com)
Variations of plasma lipids and lipoproteins have been observed in ovarian cancer patients. (researchsquare.com)
and APOC3, which slows the clearance of triglyceride-rich lipoproteins and their remnant lipoprotein particles, or RLPs, lipids that have been linked previously to cardiovascular disease. (asbmb.org)
APOE binds to cell-surface receptors to deliver lipids and to the hydrophobic amyloid-β peptide, regulating amyloid-β aggregations and clearances in the brain. (dovepress.com)
All lipids are hydrophobic and mostly insoluble in blood, so they require transport within lipoproteins. (msdmanuals.com)
Pathway defects in lipoprotein synthesis, processing, and clearance can lead to accumulation of atherogenic lipids in plasma and endothelium. (msdmanuals.com)

In the case of the latter, they specifically investigated triglycerides, LDL and high density lipoprotein cholesterol, systolic blood pressure, body mass index, waist-hip ratio and type 2 diabetes. (sciencedaily.com)
LDL cholesterol and triglycerides displayed a strong association with prostate cancer. (sciencedaily.com)
The significant risk association with LDL cholesterol and triglycerides versus the other traits at a genetic level was novel and unexpected. (sciencedaily.com)
the triglycerides are subsequently transported throughout the circulation by triglyceride-rich lipoproteins. (medscape.com)
Evinacumab inhibits ANGPTL3 and results in increased lipid metabolism, leading to decreased low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL_C), and triglycerides. (medscape.com)
Lipoproteins synthesized by the liver transport endogenous triglycerides and cholesterol. (msdmanuals.com)
Triglycerides are also measured because the value is used to calculate LDL-cholesterol concentrations. (cdc.gov)

TS-containing diets did not increase the cholesterol content of any of the major lipoprotein fractions. (cambridge.org)

15] found that oxidized low-density lipoprotein (ox-LDL) in serum was higher in ovarian cancer patients than in control subjects, but total cholesterol (TC) and high-density lipoprotein (HDL) showed no such association. (researchsquare.com)
However, the risk of developing coronary heart disease is continuous and graded over the range of cholesterol levels and many coronary events do occur in patients with total cholesterol (total-C) and LDL-C in the lower end of this range. (nih.gov)
Familial hypercholesterolemia (FH) is an autosomal dominant disorder that causes severe elevations in total cholesterol and low-density lipoprotein cholesterol (LDLc). (medscape.com)
Irisin has a significant negative correlation with levels of lipoprotein(a), coenzyme Q10, LDL receptor, total cholesterol and NPC1L1. (medscape.com)
Nicotinic acid raises high-density lipoprotein (HDL) cholesterol levels while lowering total cholesterol, LDL cholesterol, and triglyceride levels. (cdc.gov)
In this study, we investigated the associations between proteins related to CVD and triglyceride (TG), total cholesterol, LDL (low-density lipoprotein), and HDL (high-density lipoprotein) cholesterol levels in individuals from the general population. (lu.se)
35 were associated with TG, 15 with total cholesterol, 9 with LDL cholesterol, and 24 with HDL cholesterol. (lu.se)
Another common pattern of associations was concomitantly higher TG, total cholesterol, and LDL cholesterol, which is associated with higher CVD risk. (lu.se)

It belongs to the low density lipoprotein receptor gene family. (wikipedia.org)
The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. (thermofisher.com)
Complete cloning and sequencing of rat gp330/"megalin," a distinctive member of the low density lipoprotein receptor gene family. (embl.de)

This enzyme destroys your low-density lipoprotein (LDL) receptors, preventing your body from breaking down LDL cholesterol effectively. (dallasnews.com)
The body needs bile acids and makes them by breaking down LDL cholesterol. (cdc.gov)

