• The World Health Organization classification of lung tumors recognizes a variant of LCNEC, namely "combined large-cell neuroendocrine carcinoma" (c-LCNEC). (wikipedia.org)
  • Background/aim: Large-cell neuroendocrine carcinoma (LCNEC) of the lung is a relatively uncommon and aggressive subset of pulmonary neuroendocrine tumors, which include typical and atypical carcinoid, and small-cell lung cancer. (tubitak.gov.tr)
  • LCNECs show features of high-grade neuroendocrine tumors and patients with LCNEC have a very poor prognosis. (tubitak.gov.tr)
  • Neuroendocrine neoplasms (NENs) include all tumors derived from the diffuse endocrine system. (springeropen.com)
  • This cellular compartmentalization of PTEN was investigated in lung neuroendocrine tumors (lung NET). (biomedcentral.com)
  • In comparison to the carcinoids, LCNEC/SCLC tumors presented a stronger loss of nuclear and cytosolic PTEN associated with a loss of PTEN and p53 . (biomedcentral.com)
  • Lung neuroendocrine tumors (NET) comprise the four histotypes typical carcinoid (TC), atypical carcinoid (AC), large cell neuroendocrine carcinoma (LCNEC) and small cell lung carcinoma (SCLC). (biomedcentral.com)
  • Background: Neuroendocrine tumors of the lung comprise typical (TC) and atypical carcinoids (AC), large-cell neuroendocrine cancer (LCNEC) and small-cell lung cancer (SCLC). (oncotarget.com)
  • Large cell neuroendocrine carcinoma (LCNEC) is part of the neuroendocrine spectrum of pulmonary tumors. (johnshopkins.edu)
  • The assessed biomarkers and phenotypes allow for risk stratification (OS, PFS), diagnostic classification and enhance the biological understanding of the different subtypes of neuroendocrine tumors revealing potential new therapy options and clarifying known resistance mechanisms. (oncotarget.com)
  • Twenty-five percent of all lung tumors belong to the group of neuroendocrine tumors [ 2 ] including typical carcinoid (TC) and atypical carcinoid (AC), large-cell neuroendocrine cancer (LCNEC), and small-cell lung cancer (SCLC). (oncotarget.com)
  • The terms related to NETs, including "carcinoid", "endocrine", "neuroendocrine", "small cell carcinoma" and "large cell neuroendocrine carcinoma (LCNEC)", were searched among histopathological diagnoses of all neoplasm specimens obtained during surgical procedures at Tokyo Medical University Hospital during the 6 years between January 2008 and December 2013. (biomedcentral.com)
  • It's a rare tumour called (pardon my spelling) a neuroendocrine carcinoid tumour. (lungevity.org)
  • 25% of all lung cancer cases are neuroendocrine (NELC) including typical (TC) and atypical carcinoid (AC), large-cell neuroendocrine (LCNEC) and small cell lung cancer (SCLC). (oncotarget.com)
  • Molecular studies have identified two mutually exclusive subtypes in LCNEC, the co-mutated TP53 and RB1 and the STK11/KEAP1 (predominantly RB1 wildtype(wt)) group. (nrs-science.nl)
  • Genetic subtypes of large cell neuroendocrine c. (nrs-science.nl)
  • DLL3 expression in large cell neuroendocrine carcinoma (LCNEC) and association with molecular subtypes and neuroendocrine profile. (bmj.com)
  • In the huge spectrum of lung neuroendocrine neoplasms, typical and atypical carcinoids should be considered as a separate biological entity from poorly differentiated forms, harboring peculiar molecular alterations. (springeropen.com)
  • The multicentre cohort included 58 typical carcinoids (TC), 42 atypical carcinoids (AC), 32 large cell neuroendocrine carcinomas (LCNEC) and 60 small cell lung carcinomas (SCLC). (biomedcentral.com)
  • Patients with carcinoids were predominantly female and 10 years younger than patients with LCNEC/SCLC. (biomedcentral.com)
  • In contrast, CCNE1 and CDK6 showed elevated expression in carcinoids compared to carcinomas. (oncotarget.com)
  • Phenotypic sorting revealed the Ft-phenotype to be the most prominent expression profile in carcinoids, whereas SCLC presented nearly univocal with the fT and LCNEC with fT or ft. (oncotarget.com)