The N-terminal domain of the LDL receptor, which is responsible for ligand binding, is composed of seven sequence repeats (~50% identical). (wikipedia.org)
The exact mechanism of interaction between the class A repeats and ligand (LDL) is unknown, but it is thought that the repeats act as "grabbers" to hold the LDL. (wikipedia.org)
In order to be internalized, the receptor-ligand complex must first cluster into clathrin-coated pits. (embl.de)
APOE serves as a ligand for members of low-density lipoprotein (LDL) receptor family and is involved in the removal of lipoproteins from the circulation for excretion in the liver. (dovepress.com)
Among these associations, we found KIM-1 (kidney injury molecule-1), TNFR (TNF [tumor necrosis factor] receptor) 1 and 2, TRAIL-R2 (TRAIL [TNF-related apoptosis-inducing ligand] receptor 2), and RETN (resistin) to be associated with all 4 lipid fractions. (lu.se)

ANGPTL3 inhibits lipoprotein lipase and endothelial lipase, thereby reducing lipid metabolism. (medscape.com)
In the capillaries of adipose and muscle tissue, apoprotein C-II (apo C-II) on the chylomicron activates endothelial lipoprotein lipase (LPL) to convert 90% of chylomicron triglyceride to fatty acids and glycerol, which are taken up by adipocytes and muscle cells for energy use or storage. (msdmanuals.com)
Severe hypoglycemia stimulates epinephrine secretion, which activates lipoprotein lipase and the release of free fatty acids. (medscape.com)

Once absorbed into enterocytes, they are reassembled into TGs and packaged with cholesterol into chylomicrons, the largest lipoproteins. (msdmanuals.com)

Michael S. Brown and Joseph L. Goldstein were awarded the 1985 Nobel Prize in Physiology or Medicine for their identification of LDL-R and its relation to cholesterol metabolism and familial hypercholesterolemia. (wikipedia.org)
Reduction of total cholesterols (TC) and LDL-C by dietary alterations and medications that affect lipid metabolism [ 14 ] is found to reduce the occurrence of atherosclerosis in animals and clinical cardiovascular events in human [ 15 ]. (hindawi.com)
FH is a disorder of cholesterol metabolism associated with mutations in the low-density lipoprotein (LDL) receptor and a few other genes. (cdc.gov)
Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. (embl.de)

The repeat is found in a variety of proteins that include, vitellogenin receptor from Drosophila melanogaster, low-density lipoprotein (LDL) receptor [ ( PUBMED:6091915 ) ], preproepidermal growth factor, and nidogen (entactin). (embl.de)

Hyperlipoproteinemia is a metabolic disorder characterized by abnormally elevated concentrations of specific lipoprotein particles in the plasma. (medscape.com)
They may also increase removal of LDL particles and increase apoA-I and apoA-II in the liver which may contribute to increase in HDL cholesterol levels. (cdc.gov)

The cytosolic C-terminal domain contains ~50 amino acids, including a signal sequence important for localizing the receptors to clathrin-coated pits and for triggering receptor-mediated endocytosis after binding. (wikipedia.org)
Following receptor-mediated endocytosis, ApoE is recycled for the plasma membrane, and cholesterol is used for cell membrane turnover and repair, myelin formation, synaptogenesis and neurotransmitter release [146]. (nicotinic-receptor.com)
The LDL receptor binds LDL and transports it into cells by acidic endocytosis. (embl.de)

The LDL particle can actually promote atherosclerosis. (medscape.com)
Oxidized LDL may be a marker of atherosclerosis but the precise changes in oxidized LDL are not well described. (thermofisher.com)
LDL carries most of the circulating cholesterol and, when elevated, contributes to the development of coronary atherosclerosis. (cdc.gov)

Mutations in the gene encoding the LDL receptor are known to cause familial hypercholesterolaemia. (wikipedia.org)
There are 5 broad classes of mutation of the LDL receptor: Class 1 mutations affect the synthesis of the receptor in the endoplasmic reticulum (ER). (wikipedia.org)
Class 2 mutations prevent proper transport to the Golgi body needed for modifications to the receptor. (wikipedia.org)
Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. (thermofisher.com)
Mutations in the LDL receptor gene cause familial hypercholesterolemia. (embl.de)
Numerous familial hypercholestorolemia mutations of the LDL receptor alter the calcium coordinating residue of LDL-A domains or other crucial scaffolding residues. (embl.de)