  • Between SCLC and LCNEC CDK2 , CDKN1B , CDKN2A and PNN expression was significantly different with higher expression in SCLC. (oncotarget.com)
  • The large cell carcinoma class has been enriched with several variants, including the LCNEC and the basaloid carcinoma, both with a dismal prognosis. (ersjournals.com)
  • Background Extensive Stage Small Cell Lung Cancer (ES-SCLC) and Large Cell Neuroendocrine of the lung (LCNEC) are aggressive neuroendocrine carcinomas with an exceptionally poor prognosis. (bmj.com)
  • This article reviews the tumor characterization, biology, presentation and diagnosis, surgical therapy, results of therapy, and long term prognosis of patients with LCNEC. (johnshopkins.edu)
  • Large cell neuroendocrine carcinoma (LCNEC) is now recognized as a histologically high grade non small cell carcinoma showing histopathological features of neuroendocrine differentiation as well as immunohistochemical neuroendocrine markers. (ersjournals.com)
  • Large cell neuroendocrine carcinoma (LCNEC) is a rare subtype of lung cancer, accounting for 1% to 3% of all lung cancers, and is known for its aggressive behavior [ 1 ]. (e-acfs.org)
  • The aggressive nature of LCNEC, coupled with uncommon pulmonary symptoms such as cough, hemoptysis, and post-obstructive pneumonia, makes it difficult to diagnose in its early stages. (e-acfs.org)
  • Fernandez, FG & Battafarano, RJ 2006, ' Large-Cell Neuroendocrine Carcinoma of the Lung: An Aggressive Neuroendocrine Lung Cancer ', Seminars in thoracic and cardiovascular surgery , vol. 18, no. 3, pp. 206-210. (johnshopkins.edu)
  • Large-cell neuroendocrine carcinoma of the lung (LCNEC of the lung), or pulmonary large-cell neuroendocrine carcinoma (PLCNC), is a highly malignant neoplasm arising from transformed epithelial cells originating in tissues within the pulmonary tree. (wikipedia.org)
  • It is currently considered to be a subtype of large-cell lung carcinoma. (wikipedia.org)
  • As compared to the previous edition, changes include a better definition of pre-invasive lesion, a reclassification of adenocarcinoma, the description of two new tumour types as variants of large cell carcinoma, large cell neuroendocrine carcinoma (LCNEC) and basaloid carcinoma, and a new class called pleomorphic carcinoma. (ersjournals.com)
  • Surgical management of large-cell neuroendocrinelung carcinoma: an ana" by FUNDA İNCEKARA, KORAY AYDOĞDU et al. (tubitak.gov.tr)
  • range 48 to 77 years) who underwent pulmonary resection for large-cell neuroendocrine carcinoma between January 2004 and December 2014 were investigated retrospectively. (tubitak.gov.tr)
  • Large cell neuroendocrine carcinoma (LCNEC) is a rare type of lung cancer that accounts for approximately 3% of lung cancers. (e-acfs.org)
  • The second group includes large cell neuroendocrine carcinoma (LCNEC) and small cell lung cancer (SCLC). (springeropen.com)
  • The patient population is adult subjects with histologically/cytologically confirmed unresectable small cell lung carcinoma (SCLC), large cell neuroendocrine lung carcinoma (LCNEC), combined SCLC, or combined LCNEC as per WHO 2021 criteria. (bmj.com)
  • Atieh T, Huang CH. Treatment of advanced-stage large cell neuroendocrine cancer (LCNEC) of the lung: A tale of two diseases. (bmj.com)
  • Discriminating small-cell lung carcinoma (SCLC) from large-cell neuroendocrine carcinoma (LCNEC) rests on morphological criteria, and reproducibility has been shown to be poor. (warwick.ac.uk)
  • In addition of the categories of squamous dysplasia and carcinoma in situ , two additional lesions were added to the group of pre-invasive lesions: atypical adenomatous hyperplasia (AAH) and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH). (ersjournals.com)
  • 25% tumor cells) and LCNEC (74% having positive staining in at least 1% of tumor cells). (bmj.com)
  • Introduction: To treat LCNEC with non-small cell lung carcinoma type chemotherapy (NSCLC-ct, i.e. gemcitabine/taxanes or pemetrexed) or small cell lung carcinoma type (SCLC-ct, i.e. platinumetoposide) is subject of debate. (nrs-science.nl)