LDL binds to its receptor on the capillary walls and thereby mediates the uptake and clearance of cholesterol from the circulation. (thermofisher.com)
Ranibizumab is a recombinant humanized monoclonal antibody fragment which binds to and inhibits human vascular endothelial growth factor A (VEGF-A). Ranibizumab inhibits VEGF from binding to its receptors and thereby suppressing neovascularization and slowing vision loss. (geisinger.org)
Lunsumio (mosunetuzumab-axgb) is a T-cell engaging bispecific humanized monoclonal antibody that binds to the CD3 receptor expressed on the surface of T-cells and CD20 expressed on the surface of lymphoma cells and some healthy B-lineage cells. (geisinger.org)
Lutathera (lutetium Lu 177 dotatate) is a beta- and gamma-emitting radionuclide which binds to somatostatin receptors with highest affinity to subtype 2 receptors (SSRT2). (geisinger.org)

CHICAGO (March 26, 2012) -A novel monoclonal antibody identified in a new study dramatically lowered circulating LDL cholesterol by 40 percent to 72 percent, a development with potential to provide a new option for patients who are resistant to cholesterol-lowering drugs such as statins or to the current standard of care, according to research presented today at the American College of Cardiology's 61st Annual Scientific Session. (acc.org)
Circulating LDL cholesterol was lowered by 40 percent, 64 percent, and 72 percent in patients assigned to 50, 100, or 150 mg Q2W doses, respectively. (acc.org)
The placebo group reported a 5 percent reduction of circulating LDL cholesterol. (acc.org)

Disorders of the biogenesis and secretion of lipoproteins containing the B apolipoproteins. (medscape.com)

Decreased hepatic cholesterol concentrations stimulate the upregulation of hepatic low-density lipoprotein (LDL) receptors which increases hepatic uptake of LDL. (pediatriconcall.com)
Factors that stimulate hepatic lipoprotein synthesis generally lead to elevated plasma cholesterol and TG levels. (msdmanuals.com)

APOE plays multiple roles in the regulation of lipid and lipoprotein levels in the blood. (dovepress.com)
In the plasma, APOE will associate with most lipoproteins. (dovepress.com)

TZDs markedly stimulate the uptake of oxidized LDL (oxLDL) into adipocytes, and this requires OLR1. (jci.org)
This increases low-density lipoprotein-cholesterol (LDL-C) receptor recycling and expression on the hepatocyte cell surface, which increases LDL-C uptake and lowers LDL-C levels in the circulation. (geisinger.org)

Molecular basis of familial hypercholesterolaemia from structure of LDL receptor module. (expasy.org)

While it is well established that the fatty acid composition of dietary fat is important in determining plasma lipoprotein cholesterol concentrations, the effects of changing the absolute quantities of the individual fatty acids are less clear. (cambridge.org)
Lovastatin has been shown to reduce elevated LDL-C concentrations. (nih.gov)

The fifth domain is the cytoplasmic tail that directs the receptor to clathrin-coated pits. (embl.de)

The traditional statin therapy used by millions of Americans lowers LDL cholesterol - the "bad" cholesterol that leads to plaque build-up in the arteries and subsequently heart disease - by inhibiting the production of cholesterol in liver cells, causing an increase in the number of LDL receptors on the cell surface. (acc.org)
These receptors grab LDL circulating in the blood and deliver it into the liver, where it is subsequently processed and flushed out of the body. (acc.org)
More LDL receptors mean more LDL is brought out of the blood into the liver, and circulating levels of LDL cholesterol decrease. (acc.org)
Most patients with homozygous FH do not survive adulthood beyond age 30 years unless treated with unusual methods, such as liver transplantation, LDL apheresis, or ileal bypass surgery to dramatically lower their LDLc levels. (medscape.com)
Lipoproteins circulate through the blood continuously until the TGs they contain are taken up by peripheral tissues or the lipoproteins themselves are cleared by the liver. (msdmanuals.com)
Apo B is necessary for the reaction with LDL receptors in the liver and on cell walls, and is thus involved in transporting cholesterol from the liver to the vessel cell. (cdc.gov)

The TP-rich diets increased plasma LDL- and HDL-cholesterol levels in a concentration-dependent manner. (cambridge.org)
they were treated with the drug for 24 weeks, resulting in reductions of low density lipoprotein (LDL) cholesterol of almost 54%, with nearly 42% reaching target levels. (medscape.com)
Preoperative HDL-C and LDL-C levels are significant predictors of clinical outcome in patients with epithelial ovarian cancer. (researchsquare.com)
Persons with FH have very high levels of LDL cholesterol starting in childhood. (cdc.gov)
By studying outliers in the Dallas Heart Study, Hobbs ( Figure 1 ) uncovered a genetic defect responsible for low blood LDL cholesterol levels. (jci.org)
Due to the presence of dysfunctional low-density lipoprotein (LDL) receptors because of a genetic mutation, serum LDL-C levels are considerably increased from birth. (hospitalhealthcare.com)
2-This program is unique in that we find folks who would otherwise pass through a screen as "healthy" but who are actually running around with serious problems, such as very high LDL-P, despite having "normal" cholesterol levels. (robbwolf.com)
3-People who flag as high risk are placed on a low-carb/paleo diet, counseled on sleep, and exercise, vit-D levels are tracked, and in some cases a very low dose statin is used to bring lipoprotein levels down. (robbwolf.com)
The first part of the study was focused on understanding the regulation of irisin levels based on multiple baseline parameters, such as lipoprotein(a) and cholesterol levels. (medscape.com)
Niacin is a B vitamin that can improve all lipoprotein levels. (cdc.gov)

Here we report that antidiabetic thiazolidinediones (TZDs) and other ligands for the nuclear receptor PPARγ dramatically upregulate oxidized LDL receptor 1 (OLR1) in adipocytes by facilitating the exchange of coactivators for corepressors on the OLR1 gene in cultured mouse adipocytes. (jci.org)
Definitive diagnosis can be made only with gene or receptor analysis. (medscape.com)

The MIA1609 immunogen is purified human serum LDL. (thermofisher.com)

The N-terminal type A repeats in LDL receptor bind the lipoproteins. (embl.de)

Poor sleep can chronically elevate cortisol, antagonizing thyroid production, and this can lead to elevated lipoproteins due to down regulation of the LDL receptor. (robbwolf.com)

If you look at LDL cholesterol trials where they gave statins to control LDL, the best predictor at that point of recurrent events was actually the lipoprotein(a) level, not the LDL level. (medscape.com)
The discovery of the LDL receptor mutation in FH patients-for which Goldstein and Brown won the Nobel prize in 1985-led to the development of statins as a new class of drugs to combat high cholesterol, a major cause of heart disease in populations. (cdc.gov)
About one in five people with high low-density lipoprotein (LDL) are resistant to cholesterol-lowering drugs such as statins, and for many others the current standard of care does not lower cholesterol enough. (acc.org)

It should be replaced by 'The concentration of triglyceride-rich lipoproteins may also fall. (bmj.com)

Thus, on a low-cholesterol diet, increasing the absolute amount of dietary palmitic acid increases LDL-cholesterol more than either myristic or stearic acid. (cambridge.org)

Like the small dense LDL. (medscape.com)

A total of 696 patients with a median age of 56.4 years (46% female) were included and followed for a median of 3.7 years with the median baseline LDL-C being 3.8 mmol/L. Background lipid lowering therapy was a statin and ezetimibe in 74.6% of cases and statin monotherapy in 17.5% of cases. (hospitalhealthcare.com)
The study's primary endpoint was the percentage LDL cholesterol reduction from baseline to after 12 weeks. (acc.org)