  • Conclusion: Complete surgical resection is the treatment of choice for early-stage LCNEC and chemotherapy after radical surgical treatment improves survival. (tubitak.gov.tr)
  • LCNEC of the lung accounts for no more than 1% of all lung cancers. (tubitak.gov.tr)
  • Unlike other lung cancers, LCNEC is often discovered in advanced stages. (e-acfs.org)
  • Methods: For this population based retrospective cohort study all diagnoses of stage IV ct treated high grade neuroendocrine carcinomas (NEC, not being SCLC) were retrieved from the Netherlands Cancer Registry and Pathology Registry (PALGA) (2003-2012). (nrs-science.nl)
  • Pulmonary giant cell neuroendocrine carcinoma (LCNEC) is an unusual kind of non-small cell lung most cancers (NSCLC) with an incidence of roughly 3% of all lung most cancers diagnoses. (inacj.com)
  • Methods This phase 1, open-label, multicenter, dose-escalation and cohort expansion study of LB2102 will treat up to 41 subjects with ES-SCLC or LCNEC ( NCT05680922 ). (bmj.com)
  • Materials and Methods: Sixty representative FFPE-specimens (16 TC, 13 AC, 16 LCNEC and 15 SCLC) were used for mRNA expression analysis using the NanoString technique. (oncotarget.com)
  • There has been substantial evolution of concepts in neuroendocrine lung tumour classification. (ersjournals.com)
  • Gene expression profiling on laser captured frozen tumour samples from eight SCLC and eight LCNEC tumours identified a total of 888 differentially expressed genes (DEGs), 23 of which were validated by qRT-PCR. (warwick.ac.uk)
  • Antibodies to four selected gene products were then evaluated as immunohistochemical markers on a cohort of 173 formalin-fixed paraffin-embedded (FFPE) SCLC/LCNEC tumour samples, including 26 indeterminate tumours without a consensus diagnosis. (warwick.ac.uk)
  • Of the 26 indeterminate tumours 15 (58%) showed an immunophenotype suggesting either SCLC or LCNEC, eight (31%) showed staining of both tumour types, and three (11%) were negative for all markers. (warwick.ac.uk)
  • Finally, a new class was defined called carcinoma with pleomorphic, sarcomatoid, or sarcomatous elements, which brings together a number of proliferations characterized by a spectrum of epithelial to mesenchymal differentiation. (ersjournals.com)
  • NSCLC-ct or SCLC-ct was specified in 92% of patients and RB1wt LCNEC treated with NSCLC-ct (n=22) showed a trend to better OS compared to SCLC-ct (n=13) (8.5 months (95% confidence interval (CI): [6.3-10.6]) vs. 5.8 [5.5-6.1] months, p=0.055). (nrs-science.nl)
  • In patients with RB1mt LCNEC OS/PFS was not significantly different for NSCLC-ct vs. SCLC-ct. (nrs-science.nl)
  • Pathological classification of the primary lesion was NET Grade 2 (Ki-67: 3 to 20 %) in 3 patients and neuroendocrine carcinoma (NEC, Ki-67: ≥21 %) in 26 patients. (biomedcentral.com)
  • Another change is the subclassification of adenocarcinoma: the definition of bronchioalveolar carcinoma has been restricted to noninvasive tumours. (ersjournals.com)
  • Results: LCNEC was consensus diagnosed in 146/230 and 77 passed quality control for TNGS. (nrs-science.nl)
  • LCNEC is often generically grouped among the non-small-cell lung carcinomas. (wikipedia.org)
  • Journal Article] Similar protein expression profiles of ovarian and endometrial high-grade serous carcinomas. (nii.ac.jp)
  • Current treatment for non-muscle invasive bladder cancer (NMIBC) is the conventional transurethral resection of bladder tumor (CTURBT), but the en bloc transurethral resection of bladder tumor (ERBT) has been gaining more attraction in recent years considering better specimen integrity. (bvsalud.org)
  • SCLC accounts for approximately 15% of bronchogenic carcinomas. (cancer.gov)
  • We investigated if overall survival (OS) and progression free survival (PFS) correlates with targeted next-generation sequencing (TNGS) results in LCNEC treated with NSCLC-ct or SCLC-ct. (nrs-science.nl)