Inclisiran is indicated as an adjunct to diet and maximally tolerated statin therapy for adults with heterozygous familial hypercholesterolemia (HeFH) or clinical atherosclerotic cardiovascular disease (ASCVD) who require additional LDL-C lowering. (medscape.com)

This results in a decrease in LDL cholesterol circulating in the bloodstream. (cdc.gov)

Zheng SM, Chen H, Sha WH, Chen XF, Yin JB, Zhu XB, Zheng ZW, Ma J. Oxidized low-density lipoprotein stimulates CD206 positive macrophages upregulating CD44 and CD133 expression in colorectal cancer with high-fat diet. (wjgnet.com)

It is thought that this region is responsible for the pH-dependent conformational shift that causes bound LDL to be released in the endosome. (wikipedia.org)

Case series of lomitapide use in pediatric HoFH patients have shown encouraging results that are consistent with those seen in adults, he noted, with many able to achieve their LDL cholesterol target and stop or reduce apheresis. (medscape.com)

This condition looks quite similar to Familial Hypercholesterolemia and needs to be treated in a completely different way than elevated LDL-P from "simple" insulin resistance. (robbwolf.com)
Evinacumab is indicated as an adjunct to other LDL-C-lowering therapies for homozygous familial hypercholesterolemia in adults and adolescents aged 12 years and older. (medscape.com)

A, B and C. A and B are closely linked while C is separated by the YWTD repeat region, which adopts a beta-propeller conformation (LDL-R class B domain). (wikipedia.org)

Here, we describe an association of the 3′-UTR +1073 C/T polymorphism of the OLR1 (oxidised LDL receptor 1) on chromosome 12 with AD in French sporadic (589 cases and 663 controls) and American familial (230 affected sibs and 143 unaffected sibs) populations. (bmj.com)

June 22, 2020 For decades, high-density lipoprotein (HDL) cholesterol has been dubbed 'good cholesterol' because of its role in moving fats and other cholesterol molecules out of artery walls. (sciencedaily.com)
Epidemiological and clinical studies have established that high LDL-C and low high-density lipoprotein cholesterol (HDL-C) are both associated with coronary heart disease. (nih.gov)
If you have high low-density lipoprotein (LDL) cholesterol, your health care team may prescribe medicine in addition to lifestyle changes to manage your LDL cholesterol level. (cdc.gov)
You are 40-75 years old and have a high risk of developing heart disease or stroke and an LDL cholesterol level of 70 mg/dL or higher. (cdc.gov)
and very high LDL-cholesterol is greater than or equal to 190 mg/dL. (cdc.gov)

In atherosclerotic lesions oxidatively modified LDL is found and oxidized LDL is specifically recognized and ingested by macrophages via scavenger receptor A and CD36. (thermofisher.com)

At least three isoforms of LDL-R are known to exist. (thermofisher.com)

Anatomy24

Organisms12

Diseases21

Chemicals and Drugs130

Analytical, Diagnostic and Therapeutic Techniques and Equipment23

Phenomena and Processes48

Technology, Industry, Agriculture3

Information Science3

Health Care1

VLDL13

Apolipoprotein14

LDLR11

PCSK912

ApoB3

Protein10

Lower LDL cholesterol5

Lipids7

Triglycerides7

Major lipoprotein fractions1

Total cholesterol8

Density lipoprotein receptor3

Breaking down LDL cholesterol2

Ligand5

Lipase3

Chylomicrons1

Metabolism4

Proteins1

Particles2

Endocytosis3

Atherosclerosis3

Mutations6

Binds4

Circulating LDL cholesterol3

Secretion1

Hepatic2

ApoE2

Uptake2

Familial hypercholesterolaemia1

Concentrations2

Clathrin-coated pits1

Liver6

Levels10

Gene2

Serum1

Repeats1

Lead to elevated1

Statins3

Concentration1

Increases1

Small dense1

Baseline2

Statin therapy1

Bloodstream1

Stimulates1

Bound1

Apheresis1

Hypercholesterolemia2

YWTD1

OLR11

High5

Atherosclerotic1

Isoforms1